Preprints (not yet peer-reviewed)

230 downloads
359 views

The rapid decrease in DNA sequencing cost is revolutionizing medicine and science. In medicine, genome sequencing has revealed millions of missense variants that change protein sequences, yet we only understand the molecular and phenotypic consequences of a small...

["Bioinformatics","Biophysics","Computational Biology","Genomics","Medical Genetics"]
doi:10.7287/peerj.preprints.27379v1
25 downloads
81 views

The exploring of biological processes in vitro under conditions of macromolecular crowding is a way to achieve an understanding of how these processes occur in vivo. In this work, we study the unfolding of the fluorescent probe iRFP713 in crowded environment in...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7287/peerj.preprints.27368v1
40 downloads
86 views

Tuberculosis (TB) has a long history as a major disease in humans and animals. New resistant strains are jeopardizing the advances in the battle against TB. 40% of HIV deaths occur due to concurrent TB illness. A causative agent of TB, Mycobacterium tuberculosis,...

["Biophysics","Infectious Diseases"]
doi:10.7287/peerj.preprints.27351v1
60 downloads
103 views

Multiple associative learning events can take place within sub-second time and the "completed" mechanism can then be used for specific memory retrieval without any lapse of time. This indicates that a biological process is completed within the matching time-scales...

["Animal Behavior","Biophysics","Neuroscience","Cognitive Disorders","Computational Science"]
doi:10.7287/peerj.preprints.27343v1
240 downloads
316 views

Possible combinations of inputs in the order of 10100 can fire (axonal spike or action potential) a neuron that has nearly 104 inputs (dendritic spines). This extreme degeneracy of inputs that can fire a neuron is associated with significant loss of information...

["Biophysics","Computational Biology","Neuroscience","Cognitive Disorders","Computational Science"]
doi:10.7287/peerj.preprints.27228v4
123 downloads
294 views

The study of animal locomotion can be logistically challenging, especially in the case of large or unhandleable animals in uncontrolled environments. Recent technological advances have permitted the use of Global Positioning System and inertial sensors in locomotion...

["Biophysics","Zoology"]
doi:10.7287/peerj.preprints.27310v1
350 downloads
611 views

The actin cytoskeleton comprises a set of filament networks that perform essential functions in eukaryotic cells. The idea that actin filaments incorporate monomers directly from solution forms both the “textbook picture” of filament elongation and a conventional...

["Biochemistry","Biophysics","Cell Biology"]
doi:10.7287/peerj.preprints.27254v1
92 downloads
138 views

Understanding how biological systems convert and store energy is a primary goal of biological research. However, despite the formulation of Mitchell’s chemiosmotic theory, which allowed taking fundamental steps forward, we are still far from the complete decryption...

["Biochemistry","Biophysics"]
doi:10.7287/peerj.preprints.27241v1
51 downloads
149 views

Butterflies can directly absorb heat from the sun via their wings to facilitate autonomous flight. However, how is the heat absorbed by the butterfly from sunlight stored and transmitted in the wing? The scientifc question remains unclear. Thus, in this study,...

["Animal Behavior","Biophysics","Entomology"]
doi:10.7287/peerj.preprints.27200v1
141 downloads
673 views

Background. To gain a greater insight into normal and laminitic hoof growth and to be able to make comparisons between the two groups. Methods. Ten normal and three laminitic equines completed the survey, each hoof was marked with a horizontal file mark in three...

["Biophysics","Veterinary Medicine"]
doi:10.7287/peerj.preprints.26992v2
45 downloads
145 views

Intact biomolecules carry its identity through its atomic constituents and mass, while fragmented biomolecules require reconstruction for their identity to be retrieved. Hence, for profiling biomolecules in mixtures, the goal would be the gentle ionization of biomolecules...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.26983v1
77 downloads
231 views

Protein sites present different amino acids during their evolution, whose number reflects the selective constraints operating on them. This evolutionary variability is strongly influenced by the structural properties of the site in the native structure, and it...

["Bioinformatics","Biophysics","Computational Biology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.26868v1
650 downloads
1,627 views

Physiological mechanisms for passive and active transmembrane transport have been theoretically described using many different approaches. A generic formulation for both passive and active transmembrane transport, is derived from basic thermodynamical principles...

["Biophysics","Mathematical Biology","Neuroscience"]
doi:10.7287/peerj.preprints.1312v8
80 downloads
211 views

New technological approaches in marine ecology, such as (1) passive acoustics to characterize underwater soundscapes, and (2) habitat photogrammetry, which provides high-res, 3D images of habitats, can facilitate efficient and accurate assessments of coral reefs....

["Aquaculture, Fisheries and Fish Science","Biodiversity","Biophysics","Conservation Biology","Marine Biology"]
doi:10.7287/peerj.preprints.26720v1
99 downloads
212 views

Proteins and metabolites typically adsorb to bacterial cell surface through a variety of mechanisms such as van der Waals attraction and electrostatic interactions, and forms a layer of nonspecifically adsorbed ions and molecules on the cell surface. Thus, the...

["Biochemistry","Biophysics","Biotechnology","Microbiology","Biogeochemistry"]
doi:10.7287/peerj.preprints.26697v1
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