Preprints (not yet peer-reviewed)

17 downloads
88 views

In recent years, the pharmaceutical industry has been confronted with rising R&D costs paired with decreasing productivity. Attrition rates for new molecules are tremendous, with a substantial number of molecules failing in an advanced stage of development. Repositioning...

["Bioinformatics","Drugs and Devices","Computational Science","Data Mining and Machine Learning","Data Science"]
doi:10.7287/peerj.preprints.27002v1
34 downloads
136 views

Antibodies are proteins generated by the adaptive immune system to recognize and counteract a plethora of pathogens through specific binding. This adaptive binding is mediated by structural diversity in the six complementary determining region (CDR) loops (H1,...

["Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.26996v1
74 downloads
198 views

Aggression is a serious behavioral disorder in domestic dogs that endangers both dogs and humans. The underlying causes of canine aggression are poorly resolved and require illumination to ensure effective therapy. Recent research links the compositional diversity...

["Animal Behavior","Bioinformatics","Microbiology"]
doi:10.7287/peerj.preprints.26990v1
24 downloads
117 views

Background. Intramuscular fat (IMF) is an important economic trait for pork quality and a complex quantitative trait regulated by multiple genes. The objective of this work was to investigate the novel transcriptional effects of a multigene pathways on IMF deposition...

["Agricultural Science","Bioinformatics","Molecular Biology"]
doi:10.7287/peerj.preprints.26976v1
34 downloads
201 views

Bacterial small non-coding RNAs (sRNAs) are involved in the control of several cellular processes. Hundreds of putative sRNAs have been identified in many bacterial species through RNA sequencing. The existence of putative sRNAs is usually validated by Northern...

["Bioinformatics","Microbiology","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.26974v1
129 downloads
418 views

The most abundant and ubiquitous microbes in the surface ocean use light as an energy source, capturing it via complex chlorophyll-based photosystems or simple retinal-based rhodopsins. Studies in various ocean regimes compared the abundance of these mechanisms,...

["Biodiversity","Bioinformatics","Ecology","Microbiology","Biological Oceanography"]
doi:10.7287/peerj.preprints.26950v1
73 downloads
233 views

Biodiversity information is made available through numerous databases that each have their own data models, web services, and data types. Combining data across databases leads to new insights, but is not easy because each database uses its own system of identifiers....

["Bioinformatics","Databases"]
doi:10.7287/peerj.preprints.26951v1
57 downloads
104 views

Flow cytometry (FCM) is a powerful analytical tool that is widely used worldwide, as it allows the depiction of the innate complexity of a vast range of biological systems in few seconds. It is a technique based on the spectroscopic properties of suspended particles...

["Bioinformatics","Computational Biology","Ecology","Ecosystem Science","Data Science"]
doi:10.7287/peerj.preprints.26934v1
159 downloads
332 views

Microbes are identified based on their distinguishing characteristics such as gene sequence or metabolic profile. Nucleic acid approaches such as 16S rRNA gene sequencing provide the gold standard method for microbial identification in the contemporary era. However,...

["Biochemistry","Bioinformatics","Biotechnology","Computational Biology","Microbiology"]
doi:10.7287/peerj.preprints.3524v2
141 downloads
471 views

Statistical books are an opportunity for accessing relatively deeper insights into statistics and software even outside the introductory classroom setting. There are however many resources available to the practitioner in addition to the traditional text model....

["Bioinformatics","Computer Education","Data Science","Programming Languages"]
doi:10.7287/peerj.preprints.26924v1
54 downloads
122 views

This paper discusses the difficulties experienced by bioinformaticians while working with extensive data generated from extended molecular dynamics simulations. For better experimental analysis, it often becomes crucial to conduct simulations up to extended periods...

["Bioinformatics","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.26920v1
150 downloads
485 views

Background. Comparative genomics between closely related bacterial strains can distinguish important features determining pathogenesis, antibiotic resistance, and phylogenetic structure. The Streptococcus genus is relevant to public health and food safety and it...

["Biodiversity","Bioinformatics","Genomics","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26665v2
180 downloads
892 views

Studies involving gut microbiome analysis play an increasing role in the evaluation of health and disease in humans and animals alike. Fecal sampling methods for DNA preservation in laboratory, clinical, and field settings can greatly influence inferences of microbial...

["Biodiversity","Bioinformatics","Genomics","Microbiology","Veterinary Medicine"]
doi:10.7287/peerj.preprints.26912v1
400 downloads
1,170 views

Low-cost Illumina sequencing of clinically-important bacterial pathogens has generated thousands of publicly available genomic datasets. Analyzing these genomes and extracting relevant information for each pathogen and the associated clinical phenotypes requires...

["Bioinformatics","Genomics","Infectious Diseases","Public Health"]
doi:10.7287/peerj.preprints.26890v2
71 downloads
117 views

Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions by targeting host mRNAs. To date, hundreds of xeno-miRNAs...

["Bioinformatics","Computational Biology","Genetics","Genomics","Parasitology"]
doi:10.7287/peerj.preprints.26887v1
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