Preprints (not yet peer-reviewed)

311 downloads
293 views

In the fifty years since Evarts first recorded single neurons in motor cortex of behaving monkeys, great effort has been devoted to understanding their relation to movement. Yet these single neurons exist within a vast network, the nature of which has been largely...

["Bioengineering","Neuroscience","Computational Science","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.27217v1
57 downloads
104 views

Microbes live in communities known as biofilm on many surfaces. Thus, understanding the spatially-resolved intercellular communication and signalling link would be important to elucidate the fundamental mechanisms that govern the division of labour within biofilm...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27117v1
202 downloads
453 views

Background The Human hand can perform a range of manipulation tasks, from holding a pen to holding a hammer. Central Nervous System (CNS) uses different strategies in different manipulation tasks based on task requirements. Several attempts to compare postures...

["Bioengineering","Neuroscience","Kinesiology","Computational Science"]
doi:10.7287/peerj.preprints.3080v2
43 downloads
109 views

Large culture volume in bioreactor necessitates aeration for providing sufficient oxygen for cell growth. Thus, extend of aeration and amount of anti-foam needed for suppressing foam formation are key parameters determining the success of bioreactor fermentation....

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27014v1
747 downloads
1,414 views

Many pressing medical challenges - such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers - have long been hindered by limitations in our ability to quantify proteins in single cells. Mass-spectrometry (MS) is poised to...

["Bioengineering","Biotechnology","Cell Biology","Computational Biology","Genomics"]
doi:10.7287/peerj.preprints.26821v2
35 downloads
133 views

Intact biomolecules carry its identity through its atomic constituents and mass, while fragmented biomolecules require reconstruction for their identity to be retrieved. Hence, for profiling biomolecules in mixtures, the goal would be the gentle ionization of biomolecules...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.26983v1
99 downloads
256 views

Clustered regularly interspersed short palindromic repeats (CRISPR) is a natural defense system for bacteria and archaea against foreign DNA and RNA. Specifically, short snippets of foreign DNA or RNA are incorporated into protospacer adjacent motif (PAM) repeats...

["Biochemistry","Bioengineering","Biotechnology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26975v1
238 downloads
148 views

LB Lennox medium is commonly used for bacterial cell culture, but the amount of biomass obtained while sufficient for molecular biology and biochemical studies, is insufficient for applied microbiology research. Thus, supplementation of LB Lennox with glucose is...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.26949v1
68 downloads
152 views

Coping with nutritional stress is essential for cell survival, of which many strategies at the cellular level lend support for ensuring the survival of the population at a particular habitat. One postulated mechanism is swarming motility in bacterial cells, where,...

["Biochemistry","Bioengineering","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26914v1
76 downloads
318 views

We present PromoterPredict, a dynamic multiple regression approach to predict the strength of Escherichia coli promoters binding the σ70 factor of RNA polymerase. σ70 promoters are ubiquitously used in recombinant DNA technology, but characterizing their strength...

["Bioengineering","Bioinformatics","Biotechnology","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.26759v2
83 downloads
161 views

Polyethylene glycol is commonly used in fermentations as an anti-foam for preventing the rise of foam to the top plate of the bioreactor, which increases contamination risk. However, its potential toxicity to growth of various microorganisms is not well understood...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.26817v1
70 downloads
319 views

Background. Entolimod is a Salmonella enterica flagellin derivate. Previous work has demonstrated that entolimod effectively protects mice and non-human primates from ionizing radiation. However, it caused a “flu-like” syndrome after radioprotective and anticancer...

["Biochemistry","Bioengineering","Biotechnology"]
doi:10.7287/peerj.preprints.26803v1
79 downloads
205 views

The production of lignocellulosic ethanol is one of the most promising alternatives to fossil fuels, however, this technology still faces many challenges related to the viability of the alcohol in the market. In this paper the endocarp of buriti fruit was assessed...

["Agricultural Science","Bioengineering","Food, Water and Energy Nexus"]
doi:10.7287/peerj.preprints.26777v1
249 downloads
165 views

Background. Brain function requires a coordinated flow of information among functionally specialized areas. Quantitative methods provide a multitude of metrics to quantify the oscillatory interactions measured by invasive or non-invasive recording techniques. Granger...

["Bioengineering","Neuroscience"]
doi:10.7287/peerj.preprints.26703v1
183 downloads
161 views

Currently, a variety of display technologies have been developed in the life science field, such as phage display, ribosome display, and yeast display. Many studies have found that display technologies are powerful and universal methods when they are combined with...

["Bioengineering","Biotechnology","Molecular Biology"]
doi:10.7287/peerj.preprints.26702v1
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