Preprints (not yet peer-reviewed)

331 downloads
642 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.3094v2
30 downloads
108 views

Characterized by high blood glucose concentration, resistance of cells to glucose uptake and reduced insulin sensitivity, Type II diabetes is a major health problem afflicting both developing and developed countries in increasing extent as populations around the...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Internal Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27024v1
23 downloads
88 views

Large culture volume in bioreactor necessitates aeration for providing sufficient oxygen for cell growth. Thus, extend of aeration and amount of anti-foam needed for suppressing foam formation are key parameters determining the success of bioreactor fermentation....

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27014v1
58 downloads
156 views

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects...

["Biochemistry","Bioinformatics","Cell Biology","Neuroscience","Evidence Based Medicine"]
doi:10.7287/peerj.preprints.27003v1
55 downloads
178 views

The processes of association and dissociation of ribosomal subunits are of great importance for the protein biosynthesis. The mechanistic details of these processes, however, are not well known. In bacteria, upon translation termination, ribosome dissociates into...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.26997v1
235 downloads
318 views

The existence of eukaryotic ribosomes with distinct ribosomal protein (RP) stoichiometry and regulatory roles in protein synthesis been speculated for over sixty years. Recent advances in mass spectrometry and high throughput analysis have begun to identify and...

["Biochemistry","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.26991v1
24 downloads
112 views

Intact biomolecules carry its identity through its atomic constituents and mass, while fragmented biomolecules require reconstruction for their identity to be retrieved. Hence, for profiling biomolecules in mixtures, the goal would be the gentle ionization of biomolecules...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.26983v1
86 downloads
229 views

Clustered regularly interspersed short palindromic repeats (CRISPR) is a natural defense system for bacteria and archaea against foreign DNA and RNA. Specifically, short snippets of foreign DNA or RNA are incorporated into protospacer adjacent motif (PAM) repeats...

["Biochemistry","Bioengineering","Biotechnology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26975v1
34 downloads
135 views

Growth in minimal salts medium meant that a microorganism has the full repertoire of biosynthetic machinery for surviving in habitats lacking in vitamins and growth factors. This significantly expands the types of habitats suitable for colonization by the microbe....

["Biochemistry","Biotechnology","Cell Biology","Ecology","Microbiology"]
doi:10.7287/peerj.preprints.26970v1
160 downloads
105 views

LB Lennox medium is commonly used for bacterial cell culture, but the amount of biomass obtained while sufficient for molecular biology and biochemical studies, is insufficient for applied microbiology research. Thus, supplementation of LB Lennox with glucose is...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.26949v1
122 downloads
487 views

Background. Carnivorous plants have been fascinating researchers with their unique characters and bioinspired applications. These include medicinal trait of some carnivorous plants with potentials for pharmaceutical industry. Methods. This review will cover recent...

["Biochemistry","Biotechnology","Genomics","Plant Science"]
doi:10.7287/peerj.preprints.26940v1
90 downloads
116 views

Circular RNA (CircRNA) is an endogenous noncoding RNA with covalently closed cyclic structure. It is divided into exonic circRNA, intronic circRNA and exon-intron circRNA, based on their components. CircRNAs are well conserved in sequence and abundantly expressed...

["Biochemistry","Cell Biology"]
doi:10.7287/peerj.preprints.26936v1
184 downloads
345 views

Microbes are identified based on their distinguishing characteristics such as gene sequence or metabolic profile. Nucleic acid approaches such as 16S rRNA gene sequencing provide the gold standard method for microbial identification in the contemporary era. However,...

["Biochemistry","Bioinformatics","Biotechnology","Computational Biology","Microbiology"]
doi:10.7287/peerj.preprints.3524v2
46 downloads
127 views

Coping with nutritional stress is essential for cell survival, of which many strategies at the cellular level lend support for ensuring the survival of the population at a particular habitat. One postulated mechanism is swarming motility in bacterial cells, where,...

["Biochemistry","Bioengineering","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26914v1
120 downloads
143 views

Temperature affects growth of bacteria by influencing enzyme and growth kinetics. Specifically, evolution selects for specific temperature range in which a microbe could thrive, and thus fix the temperature range in which biomolecule structure and function are...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26901v1
What is a PeerJ Preprint?

A PeerJ Preprint is a draft of an article, abstract, or poster that has not yet been peer-reviewed for formal publication. Submit a draft, incomplete, or final version of your work for free.

Submissions today can be approved by Editorial Staff and online in 24 hours.

Establish precedent. Solicit feedback. Publish updates.

Refine by manuscript type

Top subject areas - Preprints

Top subject areas - People

View all subject areas