Preprints (not yet peer-reviewed)

25 downloads
81 views

The exploring of biological processes in vitro under conditions of macromolecular crowding is a way to achieve an understanding of how these processes occur in vivo. In this work, we study the unfolding of the fluorescent probe iRFP713 in crowded environment in...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7287/peerj.preprints.27368v1
51 downloads
115 views

Background. Methylmalonic acidemia is a rare inborn error of metabolism caused by mutations in methylmalonyl−CoA mutase (MUT) gene. As intermediate of propionate metabolism, MUT converts methylmalonyl−CoA into succinyl−CoA, which enters the Krebs cycle. Downstream...

["Biochemistry","Bioinformatics","Biotechnology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27335v1
29 downloads
109 views

Several programs have been developed that are able to replace a residue with another one in a protein structure, but usually they are not able to simulate the short- and long-range effects of a real single point mutation. We tested if the approach of re-modelling...

["Biochemistry","Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.27326v1
31 downloads
85 views

The prediction of the stability of a protein is a very important issue in computational biology. Indeed, missense mutations are frequently associated to a change in protein stability, leading usually to destabilization, unfolding and aggregation. However, the direct...

["Biochemistry","Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.27319v1
350 downloads
611 views

The actin cytoskeleton comprises a set of filament networks that perform essential functions in eukaryotic cells. The idea that actin filaments incorporate monomers directly from solution forms both the “textbook picture” of filament elongation and a conventional...

["Biochemistry","Biophysics","Cell Biology"]
doi:10.7287/peerj.preprints.27254v1
87 downloads
153 views

Background: Limited study on different organs of Diospyros kaki in biochemical figure of Pakistani plants still require considerable research activities due to its remarkable antioxidant properties. Objective: This study was an effort to characterize antioxidant...

["Biochemistry","Plant Science"]
doi:10.7287/peerj.preprints.27245v1
92 downloads
138 views

Understanding how biological systems convert and store energy is a primary goal of biological research. However, despite the formulation of Mitchell’s chemiosmotic theory, which allowed taking fundamental steps forward, we are still far from the complete decryption...

["Biochemistry","Biophysics"]
doi:10.7287/peerj.preprints.27241v1
165 downloads
297 views

Life is essentially an organised network of chemical reactions (metabolic pathways) that can create copies of itself given a source of energy. How was this complex reaction network formed from the simple molecules that were present on the early Earth? I will answer...

["Biochemistry"]
doi:10.7287/peerj.preprints.27233v1
55 downloads
129 views

Tropomodulins (Tmods) are proteins that cap the slow growing (pointed) ends of actin filaments (F-actin). The basis for our current understanding of Tmod function comes from studies in cells with relatively stable and highly organized F-actin networks, leading...

["Biochemistry","Cell Biology","Molecular Biology","Anatomy and Physiology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.27172v1
78 downloads
121 views

Microbes live in communities known as biofilm on many surfaces. Thus, understanding the spatially-resolved intercellular communication and signalling link would be important to elucidate the fundamental mechanisms that govern the division of labour within biofilm...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27117v1
517 downloads
847 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.3094v2
51 downloads
160 views

Characterized by high blood glucose concentration, resistance of cells to glucose uptake and reduced insulin sensitivity, Type II diabetes is a major health problem afflicting both developing and developed countries in increasing extent as populations around the...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Internal Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27024v1
66 downloads
124 views

Large culture volume in bioreactor necessitates aeration for providing sufficient oxygen for cell growth. Thus, extend of aeration and amount of anti-foam needed for suppressing foam formation are key parameters determining the success of bioreactor fermentation....

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27014v1
96 downloads
273 views

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects...

["Biochemistry","Bioinformatics","Cell Biology","Neuroscience","Evidence Based Medicine"]
doi:10.7287/peerj.preprints.27003v1
130 downloads
296 views

The processes of association and dissociation of ribosomal subunits are of great importance for the protein biosynthesis. The mechanistic details of these processes, however, are not well known. In bacteria, upon translation termination, ribosome dissociates into...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.26997v1
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