Preprints (not yet peer-reviewed)

26 downloads
201 views

Previously, we revealed that several kampo medicines that are used for patients with excess and/or medium patterns [kakkonto (TJ-1), shosaikoto (TJ-9), hangeshashinto (TJ-14), and orento (TJ-120)] reduced prostaglandin (PG)E<2 levels using LPS-treated human gingival...

["Cell Biology","Dentistry","Pharmacology"]
doi:10.7287/peerj.preprints.3227v2
12 downloads
119 views

Background. Microdialysis is a valued method to study the pharmacokinetics of drug distribution from an injection site or to a tumor site. The objective of this study was to assess the feasibility of prolonged use of subcutaneously implanted microdialysis catheters...

["Drugs and Devices","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.3324v1
68 downloads
145 views

Backgroud. Mercuric sulfide (HgS) has been used in traditional medicines for thousands of years, such as cinnabar, Zuotai and so on. Increasing research supports that HgS is different from mercury chloride (HgCl2) and methylmercury (MeHg) in toxicity and pharmacology,...

["Toxicology","Pharmacology"]
doi:10.7287/peerj.preprints.3308v1
15 downloads
244 views

Background: Drugs for dementia have been available in England from 1997. Since their launch, there have been several changes to national guidelines and initiatives that may have influenced prescribing. These include changes in National Institute for health and...

["Neuroscience","Epidemiology","Pharmacology","Statistics"]
doi:10.7287/peerj.preprints.3238v1
56 downloads
173 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.3094v1
102 downloads
260 views

Abstract Ginsenoside Rk1 (G-Rk1) is one of the unique components created by processing ginseng at high temperature, in particular of Sun Ginseng (SG). The aim of our study was to systematically review the pharmacological effects of G-Rk1.we conducted our search...

["Plant Science","Evidence Based Medicine","Pharmacology"]
doi:10.7287/peerj.preprints.3013v1
381 downloads
534 views

In this review, we present a summary of how computer modeling has been used in the development of covalent modifier drugs. Covalent modifier drugs bind by forming a chemical bond with their target. This covalent binding can improve the selectivity of the drug for...

["Biochemistry","Bioinformatics","Biophysics","Pharmacology","Computational Science"]
doi:10.7287/peerj.preprints.2857v2
38 downloads
194 views

Propofol is an intravenous anesthetic commonly used due to its favorable pharmacokinetic and pharmacodynamic profile. There are discrepancies in the literature about the most appropriate sample for determining propofol concentrations. Although plasma has been used...

["Veterinary Medicine","Pharmacology"]
doi:10.7287/peerj.preprints.2885v1
45 downloads
272 views

Background. Osteoarthritis is the leading cause of chronic joint pain, causing important productivity and economic losses. It is believed that peripheral and centralized sensitization play a role in the creation and maintenance of a chronic painful state. Different...

["Anaesthesiology and Pain Management","Pharmacology","Rheumatology","Translational Medicine"]
doi:10.7287/peerj.preprints.2704v1
21 downloads
221 views

The biological activities of quinoxalone, a novel small molecular substance isolated from the broth of the myxobacterium Stigmatella eracta WXNXJ-B, was investigated. This study was designed to determine the anti-proliferative, apoptotic property of quinoxalone,...

["Biotechnology","Microbiology","Pharmacology"]
doi:10.7287/peerj.preprints.2703v1
26 downloads
197 views

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance...

["Cardiology","Pharmacology"]
doi:10.7287/peerj.preprints.2641v1
51 downloads
295 views

Benign prostatic hyperplasia is a common disease in men aged over 50 years old, with an incidence increasing to more than 80% over the age of 70, that is increasingly going to attract pharmaceutical interest. Within conventional therapies, such as α-adrenoreceptor...

["Computational Biology","Pharmacology"]
doi:10.7287/peerj.preprints.2543v1
50 downloads
269 views

The study of subjective, first-person experience is a topic with both philosophical and practical implications. In this article, I discuss the value of collecting a critical mass of prose or verbal descriptions of introspectively determined, subjective effects...

["Toxicology","Evidence Based Medicine","Neurology","Pharmacology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2424v1
207 downloads
383 views

The late detection of non-genotoxic carcinogens in the drug development process can delay drug candidates for unmet medical needs from reaching the market despite considerable investments in their development. To enable faster, safer, and less expensive development...

["Bioinformatics","Computational Biology","Molecular Biology","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.2393v1
108 downloads
257 views

This study examined developmental toxicity of different mercury compounds, including some used in traditional medicines. Medaka (Oryzias latipes) embryos were exposed to 0.001-10 μM concentrations of MeHg, HgCl2, α-HgS (Zhu Sha), and β-HgS (Zuotai) from stage 10...

["Aquaculture, Fisheries and Fish Science","Developmental Biology","Toxicology","Pharmacology","Public Health"]
doi:10.7287/peerj.preprints.2329v1
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