Preprints (not yet peer-reviewed)

137 downloads
416 views

In this review, we present a summary of how computer modeling has been used in the development of covalent modifier drugs. Covalent modifier drugs bind by forming a chemical bond with their target. This covalent binding can improve the selectivity of the drug for...

["Biochemistry","Bioinformatics","Biophysics","Pharmacology","Computational Science"]
doi:10.7287/peerj.preprints.2857v2
16 downloads
130 views

Propofol is an intravenous anesthetic commonly used due to its favorable pharmacokinetic and pharmacodynamic profile. There are discrepancies in the literature about the most appropriate sample for determining propofol concentrations. Although plasma has been used...

["Veterinary Medicine","Pharmacology"]
doi:10.7287/peerj.preprints.2885v1
31 downloads
130 views

Background. Osteoarthritis is the leading cause of chronic joint pain, causing important productivity and economic losses. It is believed that peripheral and centralized sensitization play a role in the creation and maintenance of a chronic painful state. Different...

["Anaesthesiology and Pain Management","Pharmacology","Rheumatology","Translational Medicine"]
doi:10.7287/peerj.preprints.2704v1
10 downloads
115 views

The biological activities of quinoxalone, a novel small molecular substance isolated from the broth of the myxobacterium Stigmatella eracta WXNXJ-B, was investigated. This study was designed to determine the anti-proliferative, apoptotic property of quinoxalone,...

["Biotechnology","Microbiology","Pharmacology"]
doi:10.7287/peerj.preprints.2703v1
18 downloads
148 views

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance...

["Cardiology","Pharmacology"]
doi:10.7287/peerj.preprints.2641v1
43 downloads
218 views

Benign prostatic hyperplasia is a common disease in men aged over 50 years old, with an incidence increasing to more than 80% over the age of 70, that is increasingly going to attract pharmaceutical interest. Within conventional therapies, such as α-adrenoreceptor...

["Computational Biology","Pharmacology"]
doi:10.7287/peerj.preprints.2543v1
32 downloads
221 views

The study of subjective, first-person experience is a topic with both philosophical and practical implications. In this article, I discuss the value of collecting a critical mass of prose or verbal descriptions of introspectively determined, subjective effects...

["Toxicology","Evidence Based Medicine","Neurology","Pharmacology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2424v1
168 downloads
286 views

The late detection of non-genotoxic carcinogens in the drug development process can delay drug candidates for unmet medical needs from reaching the market despite considerable investments in their development. To enable faster, safer, and less expensive development...

["Bioinformatics","Computational Biology","Molecular Biology","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.2393v1
73 downloads
194 views

This study examined developmental toxicity of different mercury compounds, including some used in traditional medicines. Medaka (Oryzias latipes) embryos were exposed to 0.001-10 μM concentrations of MeHg, HgCl2, α-HgS (Zhu Sha), and β-HgS (Zuotai) from stage 10...

["Aquaculture, Fisheries and Fish Science","Developmental Biology","Toxicology","Pharmacology","Public Health"]
doi:10.7287/peerj.preprints.2329v1
821 downloads
352 views

Zebrafish (Danio rerio) have emerged as a popular model for studying pharmacological effects on behavior and anxiety. While there have been numerous studies documenting the anxiolytic and anxiogenic effects of common drugs in zebrafish, many do not report or test...

["Animal Behavior","Zoology","Pharmacology"]
doi:10.7287/peerj.preprints.1718v3
126 downloads
246 views

A 6-year-old female Shetland Sheepdog with a history of cardiorespiratory compromise during general anaesthesia was referred for ovariohysterectomy surgery. Clinical examination was unremarkable at presentation and physiologic parameters under general anaesthesia...

["Veterinary Medicine","Allergy and Clinical Immunology","Anaesthesiology and Pain Management","Emergency and Critical Care","Pharmacology"]
doi:10.7287/peerj.preprints.2275v1
213 downloads
176 views

The present study aimed to characterize a lactic acid bacterium Pediococcus pentosaceus 4I1, isolated from the intestine of fresh water fish sample Zacco koreanus. Biochemical analysis using the API 50 CHL kit and molecular characterization of 4I1 revealed its...

["Food Science and Technology","Microbiology","Pharmacology"]
doi:10.7287/peerj.preprints.2121v1
107 downloads
207 views

N-Acetyl-p-Aminophenol (APAP), aka acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes of acute...

["Food Science and Technology","Neuroscience","Toxicology","Pathology","Pharmacology"]
doi:10.7287/peerj.preprints.2063v1
51 downloads
247 views

A lot of literature show that social isolation stress could be a key reason that leads to cognitive deficits for both humans and rodent models; however, the detailed mechanisms are still not clear completely. ADAR1 (Adenosine deaminase acting on RNA) is an enzyme...

["Animal Behavior","Biochemistry","Neuroscience","Toxicology","Pharmacology"]
doi:10.7287/peerj.preprints.1997v1
544 downloads
1,123 views

The Zika virus is the primary suspect in the large increase in microcephaly cases in 2015-6 in Brazil, however its role is unconfirmed despite individual cases of viral infections found in neural tissue. Here we consider the alternative that the insecticide pyriproxyfen,...

["Toxicology","Pharmacology","Public Health","Science Policy"]
doi:10.7287/peerj.preprints.1959v1
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