Preprints (not yet peer-reviewed)

15 downloads
90 views

The identification of Parrot bornaviruses in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease since not all infected birds develop clinical signs. One hypothesis suggests that...

["Veterinary Medicine","Virology","Pathology"]
doi:10.7287/peerj.preprints.2852v1
112 downloads
116 views

Background: Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study we explore the attributes...

["Bioengineering","Biophysics","Oncology","Pathology","Histology"]
doi:10.7287/peerj.preprints.2549v1
210 downloads
416 views

Visual medical analogies have been utilized by multiple medical disciplines for decades. Despite misgivings that some might have about such analogies, they act as excellent learning aids and will undoubtedly remain useful for decades to come. The microscope from...

["Pathology"]
doi:10.7287/peerj.preprints.2147v2
105 downloads
194 views

N-Acetyl-p-Aminophenol (APAP), aka acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes of acute...

["Food Science and Technology","Neuroscience","Toxicology","Pathology","Pharmacology"]
doi:10.7287/peerj.preprints.2063v1
65 downloads
208 views

Bladder Cancer is one of the most frequent human cancer which develops on two tracks, papillary and non-papillary that correspond to clinically different forms of the disease. Most bladder cancers are chemically induced with tobacco smoking being the leading risk...

["Genomics","Molecular Biology","Pathology","Urology"]
doi:10.7287/peerj.preprints.1778v1
130 downloads
177 views

Phenotypic characterization of cellular responses in equine infectious encephalitides has had limited description of both peripheral and resident cell populations in central nervous system (CNS) tissues due to limited species-specific reagents that react with formalin-fixed,...

["Veterinary Medicine","Infectious Diseases","Pathology","Histology"]
doi:10.7287/peerj.preprints.1641v1
308 downloads
324 views

Purpose. Type 2 diabetes is the leading cause of end stage renal disease in the United States. Atherosclerotic renal artery stenosis is commonly observed in diabetic patients and impacts the rate of renal and cardiovascular disease progression. We hypothesized...

["Cardiology","Diabetes and Endocrinology","Nephrology","Pathology","Translational Medicine"]
doi:10.7287/peerj.preprints.1323v2
922 downloads
509 views

Whether obesity is a disease or a risk factor of chronic diseases including diabetes and fatty liver remains debating. We report here that a high-fat diet (HFD) alone or HFD and intramuscular injection of mice with a high dose (1.2 mg/kg) of lipopolysaccharide...

["Diabetes and Endocrinology","Pathology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.1229v1
62 downloads
247 views

Background: In a region of Caribbean states with limited human and financial resources institutions of higher education must use the technology available to reach its students across the region and allow professionals in the Biomedical Sciences to teach, interact...

["Anatomy and Physiology","Pathology","Science and Medical Education"]
doi:10.7287/peerj.preprints.1104v1
143 downloads
421 views

Rothschild (2013) suggested that many of the facial and postcranial scars in tyrannosaurid specimens are in fact caused by claws of the other tyrannosaurids. However, the evidences suggested by Rothschild (2013) are very weak. Tooth marks can have very different...

["Animal Behavior","Ecosystem Science","Paleontology","Zoology","Pathology"]
doi:10.7287/peerj.preprints.980v1
179 downloads
278 views

Previous studies using the Golgi technique have demonstrated alterations in the dendritic morphology of pyramidal neurons of the cerebral cortex of mice inoculated with the rabies virus. However, knowledge about the fine structure of dendrites in rabies infection...

["Neuroscience","Virology","Infectious Diseases","Pathology","Histology"]
doi:10.7287/peerj.preprints.847v1
444 downloads
1,712 views

Adult large-bodied theropods are often found with numerous pathologies. A large, almost complete, probably adult Allosaurus specimen from the Howe Stephens Quarry, Morrison Formation (Late Kimmeridgian–Early Tithonian), Wyoming, shows multiple pathologies. Pathologic...

["Animal Behavior","Paleontology","Veterinary Medicine","Zoology","Pathology"]
doi:10.7287/peerj.preprints.824v1
64 downloads
187 views

Purpose: The authors proposed that introducing real patients into a pathology classroom early in medical education would help integrate fundamental principles and disease pathology with clinical presentation and medical history. Methods: Three patients with different...

["Pathology","Science and Medical Education"]
doi:10.7287/peerj.preprints.744v1
83 downloads
230 views

Histopathology is the most useful tool for diagnosis of a number of diseases, especially cancer. To be effective, histopathology requires that tissues be fixed prior to processing. Formalin is currently the most common histologic fixative, offering many advantages:...

["Veterinary Medicine","Pathology"]
doi:10.7287/peerj.preprints.296v1
95 downloads
297 views

Pendred syndrome (PDS) and DFNB4 comprise a phenotypic spectrum of sensorineural hearing loss disorders that typically result from biallelic mutations of the SLC26A4 gene. Although PDS and DFNB4 are recessively inherited, sequencing of the coding regions and splice...

["Genetics","Medical Genetics","Otorhinolaryngology","Pathology","Pediatrics"]
doi:10.7287/peerj.preprints.275v1
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