Preprints (not yet peer-reviewed)

31 downloads
183 views

Small interference RNA has been widely used to suppress gene expression. Three different short-hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal...

["Neuroscience","Neurology","Pathology"]
doi:10.7287/peerj.preprints.3117v1
39 downloads
172 views

Increased levels of long noncoding RNA H19 (H19) have been observed in many inflammatory and organ fibrosis diseases including ulcerative colitis, osteoarthritis, liver fibrosis, renal fibrosis and pulmonary fibrosis. However, the role of H19 in bovine mastitis...

["Cell Biology","Veterinary Medicine","Pathology"]
doi:10.7287/peerj.preprints.3089v1
23 downloads
145 views

The identification of Parrot bornaviruses in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease since not all infected birds develop clinical signs. One hypothesis suggests that...

["Veterinary Medicine","Virology","Pathology"]
doi:10.7287/peerj.preprints.2852v1
151 downloads
188 views

Background: Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study we explore the attributes...

["Bioengineering","Biophysics","Oncology","Pathology","Histology"]
doi:10.7287/peerj.preprints.2549v1
321 downloads
513 views

Visual medical analogies have been utilized by multiple medical disciplines for decades. Despite misgivings that some might have about such analogies, they act as excellent learning aids and will undoubtedly remain useful for decades to come. The microscope from...

["Pathology"]
doi:10.7287/peerj.preprints.2147v2
116 downloads
246 views

N-Acetyl-p-Aminophenol (APAP), aka acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes of acute...

["Food Science and Technology","Neuroscience","Toxicology","Pathology","Pharmacology"]
doi:10.7287/peerj.preprints.2063v1
79 downloads
276 views

Bladder Cancer is one of the most frequent human cancer which develops on two tracks, papillary and non-papillary that correspond to clinically different forms of the disease. Most bladder cancers are chemically induced with tobacco smoking being the leading risk...

["Genomics","Molecular Biology","Pathology","Urology"]
doi:10.7287/peerj.preprints.1778v1
187 downloads
228 views

Phenotypic characterization of cellular responses in equine infectious encephalitides has had limited description of both peripheral and resident cell populations in central nervous system (CNS) tissues due to limited species-specific reagents that react with formalin-fixed,...

["Veterinary Medicine","Infectious Diseases","Pathology","Histology"]
doi:10.7287/peerj.preprints.1641v1
332 downloads
427 views

Purpose. Type 2 diabetes is the leading cause of end stage renal disease in the United States. Atherosclerotic renal artery stenosis is commonly observed in diabetic patients and impacts the rate of renal and cardiovascular disease progression. We hypothesized...

["Cardiology","Diabetes and Endocrinology","Nephrology","Pathology","Translational Medicine"]
doi:10.7287/peerj.preprints.1323v2
1,021 downloads
625 views

Whether obesity is a disease or a risk factor of chronic diseases including diabetes and fatty liver remains debating. We report here that a high-fat diet (HFD) alone or HFD and intramuscular injection of mice with a high dose (1.2 mg/kg) of lipopolysaccharide...

["Diabetes and Endocrinology","Pathology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.1229v1
68 downloads
293 views

Background: In a region of Caribbean states with limited human and financial resources institutions of higher education must use the technology available to reach its students across the region and allow professionals in the Biomedical Sciences to teach, interact...

["Anatomy and Physiology","Pathology","Science and Medical Education"]
doi:10.7287/peerj.preprints.1104v1
154 downloads
465 views

Rothschild (2013) suggested that many of the facial and postcranial scars in tyrannosaurid specimens are in fact caused by claws of the other tyrannosaurids. However, the evidences suggested by Rothschild (2013) are very weak. Tooth marks can have very different...

["Animal Behavior","Ecosystem Science","Paleontology","Zoology","Pathology"]
doi:10.7287/peerj.preprints.980v1
200 downloads
345 views

Previous studies using the Golgi technique have demonstrated alterations in the dendritic morphology of pyramidal neurons of the cerebral cortex of mice inoculated with the rabies virus. However, knowledge about the fine structure of dendrites in rabies infection...

["Neuroscience","Virology","Infectious Diseases","Pathology","Histology"]
doi:10.7287/peerj.preprints.847v1
503 downloads
1,817 views

Adult large-bodied theropods are often found with numerous pathologies. A large, almost complete, probably adult Allosaurus specimen from the Howe Stephens Quarry, Morrison Formation (Late Kimmeridgian–Early Tithonian), Wyoming, shows multiple pathologies. Pathologic...

["Animal Behavior","Paleontology","Veterinary Medicine","Zoology","Pathology"]
doi:10.7287/peerj.preprints.824v1
69 downloads
219 views

Purpose: The authors proposed that introducing real patients into a pathology classroom early in medical education would help integrate fundamental principles and disease pathology with clinical presentation and medical history. Methods: Three patients with different...

["Pathology","Science and Medical Education"]
doi:10.7287/peerj.preprints.744v1
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