Preprints (not yet peer-reviewed)

21 downloads
99 views

Background. The c-mos proto-oncogene was one of the first proto-oncogenes to be cloned. Apart from its role in meiosis, many efforts have been made to illuminate the mechanisms by which c-mos acts as an oncogene. c-mos or its coding messenger RNA have been confirmed...

["Cell Biology","Oncology"]
doi:10.7287/peerj.preprints.3426v1
79 downloads
340 views

Statistical significance provides evidence for or against an explanation of a population of interest, not a description of data sampled from the population. This simple distinction gets ignored in hundreds of thousands of research publications yearly, which confuse...

["Ecology","Evidence Based Medicine","Oncology","Statistics","Environmental Impacts"]
doi:10.7287/peerj.preprints.3394v1
17 downloads
95 views

While biochemistry evidently affects the growth rate of cells, many biochemists routinely ignore population variation, just like population geneticists usually ignore causal details of biochemistry that underpin a change in growth rate caused by a mutation. A true...

["Biochemistry","Cell Biology","Computational Biology","Oncology","Computational Science"]
doi:10.7287/peerj.preprints.3371v1
253 downloads
1,394 views

Exposure to non-ionizing radiation used in wireless communication remains a contentious topic in the public mind - while the overwhelming scientific evidence to date suggests that microwave and radio frequencies used in modern communications are safe, public apprehension...

["Biophysics","Environmental Sciences","Cognitive Disorders","Oncology","Science and Medical Education"]
doi:10.7287/peerj.preprints.3355v1
16 downloads
126 views

Background. Microdialysis is a valued method to study the pharmacokinetics of drug distribution from an injection site or to a tumor site. The objective of this study was to assess the feasibility of prolonged use of subcutaneously implanted microdialysis catheters...

["Drugs and Devices","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.3324v1
85 downloads
154 views

The mutational processes responsible for the somatic mutations observed in tumor samples can significantly vary not only between tumor types but also among the individual cancers within a tumor class. Mutational processes can be represented by so called “mutational...

["Bioinformatics","Computational Biology","Genomics","Oncology"]
doi:10.7287/peerj.preprints.3257v1
43 downloads
221 views

We previously demonstrated how CITED1 knockdown in melanoma cells had the capacity to perturb expression of a significant number of genes that comprised MITF and several of its known transcriptional targets. This manifest as a switch from a more invasive to a more...

["Cell Biology","Genomics","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.3146v1
20 downloads
243 views

Human papillomavirus type 16 (HPV16) is the most carcinogenic HPV, causing >50% of cervical cancers. Its unique oncogenicity is unsolved, e.g., the second most carcinogenic type (HPV18, causing ~16% of cancers) is relatively distantly related to HPV16. Mirabello...

["Bioinformatics","Evolutionary Studies","Infectious Diseases","Oncology","Women's Health"]
doi:10.7287/peerj.preprints.3070v1
36 downloads
253 views

Cancer development as an ecological and evolutionary process is poorly understood, which includes early cancer evolution, malignancy and metastasis. It was hypothesised that the tumour microenvironment (TME) plays a critical role in this process. Unfortunately,...

["Computational Biology","Ecology","Evolutionary Studies","Genetics","Oncology"]
doi:10.7287/peerj.preprints.3052v1
101 downloads
219 views

In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having...

["Biochemistry","Biotechnology","Oncology"]
doi:10.7287/peerj.preprints.3035v1
192 downloads
332 views

Technology has been a part of everyone’s life for decades now, and its impact on our lifestyle only seems to increase with time. Considering applications in the field of scientific research till date, it has made exponential advancements and created a new hallmark....

["Bioinformatics","Oncology","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.2960v1
64 downloads
334 views

Background: Traditionally, EBRT prostate treatments have been administered using three different techniques: three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). These...

["Oncology","Radiology and Medical Imaging","Translational Medicine"]
doi:10.7287/peerj.preprints.2938v1
150 downloads
254 views

Background: The gamma analysis index (γ) is the most commonly used method to compare a calculated and measured dose distribution. A caveat to the clinical use of γ is that the formalism does have a sensitivity to noise present in either distribution. Monte Carlo...

["Oncology","Radiology and Medical Imaging","Translational Medicine"]
doi:10.7287/peerj.preprints.2904v1
103 downloads
187 views

BACKGROUNDː This article describes the characterization of a new cell line (IRB-1), which was established from an Iranian child with retinoblastoma. METHODSː Using cell culture techniques, we isolated a clonal population from primary Cultures of retinoblastoma...

["Cell Biology","Oncology","Ophthalmology"]
doi:10.7287/peerj.preprints.2780v1
77 downloads
394 views

Background: Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the ablation techniques of electrolytic ablation with cryosurgery. The goal of this study is to examine the hypothesis that electrolysis can take place in...

["Bioengineering","Biophysics","Oncology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.2474v2
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