Preprints (not yet peer-reviewed)

18 downloads
71 views

BACKGROUNDː This article describes the characterization of a new cell line (IRB-1), which was established from an Iranian child with retinoblastoma. METHODSː Using cell culture techniques, we isolated a clonal population from primary Cultures of retinoblastoma...

["Cell Biology","Oncology","Ophthalmology"]
doi:10.7287/peerj.preprints.2780v1
48 downloads
210 views

Background: Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the ablation techniques of electrolytic ablation with cryosurgery. The goal of this study is to examine the hypothesis that electrolysis can take place in...

["Bioengineering","Biophysics","Oncology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.2474v2
40 downloads
84 views

Portraying a robust working-team model in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC) initiative is an interdisciplinary clinical forum promoting the connect-approach across involved disciplines...

["Oncology"]
doi:10.7287/peerj.preprints.2575v1
113 downloads
1,010 views

OncoRank adopts a method for finding recurrent miRNA-target interactions to find genes with consistent relationships to patient survival across cancers. Genes are first ranked in each cancer by their Cox coefficients, and these ranks are then combined by applying...

["Bioinformatics","Genomics","Oncology"]
doi:10.7287/peerj.preprints.2574v1
100 downloads
83 views

Background: Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study we explore the attributes...

["Bioengineering","Biophysics","Oncology","Pathology","Histology"]
doi:10.7287/peerj.preprints.2549v1
36 downloads
97 views

Here we shall apply the approach presented in the paper Dynamics of resource allocation in biological systems in considering resource allocation in cancer cell metabolism, specifically, aerobic glycolysis (Warburg effect). Aerobic glycolysis, the metabolic phenomenon...

["Biochemistry","Cell Biology","Mathematical Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2533v1
85 downloads
201 views

Microbes, particularly viruses, have had a chequered history in cancer research. Considered in the 1960s and 1970s as the main cause of cancers, a decade later microbes were set aside as inconsequential to the field. However, with confirmed links established between...

["Infectious Diseases","Oncology"]
doi:10.7287/peerj.preprints.2448v1
102 downloads
227 views

The late detection of non-genotoxic carcinogens in the drug development process can delay drug candidates for unmet medical needs from reaching the market despite considerable investments in their development. To enable faster, safer, and less expensive development...

["Bioinformatics","Computational Biology","Molecular Biology","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.2393v1
109 downloads
361 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7287/peerj.preprints.2331v1
27 downloads
118 views

Background. Mitotic arrest deficient 2 (Mad2) is a key component of spindle assembly checkpoint and overexpressed in human lung cancers, but the mechanism of the deregulation of Mad2 in lung cancer is largely unknown. We aim to investigate the regulation of Mad2...

["Cell Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2298v1
25 downloads
150 views

Motivation Neuroblastoma (NB) is the most common solid pediatric tumor, deriving from ganglionic lineage precursors of the sympathetic nervous system. Half of the patients with high-risk NB die despite treatment and more accurate outcome prediction models are needed...

["Bioinformatics","Molecular Biology","Oncology","Pediatrics"]
doi:10.7287/peerj.preprints.2263v1
30 downloads
121 views

Cross-contamination of human and animal cell lines is a frequent event. For this reason, the results obtained with the same cell lines by different research groups are often not fully comparable, this leading to main reproducibility issues. The short tandem repeat...

["Bioinformatics","Cell Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2194v1
174 downloads
308 views

Background: Colorectal cancer (CRC) is one of the commonest cancers in Malaysia and majority of the patients will present with advanced disease at diagnosis particularly in cases of proximal CRCs. Little is known about the relationship between the genetic landscape...

["Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2109v1
114 downloads
637 views

While there have been enormous advances in our understanding of the genetic drivers and molecular pathways involved in cancer in recent decades, there also remain key areas of dispute with respect to fundamental theories of cancer. The accumulation of vast new...

["Computational Biology","Oncology","Computational Science"]
doi:10.7287/peerj.preprints.1558v4
51 downloads
155 views

Objective: The aim of this study was to use the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines to evaluate the quality of reporting of recent gastric cancer animal experiments. Materials and Methods: A literature search of studies was performed...

["Veterinary Medicine","Gastroenterology and Hepatology","Oncology","Translational Medicine","Statistics"]
doi:10.7287/peerj.preprints.2049v1
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