Preprints (not yet peer-reviewed)

11 downloads
143 views

We previously demonstrated how CITED1 knockdown in melanoma cells had the capacity to perturb expression of a significant number of genes that comprised MITF and several of its known transcriptional targets. This manifest as a switch from a more invasive to a more...

["Cell Biology","Genomics","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.3146v1
12 downloads
190 views

Human papillomavirus type 16 (HPV16) is the most carcinogenic HPV, causing >50% of cervical cancers. Its unique oncogenicity is unsolved, e.g., the second most carcinogenic type (HPV18, causing ~16% of cancers) is relatively distantly related to HPV16. Mirabello...

["Bioinformatics","Evolutionary Studies","Infectious Diseases","Oncology","Women's Health"]
doi:10.7287/peerj.preprints.3070v1
24 downloads
186 views

Cancer development as an ecological and evolutionary process is poorly understood, which includes early cancer evolution, malignancy and metastasis. It was hypothesised that the tumour microenvironment (TME) plays a critical role in this process. Unfortunately,...

["Computational Biology","Ecology","Evolutionary Studies","Genetics","Oncology"]
doi:10.7287/peerj.preprints.3052v1
53 downloads
121 views

In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having...

["Biochemistry","Biotechnology","Oncology"]
doi:10.7287/peerj.preprints.3035v1
112 downloads
257 views

Technology has been a part of everyone’s life for decades now, and its impact on our lifestyle only seems to increase with time. Considering applications in the field of scientific research till date, it has made exponential advancements and created a new hallmark....

["Bioinformatics","Oncology","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.2960v1
34 downloads
289 views

Background: Traditionally, EBRT prostate treatments have been administered using three different techniques: three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). These...

["Oncology","Radiology and Medical Imaging","Translational Medicine"]
doi:10.7287/peerj.preprints.2938v1
97 downloads
218 views

Background: The gamma analysis index (γ) is the most commonly used method to compare a calculated and measured dose distribution. A caveat to the clinical use of γ is that the formalism does have a sensitivity to noise present in either distribution. Monte Carlo...

["Oncology","Radiology and Medical Imaging","Translational Medicine"]
doi:10.7287/peerj.preprints.2904v1
60 downloads
158 views

BACKGROUNDː This article describes the characterization of a new cell line (IRB-1), which was established from an Iranian child with retinoblastoma. METHODSː Using cell culture techniques, we isolated a clonal population from primary Cultures of retinoblastoma...

["Cell Biology","Oncology","Ophthalmology"]
doi:10.7287/peerj.preprints.2780v1
59 downloads
320 views

Background: Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the ablation techniques of electrolytic ablation with cryosurgery. The goal of this study is to examine the hypothesis that electrolysis can take place in...

["Bioengineering","Biophysics","Oncology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.2474v2
81 downloads
124 views

Portraying a robust working-team model in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC) initiative is an interdisciplinary clinical forum promoting the connect-approach across involved disciplines...

["Oncology"]
doi:10.7287/peerj.preprints.2575v1
221 downloads
2,371 views

OncoRank adopts a method for finding recurrent miRNA-target interactions to find genes with consistent relationships to patient survival across cancers. Genes are first ranked in each cancer by their Cox coefficients, and these ranks are then combined by applying...

["Bioinformatics","Genomics","Oncology"]
doi:10.7287/peerj.preprints.2574v1
129 downloads
160 views

Background: Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study we explore the attributes...

["Bioengineering","Biophysics","Oncology","Pathology","Histology"]
doi:10.7287/peerj.preprints.2549v1
91 downloads
146 views

Here we shall apply the approach presented in the paper Dynamics of resource allocation in biological systems in considering resource allocation in cancer cell metabolism, specifically, aerobic glycolysis (Warburg effect). Aerobic glycolysis, the metabolic phenomenon...

["Biochemistry","Cell Biology","Mathematical Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2533v1
132 downloads
256 views

Microbes, particularly viruses, have had a chequered history in cancer research. Considered in the 1960s and 1970s as the main cause of cancers, a decade later microbes were set aside as inconsequential to the field. However, with confirmed links established between...

["Infectious Diseases","Oncology"]
doi:10.7287/peerj.preprints.2448v1
188 downloads
336 views

The late detection of non-genotoxic carcinogens in the drug development process can delay drug candidates for unmet medical needs from reaching the market despite considerable investments in their development. To enable faster, safer, and less expensive development...

["Bioinformatics","Computational Biology","Molecular Biology","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.2393v1
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