Preprints (not yet peer-reviewed)

75 downloads
123 views

Period of starvation is regarded as a sound practice in aquaculture prior to handling, transportation and harvest, to minimise impacts on welfare and ensure proper hygiene after harvest. However, documentation of welfare issues such as stress following starvation...

["Aquaculture, Fisheries and Fish Science","Veterinary Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2837v1
32 downloads
185 views

Major risk factors for neurodegenerative diseases share brain hypometabolism as one common outcome. In turn, many neurodegenerative pathologies result in brain hypometabolism; both epilepsy and Alzheimer's disease are characterised by disruptions in glucose metabolism....

["Neuroscience","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2521v1
15 downloads
126 views

Here we present a single working model that attempts at reconciliation of biological systems. To do this we recognize and emphasize a universal theme of all biological systems: a need for resources. That is, we consider the dynamics of resource allocation as a...

["Biochemistry","Cell Biology","Mathematical Biology","Anatomy and Physiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2503v1
262 downloads
408 views

“Omics” studies generate long lists of genes, proteins, metabolites or other features which can be difficult to decipher. Feature set enrichment analysis utilizing annotated groups/classes of features (such as pathways, gene ontology terms or gene/metabolic modules)...

["Bioinformatics","Immunology","Statistics","Metabolic Sciences","Computational Science"]
doi:10.7287/peerj.preprints.2420v1
26 downloads
132 views

Background. White adipose tissue (WAT) is a complex, disperse, multifunctional organ which contains adipocytes, and a large proportion of fat, but also other cell types, active in defence, regeneration and signalling functions. Studies with adipocytes often require...

["Cell Biology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2371v1
38 downloads
164 views

It is shown that the mass, metabolism and length explanation (MMLE) can simultaneously compute an animal’s body mass and BMR given its characteristic length using data for humans. MMLE was advanced in 1984 to explain the relationship between metabolic rate and...

["Mathematical Biology","Anatomy and Physiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2182v1
235 downloads
348 views

Nascent, burgeoning, youngest, ‘connecting link between genotype and phenotype’ are just some of the phrases associated with this ‘omics’ where small molecules (metabolites with molecular weight < 2000 Daltons) are studied in biological systems, i.e., metabolomics....

["Bioinformatics","Computational Biology","Plant Science","Metabolic Sciences","Computational Science"]
doi:10.7287/peerj.preprints.2002v1
220 downloads
345 views

The digestive tract of mammals and other animals is colonized by trillions of metabolically active microorganisms. Changes in the gut microbiota have been associated with obesity in both humans and laboratory animals. Dietary modifications can often modulate the...

["Bioinformatics","Food Science and Technology","Microbiology","Nutrition","Metabolic Sciences"]
doi:10.7287/peerj.preprints.1458v1
922 downloads
509 views

Whether obesity is a disease or a risk factor of chronic diseases including diabetes and fatty liver remains debating. We report here that a high-fat diet (HFD) alone or HFD and intramuscular injection of mice with a high dose (1.2 mg/kg) of lipopolysaccharide...

["Diabetes and Endocrinology","Pathology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.1229v1
86 downloads
447 views

It is unclear whether the adipokine chemerin has pro- or anti-inflammatory properties, plays any role in the aetiology of obesity or type 2 diabetes, or whether agonists or antagonists of the chemerin receptor CMKLR1 have potential in the treatment of these diseases....

["Diabetes and Endocrinology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.643v1
40 downloads
212 views

Kv1 channels are shaker-related potassium channels that influence insulin sensitivity. Kv1.3 -/- mice are protected from diet-induced insulin resistance and some studies suggest that Kv1.3 inhibitors provide similar protection. However, it is unclear whether blockade...

["Biochemistry","Diabetes and Endocrinology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.498v1
366 downloads
383 views

Metabolic dysfunction in skeletal muscle is a major contributor to the development of type 2 diabetes. Endurance exercise training has long been established as an effective means to directly restore skeletal muscle glucose and lipid uptake and metabolism. However,...

["Molecular Biology","Diabetes and Endocrinology","Kinesiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.410v1
364 downloads
646 views

New results from control theory allow construction of necessary conditions statistical models of body mass regulation in the context of interaction with a complex dynamic environment. Focusing on the stress-related induction of central obesity via HPA axis regulation,...

["Biophysics","Health Policy","Metabolic Sciences"]
doi:10.7287/peerj.preprints.60v3
482 downloads
392 views

Stressors in everyday life can entail, along with emotional and behavioral reactions, a whole series of physiological reactions at different systematic levels (endocrinological, metabolic, immunological). This is also a cause for the development of stress-associated...

["Internal Medicine","Kinesiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.389v1
270 downloads
256 views

Background: Cardiovascular disease is a major cause of death in the western world. Regular physical activity is known to be highly beneficial for improving cardiovascular health status. Methods:The current abstract is based on the authors own data and a literature...

["Cell Biology","Diabetes and Endocrinology","Epidemiology","Kinesiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.367v1
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