Preprints (not yet peer-reviewed)

150 downloads
500 views

Background: Emergency department (ED) fever management algorithms require the clinician to categorize febrile children as ‘ill’ or ‘not ill’ appearing when determining the risk for serious bacterial illness (SBI). This study describes a natural experiment where...

["Emergency and Critical Care","Infectious Diseases","Pediatrics"]
doi:10.7287/peerj.preprints.527v1
67 downloads
328 views

We demonstrated that the 3-substituted benzothiophene-1,1-dioxide class of compounds are effective inhibitors of Mycobacterium tuberculosis growth under aerobic conditions. We examined substitution at the C-3 position of the benzothiophene-1,1-dioxide series systematically...

["Microbiology","Global Health","Infectious Diseases"]
doi:10.7287/peerj.preprints.502v1
361 downloads
1,403 views

Tuberculosis remains a major global health problem. Laboratory diagnostic methods that allow effective, early detection of cases are central to management of tuberculosis in the individual patient and in the community. Since the 1880s, laboratory diagnosis of tuberculosis...

["Bioinformatics","Genomics","Microbiology","Infectious Diseases","Respiratory Medicine"]
doi:10.7287/peerj.preprints.482v1
76 downloads
426 views

Acinetobacter baumannii is a nosocomial species frequently isolated from the traumatic wounds of injured military personnel and increasingly detected in civilian healthcare facilities. Many clinical isolates of A. baumannii are drug resistant, so new treatments...

["Ecology","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.436v1
247 downloads
518 views

The 2014 World Cup Brazil will create excitement around the globe, but viewership in Africa should be especially high after South Africa 2010 and the growing popularity of football. The time difference and scheduling of matches, however, means that 86% of live...

["Ecology","Infectious Diseases"]
doi:10.7287/peerj.preprints.402v1
248 downloads
569 views

HIV disclosure from parent to child is complex and challenging to HIV-positive parents and healthcare professionals. The purpose of the study was to understand the lived experiences of HIV-positive parents and their children during the disclosure process in Kenya....

["Epidemiology","Global Health","HIV","Infectious Diseases","Public Health"]
doi:10.7287/peerj.preprints.303v2
150 downloads
319 views

Caenorhabditis elegans is commonly used as an infection model for pathogenesis studies in Pseudomonas aeruginosa. While the standard virulence assays rely on the slow and fast killing or paralysis of nematodes, here we developed a behaviour assay to monitor the...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.313v1
1,298 downloads
2,453 views

Recent scientific discoveries lead inexorably to the conclusion that the ‘total human’ incorporates a necessary body of numerous microbes, including bacteria. These bacteria play a very important role in immunity by actively resisting infections by outside bacteria;...

["Ecology","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.236v1
308 downloads
783 views

In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein-­protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases. In particular,...

["Biochemistry","Biophysics","Computational Biology","Virology","Infectious Diseases"]
doi:10.7287/peerj.preprints.138v3
92 downloads
277 views

Mycobacterium species have a complex cAMP regulatory network indicated by the high number of adenylate cyclases annotated in their genomes. However the need for a high level of redundancy in adenylate cyclase genes remains unknown. We have used semiquantitiative...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.177v1
937 downloads
535 views

All strategies to prevent Pneumocystis jiroveci pneumonia (PCP) during rituximab treatment have their rationale in patients with granulomatosis with polyangiitis (GPA) and to some extent in patients with other autoimmune diseases (AID). Risk factors of PCP and...

["Allergy and Clinical Immunology","Infectious Diseases","Internal Medicine","Respiratory Medicine","Rheumatology"]
doi:10.7287/peerj.preprints.149v1
275 downloads
249 views

Injecting drug use is highly prevalent in London and is associated with specific physical health problems. These problems are related to the toxicity of the substances, their mode of consumption and as a consequence of the drug taking lifestyle. Hepatitis B and...

["Infectious Diseases","Psychiatry and Psychology","Public health"]
doi:10.7287/peerj.preprints.108v1
84 downloads
348 views

UAP56/SUB2 is a DExD/H-box RNA helicase that is critically involved in pre-mRNA splicing and mRNA nuclear export. This helicase is broadly conserved and essential in many eukaryotic lineages, including protozoan and metazoan parasites. Previous research suggests...

["Biochemistry","Bioinformatics","Molecular Biology","Parasitology","Infectious Diseases"]
doi:10.7287/peerj.preprints.106v1
1,690 downloads
1,588 views

As medical and molecular microbiologists who regularly read the scientific literature, it is our impression that many published papers contain data that is inappropriately presented and/or analysed. This is borne out by a number of studies which indicate that typically...

["Microbiology","Molecular Biology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.92v1
162 downloads
630 views

In the light of recent advances in radionuclide diagnostics of occult infectious states, it is clearly seen that positron emission tomography will have a part in routine work-up especially for critically ill patients in near future. For the purpose of further development...

["Microbiology","Infectious Diseases","Radiology and Medical Imaging","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.52v1
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