Preprints (not yet peer-reviewed)

445 downloads
505 views

Planktonic cultures of Mycobacterium tuberculosis, the bacterium responsible for the lung disease tuberculosis (TB), are highly susceptible to killing by ascorbic acid (vitamin C). As planktonically grown M. tuberculosis are unlikely to be representative of the...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.633v1
62 downloads
528 views

If malaria can be eliminated from anywhere it is from isolated areas such as the 2x7 km peninsula of Linga Linga in southern Mozambique. Currently available control strategies include bed nets impregnated with pyrethroid insecticides (long-lasting insecticidal...

["Epidemiology","Global Health","Infectious Diseases","Public Health"]
doi:10.7287/peerj.preprints.630v1
359 downloads
305 views

Rubella is a vaccine-preventable, mild rash-inducing viral disease with complications that include a spectrum of birth defects in the developing foetus, especially if the infection is acquired in the early months of pregnancy. Consequently, the primary objective...

["Epidemiology","Gynecology and Obstetrics","Infectious Diseases","Pediatrics","Women's Health"]
doi:10.7287/peerj.preprints.613v1
72 downloads
277 views

Streptococcus pneumoniae serotype 1 is one of the leading causes of invasive pneumococcal disease. However this invasive serotype is hardly found in nasopharyngeal asymptomatic carriage and therefore large epidemiological studies are needed to assess the dynamics...

["Genomics","Microbiology","Epidemiology","Global Health","Infectious Diseases"]
doi:10.7287/peerj.preprints.611v1
1,724 downloads
437 views

South Asian population suffer a particularly wide range of infectious diseases among which TB and HIV appear to produce most profound influence across various dimensions of social life, healthcare and the economy. Although the countries in this region have a relatively...

["Global Health","Health Policy","HIV","Infectious Diseases","Public Health"]
doi:10.7287/peerj.preprints.579v1
156 downloads
525 views

Background: Emergency department (ED) fever management algorithms require the clinician to categorize febrile children as ‘ill’ or ‘not ill’ appearing when determining the risk for serious bacterial illness (SBI). This study describes a natural experiment where...

["Emergency and Critical Care","Infectious Diseases","Pediatrics"]
doi:10.7287/peerj.preprints.527v1
67 downloads
336 views

We demonstrated that the 3-substituted benzothiophene-1,1-dioxide class of compounds are effective inhibitors of Mycobacterium tuberculosis growth under aerobic conditions. We examined substitution at the C-3 position of the benzothiophene-1,1-dioxide series systematically...

["Microbiology","Global Health","Infectious Diseases"]
doi:10.7287/peerj.preprints.502v1
365 downloads
1,433 views

Tuberculosis remains a major global health problem. Laboratory diagnostic methods that allow effective, early detection of cases are central to management of tuberculosis in the individual patient and in the community. Since the 1880s, laboratory diagnosis of tuberculosis...

["Bioinformatics","Genomics","Microbiology","Infectious Diseases","Respiratory Medicine"]
doi:10.7287/peerj.preprints.482v1
76 downloads
430 views

Acinetobacter baumannii is a nosocomial species frequently isolated from the traumatic wounds of injured military personnel and increasingly detected in civilian healthcare facilities. Many clinical isolates of A. baumannii are drug resistant, so new treatments...

["Ecology","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.436v1
248 downloads
530 views

The 2014 World Cup Brazil will create excitement around the globe, but viewership in Africa should be especially high after South Africa 2010 and the growing popularity of football. The time difference and scheduling of matches, however, means that 86% of live...

["Ecology","Infectious Diseases"]
doi:10.7287/peerj.preprints.402v1
250 downloads
577 views

HIV disclosure from parent to child is complex and challenging to HIV-positive parents and healthcare professionals. The purpose of the study was to understand the lived experiences of HIV-positive parents and their children during the disclosure process in Kenya....

["Epidemiology","Global Health","HIV","Infectious Diseases","Public Health"]
doi:10.7287/peerj.preprints.303v2
156 downloads
323 views

Caenorhabditis elegans is commonly used as an infection model for pathogenesis studies in Pseudomonas aeruginosa. While the standard virulence assays rely on the slow and fast killing or paralysis of nematodes, here we developed a behaviour assay to monitor the...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.313v1
1,318 downloads
2,463 views

Recent scientific discoveries lead inexorably to the conclusion that the ‘total human’ incorporates a necessary body of numerous microbes, including bacteria. These bacteria play a very important role in immunity by actively resisting infections by outside bacteria;...

["Ecology","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.236v1
309 downloads
804 views

In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein-­protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases. In particular,...

["Biochemistry","Biophysics","Computational Biology","Virology","Infectious Diseases"]
doi:10.7287/peerj.preprints.138v3
93 downloads
300 views

Mycobacterium species have a complex cAMP regulatory network indicated by the high number of adenylate cyclases annotated in their genomes. However the need for a high level of redundancy in adenylate cyclase genes remains unknown. We have used semiquantitiative...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.177v1
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