Preprints (not yet peer-reviewed)

243 downloads
482 views

The 2014 World Cup Brazil will create excitement around the globe, but viewership in Africa should be especially high after South Africa 2010 and the growing popularity of football. The time difference and scheduling of matches, however, means that 86% of live...

["Ecology","Infectious Diseases"]
doi:10.7287/peerj.preprints.402v1
240 downloads
528 views

HIV disclosure from parent to child is complex and challenging to HIV-positive parents and healthcare professionals. The purpose of the study was to understand the lived experiences of HIV-positive parents and their children during the disclosure process in Kenya....

["Epidemiology","Global Health","HIV","Infectious Diseases","Public Health"]
doi:10.7287/peerj.preprints.303v2
146 downloads
307 views

Caenorhabditis elegans is commonly used as an infection model for pathogenesis studies in Pseudomonas aeruginosa. While the standard virulence assays rely on the slow and fast killing or paralysis of nematodes, here we developed a behaviour assay to monitor the...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.313v1
1,254 downloads
2,432 views

Recent scientific discoveries lead inexorably to the conclusion that the ‘total human’ incorporates a necessary body of numerous microbes, including bacteria. These bacteria play a very important role in immunity by actively resisting infections by outside bacteria;...

["Ecology","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.236v1
304 downloads
738 views

In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein-­protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases. In particular,...

["Biochemistry","Biophysics","Computational Biology","Virology","Infectious Diseases"]
doi:10.7287/peerj.preprints.138v3
88 downloads
237 views

Mycobacterium species have a complex cAMP regulatory network indicated by the high number of adenylate cyclases annotated in their genomes. However the need for a high level of redundancy in adenylate cyclase genes remains unknown. We have used semiquantitiative...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.177v1
886 downloads
513 views

All strategies to prevent Pneumocystis jiroveci pneumonia (PCP) during rituximab treatment have their rationale in patients with granulomatosis with polyangiitis (GPA) and to some extent in patients with other autoimmune diseases (AID). Risk factors of PCP and...

["Allergy and Clinical Immunology","Infectious Diseases","Internal Medicine","Respiratory Medicine","Rheumatology"]
doi:10.7287/peerj.preprints.149v1
236 downloads
230 views

Injecting drug use is highly prevalent in London and is associated with specific physical health problems. These problems are related to the toxicity of the substances, their mode of consumption and as a consequence of the drug taking lifestyle. Hepatitis B and...

["Infectious Diseases","Psychiatry and Psychology","Public health"]
doi:10.7287/peerj.preprints.108v1
81 downloads
329 views

UAP56/SUB2 is a DExD/H-box RNA helicase that is critically involved in pre-mRNA splicing and mRNA nuclear export. This helicase is broadly conserved and essential in many eukaryotic lineages, including protozoan and metazoan parasites. Previous research suggests...

["Biochemistry","Bioinformatics","Molecular Biology","Parasitology","Infectious Diseases"]
doi:10.7287/peerj.preprints.106v1
1,589 downloads
1,509 views

As medical and molecular microbiologists who regularly read the scientific literature, it is our impression that many published papers contain data that is inappropriately presented and/or analysed. This is borne out by a number of studies which indicate that typically...

["Microbiology","Molecular Biology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.92v1
156 downloads
604 views

In the light of recent advances in radionuclide diagnostics of occult infectious states, it is clearly seen that positron emission tomography will have a part in routine work-up especially for critically ill patients in near future. For the purpose of further development...

["Microbiology","Infectious Diseases","Radiology and Medical Imaging","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.52v1
135 downloads
518 views

A 68 year old male with a history of classical Kaposi's sarcoma (KS) and precursor T-cell acute lymphoblastic leukemia (ALL) received an allogenic stem cell transplant from an unrelated donor to treat his ALL. He developed acute graft-vs.-host-disease (GVHD) which...

["Immunology","Infectious Diseases","Nephrology","Oncology","Science and Medical Education"]
doi:10.7287/peerj.preprints.48v1
101 downloads
436 views

Many bacteria antagonize each other in nature; laboratory evidence of these interactions dates from 1925 (Gratia). However, antagonism assays are typically performed between a small number of 'sensitive' strains screening a range of potential 'killers' in the hunt...

["Ecology","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.35v1
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