Preprints (not yet peer-reviewed)

110 downloads
151 views

The “reproducibility crisis” has been a highly visible source of scientific controversy and dispute. Here, I propose and review several avenues for identifying and prioritizing research studies for the purpose of targeted validation. Of the various proposals discussed,...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2830v1
39 downloads
105 views

Objective: The purpose of this study was to demonstrate the effects of the achievement motive on important variables such as the purpose in life and social participation with objective physical functions in predicting within-person fluctuations and between-person...

["Evidence Based Medicine","Geriatrics","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2801v1
37 downloads
325 views

BACKGROUND: The use of public engagement and self-management in online clinical trials is growing with benefits, boundaries and minimal methodological guidance. This analysis explores whether running self-recruited online trials can provide trustworthy and useful...

["Clinical Trials","Evidence Based Medicine","Global Health","Public Health","Science and Medical Education"]
doi:10.7287/peerj.preprints.2671v1
441 downloads
382 views

“Open access” has become a central theme of journal reform in academic publishing. In this article, I examine the consequences of an important technological loophole in which publishers can claim to be adhering to the principles of open access by releasing articles...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2566v1
105 downloads
135 views

Developing new endpoints for mobility is an important strategic aim for many groups both in industry and academia and the focus of a growing field. Bringing those novel endpoints to health authority acceptance for clinical decision making will require a concerted...

["Clinical Trials","Evidence Based Medicine","Translational Medicine","Computational Science"]
doi:10.7287/peerj.preprints.2546v1
61 downloads
128 views

This is a tutorial on how to use the GRADEPro GDT guidelines development tool for appraisal of articles. The tutorial assumes that the student has little experience of working with Gradepro and walks through in several steps how to use this tool. Grading of evidence...

["Evidence Based Medicine","Science and Medical Education"]
doi:10.7287/peerj.preprints.2520v1
22 downloads
121 views

Background: Achievement motive is expected to prevent lack of self-efficacy and hope, which negatively impact rehabilitation support, health, and psychological well-being. It has been indicated that the factor structure of the Scale for Achievement Motive in Rehabilitation...

["Epidemiology","Evidence Based Medicine","Geriatrics","Psychiatry and Psychology","Public Health"]
doi:10.7287/peerj.preprints.2459v1
28 downloads
197 views

The study of subjective, first-person experience is a topic with both philosophical and practical implications. In this article, I discuss the value of collecting a critical mass of prose or verbal descriptions of introspectively determined, subjective effects...

["Toxicology","Evidence Based Medicine","Neurology","Pharmacology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2424v1
33 downloads
413 views

Nuclear transfer techniques (a.k.a. mitochondrial replacement therapies) are currently under development to provide a route to eliminating particular instances of mitochondrial disease from the germline. Before these kinds of techniques are implemented clinically...

["Evolutionary Studies","Genetics","Genomics","Evidence Based Medicine","Statistics"]
doi:10.7287/peerj.preprints.2412v1
88 downloads
230 views

Introduction Hospital readmissions are common, expensive, and a key target of the Medicare Value Based Purchasing (VBP) program. Risk assessment tools have been developed to identify patients at high risk of hospital readmission so they can be targeted for interventions...

["Evidence Based Medicine","Health Policy","Internal Medicine"]
doi:10.7287/peerj.preprints.2093v1
74 downloads
141 views

Background: Normative feedback (NF), or receiving information about one’s drinking compared to peer drinking norms, is one of the most widely used brief interventions for prevention and intervention for hazardous alcohol use. NF has demonstrated predominantly small...

["Evidence Based Medicine","Psychiatry and Psychology","Public Health"]
doi:10.7287/peerj.preprints.2030v1
51 downloads
195 views

Background. Interventions and services for people with mental health problems can have broad remits: they are often designed to treat people with a variety of diagnoses. Furthermore, addressing mental health problems can have long term implications for economic,...

["Clinical Trials","Evidence Based Medicine","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.1988v1
50 downloads
209 views

In publication of a controlled trial article from health science research, the abstract is an important part that readers usually read first and then decide whether to read the whole article; therefore, information provided in the abstract should be adequate. The...

["Agricultural Science","Veterinary Medicine","Clinical Trials","Evidence Based Medicine"]
doi:10.7287/peerj.preprints.1945v1
154 downloads
1,398 views

Background: Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously...

["Evidence Based Medicine","Translational Medicine","Science and Medical Education","Human-Computer Interaction","Computational Science"]
doi:10.7287/peerj.preprints.1911v1
59 downloads
1,945 views

There are numerous medical disorders without effective treatments. It is possible that many of un-treatable conditions need more than one compound co-operatively for improvement or cure. Approval of drugs in the U.S. is governed by a rigorous review process by...

["Clinical Trials","Evidence Based Medicine","Health Policy","Public Health"]
doi:10.7287/peerj.preprints.1626v1
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