Preprints (not yet peer-reviewed)

52 downloads
155 views

The www has started a new era in dissemination of scientific information, which is already to such extent propagated by electronic media that it has become practically independent from the system of subscription driven printed journals. These developments of marked...

["Drugs and Devices","Science and Medical Education"]
doi:10.7287/peerj.preprints.1485v1
67 downloads
170 views

The Multidisciplinary Conference on Drug Research is being organized every two years since 1999 under auspices of Pharmaceutical Research Institute and constitutes a forum for presenting research results, exchange views and multi-faceted discussion between professionals...

["Drugs and Devices","Science and Medical Education"]
doi:10.7287/peerj.preprints.1486v1
156 downloads
677 views

Current research and development approaches to drug discovery have become less fruitful and more costly. One alternative paradigm is that of drug repositioning. Many marketed examples of repositioned drugs have been identified through serendipitous or rational...

["Bioinformatics","Computational Biology","Drugs and Devices","Pharmacology","Computational Science"]
doi:10.7287/peerj.preprints.1427v1
273 downloads
369 views

Cell communication is central to the integration of cell function required for the development and homeostasis of multicellular animals. Proteins are an important currency of cell communication, acting locally (auto-, juxta-, or paracrine) or systemically (endocrine)....

["Biochemistry","Drugs and Devices","Surgery and Surgical Specialties","Translational Medicine"]
doi:10.7287/peerj.preprints.1378v1
92 downloads
478 views

We report a method to cause cell death by remotely heating microparticles by induction heating, this technique could be used to remove vascular deposits and thrombosis. In this preliminary work, we used micrometer size spherical (ferromagnetic) particles and (pure)...

["Bioengineering","Biophysics","Drugs and Devices","Translational Medicine"]
doi:10.7287/peerj.preprints.815v1
529 downloads
404 views

This thesis describes the work that has been carried out in connection with my Masters at the University of Copenhagen. This work has led to new dispersion and hydrogen bond corrections to the PM6 method, PM6-D3H+, and its implementation in the GAMESS program....

["Biochemistry","Biophysics","Drugs and Devices","Computational Science"]
doi:10.7287/peerj.preprints.799v1
312 downloads
252 views

In this preliminary effort, we use a commercially available and chemically modified tube to selectively capture circulating tumor cells (CTCs) from the blood stream by immobilizing human anti-EpCAM antibodies on the tube's interior surface. We describe the steps...

["Bioengineering","Biophysics","Drugs and Devices"]
doi:10.7287/peerj.preprints.793v1
122 downloads
245 views

Objectives: To determine test re-test reliability and construct validity of the star-track test of manual dexterity. Design: Test re-test reliability was tested in a controlled study. Construct validity was tested in a blinded randomized crossover study. Setting:...

["Drugs and Devices","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.683v1
488 downloads
394 views

Aim Pain associated poor sleep quality has been reported among opioid dependent patients on methadone maintenance therapy (MMT) but objective pain data are lacking. This study aimed to investigate the rate of objective pain sensitivity and the relationship between...

["Anaesthesiology and Pain Management","Drugs and Devices","Internal Medicine","Nursing","Pharmacology"]
doi:10.7287/peerj.preprints.615v1
48 downloads
337 views

Reproducibility of biological data is a significant problem in research today. One potential contributor to this, which has received little attention, is the over complication of enzyme kinetic inhibition models. This over complication of inhibitory models stems...

["Biochemistry","Mathematical Biology","Neuroscience","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.521v1
436 downloads
554 views

Background: Illicit drug use influences people’s lives and elicits unwanted here is an increase in young people’s drug use in Sweden. This study aimed to investigate Swedish high-school pupils’ attitudes, impulsiveness and gender differences linked to drug use....

["Drugs and Devices","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.254v2
234 downloads
667 views

Background. An “In Silico 2D/3D Conformer Screening” for structural similar antitumor substances to Curcumin was carried out and the novel antrachinone BTB14431 was found. Emodin, contained in several Chinese medical plants and BTB14431 are known to be potential...

["Drugs and Devices","Oncology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.304v1
215 downloads
410 views

Background Traditional Chinese medicine encompasses a well established alternate system of medicine based on a broad range of herbal formulations and is practiced extensively in the region for the treatment of a wide variety of diseases. In recent years, several...

["Bioinformatics","Drugs and Devices","Pharmacology","Computational Science"]
doi:10.7287/peerj.preprints.276v1
742 downloads
1,570 views

A survey of the cultural psychology and related literatures suggests that Western biomedicine's fascination with atomistic, individual-oriented, interventions is a cultural artifact that may have little consonance with complex, subtle, multiscale, multilevel, social,...

["Drugs and Devices","Epidemiology","Evidence Based Medicine","Health Policy","Public health"]
doi:10.7287/peerj.preprints.8v2
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