Preprints (not yet peer-reviewed)

39 downloads
234 views

The ever-growing need to evaluate researchers without actually reading their work has fertilized the soil for the appearance of hundreds of scientometric indicators. The reason why they continue to emerge is simple: no perfect one has been found yet. The major...

["Ethical Issues","Science Policy","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.2414v1
59 downloads
499 views

Nuclear transfer techniques (a.k.a. mitochondrial replacement therapies) are currently under development to provide a route to eliminating particular instances of mitochondrial disease from the germline. Before these kinds of techniques are implemented clinically...

["Evolutionary Studies","Genetics","Genomics","Evidence Based Medicine","Statistics"]
doi:10.7287/peerj.preprints.2412v1
53 downloads
385 views

Complex physiological dynamics have been argued to be a signature of healthy physiological function. Here we test whether the complexity of metabolic rate fluctuations in small endotherms decreases with lower environmental temperatures. To do so we examine the...

["Computational Biology","Ecology","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.2404v1
399 downloads
3,378 views

GRIMMER (Granularity-Related Inconsistency of Means Mapped to Error Repeats) builds upon the GRIM test and allows for testing whether reported measures of variability are mathematically possible. GRIMMER relies upon the statistical phenomenon that variances display...

["Science Policy","Statistics"]
doi:10.7287/peerj.preprints.2400v1
426 downloads
1,057 views

Articles published in high Impact factor (IF) journals receive higher visibility and attached prestige, regardless of their actual scientific merit. This results in unfair gain in subsequent number of citations to these articles, which also further increases the...

["Science Policy","Statistics"]
doi:10.7287/peerj.preprints.2391v1
137 downloads
398 views

In a report issued to the UK government in 2007 on the Randomised Badger Culling Trial (RBCT), it was stated that the incidence of bovine tuberculosis (TB) in cattle increased in areas surrounding where badgers were removed. It is known that badger culling perturbs...

["Epidemiology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.2376v2
242 downloads
379 views

The reliable detection of novel bacterial pathogens from next generation sequencing data is a key challenge for microbial diagnostics. Current computational tools usually rely on sequence similarity and often fail to detect novel species when closely related genomes...

["Bioinformatics","Genomics","Microbiology","Statistics"]
doi:10.7287/peerj.preprints.2379v1
71 downloads
206 views

In a recent commentary, Amann and Rosselló-Mórab summarize how the census of Bacteria and Archaea has changed over time (1). For decades, the number of recognized microbial taxa was underestimated owing to limitations associated with culture-based methods and the...

["Biodiversity","Ecology","Microbiology","Taxonomy","Statistics"]
doi:10.7287/peerj.preprints.2357v1
144 downloads
915 views

Recent years have brought about the realisation of an irreproducibility crisis in science, which may have numerous causes, including common standards of statistical analysis. For decades, the methodological paradigm of null hypothesis significance testing (NHST)...

["Bioinformatics","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.2249v1
155 downloads
664 views

Purpose The present study aimed to verify the reliability and validity of the Assessment of Positive Occupation 15 (APO-15) in elderly individuals with physical disabilities in health science. Methods The study sample comprised 761 elderly individuals with physical...

["Nursing","Psychiatry and Psychology","Statistics"]
doi:10.7287/peerj.preprints.2219v1
83 downloads
234 views

Estimation of natural selection on protein-coding sequences is a key comparative genomics approach for de novo prediction of lineage specific adaptations. Selective pressure is measured on a per-gene basis by comparing the rate of non-synonymous substitutions to...

["Bioinformatics","Computational Biology","Evolutionary Studies","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.2218v1
78 downloads
220 views

Background: Multivariate statistical approaches (MSA), such as principal components analysis and multidimensional scaling, seek to uncover meaningful patterns within datasets by considering multiple response variables in a concerted fashion. Although these techniques...

["Environmental Sciences","Genomics","Marine Biology","Molecular Biology","Statistics"]
doi:10.7287/peerj.preprints.2200v1
78 downloads
319 views

Motivation Nowadays, advances in technology has arisen in a huge amount of data in both biomedical research and healthcare systems. This growing amount of data gives rise to the need for new research methods and analysis techniques. Analysis of these data offers...

["Bioinformatics","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.2186v1
50 downloads
306 views

MOTIVATION Alkaptonuria (AKU) is a rare and genetic disease which causes discoloration of bone (a process called ‘ochronosis’) and induces early-onset osteoarthritis. AKU data have not been organized yet and the disease has no approved biomarkers. The ability to...

["Bioinformatics","Computational Biology","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.2174v1
161 downloads
513 views

In a recent paper, Beall, Hofer, and Schaller (2016) use observational time series data to test the hypothesis that the 2014 Ebola outbreak influenced the 2014 U.S. Federal Elections. They find substantial associations between online search volume for Ebola and...

["Anthropology","Evolutionary Studies","Psychiatry and Psychology","Statistics"]
doi:10.7287/peerj.preprints.2165v2
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