Preprints (not yet peer-reviewed)

61 downloads
222 views

Objective: The aim of this study was to use the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines to evaluate the quality of reporting of recent gastric cancer animal experiments. Materials and Methods: A literature search of studies was performed...

["Veterinary Medicine","Gastroenterology and Hepatology","Oncology","Translational Medicine","Statistics"]
doi:10.7287/peerj.preprints.2049v1
42 downloads
180 views

Background. In the early and late stages of cell reprogramming to induced pluripotent stem cells (iPSCs) ectopic expression of Oct4, Sox2, Klf4 and Myc (OSKM) aroused two peaks of transcriptional and epigenetic change respectively. However, it was relatively quiet...

["Bioinformatics","Cell Biology","Mathematical Biology","Molecular Biology","Statistics"]
doi:10.7287/peerj.preprints.1991v1
72 downloads
270 views

Background. Hand gestures play an important role in face-to-face communication. Although studies have shown that the mirror neuron system and the mentalizing system are involved in gesture comprehension, evidence of how the two systems are activated during gesture...

["Neuroscience","Psychiatry and Psychology","Statistics"]
doi:10.7287/peerj.preprints.1975v1
409 downloads
323 views

Objectives: To develop a flexible software application that uses predictive analytics to enable emergency department (ED) decision-makers in virtually any environment to predict the effects of operational interventions and enhance continual process improvement...

["Emergency and Critical Care","Statistics"]
doi:10.7287/peerj.preprints.1891v2
36 downloads
237 views

Residual water is a critical parameter in assessing the quality of immunological veterinary medicinal products (IVMPs). In majority of the laboratories the Karl Fischer titration (KFT) is used for the determination of water content in IVMPs. However, the transfer...

["Veterinary Medicine","Statistics"]
doi:10.7287/peerj.preprints.1858v1
95 downloads
524 views

To statistically evaluate the performance of brain-computer interfaces (BCIs), researchers usually rely on null hypothesis significance testing (NHST), i.e. p-values. However, over-reliance on NHST is often identified as one of the causes of the recent reproducibility...

["Neuroscience","Statistics","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.1828v1
45 downloads
98 views

Multiple metrics have been developed to detect causality relations between data describing the elements constituting complex systems, all of them considering their evolution through time. Here we propose a metric able to detect causality within static data sets,...

["Bioinformatics","Neuroscience","Statistics"]
doi:10.7287/peerj.preprints.1827v1
946 downloads
436 views

The FDA adaptive trial design guidance (1) is a thoughtful but lengthy document that explains on 50 pages wide-ranging and important topics “such as ... what aspects of adaptive design trials (i.e., clinical, statistical, regulatory) call for special consideration,...

["Clinical Trials","Drugs and Devices","Statistics"]
doi:10.7287/peerj.preprints.1825v1
297 downloads
269 views

Bayesian statistics, in contrast to classical statistics, uses probability to represent uncertainty about the state of knowledge. Bayesian statistics has often been associated with the idea that knowledge is subjective and that a probability distribution represents...

["Conservation Biology","Ecology","Mathematical Biology","Science Policy","Statistics"]
doi:10.7287/peerj.preprints.1755v1
222 downloads
607 views

Data is the cornerstone of the modern academic industry, like a constant production line of consumable goods packaged with a veneer of statistical techniques. Biomedical and psychological sciences invert the traditional logic of the physical sciences where hypotheses...

["Science Policy","Statistics"]
doi:10.7287/peerj.preprints.1655v2
76 downloads
301 views

The genome–wide study of epigenetic states requires the integrative analysis of histone modification ChIP–seq data. Here, we introduce an easy–to–use analytic framework to compare profiles of enrichment in histone modifications around classes of genomic elements,...

["Bioinformatics","Computational Biology","Genomics","Statistics"]
doi:10.7287/peerj.preprints.1723v2
183 downloads
657 views

Purpose: To verify the reliability and validity of the Assessment of Positive Occupation 15 (APO-15) in individuals with mental disabilities living in communities or admitted in hospitals. Methods: A sample of 408 individuals with mental disabilities completed...

["Epidemiology","Nursing","Psychiatry and Psychology","Public Health","Statistics"]
doi:10.7287/peerj.preprints.1722v1
1,041 downloads
395 views

The natural sciences, such as ecology and earth science, study complex interactions between biotic and abiotic systems in order to infer understanding and make predictions. Machine-learning-based methods have an advantage over traditional statistical methods in...

["Bioinformatics","Ecology","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.1720v1
147 downloads
425 views

Time-of-day effects in human psychological functioning have been known of since the 1800s. However, outside of those specifically focused on the quantification of circadian rhythms, they have largely been neglected. Moves toward online data collection now mean...

["Anatomy and Physiology","Psychiatry and Psychology","Statistics"]
doi:10.7287/peerj.preprints.1475v3
594 downloads
4,531 views

Background: The p-curve is a plot of the distribution of p-values reported in a set of scientific studies. Comparisons between ranges of p-values have been used to evaluate fields of research in terms of the extent to which studies have genuine evidential value,...

["Science Policy","Statistics"]
doi:10.7287/peerj.preprints.1266v4
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