Preprints (not yet peer-reviewed)

19 downloads
75 views

Normalization is the first critical step in microbiome sequencing data analysis used to account for variable library sizes. Current RNA-Seq based normalization methods that have been adapted for microbiome data fail to consider the unique characteristics of microbiome...

["Bioinformatics","Genomics","Statistics"]
doi:10.7287/peerj.preprints.3417v1
11 downloads
50 views

Improper reporting of diagnostic studies leads to an incorrect assessment of their clinical performance. STARD (Standards for Reporting of Diagnostic Accuracy Studies) checklist was launched in 2003 with the intention of improving reporting quality in diagnostic...

["Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.3413v1
46 downloads
264 views

Statistical significance provides evidence for or against an explanation of a population of interest, not a description of data sampled from the population. This simple distinction gets ignored in hundreds of thousands of research publications yearly, which confuse...

["Ecology","Evidence Based Medicine","Oncology","Statistics","Environmental Impacts"]
doi:10.7287/peerj.preprints.3394v1
94 downloads
520 views

Checking that models adequately represent data is an essential component of applied statistical inference. Ecologists increasingly use hierarchical Bayesian statistical models in their research. The appeal of this modeling paradigm is undeniable, as researchers...

["Ecology","Marine Biology","Statistics"]
doi:10.7287/peerj.preprints.3390v1
17 downloads
90 views

Background: Haemophilus parasuis is a common porcine respiratory disease that causes high rates of morbidity and mortality in farmed swine. We performed a molecular characterization of antimicrobial resistance genes harbored by H. parasuis from pig farms in China....

["Microbiology","Molecular Biology","Epidemiology","Statistics"]
doi:10.7287/peerj.preprints.3386v1
33 downloads
212 views

The sixth mass extinction poses an unparalleled quantitative challenge to conservation biologists. Mathematicians and ecologists alike face the problem of developing models that can scale predictions of extinction rates from populations to the level of a species,...

["Conservation Biology","Ecology","Mathematical Biology","Statistics","Climate Change Biology"]
doi:10.7287/peerj.preprints.3367v1
41 downloads
124 views

Underpowered experiments have three problems: the probability of a false positive result is higher, true effects are harder to detect, and the true effects that are detected tend to have inflated effect sizes. Many biology experiments are underpowered and recent...

["Animal Behavior","Neuroscience","Drugs and Devices","Ethical Issues","Statistics"]
doi:10.7287/peerj.preprints.3363v1
75 downloads
252 views

Structural equation modeling (SEM) is an important research tool, both for path-based model specification, common in the social sciences, and also matrix-based models in heavy use in behavior genetics. We developed umx to give more immediate access, concise syntax...

["Genetics","Psychiatry and Psychology","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.3354v1
540 downloads
777 views

Choosing a model with too few parameters can involve making unrealistically simple assumptions and lead to high bias, poor prediction, and missed opportunities for insight. Such models are not flexible enough to describe the sample or the population well. A model...

["Statistics"]
doi:10.7287/peerj.preprints.1103v3
5,015 downloads
27,923 views

The website Sci-Hub provides access to scholarly literature via full text PDF downloads. The site enables users to access articles that would otherwise be paywalled. Since its creation in 2011, Sci-Hub has grown rapidly in popularity. However, until now, the extent...

["Bioinformatics","Legal Issues","Science and Medical Education","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.3100v2
56 downloads
137 views

In daily life we are often forced to choose between the “lesser of two evils,” yet there remains limited understanding of how the brain encodes choices between aversive stimuli, particularly choices involving hypothetical futures. We tested how choice framing affects...

["Psychiatry and Psychology","Statistics"]
doi:10.7287/peerj.preprints.3340v1
26 downloads
107 views

Celiac disease is a chronic condition, which can be described as inflammatory and autoimmune. The well-known treatment is a lifelong gluten-free diet, but it can be not totally effective for a high percentage of the patients. The aim of this work is to approach...

["Bioinformatics","Biotechnology","Computational Biology","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.3315v1
23 downloads
233 views

Objective: The objective of this work is to obtain validity evidence for an evaluation instrument used to assess the performance level of a mastoidectomy. The instrument has been previously described and had been formulated by a multi-institutional consortium....

["Otorhinolaryngology","Surgery and Surgical Specialties","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.2954v2
35 downloads
136 views

Background. The Procrustean residual vector (or PAM, an acronym for the alternative equivalent term Procrustean association metric) derived from Procrustes analysis can be seen as the univariate form of relationship between two or more data tables, which provides...

["Biodiversity","Ecology","Plant Science","Soil Science","Statistics"]
doi:10.7287/peerj.preprints.3272v1
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