Preprints (not yet peer-reviewed)

56 downloads
301 views

Viruses could have originated from the frantic competition to survive among primitive life forms. This is the result of this new hypothesis which proposes that viruses could have originated as remnants of the disintegration of primitive microorganisms. The disintegration...

["Evolutionary Studies","Virology"]
doi:10.7287/peerj.preprints.1801v2
21 downloads
196 views

With the emergence of Next Generation Sequencing, major advances were made with regard to identifying viruses in natural environments. However, bioinformatical research on viruses is still limited because of the low amounts of viral DNA that can be obtained for...

["Biodiversity","Genomics","Microbiology","Virology"]
doi:10.7287/peerj.preprints.2912v1
16 downloads
105 views

The identification of Parrot bornaviruses in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease since not all infected birds develop clinical signs. One hypothesis suggests that...

["Veterinary Medicine","Virology","Pathology"]
doi:10.7287/peerj.preprints.2852v1
49 downloads
207 views

Background: Geminivirus (family Geminiviridae) is a prevalent plant virus that imperils agriculture globally, causing serious damage to the livelihood of farmers, particularly in developing countries. The virus evolves rapidly, attributing to its single-stranded...

["Agricultural Science","Bioinformatics","Genomics","Virology"]
doi:10.7287/peerj.preprints.2705v1
36 downloads
180 views

Diseases of marine mammals can be difficult to diagnose because of the life history and protected status of these animals. Stranded marine mammals have been a particularly useful resource to discover and comprehend the diseases that plague these top predators....

["Aquaculture, Fisheries and Fish Science","Marine Biology","Microbiology","Veterinary Medicine","Virology"]
doi:10.7287/peerj.preprints.2457v1
58 downloads
139 views

An acute outbreak of porcine hemagglutinating encephalomyelitis virus (PHEV) infection in piglets, characterized with neurological symptoms, vomiting, diarrhea, and wasting, occurred in China. Coronavirus-like particles were observed in the homogenized tissue suspensions...

["Veterinary Medicine","Virology"]
doi:10.7287/peerj.preprints.2351v1
86 downloads
253 views

Background – Corns are hard protuberances that occur on the digital footpads of Greyhound dogs. The cause of these lesions is unknown and there is little information about them in the veterinary literature. We received anecdotal examples of dog to dog spread of...

["Molecular Biology","Veterinary Medicine","Virology"]
doi:10.7287/peerj.preprints.2290v1
167 downloads
483 views

Zika virus (ZIKV), a mosquito borne disease, has been linked to congenital anomalies in humans. Recent outbreaks of ZIKV have caused the scientific community to focus on this previously neglected pathogen. Information regarding phosphorylation potential of ZIKV...

["Bioinformatics","Computational Biology","Virology"]
doi:10.7287/peerj.preprints.2047v2
41 downloads
302 views

The baculovirus expression vector system (BEVS) has been widely used to produce a large number of recombinant proteins, and is becoming one of the most powerful, robust, and cost-effective systems for the production of eukaryotic proteins. Nevertheless, as in any...

["Biotechnology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.2024v1
269 downloads
311 views

A major limitation with traditional phage preparations is the variability in titer, salts, and bacterial contaminants between successive propagations. Here we introduce the Phage On Tap (PoT) protocol for the quick and efficient preparation of homogenous bacteriophage...

["Microbiology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.1966v1
91 downloads
328 views

Members of the Caliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals. The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell culture systems and experimental...

["Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.1960v1
199 downloads
463 views

The advent of metagenomic methods to sequence DNA directly from an environment has revolutionized viral ecology, making it possible to “see” natural viral communities that could not be previously studied through culture. This technological leap has enabled further...

["Bioinformatics","Genomics","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.1901v1
98 downloads
867 views

The replication of foot-and-mouth disease virus (FMDV) is dependent on the virus-encoded 3C protease (3Cpro). As in other picornaviruses, 3Cpro performs most of the proteolytic processing of the polyprotein expressed from the single open reading frame in the RNA...

["Agricultural Science","Biochemistry","Microbiology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.1750v1
133 downloads
527 views

In July 2014, we observed premature feather loss (PFL) among non-sibling, common tern Sterna hirundo chicks between 2 and 4 weeks of age at Gull Island in northern Lake Ontario, Canada. Rarely observed in wild birds, to our knowledge PFL has not been recorded in...

["Ecology","Marine Biology","Toxicology","Virology","Public Health"]
doi:10.7287/peerj.preprints.1196v2
74 downloads
383 views

The H5N8 influenza subtype is a relatively new highly pathogenic avian influenza. Until the recent Korean outbreak of H5N8 the viral subtype had only been detected sporadically. This paper looks at the multiple reassortment events between H5 hemagglutinin and N8...

["Bioinformatics","Evolutionary Studies","Virology"]
doi:10.7287/peerj.preprints.1489v1
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