Preprints (not yet peer-reviewed)

29 downloads
204 views

The maintenance of a G+C content that is higher than the mutational input to a genome supports the view that selection serves to increase G+C contents in many bacteria. Recent experimental evidence from Escherichia coli has demonstrated that selection for increasing...

["Biotechnology","Evolutionary Studies","Genetics","Molecular Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.3011v1
59 downloads
207 views

We investigated the structure and properties of PCL10 nanofiber, PCL5/PCL10 core-shell type nanofibers, as well as PCL5/PCLAg nanofibres prepared by electrospinning. For the production of the fibre variants, a 5-10% solution of polycaprolactone (Mw = 70000-90000),...

["Bioengineering","Biotechnology","Synthetic Biology"]
doi:10.7287/peerj.preprints.2971v1
68 downloads
427 views

Background. The diatom Phaeodactylum tricornutum is a model photosynthetic organism. Functional genomic work in this organism has established a variety of genetic tools including RNA interference (RNAi). RNAi is a post-transcriptional regulatory process that can...

["Biotechnology","Genetics","Marine Biology","Molecular Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.2907v1
65 downloads
198 views

CodonGenie, freely available from http://codon.synbiochem.co.uk, is a simple web application for designing ambiguous codons to support protein mutagenesis applications. Ambiguous codons are derived from specific heterogeneous nucleotide mixtures, which create sequence...

["Bioengineering","Bioinformatics","Biotechnology","Computational Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.2797v1
67 downloads
191 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7287/peerj.preprints.2364v1
27 downloads
161 views

The copper(I)-mediated reaction of nitrones with terminal acetylenes, known as the Kinugasa reaction, represents an attractive method of direct formation of the β-lactam ring. The reaction can be performed in many ways. Diastereoselective versions, including cyclic...

["Drugs and Devices","Synthetic Biology"]
doi:10.7287/peerj.preprints.1917v1
2,436 downloads
658 views

Background: There is worldwide interest in silver nanoparticles (AgNPs) synthesized by various chemical reactions for use in applications exploiting their antibacterial activity, even though these processes exhibit a broad range of toxicity in vertebrates and invertebrates...

["Biotechnology","Microbiology","Synthetic Biology"]
doi:10.7287/peerj.preprints.1912v1
68 downloads
196 views

Amides represent an important class of compounds in chemistry, chemical biology and pharmaceutical industry. Their broad utility in many fields is closely tied to the structure of the amide moiety which endows these compounds with unique features. The low reactivity...

["Drugs and Devices","Synthetic Biology"]
doi:10.7287/peerj.preprints.1770v2
88 downloads
212 views

Indoles represent a structural element in a myriad of natural products and biologically active molecules. Of special importance are 2,3-disubstituted indoles. Thus, a number of methods for their synthesis have been described. However, these are often hampered by...

["Biochemistry","Computational Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.1842v1
255 downloads
490 views

In the early days of the human genome project (HGP), during the late 1980s and early 1990s, there was skepticism that the genome project would produce biologically meaningful information. The reality is that bioinformatics has allowed us to extract far more biology...

["Bioinformatics","Biotechnology","Computational Biology","Genomics","Synthetic Biology"]
doi:10.7287/peerj.preprints.1501v1
53 downloads
344 views

Two Component Systems and Phosphorelays (TCS/PR) are environmental signal transduction cascades in prokaryotes and, less frequently, in eukaryotes. The internal domain organization of proteins and the topology of TCS/PR cascades play an important role in shaping...

["Bioinformatics","Computational Biology","Mathematical Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.1267v1
169 downloads
306 views

Bacterial populations transition between growing and non-growing phases, based on nutrient availability and stress conditions. The hallmark of a growing state is anabolism, including DNA replication and cell division. In contrast, bacteria in a growth-arrested...

["Bioinformatics","Computational Biology","Microbiology","Synthetic Biology"]
doi:10.7287/peerj.preprints.866v1
181 downloads
1,071 views

Natural photosynthesis allows biological systems to remarkably combine carbon dioxide and water molecules under sunlight to produce energy in the form of stored sugars. The stored sugar is then used by plants and animals to exert vital biological functions. If...

["Bioengineering","Biotechnology","Plant Science","Synthetic Biology"]
doi:10.7287/peerj.preprints.66v1
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