Preprints (not yet peer-reviewed)

174 downloads
308 views

Background: Colorectal cancer (CRC) is one of the commonest cancers in Malaysia and majority of the patients will present with advanced disease at diagnosis particularly in cases of proximal CRCs. Little is known about the relationship between the genetic landscape...

["Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2109v1
69 downloads
254 views

Background. Feirana quadranus and Feirana taihangnica, two species of frogs inhabiting in waterbodies in the Qinling Mountains, China, are believed to be sister species that diverged 4.6 million years ago. In their sympatric area, morphological variations found...

["Evolutionary Studies","Molecular Biology","Taxonomy","Zoology","Statistics"]
doi:10.7287/peerj.preprints.2058v2
42 downloads
157 views

Background. The anaerobic gut fungi (phylum Neocallimastigomycota) represent a promising source of novel lignocellulolytic enzymes. Here, we report on the cloning, expression, and characterization of a glycoside hydrolase family 39 (GH39) enzyme (Bgxg1) that is...

["Biochemistry","Biotechnology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2076v1
23 downloads
106 views

Environmental stresses select for suitably adapted genes. These stresses will promote the propagation of certain mutations, and the loss of others, throughout the evolution of a species. For organisms living two thousand meters below the ocean’s surface, one of...

["Genetics","Genomics","Marine Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2071v1
111 downloads
395 views

An adult Buteo was found dead as a road-kill south of Sacramento, California, and was thought to represent the first state record of the eastern Red-shouldered Hawk (B. lineatus lineatus; Pyle et al. 2004). It is now a specimen in the Museum of Wildlife and Fish...

["Molecular Biology","Taxonomy","Zoology"]
doi:10.7287/peerj.preprints.2039v1
912 downloads
4,197 views

Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular and cellular consequences of Zika virus circulating in Brazil to the human brain development have not been studied yet. Here we describe alterations in...

["Cell Biology","Developmental Biology","Microbiology","Molecular Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2033v1
76 downloads
178 views

Background: Chinese fir [Cunninghamia lanceolata (Lamb .) Hook.], is one of the most important native tree species for timber production in southern China. An understanding of overall fast growing stage, stem growth stage and senescence stage cambium transcriptome...

["Evolutionary Studies","Genomics","Molecular Biology","Plant Science","Soil Science"]
doi:10.7287/peerj.preprints.2032v1
36 downloads
263 views

The baculovirus expression vector system (BEVS) has been widely used to produce a large number of recombinant proteins, and is becoming one of the most powerful, robust, and cost-effective systems for the production of eukaryotic proteins. Nevertheless, as in any...

["Biotechnology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.2024v1
179 downloads
362 views

Preserving species interactions should be a key desired outcome in restoration ecology. With progress in environmental DNA techniques and the dramatic reduction in the cost of high-throughput DNA sequencing, large amounts of information can be gathered on how species...

["Biodiversity","Conservation Biology","Ecology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.2020v1
370 downloads
307 views

Background. Ice-ice disease is still a big challenge for seaweed farming that is characterized with “bleaching” symptom. Bacteria are suspected as cause of ice-ice disease on seaweed Kappaphycus alvarezii. The 16S rRNA gene sequencing is current technique used...

["Aquaculture, Fisheries and Fish Science","Marine Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2016v1
32 downloads
155 views

Background. In the early and late stages of cell reprogramming to induced pluripotent stem cells (iPSCs) ectopic expression of Oct4, Sox2, Klf4 and Myc (OSKM) aroused two peaks of transcriptional and epigenetic change respectively. However, it was relatively quiet...

["Bioinformatics","Cell Biology","Mathematical Biology","Molecular Biology","Statistics"]
doi:10.7287/peerj.preprints.1991v1
62 downloads
151 views

The chiral homogeneity of a chemical compound is the main prerequisite in safety and efficiency of drug substances and generation of single enantiomers of drug intermediates in pharmaceutical industry. Over the past several years there have been an increase wide...

["Biochemistry","Bioinformatics","Biotechnology","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.1976v1
249 downloads
277 views

A major limitation with traditional phage preparations is the variability in titer, salts, and bacterial contaminants between successive propagations. Here we introduce the Phage On Tap (PoT) protocol for the quick and efficient preparation of homogenous bacteriophage...

["Microbiology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.1966v1
367 downloads
293 views

Based upon a comprehensive analysis of current literature and by combining a molecular biology and a sports science perspective, this review examines (1) if a correlation between physical activity load and telomere length (TL) exists, and (2) comprehensively analyses...

["Biochemistry","Molecular Biology","Geriatrics","Public Health"]
doi:10.7287/peerj.preprints.1965v1
89 downloads
305 views

Members of the Caliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals. The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell culture systems and experimental...

["Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.1960v1
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