Preprints (not yet peer-reviewed)

167 downloads
286 views

The late detection of non-genotoxic carcinogens in the drug development process can delay drug candidates for unmet medical needs from reaching the market despite considerable investments in their development. To enable faster, safer, and less expensive development...

["Bioinformatics","Computational Biology","Molecular Biology","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.2393v1
20 downloads
122 views

Strange patterns of white discoloration on leaves as well as unusual outgrowth that resembles arrested generation of new branches on stem were observed on a plant in Singapore. The white discoloration patterns were random in size and shape but radiated from the...

["Biochemistry","Ecology","Microbiology","Molecular Biology","Soil Science"]
doi:10.7287/peerj.preprints.2375v1
257 downloads
439 views

1) DNA metabarcoding is a powerful tool to assess biodiversity by amplifying and sequencing a standardized gene marker region. Its success is often limited due to variable binding sites that introduce amplification biases. Thus the development of optimized primers...

["Bioinformatics","Ecology","Genetics","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2352v1
152 downloads
425 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7287/peerj.preprints.2331v1
338 downloads
603 views

Challenging disposal problems are associated with plastics use due to its poor biodegrability and emissions of hazardous chemicals during incineration. Poly-β-hydroxybutyric acids (PHB), a lipid based storage polymer in bacteria, is biodegradable, biorenewable...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.534v5
43 downloads
298 views

Winter mortality is a major factor regulating population size of the mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae). Glycerol is the major cryoprotectant in this freeze intolerant insect. We report findings from a gene expression...

["Ecology","Entomology","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2311v1
33 downloads
148 views

Background. Mitotic arrest deficient 2 (Mad2) is a key component of spindle assembly checkpoint and overexpressed in human lung cancers, but the mechanism of the deregulation of Mad2 in lung cancer is largely unknown. We aim to investigate the regulation of Mad2...

["Cell Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2298v1
86 downloads
253 views

Background – Corns are hard protuberances that occur on the digital footpads of Greyhound dogs. The cause of these lesions is unknown and there is little information about them in the veterinary literature. We received anecdotal examples of dog to dog spread of...

["Molecular Biology","Veterinary Medicine","Virology"]
doi:10.7287/peerj.preprints.2290v1
63 downloads
181 views

Root hairs are unicellular elongations of certain rhizodermal cells that improve the uptake of sparingly soluble and immobile soil nutrients. Among different Arabidopsis thaliana genotypes, root hair density, length and the local acclimation to low inorganic phosphate...

["Agricultural Science","Cell Biology","Genetics","Molecular Biology","Plant Science"]
doi:10.7287/peerj.preprints.2267v1
27 downloads
175 views

Motivation Neuroblastoma (NB) is the most common solid pediatric tumor, deriving from ganglionic lineage precursors of the sympathetic nervous system. Half of the patients with high-risk NB die despite treatment and more accurate outcome prediction models are needed...

["Bioinformatics","Molecular Biology","Oncology","Pediatrics"]
doi:10.7287/peerj.preprints.2263v1
66 downloads
303 views

A comprehensive understanding of microcystin (MC) effects and mode(s) of action(s) on aquatic biota has not been achieved yet. In the present study, Nile tilapia (Oreochromis niloticus) were sub-lethally exposed to the microcystin analogue MC-LA for 12, 24, 48...

["Aquaculture, Fisheries and Fish Science","Environmental Sciences","Molecular Biology"]
doi:10.7287/peerj.preprints.2257v1
107 downloads
254 views

Advances in biodiversity genomic sequencing will increasingly depend on the availability of DNA samples—and their quantifiable metadata—preserved in large institutional biorepositories that are discoverable to the scientific community. Improvements in sequencing...

["Biodiversity","Bioinformatics","Genomics","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2202v1
61 downloads
164 views

Background: Multivariate statistical approaches (MSA), such as principal components analysis and multidimensional scaling, seek to uncover meaningful patterns within datasets by considering multiple response variables in a concerted fashion. Although these techniques...

["Environmental Sciences","Genomics","Marine Biology","Molecular Biology","Statistics"]
doi:10.7287/peerj.preprints.2200v1
170 downloads
280 views

Background. Names for ”substances” used in food products are rarely precise. The term bamboo (Bambusoideae, Poaceae) comprises over 1600 distinct species of which only few are well established sources for food products on the European market (i.e. bamboo sprouts)....

["Food Science and Technology","Molecular Biology","Plant Science","Taxonomy"]
doi:10.7287/peerj.preprints.2198v1
42 downloads
146 views

Cross-contamination of human and animal cell lines is a frequent event. For this reason, the results obtained with the same cell lines by different research groups are often not fully comparable, this leading to main reproducibility issues. The short tandem repeat...

["Bioinformatics","Cell Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2194v1
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