Preprints (not yet peer-reviewed)

36 downloads
156 views

Background: Lysyl oxidases (LOX) were studied mostly in mammals, whereas properties of recently found homologs in prokaryotic genomes remain enigmatic. Methods: LOX gene from Haloterrigena turkmenica has been cloned by PCR in a E. coli expression vector. Protein...

["Biochemistry","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2691v1
21 downloads
147 views

The repair of DNA from alkylation damage is generally performed by evolutionary conserved protein complexes. However, specific repair of O6-alkylated-guanines is a task of a small class of proteins called AGTs (alkylated DNA-protein alkyl-transferases): by using...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.2683v1
26 downloads
194 views

Type I restriction-modification enzymes are multisubunit, multifunctional molecular machines that recognize specific DNA target sequences, and their multisubunit organization underlies their multifunctionality. EcoR124I is the archetype of Type I restriction-modification...

["Biochemistry","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2680v1
17 downloads
276 views

Intracellular calcium ion (Ca2+) signaling is deeply involved in development, as demonstrated by the use of various Ca2+ sensors. Ca2+ patterns in wildtype and mutant zebrafish have been reported to date, however, not many zebrafish embryos with congenital anomaly...

["Developmental Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2644v1
42 downloads
214 views

Quality disciplines have been widely used for decades in industrial and business fields. It is only in recent times, however, that Quality management and approaches have received proper attention in life science. In particular, the need for Quality standards in...

["Cell Biology","Food Science and Technology","Genetics","Molecular Biology","Science Policy"]
doi:10.7287/peerj.preprints.2637v1
104 downloads
191 views

Synthetic biology is often misunderstood as creation of artificial life or new biology using principles different from those of extant organisms around us. But, fundamentally, the field is about engineering biology in a more efficient and effective way, and endowing...

["Biochemistry","Bioengineering","Biotechnology","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2634v1
152 downloads
281 views

Microorganisms are tightly bounded to the animals on Earth. Bacteria, among other types of microbes, interact with their hosts in several ways regarding metabolic pathways, development, complex behavioral processes such as mate recognition, among others. The adult...

["Animal Behavior","Biodiversity","Conservation Biology","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2627v1
127 downloads
370 views

In the face of increasing threats to biodiversity, the advancement of methods for surveying biological communities is a major priority for ecologists. Recent advances in molecular biological technologies have made it possible to detect and sequence DNA from environmental...

["Biodiversity","Ecology","Marine Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2608v1
45 downloads
324 views

The adaptative bleaching hypothesis (ABH) states that depending on the symbiotic flexibility of coral hosts (i.e., the ability of corals to “switch” or “shuffle” their algal symbionts), coral bleaching can lead to a change in the composition of their associated...

["Biodiversity","Ecology","Marine Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2607v1
227 downloads
171 views

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In 2008 alone, 17.3 million deaths (representing 30% of all deaths) were attributable to the complications of cardiovascular disease. Of these deaths, 7.3 million were due to coronary...

["Cell Biology","Molecular Biology","Cardiology","Science and Medical Education"]
doi:10.7287/peerj.preprints.2586v1
208 downloads
958 views

Community assembly processes generate shifts in species abundances that influence ecosystem cycling of carbon and nutrients, yet our understanding of assembly remains largely separate from ecosystem-level functioning. Here, we investigate relationships between...

["Ecology","Ecosystem Science","Environmental Sciences","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2102v3
83 downloads
425 views

The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate the...

["Cell Biology","Developmental Biology","Evolutionary Studies","Molecular Biology"]
doi:10.7287/peerj.preprints.2530v2
91 downloads
146 views

Here we shall apply the approach presented in the paper Dynamics of resource allocation in biological systems in considering resource allocation in cancer cell metabolism, specifically, aerobic glycolysis (Warburg effect). Aerobic glycolysis, the metabolic phenomenon...

["Biochemistry","Cell Biology","Mathematical Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2533v1
52 downloads
207 views

The Simulation Experiment Description Markup Language (SED-ML) is a standardized format for exchanging simulation studies independently of software tools. We present the SED-ML Web Tools, a software that supports SED-ML Level 1 Version 2, including complex modifications...

["Bioinformatics","Computational Biology","Mathematical Biology","Molecular Biology","Computational Science"]
doi:10.7287/peerj.preprints.2515v1
54 downloads
177 views

Background. This study investigates orbitally-forced range dynamics at a regional scale by exploring the evolutionary history of Nymania capensis (Meliaceae) across the deeply incised landscapes of the subescarpment coastal lowlands of South Africa; a region home...

["Biogeography","Conservation Biology","Molecular Biology","Plant Science"]
doi:10.7287/peerj.preprints.2506v1
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