Preprints (not yet peer-reviewed)

40 downloads
253 views

The Louisiana Waterthrush (Parkesia motacilla) breeds along wooded streams throughout much of eastern North America, and winters in the Caribbean and Central America. Because of its dependence on stream macroinvertebrates—which are themselves dependent on high...

["Ecology","Genetics","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2498v1
50 downloads
328 views

Chlamydia suis is a swine pathogen that also causes zoonotic infections. Many strains contain a tet(C) cassette conferring tetracycline resistance originally acquired by horizontal gene transfer from a Gram-negative donor. As we and others have described the capacity...

["Cell Biology","Genomics","Microbiology","Molecular Biology","Infectious Diseases"]
doi:10.7287/peerj.preprints.2489v1
328 downloads
1,402 views

The high cost of library preparation remains a major obstacle to sequencing large numbers of individual genomes. Illumina’s proprietary tagmentation technology allows for rapid and easy preparation of sequencing libraries, but remains prohibitively expensive for...

["Bioinformatics","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2475v1
68 downloads
172 views

Background. Oxidative stress could induce cell injury in vascular endothelial cells, which is the initial event in the development of atherosclerosis. Although quantitative real-time polymerase chain reaction (qRT-PCR) has been widely used in gene expression studies...

["Cell Biology","Molecular Biology","Cardiology"]
doi:10.7287/peerj.preprints.2460v1
60 downloads
281 views

The majority of bacterial foliar plant pathogens must invade the apoplast of host plants through points of ingress, such as stomata or wounds, to replicate to high population density and cause disease. How pathogens navigate plant surfaces to locate invasion sites...

["Genetics","Microbiology","Molecular Biology","Plant Science"]
doi:10.7287/peerj.preprints.2438v1
55 downloads
231 views

microRNAs are small, non-coding RNAs involved in post-transcriptional gene regulation. Since the dysregulation of only a few miRNAs can affect many biological pathways, miRNAs are thought to play a key role in cancer development and can be used as biomarkers for...

["Bioinformatics","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2423v1
20 downloads
238 views

Background: Reference genes serve an important role as an endogenous control/standard for data normalisation in gene expression studies. Although reference genes have recently been suggested for marsupials, independent analysis of reference genes on different immune...

["Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2422v1
420 downloads
462 views

Circular RNAs (circRNAs) belong to a recently re-discovered species of RNA that emerge during RNA maturation through a process called back-splicing. A downstream 5’ splice site is linked to an upstream 3’ splice site to form a circular transcript instead of a canonical...

["Bioinformatics","Computational Biology","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2418v1
156 downloads
456 views

RNA interference (RNAi), a gene-silencing mechanism that involves providing double-stranded RNA molecules that match a specific target gene sequence, is now widely used in functional genetic studies. The potential application of RNAi-mediated control of agricultural...

["Agricultural Science","Molecular Biology","Plant Science"]
doi:10.7287/peerj.preprints.2406v1
178 downloads
304 views

The late detection of non-genotoxic carcinogens in the drug development process can delay drug candidates for unmet medical needs from reaching the market despite considerable investments in their development. To enable faster, safer, and less expensive development...

["Bioinformatics","Computational Biology","Molecular Biology","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.2393v1
20 downloads
128 views

Strange patterns of white discoloration on leaves as well as unusual outgrowth that resembles arrested generation of new branches on stem were observed on a plant in Singapore. The white discoloration patterns were random in size and shape but radiated from the...

["Biochemistry","Ecology","Microbiology","Molecular Biology","Soil Science"]
doi:10.7287/peerj.preprints.2375v1
293 downloads
457 views

1) DNA metabarcoding is a powerful tool to assess biodiversity by amplifying and sequencing a standardized gene marker region. Its success is often limited due to variable binding sites that introduce amplification biases. Thus the development of optimized primers...

["Bioinformatics","Ecology","Genetics","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2352v1
172 downloads
451 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7287/peerj.preprints.2331v1
343 downloads
619 views

Challenging disposal problems are associated with plastics use due to its poor biodegrability and emissions of hazardous chemicals during incineration. Poly-β-hydroxybutyric acids (PHB), a lipid based storage polymer in bacteria, is biodegradable, biorenewable...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.534v5
45 downloads
319 views

Winter mortality is a major factor regulating population size of the mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae). Glycerol is the major cryoprotectant in this freeze intolerant insect. We report findings from a gene expression...

["Ecology","Entomology","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2311v1
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