Preprints (not yet peer-reviewed)

46 downloads
156 views

Cancer spread away from the primary tumour towards other parts of the body is what is most feared in cancer treatment, and is the leading cause of relapse for patients who are in remission after initial rounds of treatment with surgery, radiation or chemotherapy....

["Biochemistry","Cell Biology","Marine Biology","Molecular Biology","Histology"]
doi:10.7287/peerj.preprints.2800v1
38 downloads
204 views

Symbiotic bacteria are common in insects and can affect various aspects of their hosts’ biology. Although the effects of insect symbionts have been clarified for various insect symbiosis models, due to the difficulty of cultivating them in vitro, there is still...

["Cell Biology","Entomology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2799v1
31 downloads
219 views

American trypanosomiasis is a chronic and endemic disease, which affects millions of people. Trypanosoma cruzi, its causative agent, has a life cycle that involves complex morphological and functional transitions, as well as a variety of environmental conditions....

["Biochemistry","Genomics","Molecular Biology","Parasitology","Infectious Diseases"]
doi:10.7287/peerj.preprints.2782v1
139 downloads
455 views

Introduction 2nd generation sequencing or better known as next-generation sequencing (NGS) represents a cutting-edge technology in life sciences and current foundation for unravelling nucleotide sequences. Since advent of first platforms in 2005 the number of different...

["Bioinformatics","Biotechnology","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2771v1
120 downloads
408 views

Mitochondrial response to oxidative stress is intricately related to cellular homeostasis due to the high susceptibility of the mitochondrial genome to oxidative damage. Octocoral mitogenomes possess a unique DNA repair gene, mtMutS, potentially capable of counteracting...

["Marine Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2770v1
121 downloads
340 views

Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of existing methods for quantifying protein levels in single cells. To alleviate these...

["Biochemistry","Cell Biology","Computational Biology","Developmental Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2767v1
113 downloads
480 views

We estimated the genetic diversity of 50 Jatropha curcas Costa Rican samples using 18 EST-SSR, one G-SSR and nrDNA-ITS markers. We also evaluated the phylogenetic relationships among samples using nuclear ribosomal ITS markers. Non-toxicity was also evaluated using...

["Biodiversity","Molecular Biology","Plant Science"]
doi:10.7287/peerj.preprints.2469v2
147 downloads
369 views

Introduction Next Generation Sequencing (NGS) platforms have radically changed the field of genomics and are routinely applied to a variety of functional genomics problems. Although NGS has markedly accelerated multiple areas of genomics research it is a massively...

["Bioinformatics","Genomics","Molecular Biology","Computational Science"]
doi:10.7287/peerj.preprints.2752v1
84 downloads
286 views

Background. The Balkans are a major biodiversity and endemism hotspot, worldwide. Among the freshwater biota, amphipods are known for their high cryptic diversity. However, little is known about the temporal and paleogeographic aspects of their evolutionary history....

["Aquaculture, Fisheries and Fish Science","Biogeography","Evolutionary Studies","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2741v1
55 downloads
195 views

Cytokines are fundamental for a functioning immune system, and thus, potentially serve as important indicators of animal health. Quantitation of mRNA using quantitative reverse transcription polymerase chain reaction (qRT-PCR) is an established immunological technique....

["Marine Biology","Molecular Biology","Veterinary Medicine","Immunology"]
doi:10.7287/peerj.preprints.2735v1
105 downloads
308 views

Development of drug resistance limits the effectiveness of anticancer treatments. Understanding the molecular mechanisms triggering this event in tumor cells may lead to improved therapeutic strategies. Here we used RNA-seq to compare the transcriptomes of an erythroleukemia...

["Molecular Biology","Hematology"]
doi:10.7287/peerj.preprints.2731v1
30 downloads
129 views

Structure informs function, and this may be the evolutionary reason why alternative splicing, which is capable of generating different variants of the same protein, arise. But, given the energetic cost of generating different splice variants for testing their capability...

["Biochemistry","Bioinformatics","Genomics","Molecular Biology","Anatomy and Physiology"]
doi:10.7287/peerj.preprints.2717v1
46 downloads
174 views

Background: Lysyl oxidases (LOX) were studied mostly in mammals, whereas properties of recently found homologs in prokaryotic genomes remain enigmatic. Methods: LOX gene from Haloterrigena turkmenica has been cloned by PCR in a E. coli expression vector. Protein...

["Biochemistry","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2691v1
23 downloads
159 views

The repair of DNA from alkylation damage is generally performed by evolutionary conserved protein complexes. However, specific repair of O6-alkylated-guanines is a task of a small class of proteins called AGTs (alkylated DNA-protein alkyl-transferases): by using...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.2683v1
29 downloads
212 views

Type I restriction-modification enzymes are multisubunit, multifunctional molecular machines that recognize specific DNA target sequences, and their multisubunit organization underlies their multifunctionality. EcoR124I is the archetype of Type I restriction-modification...

["Biochemistry","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2680v1
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