Preprints (not yet peer-reviewed)

4 downloads
82 views

Background: Tibetans have lived at high altitudes for thousands of years, and they have a unique composition of physiological traits that enable them to tolerate this hypoxic environment. However, the genetic basis of these traits is still unknown. As a sensitive...

["Molecular Biology","Hematology"]
doi:10.7287/peerj.preprints.2929v1
28 downloads
117 views

In the past decades, novel pharmaceutical compounds have been produced by a wide diverse groups of marine bacteria. These marine bacteria are potential reservoirs for antimicrobial products. In this study, we investigated 40 soil samples collected from the Great...

["Biodiversity","Genomics","Marine Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2910v1
17 downloads
188 views

Background. The diatom Phaeodactylum tricornutum is a model photosynthetic organism. Functional genomic work in this organism has established a variety of genetic tools including RNA interference (RNAi). RNAi is a post-transcriptional regulatory process that can...

["Biotechnology","Genetics","Marine Biology","Molecular Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.2907v1
11 downloads
186 views

12R-LOX over-expression has been reported in various pathologies such as psoriasis, proliferative dermatitis as well as pulmonary obstructive diseases indicating that this enzyme plays significant role in pathogenesis of inflammatory diseases. 12R-LOX, therefore,...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.2906v1
21 downloads
111 views

Background. Members of the genus Bifidobacterium are abundant in the feces of babies during the exclusively-milk-diet period of life. Bifidobacterium longum is reported to be a common member of the infant fecal microbiota. However, B. longum is composed of three...

["Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2899v1
9 downloads
177 views

Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or whether mammalian...

["Developmental Biology","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7287/peerj.preprints.2889v1
176 downloads
965 views

1) DNA metabarcoding holds great promise for the assessment of macroinvertebrates in stream ecosystems. However, few large-scale studies have compared the performance of DNA metabarcoding with that of routine morphological identification. 2) We performed metabarcoding...

["Biodiversity","Environmental Sciences","Molecular Biology","Zoology","Science Policy"]
doi:10.7287/peerj.preprints.2759v3
723 downloads
2,233 views

A central challenge in the present era of biodiversity loss is to assess and manage human impacts on freshwater ecosystems. Macroinvertebrates are an important group for bioassessment as many taxa show specific responses to environmental conditions. However, generating...

["Biodiversity","Bioinformatics","Ecology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.2044v5
20 downloads
105 views

Background. Sturnira is one of the most species-richness in the Neotropic, and it is found from Mexico, Lesser Antilles to Argentina. Genus forms a well-supported monophyletic clade with at least twenty-one recognized species, and several under taxonomic review....

["Ecology","Genetics","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2886v1
374 downloads
773 views

Microbes, while living in close proximity in biofilms, may in other cases not be closely localized in the environment. In the latter case, their interactions and communications are dependent on myriad factors such as existence of direct connections (e.g., web of...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.349v6
36 downloads
152 views

Pontoscolex corethrurus (Müller, 1857) plays an important role in soil terrestrial ecosystems and has been widely used as an animal model for a large variety of ecological studies, in particular due to its common presence and generally high abundance in human-disturbed...

["Environmental Sciences","Genetics","Molecular Biology","Soil Science"]
doi:10.7287/peerj.preprints.2847v1
38 downloads
139 views

Background. Species identification is essential for controlling disease, understanding epidemiology, and to guide the implementation of phytosanitary measures against fungi from the genus Diaporthe. Accurate Diaporthe species separation requires using multi-loci...

["Microbiology","Molecular Biology","Mycology"]
doi:10.7287/peerj.preprints.2822v1
14 downloads
98 views

The importance of histidine tautomerism for an accurate drug/protein structure determination and their relevance for the interaction between biological systems is recognized. Consequently, here we used a recently introduced method to determine the pKa values of...

["Bioinformatics","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2816v1
22 downloads
118 views

It is now widely accepted that oligomers consisting of Aβ peptide are the cytotoxic species contributing mostly to the development of Alzheimer’s disease. Aβ peptide production results from the specific proteolytic processing of the amyloid precursor protein (APP)....

["Biophysics","Biotechnology","Cell Biology","Molecular Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2804v1
26 downloads
98 views

Cancer spread away from the primary tumour towards other parts of the body is what is most feared in cancer treatment, and is the leading cause of relapse for patients who are in remission after initial rounds of treatment with surgery, radiation or chemotherapy....

["Biochemistry","Cell Biology","Marine Biology","Molecular Biology","Histology"]
doi:10.7287/peerj.preprints.2800v1
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