Preprints (not yet peer-reviewed)

299 downloads
888 views

The dynamics of ecological communities have been described by neutral and niche theories that are now increasingly integrated into unified models. It is known that a critical transition exists between these two states, but the spatial aspect of this transition...

["Biodiversity","Computational Biology","Ecology","Mathematical Biology"]
doi:10.7287/peerj.preprints.1589v4
203 downloads
1,065 views

1. Stable isotope analysis is a widely used tool for the reconstruction and interpretation of animal diets and trophic relationships. Analytical tools have improved the robustness of inferring the relative contribution of different prey sources to an animal’s diet...

["Computational Biology","Ecology","Ecosystem Science","Zoology","Statistics"]
doi:10.7287/peerj.preprints.1950v2
80 downloads
420 views

A detailed review of a recent data science book by Hadley Wickham and Garrett Grolemund is developed herein. Technical book reviews should provide a guide to the readers, a sense of the appropriate audience, the specifics of the software/language, and identify...

["Computational Biology","Data Science"]
doi:10.7287/peerj.preprints.2873v1
20 downloads
102 views

Membrane proteins are the most medicinally important yet to be fully exploited pharmaceutical targets. Here druggability analyses are conducted on three different membrane proteins, namely, the human P2Y12 receptor, glycoprotein-41 that mediates the HIV-1 virus...

["Biochemistry","Bioinformatics","Biophysics","Computational Biology"]
doi:10.7287/peerj.preprints.2868v1
42 downloads
144 views

Incorrect snake identification from the observable visual traits is a major reason of death resulting from snake bites. So far no automatic classification method has been proposed to distinguish snakes by deciphering the taxonomy features of snake for the two major...

["Bioinformatics","Computational Biology","Taxonomy","Zoology"]
doi:10.7287/peerj.preprints.2867v1
36 downloads
111 views

Emerging viruses cause a lot of fatalities as they jump to humans from other species. Here we develop a novel technique to computationally estimate an important parameter of within-host viral infection: the lifespan of infected cells. Our approach is general and...

["Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.2621v2
518 downloads
310 views

ATLAS (Automatic Tool for Local Assembly Structures) is a comprehensive multi-omics data analysis pipeline that is massively parallel and scalable. ATLAS contains a modular analysis pipeline for assembly, annotation, quantification and genome binning of metagenomics...

["Bioinformatics","Computational Biology","Data Science","Scientific Computing and Simulation","Software Engineering"]
doi:10.7287/peerj.preprints.2843v1
2 downloads
26 views

Modern biomedical research aims at drawing biological conclusions from large, highly complex biological datasets. Nowadays, it is common practice to make extensive use of high-throughput technologies that produce big amounts of heterogeneous data. In addition to...

["Bioinformatics","Computational Biology","Data Science","Databases","Distributed and Parallel Computing"]
doi:10.7287/peerj.preprints.2839v1
54 downloads
222 views

MerCat (“ Mer - Cat enate”) is a parallel, highly scalable and modular property software package for robust analysis of features in next-generation sequencing data. Using assembled contigs and raw sequence reads from any platform as input, MerCat performs k-mer...

["Bioinformatics","Computational Biology","Data Science","Scientific Computing and Simulation","Software Engineering"]
doi:10.7287/peerj.preprints.2825v1
8 downloads
57 views

Introduction Computational reproducibility refers to the possibility of reconstructing all the steps of a workflow that connects raw data, processed data and results: it is a fundamental issue in the omic studies because of the complex and high-dimensional nature...

["Bioinformatics","Computational Biology","Data Science"]
doi:10.7287/peerj.preprints.2823v1
8 downloads
88 views

The importance of histidine tautomerism for an accurate drug/protein structure determination and their relevance for the interaction between biological systems is recognized. Consequently, here we used a recently introduced method to determine the pKa values of...

["Bioinformatics","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2816v1
20 downloads
106 views

Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, 3-dimensional molecular structure analysis of P-type ATPases...

["Biochemistry","Bioinformatics","Biophysics","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.2812v1
114 downloads
450 views

Numerous investigations of bacterial communities using sequence analysis of environmental DNA have revealed extensive diversity of microbial taxa in an array of different environmental habitats. Community analysis based solely on DNA, however, does not reveal whether...

["Computational Biology","Ecology","Microbiology"]
doi:10.7287/peerj.preprints.2051v2
798 downloads
695 views

The past influences the present and future; for example, in computational chemistry, simplifying assumptions and approximations important in the pre-computing era remains relevant today in allowing simulation of larger systems with reasonable amount of computer...

["Biochemistry","Bioengineering","Biophysics","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.365v4
51 downloads
529 views

The nonparametric minimum hypergeometric (mHG) test is a popular alternative to Kolmogorov-Smirnov (KS)-type tests for determining gene set enrichment. However, these approaches have not been compared to each other in a quantitative manner. Here, I first perform...

["Computational Biology","Algorithms and Analysis of Algorithms","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.1962v3
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