Preprints (not yet peer-reviewed)

21 downloads
151 views

Background: Standard two-dimensional (2D) cell migration assays do not provide information about vertical invasion processes, which are critical for melanoma progression. We provide information about three-dimensional (3D) melanoma cell migration, proliferation...

["Cell Biology","Histology"]
doi:10.7287/peerj.preprints.2984v1
35 downloads
94 views

A scientific theory or hypothesis is presented, in which mineral particles may play a pivotal role in the prion disease transmissible spongiform encephalopathy (TSE), and possibly also in other protein-misfolding diseases. Montmorillonite clay (Mte) and other minerals...

["Cell Biology","Molecular Biology","Infectious Diseases","Neurology"]
doi:10.7287/peerj.preprints.2982v1
10 downloads
104 views

Movement in proteins requires energy. To this end, natural selection has selected phosphate as the principal energy currency in cells. On the other hand, depicting the state of transcription could come in the form of epigenetic markers, which are modifications...

["Biochemistry","Cell Biology","Computational Biology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.2966v1
6 downloads
159 views

BACKGROUND: 2’-4’ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine the role of PECAM-1...

["Cell Biology","Dermatology","Immunology"]
doi:10.7287/peerj.preprints.2947v1
382 downloads
802 views

Microbes, while living in close proximity in biofilms, may in other cases not be closely localized in the environment. In the latter case, their interactions and communications are dependent on myriad factors such as existence of direct connections (e.g., web of...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.349v6
21 downloads
239 views

The secretory pathway in Plasmodium falciparum has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. The latter can occur via the ER or the ER-Golgi route. Here, we study these three routes using proteins...

["Cell Biology","Parasitology"]
doi:10.7287/peerj.preprints.2813v2
22 downloads
146 views

It is now widely accepted that oligomers consisting of Aβ peptide are the cytotoxic species contributing mostly to the development of Alzheimer’s disease. Aβ peptide production results from the specific proteolytic processing of the amyloid precursor protein (APP)....

["Biophysics","Biotechnology","Cell Biology","Molecular Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2804v1
29 downloads
113 views

Cancer spread away from the primary tumour towards other parts of the body is what is most feared in cancer treatment, and is the leading cause of relapse for patients who are in remission after initial rounds of treatment with surgery, radiation or chemotherapy....

["Biochemistry","Cell Biology","Marine Biology","Molecular Biology","Histology"]
doi:10.7287/peerj.preprints.2800v1
35 downloads
162 views

Symbiotic bacteria are common in insects and can affect various aspects of their hosts’ biology. Although the effects of insect symbionts have been clarified for various insect symbiosis models, due to the difficulty of cultivating them in vitro, there is still...

["Cell Biology","Entomology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2799v1
800 downloads
601 views

Divergence of treatment responses to chemotherapy exists across patients (often with unknown underlying mechanisms), with some patients exhibiting worsened outcome upon treatment. Genomic approaches (such as microarray profiling and whole genome sequencing) hold...

["Bioengineering","Bioinformatics","Cell Biology","Genomics","Histology"]
doi:10.7287/peerj.preprints.1049v6
42 downloads
134 views

BACKGROUNDː This article describes the characterization of a new cell line (IRB-1), which was established from an Iranian child with retinoblastoma. METHODSː Using cell culture techniques, we isolated a clonal population from primary Cultures of retinoblastoma...

["Cell Biology","Oncology","Ophthalmology"]
doi:10.7287/peerj.preprints.2780v1
66 downloads
222 views

Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of existing methods for quantifying protein levels in single cells. To alleviate these...

["Biochemistry","Cell Biology","Computational Biology","Developmental Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2767v1
41 downloads
160 views

Background: Food preservation is essential to the growing world population, food economy. Freezing is a commonly used method for food preservation. While extending the life of the product, freezing has detrimental effects. It is causing loss of food weight and...

["Agricultural Science","Biophysics","Cell Biology","Food Science and Technology","Plant Science"]
doi:10.7287/peerj.preprints.2740v1
29 downloads
154 views

Background. Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2729v1
121 downloads
334 views

It has been reported that the intracellular pH of the budding yeast Saccharomyces cerevisiae is asymmetric between mother and daughter cells, and this asymmetry in pH underlies replicative aging and rejuvenation. S. cerevisiae growth morphology changes between...

["Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.2684v1
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