Preprints (not yet peer-reviewed)

219 downloads
1,405 views

Data in the life sciences are extremely diverse and are stored in a broad spectrum of repositories ranging from those designed for particular data types (such as KEGG for pathway data or UniProt for protein data) to those that are general-purpose (such as FigShare,...

["Bioinformatics","Data Science","Databases","Emerging Technologies","World Wide Web and Web Science"]
doi:10.7287/peerj.preprints.2522v2
126 downloads
485 views

Cyanobacteria are major contributors to global biogeochemical cycles. The genetic diversity among Cyanobacteria enables them to thrive across many habitats. However, the taxonomy of Cyanobacteria remains unstable because of an inadequate taxonomic classification...

["Bioinformatics","Ecology","Genomics","Microbiology","Taxonomy"]
doi:10.7287/peerj.preprints.2676v1
6 downloads
103 views

The definition of the structural basis of the conformational preferences of the genetically encoded aminoacid residues is crucial to decipher the physical code of protein folding and would have a huge impact on our understanding of protein structure and function....

["Bioinformatics","Computational Biology","Databases"]
doi:10.7287/peerj.preprints.2665v1
41 downloads
113 views

Nowadays, with the development of people's life, obesity become one of the largest health problems today. Solute carrier family 35, member D3 (SLC35D3) protein has been reported to be involved in adipose deposition and metabolic control in mice. Because organ size...

["Bioinformatics","Genetics"]
doi:10.7287/peerj.preprints.2661v1
31 downloads
99 views

Food components are object of many studies aimed to identify compounds responsible of positive effects in nutrition and food science. Compound categories include antioxidants, whose positive activity is commonly related to their activity in deactivating free radicals....

["Biochemistry","Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.2658v1
57 downloads
913 views

Background Transposable element (TE) polymorphisms are important components of population genetic variation. The functional impacts of TEs in gene regulation and generating genetic diversity have been observed in multiple species, but the frequency and magnitude...

["Bioinformatics","Genomics","Plant Science"]
doi:10.7287/peerj.preprints.2447v2
36 downloads
264 views

This document is an open response to the NIH Request for Information (RFI): Strategies for NIH Data Management, Sharing, and Citation, Notice Number: NOT-OD-17-015, written by the leaders of the FORCE11 Software Citation Working Group from its inception in mid-2015...

["Bioinformatics","Science Policy"]
doi:10.7287/peerj.preprints.2640v1
107 downloads
603 views

Shotgun metagenomics of microbial communities reveals information about strains of relevance for applications in medicine, biotechnology and ecology. Recovering their genomes is a crucial, but very challenging step, due to the complexity of the underlying biological...

["Bioinformatics","Computational Biology","Data Science"]
doi:10.7287/peerj.preprints.2626v3
34 downloads
130 views

Drug discovery is a step-by-step process very important in biopharmaceutical field. We are interested in identifying new investigational drug-likes as potential inhibitors of determinate biological-therapeutic targets, trying to decrease the side effects and to...

["Bioinformatics","Computational Biology","Drugs and Devices"]
doi:10.7287/peerj.preprints.2639v1
14 downloads
102 views

Data mining is one of the main activities in bioinformatics, specifically to extract knowledge from massive data sets related with gene expression measurement, CNV, DNA strings, and others. A long array of methods are used to perform such task, ranging from the...

["Bioinformatics","Computational Biology","Algorithms and Analysis of Algorithms","Data Mining and Machine Learning","Optimization Theory and Computation"]
doi:10.7287/peerj.preprints.2635v1
50 downloads
210 views

There are a lot of algorithms and programs for reconstruction of phylogeny of a set of proteins basing on multiple sequence alignment. Many programs allow users to choose a number of parameters, for example, a model for maximum likelihood programs. Different programs...

["Bioinformatics","Computational Biology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.2628v1
211 downloads
478 views

Metastatic cutaneous melanoma is an aggressive skin cancer with some progression-slowing treatments but no known cure. The omics data explosion has created many possible drug candidates, however filtering criteria remain challenging, and systems biology approaches...

["Bioinformatics","Computational Biology","Data Science","World Wide Web and Web Science"]
doi:10.7287/peerj.preprints.2007v2
55 downloads
165 views

Acidithiobacillus ferrooxidans ( A. ferrooxidans ) is a gram-negative, extremely acidophilic, mesophilic, chemolithotrophic bacterium and the most well-studied acidophilic organism which is usually found in acid environments such as acid mine drainage. The draft...

["Bioinformatics","Genomics","Microbiology"]
doi:10.7287/peerj.preprints.2620v1
174 downloads
512 views

To answer many of the major questions in comparative botany, ecology, and global change biology it is necessary to extrapolate across enormous geographic, temporal and taxonomic scales. Yet much ecological knowledge is still based on observations conducted within...

["Biodiversity","Biogeography","Bioinformatics","Ecology","Computational Science"]
doi:10.7287/peerj.preprints.2615v2
195 downloads
611 views

The global deep subsurface biosphere is thought to be one of the largest reservoirs for microbial life on our planet. This study takes advantage of new sampling technologies and couples them with improvements to DNA sequencing and associated informatics tools to...

["Bioinformatics","Environmental Sciences","Genomics","Microbiology"]
doi:10.7287/peerj.preprints.2613v1
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