Preprints (not yet peer-reviewed)

215 downloads
644 views

Targeted high-throughput sequencing using hybrid-enrichment offers a promising source of data for inferring multiple, meaningfully resolved, independent gene trees suitable to address challenging phylogenetic problems in species complexes and rapid radiations....

["Bioinformatics","Evolutionary Studies","Plant Science"]
doi:10.7287/peerj.preprints.2763v3
38 downloads
141 views

Clinical bioinformatics is an emerging field in diagnostic genetics laboratories that are harnessing next-generation sequencing technologies to improve patient care. This document provides guidance for the development and validation of software used for delivery...

["Bioinformatics","Genomics","Science Policy"]
doi:10.7287/peerj.preprints.2996v1
170 downloads
665 views

Background: For more than 25 years the golden mussel Limnoperna fortunei has been an aggressive invader in South America freshwaters, having travelled more than 5,000 km upstream across 5 countries. The mussel has outcompeted native species in the invaded environments...

["Bioinformatics","Computational Biology","Conservation Biology","Genetics","Genomics"]
doi:10.7287/peerj.preprints.2995v1
98 downloads
402 views

Sharing and reusing data in research is a welcome and encouraged practice since it maximises the scientific outcomes given limited financial, material and human resources. Interdisciplinary research is considered to benefit from this practice, uniting researchers...

["Bioinformatics","Computational Biology","Data Science","Spatial and Geographic Information Systems"]
doi:10.7287/peerj.preprints.2248v4
54 downloads
174 views

Background. There is huge amount of full-text biomedical literatures available in public repositories like PubMed Central (PMC). However, a substantial number of the papers are in Portable Document Format (PDF) and do not provide plain text format ready for text...

["Bioinformatics","Data Science","Databases","Digital Libraries","World Wide Web and Web Science"]
doi:10.7287/peerj.preprints.2993v1
112 downloads
697 views

The genetic structure of bacterial populations can be related to geographical locations of isolation. In some species, there is a strong correlation between geographical distance and genetic distance, which can be caused by different evolutionary mechanisms. Patterns...

["Biogeography","Bioinformatics","Genomics","Microbiology","Epidemiology"]
doi:10.7287/peerj.preprints.2638v2
168 downloads
549 views

Whole genome sequencing is opening the door to novel insights into the population structure and evolutionary history of poorly known species. In organisms with large genomes, which includes most amphibians, whole-genome sequencing is excessively challenging and...

["Bioinformatics","Evolutionary Studies","Genomics","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2980v1
88 downloads
268 views

Digital repositories bring direct impact and influence on the research community and society but measuring their value using formal metrics remains challenging. their value. It is challenging to define a single perfect metric that covers all quality aspects. Here,...

["Bioinformatics","Computational Biology","Digital Libraries","World Wide Web and Web Science"]
doi:10.7287/peerj.preprints.2688v2
316 downloads
527 views

In this review, we present a summary of how computer modeling has been used in the development of covalent modifier drugs. Covalent modifier drugs bind by forming a chemical bond with their target. This covalent binding can improve the selectivity of the drug for...

["Biochemistry","Bioinformatics","Biophysics","Pharmacology","Computational Science"]
doi:10.7287/peerj.preprints.2857v2
32 downloads
139 views

Most biological processes within a cell are carried out by protein-protein interaction (PPI) networks, or so called interactomics. Therefore, identification of PPIs is crucial to elucidating protein functions and further understanding of various cellular biological...

["Bioinformatics","Biotechnology","Computational Biology"]
doi:10.7287/peerj.preprints.2964v1
233 downloads
278 views

Generating heatmaps of genes datasets have been known to be a graphical representation of data where the individual values contained in a matrix are represented as colors. Herein, we describe AFCMHeatMap a shiny web App that integrates quantitative interaction...

["Bioinformatics","Genetics","Genomics","Computational Science"]
doi:10.7287/peerj.preprints.2961v1
145 downloads
299 views

Technology has been a part of everyone’s life for decades now, and its impact on our lifestyle only seems to increase with time. Considering applications in the field of scientific research till date, it has made exponential advancements and created a new hallmark....

["Bioinformatics","Oncology","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.2960v1
84 downloads
371 views

The Ebola virus, a negative-sense single-stranded RNA virus, causes severe viral hemorrhagic fever and is highly lethal. Histopathology and immunopathologic study of Ebola virus have revealed that histopathologic changes in skin tissue were mainly various degrees...

["Bioinformatics","Microbiology","Infectious Diseases","Medical Genetics"]
doi:10.7287/peerj.preprints.2959v1
46 downloads
348 views

Background: Technological advances in sequencing, assembly and segregation of resulting contigs into species-specific bins has enabled the reconstruction of individual genomes from environmental metagenomic data sets. Though a powerful technique, it is shadowed...

["Bioinformatics","Genomics","Microbiology"]
doi:10.7287/peerj.preprints.2953v1
85 downloads
393 views

Assay for Transposase Accessible Chromatin (ATAC-seq) is an open chromatin profiling assay that is adapted to interrogate chromatin accessibility from small cell numbers. ATAC-seq surmounted a major technical barrier and enabled epigenome profiling of clinical...

["Bioinformatics","Computational Biology","Genomics"]
doi:10.7287/peerj.preprints.2942v1
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