Preprints (not yet peer-reviewed)

20 downloads
243 views

Human papillomavirus type 16 (HPV16) is the most carcinogenic HPV, causing >50% of cervical cancers. Its unique oncogenicity is unsolved, e.g., the second most carcinogenic type (HPV18, causing ~16% of cancers) is relatively distantly related to HPV16. Mirabello...

["Bioinformatics","Evolutionary Studies","Infectious Diseases","Oncology","Women's Health"]
doi:10.7287/peerj.preprints.3070v1
76 downloads
296 views

Symbiotic interactions between insects and bacteria are ubiquitous and form a continuum from loose facultative symbiosis to greatly intimate and stable obligate symbiosis. In blood-sucking insects living exclusively on vertebrate blood, obligate endosymbionts are...

["Biodiversity","Bioinformatics","Evolutionary Studies"]
doi:10.7287/peerj.preprints.3057v1
47 downloads
446 views

Recent years have witnessed the discovery of protein–coding genes which appear to have evolved de novo from previously non-coding sequences. This has changed the long-standing view that coding sequences can only evolve from other coding sequences. However, there...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genetics","Genomics"]
doi:10.7287/peerj.preprints.3031v2
167 downloads
713 views

Background. Viral metagenomics (viromics) is increasingly used to obtain uncultivated viral genomes, evaluate community diversity, and assess ecological hypotheses. While viromic experimental methods are relatively mature and widely accepted by the research community,...

["Bioinformatics","Ecology","Genomics","Microbiology"]
doi:10.7287/peerj.preprints.3053v1
24 downloads
124 views

Aminoacyl-tRNA synthetases (aaRS) are enzymes that catalyze the ligation of tRNAs to their cognate amino acids. There are aaRSs specific to each of the 20 standard amino acids. These enzymes are divided into two classes, class I and class II, which are unrelated...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genomics"]
doi:10.7287/peerj.preprints.3045v1
79 downloads
182 views

Recently, Docker technology has received increasing attention throughout the bioinformatics community. However, its implementation has not yet been mastered by most biologists, and thus its application in biological research has been limited. In order to popularize...

["Bioinformatics","Computational Biology","Genomics","Microbiology"]
doi:10.7287/peerj.preprints.3040v1
68 downloads
154 views

The Arabian Peninsula (AP) is the first site of human migration and habitation outside of Africa. As a major crossroad for human populations, the AP provides an opportunity to better understand early to modern changes in human demographic patterns through selections,...

["Bioinformatics","Evolutionary Studies","Genomics"]
doi:10.7287/peerj.preprints.3039v1
116 downloads
203 views

Many difficulties are encountered by people with disabilities, especially when a diagnosis is made up of more than one dysfunction, as is the case of visually impaired wheelchair users. In fact, this scenario generates a degree of incapacity in terms of the performing...

["Bioengineering","Bioinformatics","Neuroscience","Clinical Trials","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.3036v1
25 downloads
229 views

In de novo gene emergence, a segment of non-coding DNA undergoes a series of changes which enables transcription, potentially leading to a new protein that could eventually acquire a novel function. Due to their recent origins, young de novo genes have no homology...

["Bioinformatics","Evolutionary Studies","Genomics"]
doi:10.7287/peerj.preprints.3030v1
138 downloads
206 views

Life science ontologies play an important role in semantic web. In the fish and fisheries research field, it is imperative to have an ontology that can automatically provide information for biological objects annotations and links to relevant data pieces. As such,...

["Aquaculture, Fisheries and Fish Science","Bioinformatics","Computational Science"]
doi:10.7287/peerj.preprints.3020v1
69 downloads
221 views

Many applications require the calculation of site-specific evolutionary rates from alignments of amino-acid sequences. For example, catalytic residues in enzymes and interface regions in protein complexes can be inferred from observed relative rates. While numerous...

["Bioinformatics","Evolutionary Studies","Mathematical Biology"]
doi:10.7287/peerj.preprints.3002v1
234 downloads
692 views

Targeted high-throughput sequencing using hybrid-enrichment offers a promising source of data for inferring multiple, meaningfully resolved, independent gene trees suitable to address challenging phylogenetic problems in species complexes and rapid radiations....

["Bioinformatics","Evolutionary Studies","Plant Science"]
doi:10.7287/peerj.preprints.2763v3
71 downloads
169 views

Clinical bioinformatics is an emerging field in diagnostic genetics laboratories that are harnessing next-generation sequencing technologies to improve patient care. This document provides guidance for the development and validation of software used for delivery...

["Bioinformatics","Genomics","Science Policy"]
doi:10.7287/peerj.preprints.2996v1
258 downloads
862 views

Background: For more than 25 years the golden mussel Limnoperna fortunei has been an aggressive invader in South America freshwaters, having travelled more than 5,000 km upstream across 5 countries. The mussel has outcompeted native species in the invaded environments...

["Bioinformatics","Computational Biology","Conservation Biology","Genetics","Genomics"]
doi:10.7287/peerj.preprints.2995v1
109 downloads
431 views

Sharing and reusing data in research is a welcome and encouraged practice since it maximises the scientific outcomes given limited financial, material and human resources. Interdisciplinary research is considered to benefit from this practice, uniting researchers...

["Bioinformatics","Computational Biology","Data Science","Spatial and Geographic Information Systems"]
doi:10.7287/peerj.preprints.2248v4
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