Preprints (not yet peer-reviewed)

3 downloads
50 views

Scale transcends multiple levels of biological and physical organization, and is the critical factor that determines success of any scientific investigation. Specifically, the scale at which a question is posed plays a crucial role in influencing the type of experiments...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.3261v1
6 downloads
55 views

Microfluidic cell culture chambers have enabled the isolation, culture and growth of various species of microorganisms and human cells. However, based on elastomers such as poly(dimethyl siloxane) (PDMS), these culture devices are not readily amenable to imaging...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.3245v1
3 downloads
60 views

Co-existence of microbes in a community is the de facto state of microbial lifestyle in almost all niches on Earth. Thus, microbes live with other microbial species in close proximity, and evolution has selected for specific methods of communication between microbes...

["Biochemistry","Biodiversity","Cell Biology","Ecology","Microbiology"]
doi:10.7287/peerj.preprints.3239v1
8 downloads
135 views

Contemporary proteins can be traced back to a basic set of a few thousand domain prototypes. The origin of these domain prototypes, however, remains poorly understood. We have proposed that they arose from an ancestral set of peptides, which acted as cofactors...

["Biochemistry","Bioinformatics","Evolutionary Studies"]
doi:10.7287/peerj.preprints.3234v1
47 downloads
103 views

Single cell studies increasing reveal myriad cellular subtypes beyond those postulated or observed through optical and fluorescence microscopy as well as DNA sequencing studies. While gene sequencing at the single cell level offer a path towards illuminating, in...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.3193v1
40 downloads
141 views

Background. Carrot is a multi-nutritional food source. It is an important root vegetable, rich in natural bioactive compounds with health-promoting properties, such as antioxidants that have anti-carcinogenic properties. Aim. This review summarises the occurrences...

["Agricultural Science","Biochemistry","Food Science and Technology","Plant Science","Nutrition"]
doi:10.7287/peerj.preprints.3187v1
262 downloads
704 views

Microbes for environmental research should be cultured in growth media with characteristics (e.g., pH, ionic strength, and ionic composition) as close to their original habitat as possible. Additionally, the medium should also enable high cell density to be obtained,...

["Biochemistry","Bioengineering","Biotechnology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.1406v6
306 downloads
4,548 views

In 1961, the NIH began to circulate biological preprints in a forgotten experiment called the Information Exchange Groups (IEGs). This system eventually attracted over 3600 participants and saw the production of over 2,500 different documents, but by 1967 it was...

["Biochemistry","Science Policy"]
doi:10.7287/peerj.preprints.3174v1
19 downloads
135 views

Scientific terms should be as accurate and meaningful as possible for both researchers and the general science readership. Currently, some scientific terms do not properly describe the activity or function to which they are associated to, being frequently characterized...

["Biochemistry","Genetics","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.3102v1
22 downloads
96 views

Survival of microbes on various surfaces and environment is a question of importance to basic science, as well as health care, water treatment and distribution, ecology, and search for life in other planetary bodies. To this end, various model organisms, known...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.3103v1
27 downloads
144 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.3094v1
28 downloads
125 views

The osmotic pressure of chondroitin sulfate glycosaminoglycans (CS-GAGs) in a simulated physiological environment of articular cartilage is thoroughly examined in silico using full atomistic models. The effects of chemical and physical properties were investigated...

["Biochemistry","Biophysics","Computational Biology","Anatomy and Physiology","Rheumatology"]
doi:10.7287/peerj.preprints.3063v1
16 downloads
107 views

Chlamydia trachomatis is usally isolated only from humans and is often infected together with other sexually transmitted diseases(STD). C. trachomatis is a serious disease which infects 500 million people per year globally and causes blindness in 7 to 9 million...

["Biochemistry","Microbiology","Molecular Biology","Immunology","Infectious Diseases"]
doi:10.7287/peerj.preprints.3056v1
19 downloads
191 views

Background. Aspergillus niger along with many other lignocellulolytic fungi, has been widely used as a commercial workhorse for cellulase production. A fungal cellulase system generally includes three major classes of enzymes i.e. β-glucosidases, endoglucanases...

["Biochemistry","Biotechnology","Molecular Biology"]
doi:10.7287/peerj.preprints.3044v1
78 downloads
150 views

In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having...

["Biochemistry","Biotechnology","Oncology"]
doi:10.7287/peerj.preprints.3035v1
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