Peer-reviewed Articles - Medicine

40 downloads
347 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.6082
4 citations
436 downloads
1,712 views

Rhodomyrtone, a natural antimicrobial compound, displays potent activity against many Gram-positive pathogenic bacteria, comparable to last-defence antibiotics including vancomycin and daptomycin. Our previous studies pointed towards effects of rhodomyrtone on...

["Biochemistry","Computational Biology","Microbiology","Drugs and Devices","Infectious Diseases"]
doi:10.7717/peerj.2962
16 citations
617 downloads
2,886 views

Alzheimer’s disease (AD) is a chronic neurodegenerative disease which leads to the gradual loss of neuronal cells. Several hypotheses for AD exists (e.g., cholinergic, amyloid, tau hypotheses, etc.). As per the cholinergic hypothesis, the deficiency of choline...

["Bioinformatics","Computational Biology","Drugs and Devices","Neuroscience","Pharmacology"]
doi:10.7717/peerj.2322
6 citations
429 downloads
1,811 views

Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel inhibitor...

["Bioinformatics","Computational Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.1979
5 citations
363 downloads
2,327 views

The fight against the emergence of mutant influenza strains has led to the screening of an increasing number of compounds for inhibitory activity against influenza neuraminidase. This study explores the chemical space of neuraminidase inhibitors (NAIs), which provides...

["Bioinformatics","Computational Biology","Drugs and Devices","Computational Science"]
doi:10.7717/peerj.1958
6 citations
590 downloads
2,953 views

Current research and development approaches to drug discovery have become less fruitful and more costly. One alternative paradigm is that of drug repositioning. Many marketed examples of repositioned drugs have been identified through serendipitous or rational...

["Bioinformatics","Computational Biology","Computational Science","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.1558
6 citations
521 downloads
2,030 views

Substantial evidence has shown that most exogenous substances are metabolized by multiple cytochrome P450 (P450) enzymes instead of by merely one P450 isoform. Thus, multi-P450 inhibition leads to greater drug-drug interaction risk than specific P450 inhibition....

["Computational Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.1524
9 citations
878 downloads
2,013 views

The distortion of biomedical signals by powerline noise from recording biomedical devices has the potential to reduce the quality and convolute the interpretations of the data. Usually, powerline noise in biomedical recordings are extinguished via band-stop filters....

["Bioengineering","Computational Biology","Cardiology","Drugs and Devices","Neurology"]
doi:10.7717/peerj.1086
14 citations
1,025 downloads
6,558 views

Viral RNA helicases are involved in duplex unwinding during the RNA replication of the virus. It is suggested that these helicases represent very promising antiviral targets. Viruses of the flaviviridae family are the causative agents of many common and devastating...

["Bioinformatics","Computational Biology","Evolutionary Studies","Drugs and Devices","Infectious Diseases"]
doi:10.7717/peerj.74

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