Peer-reviewed Articles

9 downloads
84 views

Background Herb-drug interactions (HDIs) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions. Organic anion transporter 1 (OAT1) and 3 (OAT3) are highly expressed in the kidney and play a key role in the renal elimination...

["Plant Science","Toxicology","Pharmacology"]
doi:10.7717/peerj.3333
42 downloads
266 views

Aim Atorvastatin is a HMG-CoA reductase inhibitor used for hyperlipidemia. Atorvastatin is generally safe but may induce cholestasis. The present study aimed to examine the effects of atorvastatin on hepatic gene expression related to bile acid metabolism and homeostasis,...

["Toxicology","Pharmacology"]
doi:10.7717/peerj.3348
25 downloads
161 views

DEET and IR3535 are insect repellents present worldwide in commercial products; their efficacy has been mainly evaluated in mosquitoes. This study compares the toxicological effects and the behavioral responses induced by both repellents on the blood-sucking bug...

["Entomology","Toxicology"]
doi:10.7717/peerj.3292
32 downloads
224 views

Cations have generally been reported to prevent jellyfish venom-induced hemolysis through multiple mechanisms by spectrophotometry. Little attention has been paid to the potential interaction between cations and hemoglobin, potentially influencing the antagonistic...

["Cell Biology","Toxicology"]
doi:10.7717/peerj.3338
77 downloads
1,038 views

The same selective forces that give rise to rapid inter- and intraspecific divergence in snake venoms can also favor differences in venoms across life-history stages. Ontogenetic changes in venom composition are well known and widespread in snakes but have not...

["Genetics","Toxicology"]
doi:10.7717/peerj.3249
84 downloads
347 views

Background Essential oil components (EOCs) are molecules with interesting application in pest control, these have been evaluated against different insect pest from more than 100 years, but their practical use is rather limited. Thus, the enhancement of their bioavailability...

["Entomology","Environmental Sciences","Toxicology"]
doi:10.7717/peerj.3171
54 downloads
342 views

Metals are present in aquatic environments as a result of natural and anthropogenic inputs, and may induce toxicity to organisms. One of the main factors that influence this toxicity in fresh water is natural organic matter (NOM) but all NOMs are not the same in...

["Biochemistry","Environmental Sciences","Marine Biology","Toxicology"]
doi:10.7717/peerj.3141
64 downloads
339 views

Although neonicotinoids are targeted at insects, their predominant use as a seed dressing and their long persistence in soils mean that non-target soil organisms such as earthworms are likely to be chronically exposed to them. Chronic exposure may pose risks that...

["Agricultural Science","Entomology","Environmental Sciences","Toxicology"]
doi:10.7717/peerj.3177
1 citation
131 downloads
462 views

Background The monocled cobra (Naja kaouthia) is a medically important venomous snake in Southeast Asia. Its venom has been shown to vary geographically in relation to venom composition and neurotoxic activity, indicating vast diversity of the toxin genes within...

["Genetics","Molecular Biology","Toxicology","Zoology"]
doi:10.7717/peerj.3142
75 downloads
422 views

Background Deficiencies in lysosomal a-mannosidase (LAM) activity in animals, caused either by mutations or by consuming toxic alkaloids, lead to severe phenotypic and behavioural consequences. Yet, epialleles adversely affecting LAM expression exist in the honey...

["Biochemistry","Developmental Biology","Molecular Biology","Toxicology"]
doi:10.7717/peerj.3109
67 downloads
370 views

Moult of feathers entails considerable physiological and energetic costs to an avian organism. Even under favourable feeding conditions, endogenous body stores and energy reserves of moulting birds are usually severely depleted. Thus, most species of birds separate...

["Animal Behavior","Ecology","Toxicology","Veterinary Medicine","Zoology"]
doi:10.7717/peerj.3057
1 citation
77 downloads
357 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7717/peerj.2924
2 citations
485 downloads
1,831 views

Background Seed-applied neonicotinoids are widely used in agriculture, yet their effects on non-target species remain incompletely understood. One important group of non-target species is arthropod natural enemies (predators and parasitoids), which contribute considerably...

["Agricultural Science","Ecology","Entomology","Environmental Sciences","Toxicology"]
doi:10.7717/peerj.2776
119 downloads
557 views

Background Licorice, a popular traditional Chinese medicine (TCM), is widely used to moderate the effects (detoxification) of other herbs in TCM and often combined with Fructus Psoraleae. However, the classical TCM book states that Fructus Psoraleae is incompatible...

["Cell Biology","Toxicology","Pharmacology"]
doi:10.7717/peerj.2723
286 downloads
696 views

Lithocholic acid (LCA) is a secondary bile acid that is selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported that LCA inhibited cell viability and proliferation and induced apoptosis and...

["Toxicology","Oncology"]
doi:10.7717/peerj.2445

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