Peer-reviewed Articles

36 downloads
286 views

Background Deficiencies in lysosomal a-mannosidase (LAM) activity in animals, caused either by mutations or by consuming toxic alkaloids, lead to severe phenotypic and behavioural consequences. Yet, epialleles adversely affecting LAM expression exist in the honey...

["Biochemistry","Developmental Biology","Molecular Biology","Toxicology"]
doi:10.7717/peerj.3109
50 downloads
305 views

Moult of feathers entails considerable physiological and energetic costs to an avian organism. Even under favourable feeding conditions, endogenous body stores and energy reserves of moulting birds are usually severely depleted. Thus, most species of birds separate...

["Animal Behavior","Ecology","Toxicology","Veterinary Medicine","Zoology"]
doi:10.7717/peerj.3057
58 downloads
272 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7717/peerj.2924
2 citations
432 downloads
1,659 views

Background Seed-applied neonicotinoids are widely used in agriculture, yet their effects on non-target species remain incompletely understood. One important group of non-target species is arthropod natural enemies (predators and parasitoids), which contribute considerably...

["Agricultural Science","Ecology","Entomology","Environmental Sciences","Toxicology"]
doi:10.7717/peerj.2776
94 downloads
491 views

Background Licorice, a popular traditional Chinese medicine (TCM), is widely used to moderate the effects (detoxification) of other herbs in TCM and often combined with Fructus Psoraleae. However, the classical TCM book states that Fructus Psoraleae is incompatible...

["Cell Biology","Toxicology","Pharmacology"]
doi:10.7717/peerj.2723
246 downloads
575 views

Lithocholic acid (LCA) is a secondary bile acid that is selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported that LCA inhibited cell viability and proliferation and induced apoptosis and...

["Toxicology","Oncology"]
doi:10.7717/peerj.2445
114 downloads
502 views

Hepatocyte growth factor (HGF) is a paracrine hormone that plays an important role in epithelial-mesenchymal transition. HGF secreted by mesenchymal cells affects many properties of epithelial cells, such as proliferation, motility, and morphology. HGF has been...

["Biochemistry","Cell Biology","Molecular Biology","Toxicology"]
doi:10.7717/peerj.2624
190 downloads
449 views

Selenium (Se) is an essential element with a small difference between physiological and toxic doses. To provide more effective and safe Se dosing regimens, as compared to dosing with ionic selenium, nanoparticle formulations have been developed. However, due to...

["Food Science and Technology","Toxicology","Pharmacology","Metabolic Sciences"]
doi:10.7717/peerj.2601
234 downloads
715 views

Background The wide use of pesticides raises concerns on the health risks associated with pesticide exposure. For developing countries, like Thailand, pesticide monitoring program (in vegetables and fruits) and also the maximum residue limits (MRL) regulation have...

["Agricultural Science","Environmental Sciences","Food Science and Technology","Toxicology","Nutrition"]
doi:10.7717/peerj.2432
107 downloads
391 views

Background Manganese (Mn) is widely used in industries including the manufacture of Mn-iron (Fe) alloy. Occupational Mn overexposure causes manganism. Mn is known to affect Fe metabolism; this study was designed to test the hypothesis that workers exposed to Mn...

["Environmental Sciences","Toxicology","Public Health"]
doi:10.7717/peerj.2413
194 downloads
755 views

Exploiting microalgae as feedstock for biofuel production is a growing field of research and application, but there remain challenges related to industrial viability and economic sustainability. A solution to the water requirements of industrial-scale production...

["Biotechnology","Genetics","Microbiology","Taxonomy","Toxicology"]
doi:10.7717/peerj.2396
1 citation
183 downloads
849 views

This study examined developmental toxicity of different mercury compounds, including some used in traditional medicines. Medaka (Oryzias latipes) embryos were exposed to 0.001–10 µM concentrations of MeHg, HgCl2, α-HgS (Zhu Sha), and β-HgS (Zuotai) from stage 10...

["Aquaculture, Fisheries and Fish Science","Developmental Biology","Toxicology","Pharmacology","Public Health"]
doi:10.7717/peerj.2282
1 citation
164 downloads
627 views

It has been reported that social isolation stress could be a key factor that leads to cognitive deficit for both humans and rodent models. However, detailed mechanisms are not yet clear. ADAR1 (Adenosine deaminase acting on RNA) is an enzyme involved in RNA editing...

["Animal Behavior","Biochemistry","Neuroscience","Toxicology","Pharmacology"]
doi:10.7717/peerj.2306
133 downloads
723 views

Background. Bumble bees (Bombus spp.) are important wild and managed pollinators. There is increased interest in incorporating data on bumble bees into risk assessments for pesticides, but standardized methods for assessing hazards of pesticides in semi-field and...

["Ecology","Entomology","Environmental Sciences","Plant Science","Toxicology"]
doi:10.7717/peerj.2228
369 downloads
726 views

N-Acetyl-p-Aminophenol (APAP), also known as acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes...

["Food Science and Technology","Neuroscience","Toxicology","Pathology","Pharmacology"]
doi:10.7717/peerj.2127

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