Peer-reviewed Articles

46 downloads
225 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7717/peerj.2924
1 citation
398 downloads
1,548 views

Background Seed-applied neonicotinoids are widely used in agriculture, yet their effects on non-target species remain incompletely understood. One important group of non-target species is arthropod natural enemies (predators and parasitoids), which contribute considerably...

["Agricultural Science","Ecology","Entomology","Environmental Sciences","Toxicology"]
doi:10.7717/peerj.2776
77 downloads
436 views

Background Licorice, a popular traditional Chinese medicine (TCM), is widely used to moderate the effects (detoxification) of other herbs in TCM and often combined with Fructus Psoraleae. However, the classical TCM book states that Fructus Psoraleae is incompatible...

["Cell Biology","Toxicology","Pharmacology"]
doi:10.7717/peerj.2723
225 downloads
514 views

Lithocholic acid (LCA) is a secondary bile acid that is selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported that LCA inhibited cell viability and proliferation and induced apoptosis and...

["Toxicology","Oncology"]
doi:10.7717/peerj.2445
103 downloads
432 views

Hepatocyte growth factor (HGF) is a paracrine hormone that plays an important role in epithelial-mesenchymal transition. HGF secreted by mesenchymal cells affects many properties of epithelial cells, such as proliferation, motility, and morphology. HGF has been...

["Biochemistry","Cell Biology","Molecular Biology","Toxicology"]
doi:10.7717/peerj.2624
167 downloads
397 views

Selenium (Se) is an essential element with a small difference between physiological and toxic doses. To provide more effective and safe Se dosing regimens, as compared to dosing with ionic selenium, nanoparticle formulations have been developed. However, due to...

["Food Science and Technology","Toxicology","Pharmacology","Metabolic Sciences"]
doi:10.7717/peerj.2601
214 downloads
649 views

Background The wide use of pesticides raises concerns on the health risks associated with pesticide exposure. For developing countries, like Thailand, pesticide monitoring program (in vegetables and fruits) and also the maximum residue limits (MRL) regulation have...

["Agricultural Science","Environmental Sciences","Food Science and Technology","Toxicology","Nutrition"]
doi:10.7717/peerj.2432
104 downloads
366 views

Background Manganese (Mn) is widely used in industries including the manufacture of Mn-iron (Fe) alloy. Occupational Mn overexposure causes manganism. Mn is known to affect Fe metabolism; this study was designed to test the hypothesis that workers exposed to Mn...

["Environmental Sciences","Toxicology","Public Health"]
doi:10.7717/peerj.2413
174 downloads
696 views

Exploiting microalgae as feedstock for biofuel production is a growing field of research and application, but there remain challenges related to industrial viability and economic sustainability. A solution to the water requirements of industrial-scale production...

["Biotechnology","Genetics","Microbiology","Taxonomy","Toxicology"]
doi:10.7717/peerj.2396
1 citation
163 downloads
773 views

This study examined developmental toxicity of different mercury compounds, including some used in traditional medicines. Medaka (Oryzias latipes) embryos were exposed to 0.001–10 µM concentrations of MeHg, HgCl2, α-HgS (Zhu Sha), and β-HgS (Zuotai) from stage 10...

["Aquaculture, Fisheries and Fish Science","Developmental Biology","Toxicology","Pharmacology","Public Health"]
doi:10.7717/peerj.2282
1 citation
143 downloads
580 views

It has been reported that social isolation stress could be a key factor that leads to cognitive deficit for both humans and rodent models. However, detailed mechanisms are not yet clear. ADAR1 (Adenosine deaminase acting on RNA) is an enzyme involved in RNA editing...

["Animal Behavior","Biochemistry","Neuroscience","Toxicology","Pharmacology"]
doi:10.7717/peerj.2306
122 downloads
638 views

Background. Bumble bees (Bombus spp.) are important wild and managed pollinators. There is increased interest in incorporating data on bumble bees into risk assessments for pesticides, but standardized methods for assessing hazards of pesticides in semi-field and...

["Ecology","Entomology","Environmental Sciences","Plant Science","Toxicology"]
doi:10.7717/peerj.2228
326 downloads
685 views

N-Acetyl-p-Aminophenol (APAP), also known as acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes...

["Food Science and Technology","Neuroscience","Toxicology","Pathology","Pharmacology"]
doi:10.7717/peerj.2127
79 downloads
475 views

Insects under different stimuli from the environment modify behavioural responses due to changes in the sensitivity of neurons at the peripheral and/or at the central level of the nervous system. This phenomenon is called neuronal plasticity, and sensory adaptation...

["Animal Behavior","Entomology","Toxicology"]
doi:10.7717/peerj.2150
219 downloads
757 views

This study evaluated pollution levels in water and sediments of Península de Paraguaná and related these levels with benthic macrofauna along a coastal area where the largest Venezuelan oil refineries have operated over the past 60 years. For this, the concentration...

["Ecology","Ecosystem Science","Environmental Sciences","Marine Biology","Toxicology"]
doi:10.7717/peerj.2171

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