Peer-reviewed Articles

70 downloads
346 views

The maintenance of a G + C content that is higher than the mutational input to a genome provides support for the view that selection serves to increase G + C contents in bacteria. Recent experimental evidence from Escherichia coli demonstrated that selection for...

["Biotechnology","Evolutionary Studies","Genetics","Molecular Biology","Synthetic Biology"]
doi:10.7717/peerj.4286
73 downloads
357 views

With the rapid advancement of regenerative medicine technologies, there is an urgent need for the development of new, cell-friendly techniques for obtaining nanofibers—the raw material for an artificial extracellular matrix production. We investigated the structure...

["Bioengineering","Biotechnology","Synthetic Biology"]
doi:10.7717/peerj.4125
172 downloads
681 views

Carbon nanotubes (CNTs) have a broad range of applications and are generally considered human-engineered nanomaterials. However, carbon nanostructures have been found in ice cores and oil wells, suggesting that nature may provide appropriate conditions for CNT...

["Biochemistry","Ecology","Ecosystem Science","Soil Science","Synthetic Biology"]
doi:10.7717/peerj.3658
97 downloads
698 views

Cleavage of mRNA molecules causes their rapid degradation, thereby playing an important role in regulation of gene expression and host genome defense from viruses and transposons in bacterial and eukaryotic cells. Current negative-readout, and repressor-based positive-readout...

["Bioengineering","Molecular Biology","Synthetic Biology"]
doi:10.7717/peerj.3602
1 citation
74 downloads
881 views

CodonGenie, freely available from http://codon.synbiochem.co.uk, is a simple web application for designing ambiguous codons to support protein mutagenesis applications. Ambiguous codons are derived from specific heterogeneous nucleotide mixtures, which create sequence...

["Bioengineering","Bioinformatics","Biotechnology","Computational Biology","Synthetic Biology"]
doi:10.7717/peerj-cs.120
4 citations
145 downloads
675 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7717/peerj.2924
372 downloads
1,374 views

Microbes growing in animal host environments face fluctuations that have elements of both randomness and predictability. In the mammalian gut, fluctuations in nutrient levels and other physiological parameters are structured by the host’s behavior, diet, health...

["Computational Biology","Ecology","Mathematical Biology","Microbiology","Synthetic Biology"]
doi:10.7717/peerj.2716
259 downloads
855 views

Background This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock...

["Bioengineering","Biophysics","Respiratory Medicine","Synthetic Biology"]
doi:10.7717/peerj.2635
11 citations
1,903 downloads
2,021 views

Background There is worldwide interest in silver nanoparticles (AgNPs) synthesized by various chemical reactions for use in applications exploiting their antibacterial activity, even though these processes exhibit a broad range of toxicity in vertebrates and invertebrates...

["Biotechnology","Microbiology","Synthetic Biology"]
doi:10.7717/peerj.2589
1 citation
269 downloads
1,812 views

The F1 sub-complex of ATP synthase is a biological nanomotor that converts the free energy of ATP hydrolysis into mechanical work with an astonishing efficiency of up to 100% (Kinosita et al., 2000). To probe the principal mechanics of the machine, I re-engineered...

["Biochemistry","Bioengineering","Biophysics","Synthetic Biology"]
doi:10.7717/peerj.2286
278 downloads
1,946 views

Aim. The nascent field of bio-geoengineering stands to benefit from synthetic biologists’ efforts to standardise, and in so doing democratise, biomolecular research methods. Roseobacter clade bacteria comprise 15–20% of oceanic bacterio-plankton communities, making...

["Bioengineering","Marine Biology","Molecular Biology","Science Policy","Synthetic Biology"]
doi:10.7717/peerj.2031
8 citations
746 downloads
2,035 views

Ralstonia eutropha H16 is a facultatively autotrophic hydrogen-oxidizing bacterium capable of producing polyhydroxybutyrate (PHB)-based bioplastics. As PHB’s physical properties may be improved by incorporation of medium-chain-length fatty acids (MCFAs), and MCFAs...

["Bioengineering","Microbiology","Synthetic Biology"]
doi:10.7717/peerj.1468
543 downloads
1,383 views

Two Component Systems and Phosphorelays (TCS/PR) are environmental signal transduction cascades in prokaryotes and, less frequently, in eukaryotes. The internal domain organization of proteins and the topology of TCS/PR cascades play an important role in shaping...

["Bioinformatics","Computational Biology","Mathematical Biology","Synthetic Biology"]
doi:10.7717/peerj.1183
6 citations
533 downloads
1,521 views

Using a carefully designed search query, we describe the field of synthetic biology in terms of leading countries, organizations and funding sources. Besides articles we also paid some attention to patents. The USA is the leading country in this field, followed...

["Science and Medical Education","Statistics","Synthetic Biology","Computational Science"]
doi:10.7717/peerj.728
13 citations
934 downloads
1,569 views

The cost of enzymes makes enzymatic hydrolysis one of the most expensive steps in the production of lignocellulosic ethanol. Diverse studies have used commercial enzyme cocktails assuming that change in total protein concentration during hydrolysis was solely due...

["Biotechnology","Microbiology","Synthetic Biology"]
doi:10.7717/peerj.402

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