Peer-reviewed Articles

3 downloads
2 views

Background Huntington’s disease (HD) is a rare familial autosomal dominant neurodegenerative disorder characterized by progressive degeneration of medium spiny neurons (MSNs) located in the striatum. Currently available treatments of HD are only limited to alleviating...

["Neuroscience","Pharmacology"]
doi:10.7717/peerj.3240
19 downloads
169 views

Individuals vary in their tendency to bind signals from multiple senses. For the same set of sights and sounds, one individual may frequently integrate multisensory signals and experience a unified percept, whereas another individual may rarely bind them and often...

["Neuroscience","Psychiatry and Psychology","Computational Science"]
doi:10.7717/peerj.3143
49 downloads
457 views

Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult central nervous system (CNS). For example, the FGFR1 receptor is important for proliferation and fate specification of radial glial cells...

["Developmental Biology","Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.3173
59 downloads
306 views

Alzheimer’s disease is a multifactorial disorder caused by the interaction of genetic, epigenetic and environmental factors. The formation of cytotoxic oligomers consisting of Aβ peptide is widely accepted as being one of the main key events triggering the development...

["Biophysics","Biotechnology","Cell Biology","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.3086
277 downloads
1,017 views

Synapsida, the clade including therapsids and thus also mammals, is one of the two major branches of amniotes. Organismal design, with modularity as a concept, offers insights into the evolution of therapsids, a group that experienced profound anatomical transformations...

["Developmental Biology","Evolutionary Studies","Neuroscience","Paleontology","Anatomy and Physiology"]
doi:10.7717/peerj.3119
56 downloads
689 views

Background The experience of ‘sensed presence’—a feeling or sense that another entity, individual or being is present despite no clear sensory or perceptual evidence—is known to occur in the general population, appears more frequently in religious or spiritual...

["Anthropology","Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.3149
130 downloads
649 views

Background The ergogenic effects of analgesic substances suggest that pain perception is an important regulator of work-rate during fatiguing exercise. Recent research has shown that endogenous inhibitory responses, which act to attenuate nociceptive input and...

["Neuroscience","Anaesthesiology and Pain Management","Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.3028
62 downloads
323 views

Background Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease characterised by the accumulation of aggregated proteins, microglia activation and motor neuron loss. The mechanisms underlying neurodegeneration and disease progression...

["Molecular Biology","Neuroscience"]
doi:10.7717/peerj.3064
191 downloads
1,332 views

Background Illusions that alter perception of the body provide novel opportunities to target brain-based contributions to problems such as persistent pain. One example of this, mirror therapy, uses vision to augment perceived movement of a painful limb to treat...

["Neuroscience","Anaesthesiology and Pain Management","Drugs and Devices","Human-Computer Interaction"]
doi:10.7717/peerj.3023
68 downloads
342 views

Background Bax inhibitor-1 (BI-1) is an evolutionarily conserved cytoprotective transmembrane protein that acts as a suppressor of Bax-induced apoptosis by regulation of endoplasmic reticulum stress-induced cell death. We knocked down BI-1 in the sensitive dopa...

["Cell Biology","Genetics","Neuroscience"]
doi:10.7717/peerj.2974
107 downloads
956 views

Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming...

["Animal Behavior","Aquaculture, Fisheries and Fish Science","Neuroscience","Pharmacology"]
doi:10.7717/peerj.2994
54 downloads
420 views

We created an easy-to-use device for operant licking experiments and another device that records environmental variables. Both devices use the Raspberry Pi computer to obtain data from multiple input devices (e.g., radio frequency identification tag readers, touch...

["Animal Behavior","Bioengineering","Neuroscience"]
doi:10.7717/peerj.2981
65 downloads
346 views

Synaptotagmin I (Syt I) is most abundant in the brain and is involved in multiple cellular processes. Its two C2 domains, C2A and C2B, are the main functional regions. Our present study employed a pull-down combined with proteomic strategy to identify the C2 domain-interacting...

["Biochemistry","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.2973
210 downloads
1,221 views

Systematic studies of micronutrients during brain formation are hindered by restrictions to animal models and adult post-mortem tissues. Recently, advances in stem cell biology have enabled recapitulation of the early stages of human telencephalon development in...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7717/peerj.2927
120 downloads
935 views

Philosophers have long argued that causality cannot be directly observed but requires a conscious inference (Hume, 1967). Albert Michotte however developed numerous visual phenomena in which people seemed to perceive causality akin to primary visual properties...

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.2932

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