Peer-reviewed Articles

Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17....

["Bioinformatics","Molecular Biology"]
doi:10.7717/peerj.3849
69 downloads
986 views

Background The 152 extant species of kissing bug include important vectors of the debilitating, chronic, and often fatal Chagas disease, which affects several million people mainly in Central and South America. An understanding of the natural hosts of this speciose...

["Entomology","Molecular Biology","Parasitology"]
doi:10.7717/peerj.3826
65 downloads
500 views

The phylogeny of the Salmonidae family, the only living one of the Order Salmoniformes, remains still unclear because of several reasons. Such reasons include insufficient taxon sampling and/or DNA information. The use of complete mitochondrial genomes (mitogenomics)...

["Aquaculture, Fisheries and Fish Science","Biodiversity","Evolutionary Studies","Molecular Biology","Zoology"]
doi:10.7717/peerj.3828
51 downloads
197 views

Cinnamomum camphora, a member of the Lauraceae family, is a valuable aromatic and timber tree that is indigenous to the south of China and Japan. All parts of Cinnamomum camphora have secretory cells containing different volatile chemical compounds that are utilized...

["Bioinformatics","Conservation Biology","Genetics","Molecular Biology","Plant Science"]
doi:10.7717/peerj.3820
48 downloads
158 views

Background Plasmodium is an obligate intracellular parasite. Apical membrane antigen 1 (AMA1) is the most prominent and well characterized malarial surface antigen that is essential for parasite-host cell invasion, i.e., for sporozoite to invade and replicate within...

["Molecular Biology","Parasitology"]
doi:10.7717/peerj.3794
35 downloads
214 views

Background Calcitonin expression is a well-established marker for medullary thyroid carcinoma (MTC); yet the role of calcitonin receptor (CTR), its seven-transmembrane G-protein coupled receptor, remains to be established in C-cells derived thyroid tumors. The...

["Molecular Biology","Diabetes and Endocrinology","Oncology"]
doi:10.7717/peerj.3778
34 downloads
197 views

Background Lonicera japonica is an important medicinal plant that has been widely used in traditional Chinese medicine for thousands of years. The pharmacological activities of L. japonica are mainly due to its rich natural active ingredients, most of which are...

["Molecular Biology","Plant Science"]
doi:10.7717/peerj.3781
40 downloads
287 views

A growing number of T2/S-RNases are being discovered in plant genomes. Members of this protein family have a variety of known functions, but the vast majority are still uncharacterized. We present data and analyses of phylogenetic relationships among T2/S-RNases,...

["Evolutionary Studies","Genetics","Genomics","Molecular Biology","Plant Science"]
doi:10.7717/peerj.3790
25 downloads
218 views

Particle bombardment is a powerful and relatively easy method for transient expression of genes of interest in plant cells, especially those that are recalcitrant to other transformation methods. This method has facilitated numerous analyses of subcellular localization...

["Cell Biology","Molecular Biology","Plant Science"]
doi:10.7717/peerj.3779
138 downloads
698 views

Whole genome sequencing (WGS) is a very valuable resource to understand the evolutionary history of poorly known species. However, in organisms with large genomes, as most amphibians, WGS is still excessively challenging and transcriptome sequencing (RNA-seq) represents...

["Bioinformatics","Evolutionary Studies","Genomics","Molecular Biology","Zoology"]
doi:10.7717/peerj.3702
62 downloads
352 views

Background A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses,...

["Evolutionary Studies","Molecular Biology","Zoology","Immunology"]
doi:10.7717/peerj.3679
82 downloads
367 views

Conserved homologues of the Hrd1 ubiquitin ligase target for degradation proteins that persistently or aberrantly engage the endoplasmic reticulum translocon, including mammalian apolipoprotein B (apoB; the major protein component of low-density lipoproteins) and...

["Biochemistry","Cell Biology","Genetics","Molecular Biology"]
doi:10.7717/peerj.3728
161 downloads
581 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7717/peerj.3631
43 downloads
298 views

Recently, a novel phenomenon of horizontal gene transfer of helicase-encoding sequence from positive-stranded RNA viruses to LINE transposons in insect genomes was described. TRAS family transposons encoding an ORF2 protein, which comprised all typical functional...

["Entomology","Genomics","Molecular Biology","Virology"]
doi:10.7717/peerj.3673
59 downloads
295 views

Background Hybridization between native and invasive species can facilitate introgression of native genes that increase invasive potential by providing exotic species with pre-adapted genes suitable for new environments. In this study we assessed the outcome of...

["Molecular Biology","Plant Science"]
doi:10.7717/peerj.3630

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