Peer-reviewed Articles

27 downloads
228 views

This paper describes the development and application of a suite of tools, called PBxplore, to analyze the dynamics and deformability of protein structures using Protein Blocks (PBs). Proteins are highly dynamic macromolecules, and a classical way to analyze their...

["Bioinformatics","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.4013
29 downloads
182 views

Morphological differentiation among closely related species provides opportunities to study mechanisms shaping natural phenotypic variation. Here, we address variation in the orientation of melanin-colored body stripes in three cichlid species of the tribe Haplochromini....

["Aquaculture, Fisheries and Fish Science","Biodiversity","Evolutionary Studies","Molecular Biology","Zoology"]
doi:10.7717/peerj.4080
19 downloads
173 views

Background Clear cell renal cell carcinoma (ccRCC) is the most common and lethal cancer of the adult kidney. However, its pathogenesis has not been fully understood till now, which hinders the therapeutic development of ccRCC. NADH dehydrogenase (ubiquinone) 1...

["Genomics","Molecular Biology","Oncology"]
doi:10.7717/peerj.4065
49 downloads
406 views

Stony corals (Scleractinia) are marine invertebrates that form the foundation and framework upon which tropical reefs are built. The coral animal associates with a diverse microbiome comprised of dinoflagellate algae and other protists, bacteria, archaea, fungi...

["Genomics","Marine Biology","Microbiology","Molecular Biology","Virology"]
doi:10.7717/peerj.4054
22 downloads
119 views

Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers and focal...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4063
32 downloads
197 views

The mitochondrial genomes (mitogenomes) of Formosatettix qinlingensis, Coptotettix longjiangensis and Thoradonta obtusilobata (Orthoptera: Caelifera: Tetrigoidea) were sequenced in this study, and almost the entire mitogenomes of these species were determined....

["Entomology","Evolutionary Studies","Molecular Biology","Taxonomy"]
doi:10.7717/peerj.4002
39 downloads
173 views

The presence of acetic acid during industrial alcohol fermentation reduces the yield of fermentation by imposing additional stress on the yeast cells. The biology of cellular responses to stress has been a subject of vigorous investigations. Although much has been...

["Cell Biology","Genetics","Molecular Biology"]
doi:10.7717/peerj.4037
38 downloads
244 views

Background Dengue disease is a leading cause of illness and death in the tropics and subtropics. Most severe cases occur among patients secondarily infected with a different dengue virus (DENV) serotype compared with that from the first infection, resulting in...

["Biotechnology","Molecular Biology","Virology","Infectious Diseases"]
doi:10.7717/peerj.4021
34 downloads
174 views

The wood frog (Rana sylvatica) can endure freezing of up to 65% of total body water during winter. When frozen, wood frogs enter a dormant state characterized by a cessation of vital functions (i.e., no heartbeat, blood circulation, breathing, brain activity, or...

["Biochemistry","Molecular Biology"]
doi:10.7717/peerj.4014
26 downloads
437 views

The core antigen of the hepatitis C virus (HCV Ag) presents an alternative marker to HCV RNA when screening patients for HCV viremia. This study sought to evaluate the utility of HCV Ag as a marker to assess active HCV infection in individuals residing in an HCV-endemic...

["Molecular Biology","Virology","Epidemiology","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4008
69 downloads
360 views

Extensive and in-depth investigations of high-altitude adaptation have been carried out at the level of morphology, anatomy, physiology and genomics, but few investigations focused on the roles of microRNA (miRNA) in high-altitude adaptation. We examined the differences...

["Agricultural Science","Biodiversity","Molecular Biology"]
doi:10.7717/peerj.3959
34 downloads
245 views

In female Atlantic salmon (Salmo salar), exposure to warm summer temperatures causes a reduction in plasma 17β-estradiol (E2), which impairs downstream vitellogenesis and zonagenesis, and reduces egg fertility and embryo survival. The aim of the present study was...

["Aquaculture, Fisheries and Fish Science","Marine Biology","Molecular Biology"]
doi:10.7717/peerj.3897
51 downloads
276 views

The role of glial cells in pain modulation has recently gathered attention. The objective of this study was to determine healthy spinal microglia and astrocyte morphology and disposition in equine spinal cord dorsal horns using Iba-1 and GFAP/Cx-43 immunofluorescence...

["Molecular Biology","Neuroscience","Veterinary Medicine","Anaesthesiology and Pain Management"]
doi:10.7717/peerj.3965
48 downloads
238 views

Copper plays key roles in plant physiological activities. To maintain copper cellular homeostasis, copper chaperones have important functions in binding and transporting copper to target proteins. Detailed characterization and function analysis of a copper chaperone,...

["Bioinformatics","Molecular Biology","Plant Science"]
doi:10.7717/peerj.3962
61 downloads
242 views

Limiting the juvenile phase and reducing tree size are the two main challenges for breeders to improve most fruit crops. Early maturation and dwarf cultivars have been reported for many fruit species. “Early mature” and low vigor walnut genotypes were found among...

["Agricultural Science","Biodiversity","Molecular Biology","Plant Science"]
doi:10.7717/peerj.3834

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