Peer-reviewed Articles

22 downloads
107 views

Sucrose phosphate synthase (SPS, EC 2.4.1.14) is a key enzyme that regulates sucrose biosynthesis in plants. SPS is encoded by different gene families which display differential expression patterns and functional divergence. Genome-wide identification and expression...

["Molecular Biology","Plant Science"]
doi:10.7717/peerj.4379
175 downloads
2,808 views

Comprising more than 800 extant species, the class Cephalopoda (octopuses, squid, cuttlefish, and nautiluses) is a fascinating group of marine conchiferan mollusks. Recently, the first cephalopod genome (of Octopus bimaculoides) was published, providing a genomic...

["Biodiversity","Ecology","Molecular Biology","Taxonomy"]
doi:10.7717/peerj.4331
83 downloads
838 views

Phenotypic differences between closely related taxa or populations can arise through genetic variation or be environmentally induced, leading to altered transcription of genes during development. Comparative developmental studies of closely related species or variable...

["Developmental Biology","Evolutionary Studies","Genomics","Molecular Biology","Freshwater Biology"]
doi:10.7717/peerj.4345
46 downloads
190 views

Members of the anaerobic gut fungi (AGF) reside in rumen, hindgut, and feces of ruminant and non-ruminant herbivorous mammals and reptilian herbivores. No protocols for gene insertion, deletion, silencing, or mutation are currently available for the AGF, rendering...

["Molecular Biology","Mycology"]
doi:10.7717/peerj.4276
42 downloads
210 views

Dengue is endemic throughout tropical and subtropical regions of the world. Currently, there is no clinically approved therapeutic drug available for this acute viral infection. Although the first dengue vaccine Dengvaxia has been approved for use in certain countries,...

["Molecular Biology","Evidence Based Medicine","Infectious Diseases"]
doi:10.7717/peerj.3939
140 downloads
3,694 views

Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often suffer from gastrointestinal symptoms and many are diagnosed with irritable bowel syndrome (IBS). Previous studies, including from our laboratory, have demonstrated that the ME/CFS...

["Microbiology","Molecular Biology","Neurology"]
doi:10.7717/peerj.4282
52 downloads
216 views

Cholangiocarcinoma (CCA) caused by infection of the liver fluke Opisthorchis viverrini, (Ov) is the major public health problem in northeast Thailand. Following Ov infection the subsequent molecular changes can be associated by reactive oxygen species (ROS) induced...

["Molecular Biology","Oncology"]
doi:10.7717/peerj.4281
68 downloads
327 views

Background Long non-coding RNAs (lncRNAs) have been reported to modulate cardiovascular diseases, and expression dynamics of lncRNAs in the bloodstream were proposed to be potential biomarkers for clinical diagnosis. However, few cardiovascular diseases-related...

["Molecular Biology","Cardiology","Pathology","Public Health"]
doi:10.7717/peerj.4246
70 downloads
346 views

The maintenance of a G + C content that is higher than the mutational input to a genome provides support for the view that selection serves to increase G + C contents in bacteria. Recent experimental evidence from Escherichia coli demonstrated that selection for...

["Biotechnology","Evolutionary Studies","Genetics","Molecular Biology","Synthetic Biology"]
doi:10.7717/peerj.4286
58 downloads
288 views

Background With the continuous discovery of microRNA’s (miRNA) association with a wide range of biological and cellular processes, expression profile-based functional characterization of such post-transcriptional regulation is crucial for revealing its significance...

["Biochemistry","Bioinformatics","Computational Biology","Molecular Biology","Data Mining and Machine Learning"]
doi:10.7717/peerj.4262
96 downloads
297 views

Background Pluripotent stem cells (PSCs) offer immense potential as a source for regenerative therapies. The teratoma assay is widely used in the field of stem cells and regenerative medicine, but the cell composition of teratoma is still elusive. Methods We utilized...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4177
65 downloads
225 views

Background The release of high mobility group box 1 (HMGB1) induced by inflammatory signals acts as a cellular alarmin to trigger a chain of inflammatory responses. Although the inflammatory actions of HMGB1 are well studied, less is known about the therapeutic...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4208
248 downloads
814 views

Cherries are fruits containing fiber and bioactive compounds (e.g., polyphenolics) with the potential of helping patients with diabetes and weight disorders, a phenomenon likely related to changes in the complex host-microbiota milieu. The objective of this study...

["Biochemistry","Microbiology","Molecular Biology","Diabetes and Endocrinology","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4195
72 downloads
273 views

Wheat stem rust, caused by Puccinia granimis f. sp. tritici, severely affects wheat production, but it has been effectively controlled in China since the 1970s. However, the appearance and spread of wheat stem rust races Ug99 (TTKSK, virulence to Sr31), TKTTF (virulence...

["Agricultural Science","Molecular Biology"]
doi:10.7717/peerj.4146
67 downloads
366 views

Arbutin (p-hydroxyphenyl-β-D-glucopyranoside), a well-known tyrosinase inhibitor, has been widely used as a cosmetic whitening agent. Although its natural role is to scavenge free radicals within cells, it has also exhibited useful activities for the treatment...

["Animal Behavior","Biochemistry","Molecular Biology"]
doi:10.7717/peerj.4170

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