Peer-reviewed Articles

79 downloads
492 views

There is currently unprecedented interest in quantifying variation in thermal physiology among organisms, especially in order to understand and predict the biological impacts of climate change. A key parameter in this quantification of thermal physiology is the...

["Ecology","Mathematical Biology","Climate Change Biology"]
doi:10.7717/peerj.4363
55 downloads
569 views

There is growing interest in applying detailed mathematical models of the heart for ion-channel related cardiac toxicity prediction. However, a debate as to whether such complex models are required exists. Here an assessment in the predictive performance between...

["Mathematical Biology","Toxicology","Cardiology","Pharmacology"]
doi:10.7717/peerj.4352
79 downloads
461 views

Sigmoidal and double-sigmoidal dynamics are commonly observed in many areas of biology. Here we present sicegar, an R package for the automated fitting and classification of sigmoidal and double-sigmoidal data. The package categorizes data into one of three categories,...

["Bioinformatics","Computational Biology","Mathematical Biology","Statistics","Data Science"]
doi:10.7717/peerj.4251
81 downloads
400 views

Von Bertalanffy proposed the differential equation m′(t) = p × m(t)a − q × m(t) for the description of the mass growth of animals as a function m(t) of time t. He suggested that the solution using the metabolic scaling exponent a = 2/3 (Von Bertalanffy growth function...

["Agricultural Science","Aquaculture, Fisheries and Fish Science","Computational Biology","Mathematical Biology"]
doi:10.7717/peerj.4205
137 downloads
1,498 views

The dodo (Raphus cucullatus) might be the most enigmatic bird of all times. It is, therefore, highly remarkable that no consensus has yet been reached on its body mass; previous scientific estimates of its mass vary by more than 100%. Until now, the vast amount...

["Mathematical Biology","Paleontology"]
doi:10.7717/peerj.4110
71 downloads
596 views

A recurrent question within oncology drug development is predicting phase III outcome for a new treatment using early clinical data. One approach to tackle this problem has been to derive metrics from mathematical models that describe tumour size dynamics termed...

["Mathematical Biology","Clinical Trials","Oncology","Pharmacology","Statistics"]
doi:10.7717/peerj.4111
207 downloads
1,277 views

Background In this paper, we propose a new method, named the intervals’ method, to analyse data from finite element models in a comparative multivariate framework. As a case study, several armadillo mandibles are analysed, showing that the proposed method is useful...

["Animal Behavior","Mathematical Biology","Paleontology"]
doi:10.7717/peerj.3793
118 downloads
466 views

Objective The objective of this study is to conduct a systematic review of multi-scale HIV immunoepidemiological models to improve our understanding of the synergistic impact between the HIV viral-immune dynamics at the individual level and HIV transmission dynamics...

["Computational Biology","Mathematical Biology","Epidemiology","HIV","Immunology"]
doi:10.7717/peerj.3877
1 citation
98 downloads
669 views

Extinction models vary in the information they require, the simplest considering the rate of certain sightings only. More complicated methods include uncertain sightings and allow for variation in the reliability of uncertain sightings. Generally extinction models...

["Conservation Biology","Ecology","Mathematical Biology"]
doi:10.7717/peerj.3663
1 citation
1,460 downloads
27,062 views

The running ability of Tyrannosaurus rex has been intensively studied due to its relevance to interpretations of feeding behaviour and the biomechanics of scaling in giant predatory dinosaurs. Different studies using differing methodologies have produced a very...

["Mathematical Biology","Paleontology","Zoology"]
doi:10.7717/peerj.3420
76 downloads
486 views

Objective Osteoarthritis (OA) is a disease characterized by degeneration of joint cartilage. It is associated with pain and disability and is the result of either age and activity related joint wear or an injury. Non-invasive treatment options are scarce and prevention...

["Mathematical Biology","Orthopedics"]
doi:10.7717/peerj.3468
125 downloads
574 views

Empirical and mechanistic modeling indicate that pathogens transmitted via aerially dispersed inoculum follow a power law, resulting in dispersive epidemic waves. The spread parameter (b) of the power law model, which is an indicator of the distance of the epidemic...

["Ecology","Mathematical Biology","Epidemiology","Infectious Diseases"]
doi:10.7717/peerj.3465
143 downloads
634 views

The purpose of this study was to verify a theoretical model of parents’ responses to difficulties they experienced with their child. The model presents relationships between seven variables: (a) discrepancy between parental goal and the child’s current level of...

["Mathematical Biology","Pediatrics","Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.3384
104 downloads
488 views

Recruitment is a key demographic process for population persistence. This paper focuses on barnacle (Semibalanus balanoides) recruitment. In rocky intertidal habitats from the Gulf of St. Lawrence coast of Nova Scotia (Canada), ice scour is common during the winter....

["Animal Behavior","Ecology","Marine Biology","Mathematical Biology","Zoology"]
doi:10.7717/peerj.3444
125 downloads
884 views

The changes of protein expression that are monitored in proteomic experiments are a type of biological transformation that also involves changes in chemical composition. Accompanying the myriad molecular-level interactions that underlie any proteomic transformation,...

["Biochemistry","Mathematical Biology","Oncology"]
doi:10.7717/peerj.3421

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