Peer-reviewed Articles

36 downloads
256 views

Background The globally abundant coccolithophore, Emiliania huxleyi, plays an important ecological role in oceanic carbon biogeochemistry by forming a cellular covering of plate-like CaCO3 crystals (coccoliths) and fixing CO2. It is unknown how the cells arrange...

["Mathematical Biology"]
doi:10.7717/peerj.4608
65 downloads
414 views

Background A Rohingya refugee camp in Cox’s Bazar, Bangladesh experienced a large-scale diphtheria epidemic in 2017. The background information of previously immune fraction among refugees cannot be explicitly estimated, and thus we conducted an uncertainty analysis...

["Computational Biology","Mathematical Biology","Epidemiology","Global Health","Infectious Diseases"]
doi:10.7717/peerj.4583
61 downloads
381 views

Genome rearrangements have played an important role in the evolution of Yersinia pestis from its progenitor Yersinia pseudotuberculosis. Traditional phylogenetic trees for Y. pestis based on sequence comparison have short internal branches and low bootstrap supports...

["Bioinformatics","Genomics","Mathematical Biology"]
doi:10.7717/peerj.4545
128 downloads
706 views

Background The Zika virus was first discovered in 1947. It was neglected until a major outbreak occurred on Yap Island, Micronesia, in 2007. Teratogenic effects resulting in microcephaly in newborn infants is the greatest public health threat. In 2016, the Zika...

["Mathematical Biology","Epidemiology","Infectious Diseases"]
doi:10.7717/peerj.4526
128 downloads
752 views

There is currently unprecedented interest in quantifying variation in thermal physiology among organisms, especially in order to understand and predict the biological impacts of climate change. A key parameter in this quantification of thermal physiology is the...

["Ecology","Mathematical Biology","Climate Change Biology"]
doi:10.7717/peerj.4363
84 downloads
710 views

There is growing interest in applying detailed mathematical models of the heart for ion-channel related cardiac toxicity prediction. However, a debate as to whether such complex models are required exists. Here an assessment in the predictive performance between...

["Mathematical Biology","Toxicology","Cardiology","Pharmacology"]
doi:10.7717/peerj.4352
167 downloads
650 views

Sigmoidal and double-sigmoidal dynamics are commonly observed in many areas of biology. Here we present sicegar, an R package for the automated fitting and classification of sigmoidal and double-sigmoidal data. The package categorizes data into one of three categories,...

["Bioinformatics","Computational Biology","Mathematical Biology","Statistics","Data Science"]
doi:10.7717/peerj.4251
113 downloads
524 views

Von Bertalanffy proposed the differential equation m′(t) = p × m(t)a − q × m(t) for the description of the mass growth of animals as a function m(t) of time t. He suggested that the solution using the metabolic scaling exponent a = 2/3 (Von Bertalanffy growth function...

["Agricultural Science","Aquaculture, Fisheries and Fish Science","Computational Biology","Mathematical Biology"]
doi:10.7717/peerj.4205
162 downloads
1,827 views

The dodo (Raphus cucullatus) might be the most enigmatic bird of all times. It is, therefore, highly remarkable that no consensus has yet been reached on its body mass; previous scientific estimates of its mass vary by more than 100%. Until now, the vast amount...

["Mathematical Biology","Paleontology"]
doi:10.7717/peerj.4110
98 downloads
693 views

A recurrent question within oncology drug development is predicting phase III outcome for a new treatment using early clinical data. One approach to tackle this problem has been to derive metrics from mathematical models that describe tumour size dynamics termed...

["Mathematical Biology","Clinical Trials","Oncology","Pharmacology","Statistics"]
doi:10.7717/peerj.4111
241 downloads
1,381 views

Background In this paper, we propose a new method, named the intervals’ method, to analyse data from finite element models in a comparative multivariate framework. As a case study, several armadillo mandibles are analysed, showing that the proposed method is useful...

["Animal Behavior","Mathematical Biology","Paleontology"]
doi:10.7717/peerj.3793
167 downloads
558 views

Objective The objective of this study is to conduct a systematic review of multi-scale HIV immunoepidemiological models to improve our understanding of the synergistic impact between the HIV viral-immune dynamics at the individual level and HIV transmission dynamics...

["Computational Biology","Mathematical Biology","Epidemiology","HIV","Immunology"]
doi:10.7717/peerj.3877
1 citation
107 downloads
720 views

Extinction models vary in the information they require, the simplest considering the rate of certain sightings only. More complicated methods include uncertain sightings and allow for variation in the reliability of uncertain sightings. Generally extinction models...

["Conservation Biology","Ecology","Mathematical Biology"]
doi:10.7717/peerj.3663
4 citations
1,534 downloads
27,917 views

The running ability of Tyrannosaurus rex has been intensively studied due to its relevance to interpretations of feeding behaviour and the biomechanics of scaling in giant predatory dinosaurs. Different studies using differing methodologies have produced a very...

["Mathematical Biology","Paleontology","Zoology"]
doi:10.7717/peerj.3420
100 downloads
551 views

Objective Osteoarthritis (OA) is a disease characterized by degeneration of joint cartilage. It is associated with pain and disability and is the result of either age and activity related joint wear or an injury. Non-invasive treatment options are scarce and prevention...

["Mathematical Biology","Orthopedics"]
doi:10.7717/peerj.3468

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