Peer-reviewed Articles

49 downloads
283 views

Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2. In order to be functional,...

["Biochemistry","Cell Biology","Immunology","Nutrition"]
doi:10.7717/peerj.4212
65 downloads
194 views

Background Autoimmune thyroid disease (AITD), which is characterized by an increased presence of thyroid autoantibodies (TAbs), such as antibodies against thyroid peroxidase (TPOAbs) and antibodies against thyroglobulin (TgAbs), has been reported to be associated...

["Diabetes and Endocrinology","Immunology","Rheumatology"]
doi:10.7717/peerj.4216
63 downloads
218 views

In this study, equine source polyclonal anti-Bacillus anthracis immunoglobulins were generated and utilized to demonstrate passive protection of mice in a lethal challenge assay. Four horses were hyper-immunized with B. anthracis Sterne strain for approximately...

["Immunology","Infectious Diseases"]
doi:10.7717/peerj.3907
61 downloads
776 views

Background Left-sided and right-sided colon cancers (LCCs and RCCs, respectively) differ in their epidemiology, pathogenesis, genetic and epigenetic alterations, molecular pathways and prognosis. Notably, immune response gene expression profiles have been shown...

["Immunology","Oncology"]
doi:10.7717/peerj.4153
60 downloads
305 views

Background Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children. The resurgence...

["Immunology","Infectious Diseases","Women\u2019s Health"]
doi:10.7717/peerj.4043
133 downloads
692 views

Cancers have killed millions of people in human history and are still posing a serious health problem worldwide. Therefore, there is an urgent need for developing preventive and therapeutic cancer vaccines. Among various cancer vaccine development platforms, virus-like...

["Immunology","Pharmacology"]
doi:10.7717/peerj.4053
110 downloads
679 views

Background The aim of this cross-sectional study was to identify important biopsychosocial correlates of major depression. Biological mechanisms, including the inflammatory and the tryptophan-serotonin deficiency hypotheses of major depression, were investigated...

["Immunology","Psychiatry and Psychology"]
doi:10.7717/peerj.3968
81 downloads
352 views

Tumor-infiltrating lymphocytes (TILs) are associated with better clinical outcomes in many tumors. TILs represent a cell-mediated immune response against the carcinoma. CD8+ TILs are a crucial component of cell-mediated immunity. The significance of CD8+ TILs has...

["Immunology","Oncology","Urology"]
doi:10.7717/peerj.3921
71 downloads
409 views

The cane toad (Rhinella marina) has undergone rapid evolution during its invasion of tropical Australia. Toads from invasion front populations (in Western Australia) have been reported to exhibit a stronger baseline phagocytic immune response than do conspecifics...

["Ecology","Evolutionary Studies","Zoology","Immunology"]
doi:10.7717/peerj.3856
92 downloads
424 views

Objective The objective of this study is to conduct a systematic review of multi-scale HIV immunoepidemiological models to improve our understanding of the synergistic impact between the HIV viral-immune dynamics at the individual level and HIV transmission dynamics...

["Computational Biology","Mathematical Biology","Epidemiology","HIV","Immunology"]
doi:10.7717/peerj.3877
2 citations
154 downloads
609 views

Nodaviruses are small bipartite RNA viruses which belong to the family of Nodaviridae. They are categorized into alpha-nodavirus, which infects insects, and beta-nodavirus, which infects fishes. Another distinct group of nodavirus infects shrimps and prawns, which...

["Aquaculture, Fisheries and Fish Science","Virology","Immunology"]
doi:10.7717/peerj.3841
1 citation
72 downloads
445 views

Cytokines are fundamental for a functioning immune system, and thus potentially serve as important indicators of animal health. Quantitation of mRNA using quantitative reverse transcription polymerase chain reaction (qRT-PCR) is an established immunological technique....

["Marine Biology","Molecular Biology","Veterinary Medicine","Immunology"]
doi:10.7717/peerj.3840
1 citation
215 downloads
681 views

Background Dengue viral infection is an acute infection that has the potential to have severe complications as its major sequela. Currently, there is no routine laboratory biomarker with which to predict the severity of dengue infection or monitor the effectiveness...

["Microbiology","Virology","Epidemiology","Immunology","Infectious Diseases"]
doi:10.7717/peerj.3589
115 downloads
568 views

Background A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses,...

["Evolutionary Studies","Molecular Biology","Zoology","Immunology"]
doi:10.7717/peerj.3679
128 downloads
644 views

The cynomolgus macaque (Macaca fascicularis) is an extensively utilised nonhuman primate model for biomedical research due to its biological, behavioural, and genetic similarities to humans. Genomic information of cynomolgus macaque is vital for research in various...

["Bioinformatics","Genomics","Zoology","Immunology"]
doi:10.7717/peerj.3566

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