Peer-reviewed Articles

28 downloads
165 views

Background Type 2 diabetes is characterized by insulin resistance accompanied by defective insulin secretion. Transgenic mouse models play an important role in medical research. However, single transgenic mouse models may not mimic the complex phenotypes of most...

["Agricultural Science","Biotechnology","Diabetes and Endocrinology","Histology","Medical Genetics"]
doi:10.7717/peerj.4542
764 downloads
1,669 views

Here we provide a detailed description of the postcranial skeleton of the holotype and referred specimens of Buitreraptor gonzalezorum. This taxon was recovered as an unenlagiine dromaeosaurid in several recent phylogenetic studies and is the best represented Gondwanan...

["Paleontology","Taxonomy","Histology"]
doi:10.7717/peerj.4558
57 downloads
520 views

Objective In the foveola of the eye, photoreceptors and Müller cells with a unique morphology have been described, but little is known about their 3D structure and orientation. Considering that there is an angle-dependent change in the foveolar photoreceptor response...

["Biophysics","Cell Biology","Anatomy and Physiology","Ophthalmology","Histology"]
doi:10.7717/peerj.4482
402 downloads
1,587 views

Finite Element Analysis (FEA) is a useful method for understanding form and function. However, modelling of fossil taxa invariably involves assumptions as a result of preservation-induced loss of information in the fossil record. To test the validity of predictions...

["Bioengineering","Paleontology","Histology"]
doi:10.7717/peerj.4426
112 downloads
477 views

Triple negative breast cancer (TNBC) is a belligerent carcinoma that is unresponsive to targeted receptor therapies. Development of new treatment strategies would benefit from an expanded repertoire of in vitro cell culture systems, such as those that support tridimensional...

["Cell Biology","Anatomy and Physiology","Oncology","Pathology","Histology"]
doi:10.7717/peerj.4340
291 downloads
2,290 views

Previous investigations document functional and phylogenetic signals in the histology of dinosaur teeth. In particular, incremental lines in dentin have been used to determine tooth growth and replacement rates in several dinosaurian clades. However, to date, few...

["Paleontology","Anatomy and Physiology","Dentistry","Histology"]
doi:10.7717/peerj.4129
139 downloads
893 views

Background Health of mammary glands is fundamental for milk and dairy products hygiene and quality, with huge impacts on consumers welfare. Methods This study aims to investigate the microbial agents (bacteria, fungi and lentiviruses) isolated from 89 macroscopically...

["Microbiology","Veterinary Medicine","Histology"]
doi:10.7717/peerj.3994
241 downloads
560 views

Background Biomineralization, e.g., in sea urchins or mollusks, includes the assembly of mesoscopic superstructures from inorganic crystalline components and biopolymers. The resulting mesocrystals inspire biophysicists and material scientists alike, because of...

["Aquaculture, Fisheries and Fish Science","Cell Biology","Marine Biology","Zoology","Histology"]
doi:10.7717/peerj.3923
121 downloads
418 views

Insecticidal crystal (Cry) proteins produced by the bacterium Bacillus thuringiensis (Bt) target cells in the midgut epithelium of susceptible larvae. While the mode of action of Cry toxins has been extensively investigated, the midgut response to Cry intoxication...

["Entomology","Microbiology","Histology"]
doi:10.7717/peerj.3886
1 citation
537 downloads
1,602 views

Segmentation of histopathology sections is a necessary preprocessing step for digital pathology. Due to the large variability of biological tissue, machine learning techniques have shown superior performance over conventional image processing methods. Here we present...

["Bioengineering","Oncology","Radiology and Medical Imaging","Histology","Computational Science"]
doi:10.7717/peerj.3874
1 citation
185 downloads
790 views

Background Standard two-dimensional (2D) cell migration assays do not provide information about vertical invasion processes, which are critical for melanoma progression. We provide information about three-dimensional (3D) melanoma cell migration, proliferation...

["Cell Biology","Oncology","Histology"]
doi:10.7717/peerj.3754
2 citations
669 downloads
2,382 views

Denticles are small, tooth-like protrusions that are commonly found on the palate of early tetrapods. Despite their widespread taxonomic occurrence and similar external morphology to marginal teeth, it has not been rigorously tested whether denticles are structurally...

["Paleontology","Histology"]
doi:10.7717/peerj.3727
141 downloads
869 views

Understanding how individual photoreceptor cells factor in the spectral sensitivity of a visual system is essential to explain how they contribute to the visual ecology of the animal in question. Existing methods that model the absorption of visual pigments use...

["Animal Behavior","Ecology","Neuroscience","Zoology","Histology"]
doi:10.7717/peerj.3595
154 downloads
856 views

The death-associated protein kinase 1 (DAPK1) can act as an oncogene or a tumor suppressor gene depending on the cellular context as well as external stimuli. Our study aims to investigate the prognostic significance of DAPK1 in liver cancer in both mRNA and protein...

["Biochemistry","Gastroenterology and Hepatology","Oncology","Translational Medicine","Histology"]
doi:10.7717/peerj.3568
193 downloads
644 views

Background Poly-ADP-ribose (PAR) is a polymer synthesized by poly-ADP-ribose polymerases (PARPs) as a postranslational protein modification and catabolized mainly by poly-ADP-ribose glycohydrolase (PARG). In spite of the existence of cytoplasmic PARPs and PARG,...

["Cell Biology","Neuroscience","Histology"]
doi:10.7717/peerj.3318

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