Peer-reviewed Articles

25 downloads
134 views

Previous studies have investigated the association between cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphisms and breast cancer susceptibility, but the results remained inconsistent. Therefore, we evaluated the relationship between four common CTLA-4 polymorphisms...

["Evidence Based Medicine","Oncology","Medical Genetics"]
doi:10.7717/peerj.2815
87 downloads
357 views

Background New reliable devices for range of motion (ROM) measures in older adults are necessary to improve knowledge about the functional capability in this population. Dorsiflexion ROM limitation is associated with ankle injuries, foot pain, lower limb disorders,...

["Evidence Based Medicine","Geriatrics","Kinesiology"]
doi:10.7717/peerj.2820
112 downloads
318 views

MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis...

["Genetics","Epidemiology","Evidence Based Medicine","Oncology"]
doi:10.7717/peerj.2706
117 downloads
584 views

Background Observational studies have shown inconsistent results regarding alcohol consumption and risk of fatty liver. We performed a meta-analysis of published literature to investigate the association between alcohol consumption and fatty liver disease (FLD)....

["Evidence Based Medicine","Gastroenterology and Hepatology","Public Health"]
doi:10.7717/peerj.2633
195 downloads
377 views

Background The benefit of maintenance therapy has been confirmed in patients with non-progressing non-small cell lung cancer (NSCLC) after first-line therapy by many trials and meta-analyses. However, since few head-to-head trials between different regimens have...

["Evidence Based Medicine","Oncology","Respiratory Medicine"]
doi:10.7717/peerj.2550
311 downloads
1,181 views

Context Necrotizing enterocolitis (NEC) is the most frequent gastrointestinal emergency in neonates. The microbiome of the preterm gut may regulate the integrity of the intestinal mucosa. Probiotics may positively contribute to mucosal integrity, potentially reducing...

["Clinical Trials","Drugs and Devices","Evidence Based Medicine","Pediatrics"]
doi:10.7717/peerj.2429
143 downloads
471 views

Introduction Hospital readmissions are common, expensive, and a key target of the Medicare Value Based Purchasing (VBP) program. Risk assessment tools have been developed to identify patients at high risk of hospital readmission so they can be targeted for interventions...

["Evidence Based Medicine","Health Policy","Internal Medicine"]
doi:10.7717/peerj.2441
140 downloads
456 views

8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities. In biological systems, elevation of intracellular calcium can cause calpain activation,...

["Neuroscience","Evidence Based Medicine","Neurology"]
doi:10.7717/peerj.2389
423 downloads
969 views

Background: Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously...

["Cardiology","Evidence Based Medicine","Translational Medicine","Statistics","Computational Science"]
doi:10.7717/peerj.2284
1 citation
490 downloads
2,628 views

Objective. Probiotics have been reported to support healthy digestive and immune function, aid in protein absorption, and decrease inflammation. Further, a trend to increase vertical jump power has been observed following co-administration of protein and probiotics...

["Clinical Trials","Evidence Based Medicine","Nutrition"]
doi:10.7717/peerj.2276
97 downloads
1,189 views

Introduction. Most documented rare diseases have genetic origin. Because of their low individual frequency, an initial diagnosis based on phenotypic symptoms is not always easy, as practitioners might never have been exposed to patients suffering from the relevant...

["Bioinformatics","Evidence Based Medicine","Translational Medicine","Science and Medical Education","Computational Science"]
doi:10.7717/peerj.2211
91 downloads
696 views

Background. Quantitative ultrasound measures are influenced by multiple external factors including examiner scanning force. Force feedback may foster the acquisition of reliable morphometry measures under a variety of scanning conditions. The purpose of this study...

["Evidence Based Medicine","Kinesiology","Radiology and Medical Imaging","Science and Medical Education","Human\u2013Computer Interaction"]
doi:10.7717/peerj.2146
85 downloads
477 views

Background. Epidemiological studies have reported various results relating preoperative hydronephrosis to upper tract urothelial carcinoma (UTUC). However, the clinical significance and prognostic value of preoperative hydronephrosis in UTUC remains controversial....

["Evidence Based Medicine","Oncology","Public Health","Urology"]
doi:10.7717/peerj.2144
38 downloads
298 views

Background. Normative feedback (NF), or receiving information about one’s drinking compared to peer drinking norms, is one of the most widely used brief interventions for prevention and intervention for hazardous alcohol use. NF has demonstrated predominantly small...

["Evidence Based Medicine","Psychiatry and Psychology","Public Health"]
doi:10.7717/peerj.2114
1 citation
154 downloads
428 views

Background. Geriatric syndromes (GS) exhibit high prevalence in patients with end-stage renal disease (ESRD) under chronic dialysis irrespective of age. We sought to determine whether GS influences medication adherence in ESRD patients. Methods. A prospective cohort...

["Evidence Based Medicine","Geriatrics","Hematology","Nephrology","Palliative Care"]
doi:10.7717/peerj.2122

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