Peer-reviewed Articles

58 downloads
207 views

Background Neuronal and synaptic loss is the most important risk factor for cognitive impairment. Inhibiting neuronal apoptosis and preventing synaptic loss are promising therapeutic approaches for Alzheimer’s disease (AD). In this study, we investigate the protective...

["Neuroscience","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.2739
60 downloads
376 views

Background Central vision, critical for everyday tasks such as reading and driving, is impacted by age-related changes in the eye and by diseases such as age-related macular degeneration. The detection of changes in macular function is therefore important. The...

["Drugs and Devices","Global Health","Ophthalmology"]
doi:10.7717/peerj.2650
67 downloads
274 views

This study addresses the in vitro culture as an alternative to obtain compounds with cytotoxic activity from the medicinal plant Jatropha curcas (Euphorbiaceae). We determined the presence of cytotoxic compounds in both whole plants and dedifferentiated cells....

["Biodiversity","Biotechnology","Plant Science","Drugs and Devices"]
doi:10.7717/peerj.2616
302 downloads
1,164 views

Context Necrotizing enterocolitis (NEC) is the most frequent gastrointestinal emergency in neonates. The microbiome of the preterm gut may regulate the integrity of the intestinal mucosa. Probiotics may positively contribute to mucosal integrity, potentially reducing...

["Clinical Trials","Drugs and Devices","Evidence Based Medicine","Pediatrics"]
doi:10.7717/peerj.2429
133 downloads
556 views

Background Abnormal proliferation of vascular smooth muscle cells (VSMC) is a major cause of cardiovascular diseases (CVDs). Many studies suggest that vascular injury triggers VSMC dedifferentiation, which results in VSMC changes from a contractile to a synthetic...

["Bioinformatics","Molecular Biology","Drugs and Devices"]
doi:10.7717/peerj.2478
62 downloads
711 views

Objective Bladder cancer is a cause of considerable morbidity worldwide. Electromotive Drug Administration is a method that combines intravesical chemotherapy with local electric field application. Electroporation has been suggested among other mechanisms as having...

["Biophysics","Drugs and Devices","Oncology","Radiology and Medical Imaging","Urology"]
doi:10.7717/peerj.2309
193 downloads
941 views

Alzheimer’s disease (AD) is a chronic neurodegenerative disease which leads to the gradual loss of neuronal cells. Several hypotheses for AD exists (e.g., cholinergic, amyloid, tau hypotheses, etc.). As per the cholinergic hypothesis, the deficiency of choline...

["Bioinformatics","Computational Biology","Neuroscience","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.2322
90 downloads
612 views

1,2-dihydro-1,2-azaborine is a structural and electronic analogue of benzene which is able to occupy benzene-binding pockets in T4 lysozyme and has been proposed as suitable arene-mimicking group for biological and pharmaceutical applications. Its applicability...

["Biochemistry","Biophysics","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.2299
93 downloads
406 views

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and...

["Anaesthesiology and Pain Management","Drugs and Devices","Pharmacology","Public Health","Science and Medical Education"]
doi:10.7717/peerj.2255
116 downloads
442 views

Background. Ibuprofen is used chronically in different animal models of inflammation by administration in drinking water or in diet due to its short half-life. Though this practice has been used for years, ibuprofen doses were never assayed against parenteral dose–response...

["Biochemistry","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.2239
201 downloads
948 views

Cannabidiol (CBD) is currently being investigated as a novel therapeutic for the treatment of CNS disorders like schizophrenia and epilepsy. ABC transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) mediate pharmacoresistance in...

["Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.2081
183 downloads
649 views

We previously reported that the inflammasome inhibitor cucurbitacin D (CuD) induces apoptosis in human leukemia cell lines. Here, we investigated the effects of CuD and a B-cell lymphoma extra-large (Bcl-xL) inhibitor on autophagy in peripheral blood lymphocytes...

["Cell Biology","Drugs and Devices","Hematology","Oncology"]
doi:10.7717/peerj.2026
222 downloads
770 views

Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel inhibitor...

["Bioinformatics","Computational Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.1979
1 citation
178 downloads
670 views

Cordycepin is a component of the extract obtained from Cordyceps militaris and has many biological activities, including anti-cancer, anti-metastatic and anti-inflammatory effects. Intervertebral disc degeneration (IDD) is a degenerative disease that is closely...

["Molecular Biology","Drugs and Devices","Orthopedics"]
doi:10.7717/peerj.1992
1 citation
169 downloads
940 views

The fight against the emergence of mutant influenza strains has led to the screening of an increasing number of compounds for inhibitory activity against influenza neuraminidase. This study explores the chemical space of neuraminidase inhibitors (NAIs), which provides...

["Bioinformatics","Computational Biology","Drugs and Devices","Computational Science"]
doi:10.7717/peerj.1958

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