Peer-reviewed Articles

59 downloads
339 views

Dengue virus types 1-4 (DENV-1-4) are positive-strand RNA viruses with an envelope that belongs to the Flaviviridae. DENV infection threatens human health worldwide. However, other than supportive treatments, no specific therapy is available for the infection....

["Virology","Drugs and Devices"]
doi:10.7717/peerj.3448
47 downloads
319 views

Historically, Chinese herbal medicines have been widely used in the treatment of hyperglycemia, but the mechanisms underlying their effectiveness remain largely unknown. Here, we screened a compound library primarily comprised of natural compounds extracted from...

["Cell Biology","Diabetes and Endocrinology","Drugs and Devices"]
doi:10.7717/peerj.3283
76 downloads
274 views

Background Dual-energy X-ray absorptiometry (DXA) provides separate measurements of fat mass, fat-free mass and bone mass, and is a quick, accurate, and safe technique, yet one that is not readily available in routine clinical practice. Consequently, we aimed to...

["Drugs and Devices","Epidemiology","Pediatrics"]
doi:10.7717/peerj.3238
58 downloads
451 views

Background Oxytetracycline (OTC), which is largely employed in zootechnical and veterinary practices to ensure wellness of farmed animals, is partially absorbed within the gastrointestinal tract depositing in several tissues. Therefore, the potential OTC toxicity...

["Cell Biology","Allergy and Clinical Immunology","Drugs and Devices","Immunology","Pharmacology"]
doi:10.7717/peerj.3236
75 downloads
362 views

Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity. Thus, it is possible that resveratrol increases the inotropic effect of sympathomimetic agents,...

["Cardiology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.3113
189 downloads
918 views

Drug repositioning (i.e., drug repurposing) is the process of discovering new uses for marketed drugs. Historically, such discoveries were serendipitous. However, the rapid growth in electronic clinical data and text mining tools makes it feasible to systematically...

["Bioinformatics","Clinical Trials","Drugs and Devices","Oncology","Statistics"]
doi:10.7717/peerj.3154
64 downloads
410 views

Introduction There is much literature devoted to the problem of drug resistance and decreased susceptibility of fungi to commonly used antifungals. Aim To analyze drug susceptibility of Candida albicans and non-Candida albicans strains isolated from the hands of...

["Microbiology","Mycology","Drugs and Devices","Public Health"]
doi:10.7717/peerj.3038
247 downloads
1,512 views

Background Illusions that alter perception of the body provide novel opportunities to target brain-based contributions to problems such as persistent pain. One example of this, mirror therapy, uses vision to augment perceived movement of a painful limb to treat...

["Neuroscience","Anaesthesiology and Pain Management","Drugs and Devices","Human-Computer Interaction"]
doi:10.7717/peerj.3023
90 downloads
316 views

Background Paroxysmal sympathetic hyperactivity (PSH) results and aggravates in secondary brain injury, which seriously affects the prognosis of severe traumatic brain injury patients. Although several studies have focused on the treatment of PSH, few have concentrated...

["Drugs and Devices","Emergency and Critical Care","Neurology"]
doi:10.7717/peerj.2986
200 downloads
637 views

Rhodomyrtone, a natural antimicrobial compound, displays potent activity against many Gram-positive pathogenic bacteria, comparable to last-defence antibiotics including vancomycin and daptomycin. Our previous studies pointed towards effects of rhodomyrtone on...

["Biochemistry","Computational Biology","Microbiology","Drugs and Devices","Infectious Diseases"]
doi:10.7717/peerj.2962
211 downloads
541 views

Klebsiella pneumoniae is responsible for numerous infections caused in hospitals, leading to mortality and morbidity. It has been evolving as a multi-drug resistant pathogen, acquiring multiple resistances such as such as horizontal gene transfer, transposon-mediated...

["Microbiology","Molecular Biology","Drugs and Devices","Epidemiology","Infectious Diseases"]
doi:10.7717/peerj.2896
126 downloads
345 views

Background Platinum-based agents are widely used in chemotherapy against solid tumors and insufficient intracellular drug accumulation is one of the leading causes of platinum resistance which is associated with poor survival of tumor patients. Thus, the detection...

["Cell Biology","Drugs and Devices","Oncology"]
doi:10.7717/peerj.2873
171 downloads
470 views

Background Neuronal and synaptic loss is the most important risk factor for cognitive impairment. Inhibiting neuronal apoptosis and preventing synaptic loss are promising therapeutic approaches for Alzheimer’s disease (AD). In this study, we investigate the protective...

["Neuroscience","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.2739
97 downloads
536 views

Background Central vision, critical for everyday tasks such as reading and driving, is impacted by age-related changes in the eye and by diseases such as age-related macular degeneration. The detection of changes in macular function is therefore important. The...

["Drugs and Devices","Global Health","Ophthalmology"]
doi:10.7717/peerj.2650
119 downloads
471 views

This study addresses the in vitro culture as an alternative to obtain compounds with cytotoxic activity from the medicinal plant Jatropha curcas (Euphorbiaceae). We determined the presence of cytotoxic compounds in both whole plants and dedifferentiated cells....

["Biodiversity","Biotechnology","Plant Science","Drugs and Devices"]
doi:10.7717/peerj.2616

Top subject areas - Articles

Top subject areas - People

View all subject areas