Peer-reviewed Articles

28 downloads
145 views

Background Type 2 diabetes is characterized by insulin resistance accompanied by defective insulin secretion. Transgenic mouse models play an important role in medical research. However, single transgenic mouse models may not mimic the complex phenotypes of most...

["Agricultural Science","Biotechnology","Diabetes and Endocrinology","Histology","Medical Genetics"]
doi:10.7717/peerj.4542
43 downloads
319 views

Background Cardiovascular disease is a major cause of mortality and morbidity in people with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an important risk factor for the development of macrovascular disease. The landmark...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4578
42 downloads
247 views

Background Chronic kidney disease (CKD) is characterised by long-term kidney damage and renal function decline. Diabetic CKD is the principal subtype of kidney disease in Malaysia and is associated with oxidative stress which plays an important role in development...

["Diabetes and Endocrinology","Nephrology"]
doi:10.7717/peerj.4421
37 downloads
183 views

Background Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods In a nationwide renal biopsy survey including...

["Diabetes and Endocrinology","Epidemiology","Nephrology","Pathology"]
doi:10.7717/peerj.4522
64 downloads
314 views

Background Serum uric acid (UA) has been reported as a risk factor for type 2 diabetes mellitus (T2DM). However, whether serum UA is associated with insulin resistance and insulin secretion, and the effect of gender on it in the case of the existed association,...

["Diabetes and Endocrinology","Epidemiology"]
doi:10.7717/peerj.4515
84 downloads
498 views

Background C1q TNF related protein 3 (CTRP3) is a relatively novel hormonal factor primarily derived from adipose tissue and has anti-diabetic properties. To determine if CTRP3 could play a role in early childhood development, the purpose of this study was to establish...

["Diabetes and Endocrinology","Epidemiology","Pediatrics","Women\u2019s Health"]
doi:10.7717/peerj.4472
276 downloads
612 views

Background & Aims Accumulating research has addressed the linkage between the changes to gut microbiota structure and type 2 diabetes (T2D). Inulin is one type of soluble dietary fiber that can alleviate T2D. As a prebiotic, inulin cannot be digested by humans,...

["Diabetes and Endocrinology"]
doi:10.7717/peerj.4446
57 downloads
251 views

Obesity and sleep fragmentation (SF) are often co-occurring pro-inflammatory conditions in patients with obstructive sleep apnea. Leptin is a peptide hormone produced by adipocytes that has anorexigenic effects upon appetite while regulating immunity. The role...

["Diabetes and Endocrinology","Immunology","Neurology"]
doi:10.7717/peerj.4423
68 downloads
352 views

Background Hypoglycemia occurs in an appreciable number of individuals with type 2 diabetes mellitus (T2DM) who are receiving glycemic therapy. Iatrogenic hypoglycemia induces not only complications but also a substantial medical expense. Intervention for relevant...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4348
99 downloads
457 views

Background Equine metabolic syndrome (EMS) is associated with insulin dysregulation, which often manifests as post-prandial hyperinsulinemia. Circulating concentrations of the incretin hormone, glucagon-like peptide-1 (GLP-1) correlate with an increased insulin...

["Veterinary Medicine","Diabetes and Endocrinology","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4316
2 citations
161 downloads
732 views

Background Salvia officinalis (sage) is a native plant to the Mediterranean region and has been used for a long time in traditional medicine for various diseases. We investigated possible anti-diabetic, anti-inflammatory and anti-obesity effects of sage methanol...

["Diabetes and Endocrinology","Nutrition","Translational Medicine"]
doi:10.7717/peerj.4166
126 downloads
415 views

Background Autoimmune thyroid disease (AITD), which is characterized by an increased presence of thyroid autoantibodies (TAbs), such as antibodies against thyroid peroxidase (TPOAbs) and antibodies against thyroglobulin (TgAbs), has been reported to be associated...

["Diabetes and Endocrinology","Immunology","Rheumatology"]
doi:10.7717/peerj.4216
344 downloads
1,104 views

Cherries are fruits containing fiber and bioactive compounds (e.g., polyphenolics) with the potential of helping patients with diabetes and weight disorders, a phenomenon likely related to changes in the complex host-microbiota milieu. The objective of this study...

["Biochemistry","Microbiology","Molecular Biology","Diabetes and Endocrinology","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4195
87 downloads
414 views

Background Prader-Willi syndrome (PWS) is a complex, multisystem genetic disorder characterized by a variety of physical, cognitive, and behavioral impairments. PWS is a unique sarcopenia model characterized by an abnormal increase in body fat mass and a decrease...

["Diabetes and Endocrinology","Pediatrics","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.4097
154 downloads
582 views

Background Tartary buckwheat (TB), a crop rich in protein, dietary fiber, and flavonoids, has been reported to have an effect on Type II diabetes (T2D), hypertension (HT), and hyperlipidemia (HL). However, limited information is available about the relationship...

["Bioinformatics","Diabetes and Endocrinology"]
doi:10.7717/peerj.4042

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