Peer-reviewed Articles

18 downloads
112 views

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a high-production volume organophosphate flame retardant widely used within the United States. Within zebrafish, initiation of TDCIPP exposure at 0.75 h post-fertilization (hpf) results in genome-wide alterations...

["Developmental Biology","Toxicology","Ecotoxicology"]
doi:10.7717/peerj.4156
40 downloads
214 views

The mechanistic target of rapamycin (mTOR) and ryanodine receptor (RyR) signaling pathways regulate fundamental processes of neurodevelopment, and genetic mutations within these pathways have been linked to neurodevelopmental disorders. While previous studies have...

["Developmental Biology","Neuroscience","Toxicology"]
doi:10.7717/peerj.4106
53 downloads
1,977 views

Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or whether mammalian...

["Developmental Biology","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7717/peerj.4093
51 downloads
502 views

Although in recent years the study of gene expression variation in the absence of genetic or environmental cues or gene expression heterogeneity has intensified considerably, many basic and applied biological fields still remain unaware of how useful the study...

["Developmental Biology","Genomics"]
doi:10.7717/peerj.4004
109 downloads
924 views

The study of vertebrate ontogenies has the potential to inform us of shared developmental patterns and processes among organisms. However, fossilised ontogenies of early vertebrates are extremely rare during the Palaeozoic Era. A growth series of the Late Devonian...

["Developmental Biology","Evolutionary Studies","Paleontology"]
doi:10.7717/peerj.3969
81 downloads
384 views

Background Although spermatozoa with normal morphology are assumed to have uniform fertilization ability, recent data show that even normal spermatozoa have considerable variation in their head shape which is associated with differences in fertilization ability....

["Cell Biology","Developmental Biology","Andrology"]
doi:10.7717/peerj.3913
80 downloads
407 views

Predation is the main cause of mortality during early life stages. The ability to avoid and evade potential threats is, therefore, favoured to evolve during the early stages of life. It is also during these early stages that the process of familiarization occurs....

["Animal Behavior","Aquaculture, Fisheries and Fish Science","Developmental Biology"]
doi:10.7717/peerj.3899
66 downloads
772 views

If fertilization of matured oocyte does not occur, unfertilized oocyte undergoes aging, resulting in a time-dependent reduction of the oocyte’s quality. The aging of porcine oocytes can lead to apoptosis. Carbon monoxide (CO), a signal molecule produced by the...

["Biotechnology","Cell Biology","Developmental Biology","Veterinary Medicine"]
doi:10.7717/peerj.3876
84 downloads
363 views

Objective The present study aimed to assess the effects of exercise with dietary restriction on cardiac autonomic activity, arterial stiffness, and cardiovascular biomarkers in obese individuals. Methods Seventeen obese adults completed an 8-week exercise and dietary...

["Developmental Biology","Neuroscience","Cardiology","Clinical Trials"]
doi:10.7717/peerj.3900
131 downloads
488 views

Background Obesity, a common metabolic disease, is a known cause of male infertility due to its associated health risk. Long noncoding RNAs (lncRNAs) have also been reported to be associated with male reproductive diseases; however, their role in the association...

["Developmental Biology","Molecular Biology","Metabolic Sciences"]
doi:10.7717/peerj.3518
110 downloads
645 views

Terrestrial eggs have evolved repeatedly in tropical anurans exposing embryos to the new threat of dehydration. Red-eyed treefrogs, Agalychnis callidryas, lay eggs on plants over water. Maternally provided water allows shaded eggs in humid sites to develop to hatching...

["Developmental Biology","Ecology","Zoology"]
doi:10.7717/peerj.3549
170 downloads
560 views

Melatonin is a unique multifunctional molecule that mediates reproductive functions in animals. In this study, we investigated the effects of melatonin on bovine parthenogenetic and androgenetic embryonic development, oocyte maturation, the reactive oxygen species...

["Cell Biology","Developmental Biology","Molecular Biology"]
doi:10.7717/peerj.3485
114 downloads
886 views

Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in the...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7717/peerj.3519
66 downloads
373 views

Disturbance from the normal developmental trajectory of a trait during growth—the so-called developmental instability—can be observed morphologically through phenodeviants and subtle deviations from perfect symmetry (fluctuating asymmetry). This study investigates...

["Developmental Biology","Evolutionary Studies","Zoology","Anatomy and Physiology","Pathology"]
doi:10.7717/peerj.3359
99 downloads
506 views

The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, the Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate...

["Cell Biology","Developmental Biology","Evolutionary Studies","Molecular Biology"]
doi:10.7717/peerj.3390

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