Peer-reviewed Articles

33 downloads
208 views

Background Although spermatozoa with normal morphology are assumed to have uniform fertilization ability, recent data show that even normal spermatozoa have considerable variation in their head shape which is associated with differences in fertilization ability....

["Cell Biology","Developmental Biology","Andrology"]
doi:10.7717/peerj.3913
45 downloads
303 views

Predation is the main cause of mortality during early life stages. The ability to avoid and evade potential threats is, therefore, favoured to evolve during the early stages of life. It is also during these early stages that the process of familiarization occurs....

["Animal Behavior","Aquaculture, Fisheries and Fish Science","Developmental Biology"]
doi:10.7717/peerj.3899
40 downloads
684 views

If fertilization of matured oocyte does not occur, unfertilized oocyte undergoes aging, resulting in a time-dependent reduction of the oocyte’s quality. The aging of porcine oocytes can lead to apoptosis. Carbon monoxide (CO), a signal molecule produced by the...

["Biotechnology","Cell Biology","Developmental Biology","Veterinary Medicine"]
doi:10.7717/peerj.3876
43 downloads
227 views

Objective The present study aimed to assess the effects of exercise with dietary restriction on cardiac autonomic activity, arterial stiffness, and cardiovascular biomarkers in obese individuals. Methods Seventeen obese adults completed an 8-week exercise and dietary...

["Developmental Biology","Neuroscience","Cardiology","Clinical Trials"]
doi:10.7717/peerj.3900
109 downloads
403 views

Background Obesity, a common metabolic disease, is a known cause of male infertility due to its associated health risk. Long noncoding RNAs (lncRNAs) have also been reported to be associated with male reproductive diseases; however, their role in the association...

["Developmental Biology","Molecular Biology","Metabolic Sciences"]
doi:10.7717/peerj.3518
93 downloads
532 views

Terrestrial eggs have evolved repeatedly in tropical anurans exposing embryos to the new threat of dehydration. Red-eyed treefrogs, Agalychnis callidryas, lay eggs on plants over water. Maternally provided water allows shaded eggs in humid sites to develop to hatching...

["Developmental Biology","Ecology","Zoology"]
doi:10.7717/peerj.3549
125 downloads
446 views

Melatonin is a unique multifunctional molecule that mediates reproductive functions in animals. In this study, we investigated the effects of melatonin on bovine parthenogenetic and androgenetic embryonic development, oocyte maturation, the reactive oxygen species...

["Cell Biology","Developmental Biology","Molecular Biology"]
doi:10.7717/peerj.3485
97 downloads
756 views

Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in the...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7717/peerj.3519
58 downloads
299 views

Disturbance from the normal developmental trajectory of a trait during growth—the so-called developmental instability—can be observed morphologically through phenodeviants and subtle deviations from perfect symmetry (fluctuating asymmetry). This study investigates...

["Developmental Biology","Evolutionary Studies","Zoology","Anatomy and Physiology","Pathology"]
doi:10.7717/peerj.3359
77 downloads
396 views

The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, the Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate...

["Cell Biology","Developmental Biology","Evolutionary Studies","Molecular Biology"]
doi:10.7717/peerj.3390
95 downloads
440 views

Long bone curvature in animal limbs has long been a subject of interest and much work has explored why long bones should be curved. However, the ‘when’ and ‘how’ of curvature development is poorly understood. It has been shown that the rat tibia fails to attain...

["Biophysics","Developmental Biology","Zoology"]
doi:10.7717/peerj.3386
176 downloads
484 views

Gerbera hybrida is a cut-flower crop of global importance, and an understanding of the mechanisms underlying petal development is vital for the continued commercial development of this plant species. Brassinosteroids (BRs), a class of phytohormones, are known to...

["Bioinformatics","Developmental Biology","Genetics","Plant Science"]
doi:10.7717/peerj.3382
98 downloads
349 views

Because transcription is the first step in the regulation of gene expression, understanding how transcription factors bind to their DNA binding motifs has become absolutely necessary. It has been shown that the promoters of genes with similar expression profiles...

["Bioinformatics","Computational Biology","Developmental Biology","Genomics"]
doi:10.7717/peerj.3389
149 downloads
491 views

Background The NDUFS4 gene encodes an 18-kD subunit of mitochondria complex I, and mutations in this gene lead to the development of a severe neurodegenerative disease called Leigh syndrome (LS) in humans. To investigate the disease phenotypes and molecular mechanisms...

["Developmental Biology","Molecular Biology"]
doi:10.7717/peerj.3339
114 downloads
822 views

Measuring sensory sensitivity is important in studying development and developmental disorders. However, with children, there is a need to balance reliable but lengthy sensory tasks with the child’s ability to maintain motivation and vigilance. We used simulations...

["Developmental Biology","Neuroscience","Cognitive Disorders","Psychiatry and Psychology"]
doi:10.7717/peerj.3231

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