Peer-reviewed Articles

16 downloads
128 views

Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson’s disease (PD). Alpha-synuclein is a protein that is a major component of Lewy bodies, histopathological hallmarks of PD, and is involved in regulation of dopamine (DA)...

["Developmental Biology","Neuroscience","Neurology","Pathology"]
doi:10.7717/peerj.4779
62 downloads
667 views

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was heralded as a major breakthrough of the decade in stem cell research. The ability to reprogram human somatic cells to a pluripotent embryonic stem cell-like state through the...

["Cell Biology","Developmental Biology","Genetics"]
doi:10.7717/peerj.4370
33 downloads
224 views

Asymmetries in the maternal behaviour and anatomy might play an important role in the development of primate manual lateralization. In particular, early life asymmetries in mother’s and infant’s behaviour have been suggested to be associated with the development...

["Animal Behavior","Developmental Biology","Ecology","Evolutionary Studies","Neuroscience"]
doi:10.7717/peerj.4736
99 downloads
394 views

Background Freemartinism generally occurs in female offspring of dizygotic twins in a mixed-sex pregnancy. Most bovine heterosexual twin females are freemartins. However, about 10% of bovine heterosexual twin females are fertile. Farmers mostly cull bovine fertile...

["Agricultural Science","Developmental Biology","Veterinary Medicine","Zoology"]
doi:10.7717/peerj.4616
64 downloads
255 views

Background The hatch window that varies from 24 to 48 h is known to influence post-hatch performance of chicks. A narrow hatch window is needed for commercial poultry industry to acquire a high level of uniformity of chick quality. Hatching synchronization observed...

["Agricultural Science","Animal Behavior","Conservation Biology","Developmental Biology","Zoology"]
doi:10.7717/peerj.4634
61 downloads
322 views

Purpose This study was performed to investigate the expression pattern of Wnt inhibitory factor 1 (Wif1) and β-catenin during anorectal development in normal and anorectal malformation (ARM) embryos and the possible role of Wif1 and β-catenin in the pathogenesis...

["Developmental Biology","Gastroenterology and Hepatology","Pediatrics"]
doi:10.7717/peerj.4445
86 downloads
417 views

Many plant species exhibit different leaf morphologies within a single plant, or heterophylly. The molecular mechanisms regulating this phenomenon, however, have remained elusive. In this study, the transcriptomes of submerged and floating leaves of an aquatic...

["Cell Biology","Developmental Biology","Evolutionary Studies","Genetics","Plant Science"]
doi:10.7717/peerj.4448
252 downloads
1,341 views

Background Epidendreae is one of the most diverse tribes among the orchids with remarkable variation in life form, floral morphology and pollination syndromes. Its circumscription was recently revised and subtribes Agrostophyllinae and Calypsoinae were transferred...

["Developmental Biology","Evolutionary Studies","Plant Science","Taxonomy"]
doi:10.7717/peerj.4383
181 downloads
1,273 views

Phenotypic differences between closely related taxa or populations can arise through genetic variation or be environmentally induced, leading to altered transcription of genes during development. Comparative developmental studies of closely related species or variable...

["Developmental Biology","Evolutionary Studies","Genomics","Molecular Biology","Freshwater Biology"]
doi:10.7717/peerj.4345
82 downloads
370 views

The genome of the chlorarchiniophyte Bigelowiella natans codes for a protein annotated as an α-actinin-like protein. Analysis of the primary sequence indicate that this protein has the same domain structure as other α-actinins, a N-terminal actin-binding domain...

["Biochemistry","Biophysics","Developmental Biology"]
doi:10.7717/peerj.4288
254 downloads
2,387 views

Owing to their great diversity and abundance, ammonites and belemnites represented key elements in Mesozoic food webs. Because of their extreme ontogenetic size increase by up to three orders of magnitude, their position in the food webs likely changed during ontogeny....

["Developmental Biology","Evolutionary Studies","Marine Biology","Paleontology","Zoology"]
doi:10.7717/peerj.4219
191 downloads
720 views

Ontogeny reversal, as seen in some cnidarians, is an unprecedented phenomenon in the animal kingdom involving reversal of the ordinary life cycle. Three species of Turritopsis have been shown to be capable of inverted metamorphosis, a process in which the pelagic...

["Developmental Biology","Marine Biology","Taxonomy","Zoology"]
doi:10.7717/peerj.4225
93 downloads
508 views

Histone lysine modifications are important epigenetic modifications in early embryonic development. JARID2, which is a member of the jumonji demethylase protein family, is a regulator of early embryonic development and can regulate mouse development and embryonic...

["Cell Biology","Developmental Biology"]
doi:10.7717/peerj.4189
96 downloads
583 views

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a high-production volume organophosphate flame retardant widely used within the United States. Within zebrafish, initiation of TDCIPP exposure at 0.75 h post-fertilization (hpf) results in genome-wide alterations...

["Developmental Biology","Toxicology","Ecotoxicology"]
doi:10.7717/peerj.4156
1 citation
92 downloads
462 views

The mechanistic target of rapamycin (mTOR) and ryanodine receptor (RyR) signaling pathways regulate fundamental processes of neurodevelopment, and genetic mutations within these pathways have been linked to neurodevelopmental disorders. While previous studies have...

["Developmental Biology","Neuroscience","Toxicology"]
doi:10.7717/peerj.4106

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