Peer-reviewed Articles

1 download
1 view

Gene regulation modulates RNA expression via transcription factors. Post-transcriptional gene regulation in turn influences the amount of protein product through, for example, microRNAs (miRNAs). Experimental establishment of miRNAs and their effects is complicated...

["Bioinformatics","Computational Biology","Computational Science"]
doi:10.7717/peerj.3131
1 download
1 view

The number of protein structures in the PDB database has been increasing more than 15-fold since 1999. The creation of computational models predicting enzymatic function is of major importance since such models provide the means to better understand the behavior...

["Bioinformatics","Computational Biology","Genomics","Computational Science"]
doi:10.7717/peerj.3095
18 downloads
199 views

Identification and quantification of microorganisms is a significant step in studying the alpha and beta diversities within and between microbial communities respectively. Both identification and quantification of a given microbial community can be carried out...

["Bioinformatics","Computational Biology","Genomics","Microbiology","Taxonomy"]
doi:10.7717/peerj.3138
83 downloads
328 views

This study explores how curvature in the quokka femur may help to reduce bending strain during locomotion. The quokka is a small wallaby, but the curvature of the femur and the muscles active during stance phase are similar to most quadrupedal mammals. Our hypothesis...

["Computational Biology","Evolutionary Studies","Zoology"]
doi:10.7717/peerj.3100
102 downloads
517 views

Background Gross dissection is a widespread method for studying animal anatomy, despite being highly destructive and time-consuming. X-ray computed tomography (CT) has been shown to be a non-destructive alternative for studying anatomical structures. However, in...

["Computational Biology","Zoology","Radiology and Medical Imaging"]
doi:10.7717/peerj.3039
261 downloads
1,392 views

Environmental niche modeling (ENM) is commonly used to develop probabilistic maps of species distribution. Among available ENM techniques, MaxEnt has become one of the most popular tools for modeling species distribution, with hundreds of peer-reviewed articles...

["Biogeography","Computational Biology","Conservation Biology","Ecology","Ecosystem Science"]
doi:10.7717/peerj.3093
78 downloads
445 views

Background Liver hepatocellular carcinoma accounts for the overwhelming majority of primary liver cancers and its belated diagnosis and poor prognosis call for novel biomarkers to be discovered, which, in the era of big data, innovative bioinformatics and computational...

["Bioinformatics","Computational Biology","Oncology","Pathology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.3089
84 downloads
457 views

Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, three-dimensional molecular structure analysis of P-type ATPases...

["Biochemistry","Bioinformatics","Biophysics","Computational Biology","Computational Science"]
doi:10.7717/peerj.3087
52 downloads
272 views

Most of the previous studies on Weis-Fogh clap-fling mechanism have focused on the vortex structures and velocity fields. Detailed pressure distribution results are provided for the first time in this study to reveal the differences between the full and the partial...

["Biophysics","Computational Biology","Entomology","Mathematical Biology","Computational Science"]
doi:10.7717/peerj.3002
94 downloads
719 views

Metagenomics has become an integral part of defining microbial diversity in various environments. Many ecosystems have characteristically low biomass and few cultured representatives. Linking potential metabolisms to phylogeny in environmental microorganisms is...

["Computational Biology","Genomics"]
doi:10.7717/peerj.3035
38 downloads
232 views

Trypanosoma brucei brucei (TBB) belongs to the unicellular parasitic protozoa organisms, specifically to the Trypanosoma genus of the Trypanosomatidae class. A variety of different vertebrate species can be infected by TBB, including humans and animals. Under particular...

["Biochemistry","Bioinformatics","Computational Biology","Evolutionary Studies","Parasitology"]
doi:10.7717/peerj.3061
111 downloads
893 views

We present a new supertree method that enables rapid estimation of a summary tree on the scale of millions of leaves. This supertree method summarizes a collection of input phylogenies and an input taxonomy. We introduce formal goals and criteria for such a supertree...

["Bioinformatics","Computational Biology","Evolutionary Studies","Taxonomy"]
doi:10.7717/peerj.3058
74 downloads
642 views

One of the main challenges of the post-genomic era is the understanding of how gene expression is controlled. Changes in gene expression lay behind diverse biological phenomena such as development, disease and the adaptation to different environmental conditions....

["Bioinformatics","Computational Biology","Genomics"]
doi:10.7717/peerj.3052
202 downloads
1,577 views

The 16S rRNA gene has been used as master key for studying prokaryotic diversity in almost every environment. Despite the claim of several researchers to have the best universal primers, the reality is that no primer has been demonstrated to be truly universal....

["Biodiversity","Computational Biology","Genomics"]
doi:10.7717/peerj.3036
107 downloads
320 views

Circular RNAs (circRNAs) belong to a recently re-discovered species of RNA that emerge during RNA maturation through a process called back-splicing. A downstream 5′ splice site is linked to an upstream 3′ splice site to form a circular transcript instead of a canonical...

["Bioinformatics","Computational Biology","Genomics","Molecular Biology"]
doi:10.7717/peerj.2934

Top subject areas - Articles

Top subject areas - People

View all subject areas