Peer-reviewed Articles

17 downloads
96 views

Melatonin is well known as a powerful free radical scavenger and exhibits the ability to prevent cell apoptosis. In the present study, we investigated the role of melatonin and its receptor MTNR1B in regulating the function of bovine granulosa cells (GCs) and hypothesized...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4463
33 downloads
311 views

Differentiating sieve elements in the phloem of angiosperms produce abundant phloem-specific proteins before their protein synthesis machinery is degraded. These P-proteins initially form dense bodies, which disperse into individual filaments when the sieve element...

["Cell Biology","Plant Science"]
doi:10.7717/peerj.4665
22 downloads
241 views

In 2015, as part of the Prostate Cancer Foundation–Movember Foundation Reproducibility Initiative, we published a Registered Report (Shan et al., 2015) that described how we intended to replicate selected experiments from the paper “Androgen Receptor Splice Variants...

["Cell Biology","Oncology"]
doi:10.7717/peerj.4661
25 downloads
168 views

In certain multicellular photoautotrophs, such as plants and green macroalgae, it has been demonstrated that calcium signaling importantly mediates tolerance to copper excess. However, there is no information in brown macroalgae, which are phylogenetically distant...

["Cell Biology","Plant Science","Ecotoxicology"]
doi:10.7717/peerj.4556
58 downloads
360 views

Many kinases are still ‘orphans,’ which means knowledge about their substrates, and often also about the processes they regulate, is lacking. Here, DIA1/C3orf58, a member of a novel predicted kinase-like family, is shown to be present in the endoplasmic reticulum...

["Bioinformatics","Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4599
54 downloads
277 views

Background The potent neurotoxins produced by the harmful algal bloom species Karenia brevis are activators of sodium voltage-gated channels (VGC) in animals, resulting in altered channel kinetics and membrane hyperexcitability. Recent biophysical and genomic evidence...

["Cell Biology","Marine Biology","Neuroscience","Ecotoxicology"]
doi:10.7717/peerj.4533
85 downloads
955 views

Background Real-time quantitative PCR (qPCR) is a broadly used technique in the biomedical research. Currently, few different analysis models are used to determine the quality of data and to quantify the mRNA level across the experimental conditions. Methods We...

["Bioinformatics","Cell Biology","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.4473
58 downloads
527 views

Objective In the foveola of the eye, photoreceptors and Müller cells with a unique morphology have been described, but little is known about their 3D structure and orientation. Considering that there is an angle-dependent change in the foveolar photoreceptor response...

["Biophysics","Cell Biology","Anatomy and Physiology","Ophthalmology","Histology"]
doi:10.7717/peerj.4482
71 downloads
594 views

Background Tumor-induced angiogenesis is an imperative event in pledging new vasculature for tumor metastasis. Since overexpression of neuronal proteins gamma-synuclein (γ-Syn) and cellular prion protein (PrPC) is always detected in advanced stages of cancer diseases...

["Biochemistry","Biotechnology","Cell Biology","Molecular Biology","Oncology"]
doi:10.7717/peerj.4506
76 downloads
303 views

Many plant species exhibit different leaf morphologies within a single plant, or heterophylly. The molecular mechanisms regulating this phenomenon, however, have remained elusive. In this study, the transcriptomes of submerged and floating leaves of an aquatic...

["Cell Biology","Developmental Biology","Evolutionary Studies","Genetics","Plant Science"]
doi:10.7717/peerj.4448
112 downloads
487 views

Triple negative breast cancer (TNBC) is a belligerent carcinoma that is unresponsive to targeted receptor therapies. Development of new treatment strategies would benefit from an expanded repertoire of in vitro cell culture systems, such as those that support tridimensional...

["Cell Biology","Anatomy and Physiology","Oncology","Pathology","Histology"]
doi:10.7717/peerj.4340
99 downloads
692 views

Liver fibrosis is a disease that causes high morbidity and has become a major health problem. Liver fibrosis can lead to the end stage of liver diseases (livercirrhosisand hepatocellularcarcinoma). Currently, liver transplantation is the only effective treatment...

["Cell Biology","Gastroenterology and Hepatology","Translational Medicine"]
doi:10.7717/peerj.4336
69 downloads
287 views

Background Systemic lupus erythematosus (SLE) disease has been shown to be associated with the generation of multiple auto-antibodies. Among these, anti-dsDNA antibodies (anti-DNAs) are specific and play a pathogenic role in SLE. Indeed, anti-DNA+ SLE patients...

["Cell Biology","Immunology","Rheumatology"]
doi:10.7717/peerj.4294
88 downloads
374 views

Dermal papilla (DP) plays important roles in hair follicle regeneration. Long-term culture of mouse DP cells can provide enough cells for research and application of DP cells. We optimized the culture strategy for DP cells from three dimensions: stepwise dissection,...

["Biotechnology","Cell Biology","Dermatology"]
doi:10.7717/peerj.4306
171 downloads
429 views

Background Primary cultures from Asian elephants (Elephas maximus) allow scientists to obtain representative cells that have conserved most of their original characteristics, function, physiology and biochemistry. This technique has thus gained significant importance...

["Cell Biology","Veterinary Medicine"]
doi:10.7717/peerj.4302

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