Peer-reviewed Articles

13 downloads
60 views

Triple negative breast cancer (TNBC) is a belligerent carcinoma that is unresponsive to targeted receptor therapies. Development of new treatment strategies would benefit from an expanded repertoire of in vitro cell culture systems, such as those that support tridimensional...

["Cell Biology","Anatomy and Physiology","Oncology","Pathology","Histology"]
doi:10.7717/peerj.4340
20 downloads
164 views

Liver fibrosis is a disease that causes high morbidity and has become a major health problem. Liver fibrosis can lead to the end stage of liver diseases (livercirrhosisand hepatocellularcarcinoma). Currently, liver transplantation is the only effective treatment...

["Cell Biology","Gastroenterology and Hepatology","Translational Medicine"]
doi:10.7717/peerj.4336
21 downloads
130 views

Background Systemic lupus erythematosus (SLE) disease has been shown to be associated with the generation of multiple auto-antibodies. Among these, anti-dsDNA antibodies (anti-DNAs) are specific and play a pathogenic role in SLE. Indeed, anti-DNA+ SLE patients...

["Cell Biology","Immunology","Rheumatology"]
doi:10.7717/peerj.4294
43 downloads
237 views

Dermal papilla (DP) plays important roles in hair follicle regeneration. Long-term culture of mouse DP cells can provide enough cells for research and application of DP cells. We optimized the culture strategy for DP cells from three dimensions: stepwise dissection,...

["Biotechnology","Cell Biology","Dermatology"]
doi:10.7717/peerj.4306
106 downloads
238 views

Background Primary cultures from Asian elephants (Elephas maximus) allow scientists to obtain representative cells that have conserved most of their original characteristics, function, physiology and biochemistry. This technique has thus gained significant importance...

["Cell Biology","Veterinary Medicine"]
doi:10.7717/peerj.4302
64 downloads
418 views

Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2. In order to be functional,...

["Biochemistry","Cell Biology","Immunology","Nutrition"]
doi:10.7717/peerj.4212
96 downloads
294 views

Background Pluripotent stem cells (PSCs) offer immense potential as a source for regenerative therapies. The teratoma assay is widely used in the field of stem cells and regenerative medicine, but the cell composition of teratoma is still elusive. Methods We utilized...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4177
89 downloads
1,202 views

The nanoparticle as a cancer drug delivery vehicle is rapidly under investigation due to its promising applicability as a novel drug delivery system for anticancer agents. This study describes the development, characterization and toxicity studies of a nanostructured...

["Biotechnology","Cell Biology"]
doi:10.7717/peerj.3916
62 downloads
220 views

Background The release of high mobility group box 1 (HMGB1) induced by inflammatory signals acts as a cellular alarmin to trigger a chain of inflammatory responses. Although the inflammatory actions of HMGB1 are well studied, less is known about the therapeutic...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4208
57 downloads
307 views

Histone lysine modifications are important epigenetic modifications in early embryonic development. JARID2, which is a member of the jumonji demethylase protein family, is a regulator of early embryonic development and can regulate mouse development and embryonic...

["Cell Biology","Developmental Biology"]
doi:10.7717/peerj.4189
66 downloads
315 views

Background and Purpose Oxidative stress is involved in normal and pathological functioning of skeletal muscle. Protection of myoblasts from oxidative stress may improve muscle contraction and delay aging. Here we studied the effect of R. coriaria sumac fruit extract...

["Cell Biology","Translational Medicine"]
doi:10.7717/peerj.4144
56 downloads
445 views

Previously, we revealed that several kampo medicines used for patients with excess and/or medium patterns (kakkonto (TJ-1), shosaikoto (TJ-9), hangeshashinto (TJ-14), and orento (TJ-120)) reduced prostaglandin (PG)E2 levels using LPS-treated human gingival fibroblasts...

["Cell Biology","Dentistry","Pharmacology"]
doi:10.7717/peerj.4120
52 downloads
248 views

Background The perioperative period is important for patient outcome. Colorectal cancer surgery can lead to metastatic disease due to release of disseminated tumor cells and the induction of surgical stress response. To explore the overall effects on surgically-induced...

["Cell Biology","Oncology"]
doi:10.7717/peerj.4033
79 downloads
249 views

Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers and focal...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4063
96 downloads
355 views

The presence of acetic acid during industrial alcohol fermentation reduces the yield of fermentation by imposing additional stress on the yeast cells. The biology of cellular responses to stress has been a subject of vigorous investigations. Although much has been...

["Cell Biology","Genetics","Molecular Biology"]
doi:10.7717/peerj.4037

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