Peer-reviewed Articles

33 downloads
288 views

Previously, we revealed that several kampo medicines used for patients with excess and/or medium patterns (kakkonto (TJ-1), shosaikoto (TJ-9), hangeshashinto (TJ-14), and orento (TJ-120)) reduced prostaglandin (PG)E2 levels using LPS-treated human gingival fibroblasts...

["Cell Biology","Dentistry","Pharmacology"]
doi:10.7717/peerj.4120
37 downloads
191 views

Background The perioperative period is important for patient outcome. Colorectal cancer surgery can lead to metastatic disease due to release of disseminated tumor cells and the induction of surgical stress response. To explore the overall effects on surgically-induced...

["Cell Biology","Oncology"]
doi:10.7717/peerj.4033
59 downloads
161 views

Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers and focal...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4063
63 downloads
223 views

The presence of acetic acid during industrial alcohol fermentation reduces the yield of fermentation by imposing additional stress on the yeast cells. The biology of cellular responses to stress has been a subject of vigorous investigations. Although much has been...

["Cell Biology","Genetics","Molecular Biology"]
doi:10.7717/peerj.4037
175 downloads
304 views

Background Biomineralization, e.g., in sea urchins or mollusks, includes the assembly of mesoscopic superstructures from inorganic crystalline components and biopolymers. The resulting mesocrystals inspire biophysicists and material scientists alike, because of...

["Aquaculture, Fisheries and Fish Science","Cell Biology","Marine Biology","Zoology","Histology"]
doi:10.7717/peerj.3923
132 downloads
365 views

Increased levels of long noncoding RNA H19 (H19) have been observed in many inflammatory and organ fibrosis diseases including ulcerative colitis, osteoarthritis, liver fibrosis, renal fibrosis and pulmonary fibrosis. However, the role of H19 in bovine mastitis...

["Biochemistry","Cell Biology","Veterinary Medicine"]
doi:10.7717/peerj.3950
73 downloads
728 views

In the context of a hunt for a postulated hormone that is tissue-mass inhibiting and reproductively associated, there is described probable relatedness to a granin protein. A 7–8 kDa polypeptide candidate (gels/MS) appeared in a bioassay-guided fractionation campaign...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Neurology"]
doi:10.7717/peerj.3833
73 downloads
363 views

Background Although spermatozoa with normal morphology are assumed to have uniform fertilization ability, recent data show that even normal spermatozoa have considerable variation in their head shape which is associated with differences in fertilization ability....

["Cell Biology","Developmental Biology","Andrology"]
doi:10.7717/peerj.3913
109 downloads
325 views

Background Cardiac stem cells (CSCs) play a vital role in cardiac homeostasis. A decrease in the efficiency of cardiac stem cells is speculated in various cardiac abnormalities. The maintenance of a healthy stem cell population is essential for the prevention of...

["Cell Biology","Cardiology"]
doi:10.7717/peerj.3882
62 downloads
761 views

If fertilization of matured oocyte does not occur, unfertilized oocyte undergoes aging, resulting in a time-dependent reduction of the oocyte’s quality. The aging of porcine oocytes can lead to apoptosis. Carbon monoxide (CO), a signal molecule produced by the...

["Biotechnology","Cell Biology","Developmental Biology","Veterinary Medicine"]
doi:10.7717/peerj.3876
91 downloads
279 views

Background Astragalus polysaccharide (APS) has immunomodulatory activities on porcine peripheral blood mononuclear cells. The immunomodulatory effects of APS on porcine endothelial cells (ECs) expose to classical swine fever virus (CSFV) remain unknown. Methods...

["Cell Biology","Veterinary Medicine","Infectious Diseases","Internal Medicine"]
doi:10.7717/peerj.3862
136 downloads
752 views

Rapid proliferation and Warburg effect make cancer cells consume plenty of glucose, which induces a low glucose micro-environment within the tumor. Up to date, how cancer cells keep proliferating in the condition of glucose insufficiency still remains to be explored....

["Biochemistry","Cell Biology","Oncology"]
doi:10.7717/peerj.3804
1 citation
61 downloads
419 views

Particle bombardment is a powerful and relatively easy method for transient expression of genes of interest in plant cells, especially those that are recalcitrant to other transformation methods. This method has facilitated numerous analyses of subcellular localization...

["Cell Biology","Molecular Biology","Plant Science"]
doi:10.7717/peerj.3779
119 downloads
551 views

Background Standard two-dimensional (2D) cell migration assays do not provide information about vertical invasion processes, which are critical for melanoma progression. We provide information about three-dimensional (3D) melanoma cell migration, proliferation...

["Cell Biology","Oncology","Histology"]
doi:10.7717/peerj.3754
138 downloads
453 views

Background Over the last few years multiple studies have been published showing a great diversity in size of chloroplast genomes (cpGenomes), and in the arrangement of gene clusters, in the Euglenales. However, while these genomes provided important insights into...

["Cell Biology","Evolutionary Studies","Genomics"]
doi:10.7717/peerj.3725

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