Peer-reviewed Articles

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Background Hypertension and dyssomnia are increasing significantly in Mongolians, and the related factors of ethnic differences in hypertension and dyssomnia between Mongolians and Han Chinese are unclear. This study examined the relationship of morning surge in...

["Cardiology","Global Health","Public Health"]
doi:10.7717/peerj.3758
37 downloads
367 views

Background New-onset atrial fibrillation (AF) is the most common arrhythmia in critically ill patients. Although evidence base and expert consensus opinion for management have been summarised in several international guidelines, no specific considerations for critically...

["Anaesthesiology and Pain Management","Cardiology","Emergency and Critical Care"]
doi:10.7717/peerj.3716
89 downloads
374 views

Objective Circulating endothelial progenitor cells (EPCs) correlate negatively with obesity. Previous studies have shown that exercise significantly restores circulating EPC levels in obese people; however, the underlying mechanisms have not been elucidated. Recently,...

["Neuroscience","Cardiology","Clinical Trials","Nutrition"]
doi:10.7717/peerj.3669
31 downloads
182 views

Background Hypoxia-inducible factor (HIF)-1 is involved in the regulation of hypoxic preconditioning in cardiomyocytes. Under hypoxic conditions, HIF-1α accumulates and is translocated to the nucleus, where it forms an active complex with HIF-1β and activates transcription...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.3662
87 downloads
443 views

Background Psychological factors have been suggested to have an influence in Atrial Fibrillation (AF) onset, progression, severity and outcomes, but their role is unclear and mainly focused on anxiety and depression. Methods A systematic electronic search had been...

["Cardiology","Psychiatry and Psychology","Public Health"]
doi:10.7717/peerj.3537
104 downloads
563 views

Introduction Our study aims at identifying and quantifying the relationship between the cold and heat exposure and the risk of cardiovascular mortality through a systematic review and meta-analysis. Material and Methods A systematic review and meta-analysis were...

["Cardiology","Public Health"]
doi:10.7717/peerj.3574
81 downloads
430 views

Background c-Kit is a receptor tyrosine kinase present in multiple cell types, including vascular smooth muscle cells (SMC). However, little is known about how c-Kit influences SMC biology and vascular pathogenesis. Methods High-throughput microarray assays and...

["Molecular Biology","Cardiology","Pharmacology"]
doi:10.7717/peerj.3418
157 downloads
450 views

Background The kidney is always subjected to high metabolic demand. The aim of this study was to characterize metabolic profiles of a rat model of chronic kidney disease (CKD) with cardiorenal syndrome (CRS) induced by prolonged hypertension. Methods We used inbred...

["Molecular Biology","Cardiology","Nephrology"]
doi:10.7717/peerj.3352
77 downloads
360 views

Our previous study demonstrated that tentacle extract (TE) from the jellyfish Cyanea capillata (C. capillata) could cause a weak relaxation response mediated by nitric oxide (NO) using isolated aorta rings. However, the intracellular mechanisms of TE-induced vasodilation...

["Cell Biology","Marine Biology","Cardiology"]
doi:10.7717/peerj.3172
3 citations
126 downloads
457 views

Background Sevoflurane postconditioning (S-post) has similar cardioprotective effects as ischemic preconditioning. However, the underlying mechanism of S-post has not been fully elucidated. Janus kinase signaling transduction/transcription activator (JAK2–STAT3)...

["Anesthesiology and Pain Management","Cardiology","Translational Medicine"]
doi:10.7717/peerj.3196
91 downloads
409 views

Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity. Thus, it is possible that resveratrol increases the inotropic effect of sympathomimetic agents,...

["Cardiology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.3113
283 downloads
400 views

Background The outcomes of the physician-patient discussion intervene in the satisfaction of cardiovascular disease risk patients. Adherence to treatment, provision of continuous care, clinical management of the illness and patients’ adjustment are influenced by...

["Cardiology","Public Health","Science and Medical Education"]
doi:10.7717/peerj.2983
134 downloads
375 views

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance...

["Cardiology","Pharmacology"]
doi:10.7717/peerj.2911
1 citation
168 downloads
429 views

The low survival rate of cardiac stem cells (CSCs) in the ischemic myocardium is one of the obstacles in ischemic cardiomyopathy cell therapy. The MicroRNA (miR)-21 and one of its target protein, the tensin homolog deleted on chromosome ten (PTEN), contributes...

["Cell Biology","Cardiology","Translational Medicine"]
doi:10.7717/peerj.2859
171 downloads
410 views

Background Fulminant myocarditis (FM) is an inflammatory disease of the myocardium that results in ventricular systolic dysfunction and causes acute-onset heart failure. Cardiac magnetic resonance (CMR) has become the primary noninvasive tool for the diagnosis...

["Cardiology","Pediatrics","Radiology and Medical Imaging"]
doi:10.7717/peerj.2750

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