Peer-reviewed Articles

28 downloads
168 views

Background The kidney is always subjected to high metabolic demand. The aim of this study was to characterize metabolic profiles of a rat model of chronic kidney disease (CKD) with cardiorenal syndrome (CRS) induced by prolonged hypertension. Methods We used inbred...

["Molecular Biology","Cardiology","Nephrology"]
doi:10.7717/peerj.3352
43 downloads
258 views

Our previous study demonstrated that tentacle extract (TE) from the jellyfish Cyanea capillata (C. capillata) could cause a weak relaxation response mediated by nitric oxide (NO) using isolated aorta rings. However, the intracellular mechanisms of TE-induced vasodilation...

["Cell Biology","Marine Biology","Cardiology"]
doi:10.7717/peerj.3172
70 downloads
330 views

Background Sevoflurane postconditioning (S-post) has similar cardioprotective effects as ischemic preconditioning. However, the underlying mechanism of S-post has not been fully elucidated. Janus kinase signaling transduction/transcription activator (JAK2–STAT3)...

["Anesthesiology and Pain Management","Cardiology","Translational Medicine"]
doi:10.7717/peerj.3196
70 downloads
336 views

Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity. Thus, it is possible that resveratrol increases the inotropic effect of sympathomimetic agents,...

["Cardiology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.3113
113 downloads
297 views

Background The outcomes of the physician-patient discussion intervene in the satisfaction of cardiovascular disease risk patients. Adherence to treatment, provision of continuous care, clinical management of the illness and patients’ adjustment are influenced by...

["Cardiology","Public Health","Science and Medical Education"]
doi:10.7717/peerj.2983
79 downloads
287 views

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance...

["Cardiology","Pharmacology"]
doi:10.7717/peerj.2911
129 downloads
338 views

The low survival rate of cardiac stem cells (CSCs) in the ischemic myocardium is one of the obstacles in ischemic cardiomyopathy cell therapy. The MicroRNA (miR)-21 and one of its target protein, the tensin homolog deleted on chromosome ten (PTEN), contributes...

["Cell Biology","Cardiology","Translational Medicine"]
doi:10.7717/peerj.2859
108 downloads
354 views

Background Fulminant myocarditis (FM) is an inflammatory disease of the myocardium that results in ventricular systolic dysfunction and causes acute-onset heart failure. Cardiac magnetic resonance (CMR) has become the primary noninvasive tool for the diagnosis...

["Cardiology","Pediatrics","Radiology and Medical Imaging"]
doi:10.7717/peerj.2750
1 citation
147 downloads
464 views

As we age, our hearts undergo changes that result in a reduction in complexity of physiological interactions between different control mechanisms. This results in a potential risk of cardiovascular diseases which are the number one cause of death globally. Since...

["Computational Biology","Cardiology"]
doi:10.7717/peerj.2755
166 downloads
491 views

Background Age remains a significant and unmodifiable risk factor for cardiovascular diseases, and an increasing number of patients older than 80 years of age undergo Coronary Artery Bypass Grafting (CABG). Old age is also an independent risk factor for postoperative...

["Cardiology","Epidemiology","Geriatrics","Nursing","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2667
2 citations
114 downloads
480 views

Background Anesthetic postconditioning is a cellular protective approach whereby exposure to a volatile anesthetic renders a tissue more resistant to subsequent ischemic/reperfusion event. Sevoflurane postconditioning (SPostC) has been shown to exert cardioprotection...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology","Diabetes and Endocrinology"]
doi:10.7717/peerj.2659
98 downloads
465 views

Aims We have recently created an age-dependent hypertensive-mono-arthritic animal model from the stroke-resistant spontaneously hypertensive rat to model populations with autoimmune disease who are hypertensive and are prone to stroke. The model exhibits signs...

["Cardiology","Immunology","Pharmacology","Rheumatology","Histology"]
doi:10.7717/peerj.2608
2 citations
79 downloads
327 views

Ischemic postconditioning (IPC) and ATP sensitive potassium channel (KATP) agonists (e.g. pinacidil and diazoxide) postconditioning are effective methods to defeat myocardial ischemia-reperfusion (I/R) injury, but their specific mechanisms of reducing I/R injury...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.2612
1 citation
103 downloads
440 views

C1q TNF Related Protein 3 (CTRP3) is a novel adipose tissue derived secreted factor, or adipokine, which has been linked to a number of beneficial biological effects on metabolism, inflammation, and survival signaling in a variety of tissues. However, very little...

["Cardiology","Diabetes and Endocrinology","Public Health","Metabolic Sciences"]
doi:10.7717/peerj.2573
1 citation
253 downloads
774 views

During most of the twentieth century, cardiovascular mortality increased in the United States while other causes of death declined. By 1958, the age-standardized death rate (ASDR) for cardiovascular causes for females was 1.84 times that for all other causes, combined...

["Virology","Cardiology","Epidemiology","Infectious Diseases","Public Health"]
doi:10.7717/peerj.2531

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