Peer-reviewed Articles

31 downloads
183 views

As we age, our hearts undergo changes that result in a reduction in complexity of physiological interactions between different control mechanisms. This results in a potential risk of cardiovascular diseases which are the number one cause of death globally. Since...

["Computational Biology","Cardiology"]
doi:10.7717/peerj.2755
38 downloads
209 views

Background Age remains a significant and unmodifiable risk factor for cardiovascular diseases, and an increasing number of patients older than 80 years of age undergo Coronary Artery Bypass Grafting (CABG). Old age is also an independent risk factor for postoperative...

["Cardiology","Epidemiology","Geriatrics","Nursing","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2667
62 downloads
252 views

Background Anesthetic postconditioning is a cellular protective approach whereby exposure to a volatile anesthetic renders a tissue more resistant to subsequent ischemic/reperfusion event. Sevoflurane postconditioning (SPostC) has been shown to exert cardioprotection...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology","Diabetes and Endocrinology"]
doi:10.7717/peerj.2659
52 downloads
280 views

Aims We have recently created an age-dependent hypertensive-mono-arthritic animal model from the stroke-resistant spontaneously hypertensive rat to model populations with autoimmune disease who are hypertensive and are prone to stroke. The model exhibits signs...

["Cardiology","Immunology","Pharmacology","Rheumatology","Histology"]
doi:10.7717/peerj.2608
38 downloads
150 views

Ischemic postconditioning (IPC) and ATP sensitive potassium channel (KATP) agonists (e.g. pinacidil and diazoxide) postconditioning are effective methods to defeat myocardial ischemia-reperfusion (I/R) injury, but their specific mechanisms of reducing I/R injury...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.2612
45 downloads
250 views

C1q TNF Related Protein 3 (CTRP3) is a novel adipose tissue derived secreted factor, or adipokine, which has been linked to a number of beneficial biological effects on metabolism, inflammation, and survival signaling in a variety of tissues. However, very little...

["Cardiology","Diabetes and Endocrinology","Public Health","Metabolic Sciences"]
doi:10.7717/peerj.2573
107 downloads
529 views

During most of the twentieth century, cardiovascular mortality increased in the United States while other causes of death declined. By 1958, the age-standardized death rate (ASDR) for cardiovascular causes for females was 1.84 times that for all other causes, combined...

["Virology","Cardiology","Epidemiology","Infectious Diseases","Public Health"]
doi:10.7717/peerj.2531
90 downloads
367 views

Ischemic stroke is a common neurological disorder and the burden in the world is growing. This study aims to explore the effect of sex and age difference on ischemic stroke using integrated microarray datasets. The results showed a dramatic difference in whole...

["Bioinformatics","Cardiology","Immunology"]
doi:10.7717/peerj.2470
123 downloads
499 views

Background Alterations in skeletal muscle function and architecture have been linked to the compromised exercise capacity characterizing chronic heart failure (CHF). However, how passive skeletal muscle force is affected in CHF is not clear. Understanding passive...

["Bioengineering","Computational Biology","Anatomy and Physiology","Cardiology","Kinesiology"]
doi:10.7717/peerj.2447
83 downloads
266 views

Background Left ventricular hypertrophy (LVH) is a marker of pediatric hypertension and predicts development of cardiovascular events. Electrocardiography (ECG) screening is used in pediatrics to detect LVH thanks to major accessibility, reproducibility and easy...

["Cardiology","Epidemiology","Pediatrics"]
doi:10.7717/peerj.2439
73 downloads
946 views

Background: Information on cardiovascular gene transcription is fragmented and far behind the present requirements of the systems biology field. To create a comprehensive source of data for cardiovascular gene regulation and to facilitate a deeper understanding...

["Bioinformatics","Computational Biology","Cardiology","Computational Science"]
doi:10.7717/peerj.2339
1 citation
87 downloads
828 views

Background. Mammalian hibernation in thirteen-lined ground squirrels (Ictidomys tridecemlineatus) is characterized by dramatic changes on a physiological and molecular level. During hibernation, mammalian hearts show a propensity to hypertrophy due to the need...

["Biochemistry","Molecular Biology","Anatomy and Physiology","Cardiology"]
doi:10.7717/peerj.2317
396 downloads
899 views

Background: Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously...

["Cardiology","Evidence Based Medicine","Translational Medicine","Statistics","Computational Science"]
doi:10.7717/peerj.2284
112 downloads
503 views

Background: Although atrial fibrillation (AF), a common arrhythmia, frequently presents in patients with underlying valvular disease, its hemodynamic contributions are not fully understood. The present work aimed to computationally study how physical conditions...

["Bioengineering","Computational Biology","Anatomy and Physiology","Cardiology","Computational Science"]
doi:10.7717/peerj.2240
123 downloads
698 views

Background: Low-grade chronic inflammation is a common feature of obesity and its cardio-metabolic complications. However, little is known about a possible causal role of inflammation in metabolic disorders. Mexico is among the countries with the highest obesity...

["Genetics","Cardiology","Diabetes and Endocrinology","Pediatrics"]
doi:10.7717/peerj.2090

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