Peer-reviewed Articles

64 downloads
286 views

Background Streptomyces are well known for their capability to produce many bioactive secondary metabolites with medical and industrial importance. Here we report a novel bioactive phenazine compound, 6-((2-hydroxy-4-methoxyphenoxy) carbonyl) phenazine-1-carboxylic...

["Bioinformatics","Biotechnology","Genomics","Drugs and Devices"]
doi:10.7717/peerj.3738
68 downloads
350 views

Extensive investigations over the recent decades have established the anatomical, biomechanical and functional importance of the meniscus in the knee joint. As a functioning part of the joint, it serves to prevent the deterioration of articular cartilage and subsequent...

["Biotechnology","Kinesiology","Orthopedics"]
doi:10.7717/peerj.4076
78 downloads
359 views

In industry, the yeast Rhodotorula mucilaginosa is commonly used for the production of carotenoids. The production of carotenoids is important because they are used as natural colorants in food and some carotenoids are precursors of retinol (vitamin A). However,...

["Biotechnology","Genomics","Microbiology","Mycology","Plant Science"]
doi:10.7717/peerj.4030
73 downloads
357 views

Background Dengue disease is a leading cause of illness and death in the tropics and subtropics. Most severe cases occur among patients secondarily infected with a different dengue virus (DENV) serotype compared with that from the first infection, resulting in...

["Biotechnology","Molecular Biology","Virology","Infectious Diseases"]
doi:10.7717/peerj.4021
85 downloads
262 views

Background Aspergillus niger, along with many other lignocellulolytic fungi, has been widely used as a commercial workhorse for cellulase production. A fungal cellulase system generally includes three major classes of enzymes i.e., β-glucosidases, endoglucanases...

["Biochemistry","Biotechnology","Molecular Biology"]
doi:10.7717/peerj.3909
62 downloads
761 views

If fertilization of matured oocyte does not occur, unfertilized oocyte undergoes aging, resulting in a time-dependent reduction of the oocyte’s quality. The aging of porcine oocytes can lead to apoptosis. Carbon monoxide (CO), a signal molecule produced by the...

["Biotechnology","Cell Biology","Developmental Biology","Veterinary Medicine"]
doi:10.7717/peerj.3876
110 downloads
430 views

Background High mobility group box 1 (HMGB1) is a well-known damage-related alarmin that participates in cellular inflammatory responses. However, the mechanisms leading to HMGB1 release in inflammatory conditions and the therapeutic agents that could prevent it...

["Biotechnology","Toxicology","Drugs and Devices","Evidence Based Medicine","Pharmacology"]
doi:10.7717/peerj.3808
196 downloads
663 views

In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having...

["Biochemistry","Biotechnology","Oncology"]
doi:10.7717/peerj.3784
1 citation
79 downloads
430 views

Objective The trabecular meshwork (TM) is the primary substrate of outflow resistance in glaucomatous eyes. Repopulating diseased TM with fresh, functional TM cells might be a viable therapeutic approach. Decellularized TM scaffolds have previously been produced...

["Bioengineering","Biotechnology","Ophthalmology"]
doi:10.7717/peerj.3629
139 downloads
462 views

Microbial transglutaminase (mTG) was used as a crosslinking agent in the preparation of gelatin sponges. The physical properties of the materials were evaluated by measuring their material porosity, water absorption, and elastic modulus. The stability of the sponges...

["Biotechnology","Cell Biology"]
doi:10.7717/peerj.3665
222 downloads
430 views

This paper is the first public report that Streptomyces flavogriseus can produce both actinomycin D and holomycin. The actinomycete strain NJ-4 isolated from the soil of Nanjing Agricultural University was identified as S. flavogriseus. This S. flavogriseus strain...

["Biotechnology","Microbiology"]
doi:10.7717/peerj.3601
59 downloads
783 views

CodonGenie, freely available from http://codon.synbiochem.co.uk, is a simple web application for designing ambiguous codons to support protein mutagenesis applications. Ambiguous codons are derived from specific heterogeneous nucleotide mixtures, which create sequence...

["Bioengineering","Bioinformatics","Biotechnology","Computational Biology","Synthetic Biology"]
doi:10.7717/peerj-cs.120
1 citation
156 downloads
582 views

Novel microbial phospholipases A (PLAs) can be found in actinomycetes which have been poorly explored as producers of this activity. To investigate microbial PLA production, efficient methods are necessary such as high-throughput screening (HTS) assays for direct...

["Biodiversity","Biotechnology","Microbiology"]
doi:10.7717/peerj.3524
1 citation
149 downloads
554 views

Lactococcus lactis subsp. cremoris MG1363 is an important starter culture for dairy fermentation. During industrial fermentations, L. lactis is constantly exposed to stresses that affect the growth and performance of the bacterium. Although the response of L. lactis...

["Biotechnology","Microbiology"]
doi:10.7717/peerj.3451
89 downloads
677 views

Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases containing three domains: an extracellular receptor domain, a single transmembrane helix, and an intracellular tyrosine kinase domain. FGFRs are activated by fibroblast growth...

["Biochemistry","Biotechnology"]
doi:10.7717/peerj.3512

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