Peer-reviewed Articles

28 downloads
145 views

Background Type 2 diabetes is characterized by insulin resistance accompanied by defective insulin secretion. Transgenic mouse models play an important role in medical research. However, single transgenic mouse models may not mimic the complex phenotypes of most...

["Agricultural Science","Biotechnology","Diabetes and Endocrinology","Histology","Medical Genetics"]
doi:10.7717/peerj.4542
39 downloads
589 views

Acetic acid bacteria have unique metabolic characteristics that suit them for a variety of biotechnological applications. They possess an arsenal of membrane-bound dehydrogenases in the periplasmic space that are capable of regiospecific and enantioselective partial...

["Biotechnology","Microbiology","Molecular Biology"]
doi:10.7717/peerj.4626
50 downloads
478 views

Virus-induced gene silencing (VIGS) is an attractive tool for determining gene function in plants. The present study constitutes the first application of VIGS in S. pseudocapsicum, which has great ornamental and pharmaceutical value, using tobacco rattle virus...

["Agricultural Science","Biotechnology","Molecular Biology","Plant Science"]
doi:10.7717/peerj.4424
83 downloads
629 views

Membrane-bound fatty acid desaturases perform oxygenated desaturation reactions to insert double bonds within fatty acyl chains in regioselective and stereoselective manners. The Δ9-fatty acid desaturase strictly creates the first double bond between C9 and 10...

["Biotechnology","Computational Biology","Microbiology"]
doi:10.7717/peerj.4347
79 downloads
543 views

In pursuit of developing fast and accurate species-level molecular identification methods, we tested six DNA barcodes, namely ITS2, matK, rbcLa, ITS2+matK, ITS2+rbcLa, matK+rbcLa and ITS2+matK+rbcLa, for their capacity to identify frequently consumed but geographically...

["Biochemistry","Biotechnology","Molecular Biology","Plant Science"]
doi:10.7717/peerj.4499
71 downloads
581 views

Background Tumor-induced angiogenesis is an imperative event in pledging new vasculature for tumor metastasis. Since overexpression of neuronal proteins gamma-synuclein (γ-Syn) and cellular prion protein (PrPC) is always detected in advanced stages of cancer diseases...

["Biochemistry","Biotechnology","Cell Biology","Molecular Biology","Oncology"]
doi:10.7717/peerj.4506
176 downloads
1,079 views

The Centers for Disease Control and Prevention (CDC) and many public health jurisdictions continue to advocate for the most sensitive rapid HIV test that is available. Currently, the recommendation is to utilize tests that can detect HIV infection biomarkers within...

["Biotechnology","HIV","Immunology","Infectious Diseases","Public Health"]
doi:10.7717/peerj.4430
139 downloads
675 views

African swine fever virus (ASFV) is the etiological agent of ASF, a fatal hemorrhagic fever that affects domestic pigs. There is currently no vaccine against ASFV, making it a significant threat to the pork industry. The ASFV genome sequence has been published;...

["Biochemistry","Bioinformatics","Biotechnology","Computational Biology"]
doi:10.7717/peerj.4396
85 downloads
648 views

Background Soil moisture deficiency causes yield reduction and instability in faba bean (Vicia faba L.) production. The extent of sensitivity to drought stress varies across accessions originating from diverse moisture regimes of the world. Hence, we conducted...

["Agricultural Science","Biotechnology","Plant Science","Natural Resource Management"]
doi:10.7717/peerj.4401
139 downloads
488 views

Cancer cases result in 13% of all deaths worldwide. Unwanted side effects in patients under conventional treatments have led to the search for beneficial alternative therapies. Microalgae synthesize compounds with known in vitro and in vivo biological activity...

["Biotechnology","Ecosystem Science","Oncology","Freshwater Biology"]
doi:10.7717/peerj.4358
87 downloads
357 views

Dermal papilla (DP) plays important roles in hair follicle regeneration. Long-term culture of mouse DP cells can provide enough cells for research and application of DP cells. We optimized the culture strategy for DP cells from three dimensions: stepwise dissection,...

["Biotechnology","Cell Biology","Dermatology"]
doi:10.7717/peerj.4306
161 downloads
785 views

Understanding how structural and functional alterations of individual tissues impact on whole-joint function is challenging, particularly in humans where direct invasive experimentation is difficult. Finite element (FE) computational models produce quantitative...

["Bioengineering","Biotechnology","Computational Biology"]
doi:10.7717/peerj.4298
194 downloads
787 views

Driven by the growing recognition of the influence of the gut microbiota (GM) on human health and disease, there is a rapidly increasing interest in understanding how dietary components, pharmaceuticals and pre- and probiotics influence GM. In vitro colon models...

["Biotechnology","Food Science and Technology","Genetics","Microbiology","Nutrition"]
doi:10.7717/peerj.4268
110 downloads
466 views

The maintenance of a G + C content that is higher than the mutational input to a genome provides support for the view that selection serves to increase G + C contents in bacteria. Recent experimental evidence from Escherichia coli demonstrated that selection for...

["Biotechnology","Evolutionary Studies","Genetics","Molecular Biology","Synthetic Biology"]
doi:10.7717/peerj.4286
191 downloads
497 views

Background Beaches are recreational spots for people. However, beach sand contains harmful microbes that affect human health, and there are no established methods for either sampling and identifying beach-borne pathogens or managing the quality of beach sand. Method...

["Biotechnology","Marine Biology","Allergy and Clinical Immunology","Pathology","Public Health"]
doi:10.7717/peerj.4245

Refine by manuscript type

Top subject areas - Articles

Top subject areas - People

View all subject areas