Peer-reviewed Articles

62 downloads
248 views

Cancer cases result in 13% of all deaths worldwide. Unwanted side effects in patients under conventional treatments have led to the search for beneficial alternative therapies. Microalgae synthesize compounds with known in vitro and in vivo biological activity...

["Biotechnology","Ecosystem Science","Oncology","Freshwater Biology"]
doi:10.7717/peerj.4358
47 downloads
243 views

Dermal papilla (DP) plays important roles in hair follicle regeneration. Long-term culture of mouse DP cells can provide enough cells for research and application of DP cells. We optimized the culture strategy for DP cells from three dimensions: stepwise dissection,...

["Biotechnology","Cell Biology","Dermatology"]
doi:10.7717/peerj.4306
87 downloads
404 views

Understanding how structural and functional alterations of individual tissues impact on whole-joint function is challenging, particularly in humans where direct invasive experimentation is difficult. Finite element (FE) computational models produce quantitative...

["Bioengineering","Biotechnology","Computational Biology"]
doi:10.7717/peerj.4298
125 downloads
579 views

Driven by the growing recognition of the influence of the gut microbiota (GM) on human health and disease, there is a rapidly increasing interest in understanding how dietary components, pharmaceuticals and pre- and probiotics influence GM. In vitro colon models...

["Biotechnology","Food Science and Technology","Genetics","Microbiology","Nutrition"]
doi:10.7717/peerj.4268
70 downloads
346 views

The maintenance of a G + C content that is higher than the mutational input to a genome provides support for the view that selection serves to increase G + C contents in bacteria. Recent experimental evidence from Escherichia coli demonstrated that selection for...

["Biotechnology","Evolutionary Studies","Genetics","Molecular Biology","Synthetic Biology"]
doi:10.7717/peerj.4286
90 downloads
353 views

Background Beaches are recreational spots for people. However, beach sand contains harmful microbes that affect human health, and there are no established methods for either sampling and identifying beach-borne pathogens or managing the quality of beach sand. Method...

["Biotechnology","Marine Biology","Allergy and Clinical Immunology","Pathology","Public Health"]
doi:10.7717/peerj.4245
47 downloads
205 views

Haemophilus parasuis is a member of the family Pasteurellaceae and a major causative agent of Glässer’s disease. This bacterium is normally a benign swine commensal but may become a deadly pathogen upon penetration into multiple tissues, contributing to severe...

["Agricultural Science","Biotechnology","Microbiology","Veterinary Medicine"]
doi:10.7717/peerj.4253
92 downloads
1,208 views

The nanoparticle as a cancer drug delivery vehicle is rapidly under investigation due to its promising applicability as a novel drug delivery system for anticancer agents. This study describes the development, characterization and toxicity studies of a nanostructured...

["Biotechnology","Cell Biology"]
doi:10.7717/peerj.3916
73 downloads
357 views

With the rapid advancement of regenerative medicine technologies, there is an urgent need for the development of new, cell-friendly techniques for obtaining nanofibers—the raw material for an artificial extracellular matrix production. We investigated the structure...

["Bioengineering","Biotechnology","Synthetic Biology"]
doi:10.7717/peerj.4125
143 downloads
1,925 views

Background Pesticidal RNAs that silence critical gene function have great potential in pest management, but the benefits of this technology must be weighed against non-target organism risks. Methods Published studies that developed pesticidal double stranded RNAs...

["Biotechnology","Ecology","Entomology","Toxicology","Ecotoxicology"]
doi:10.7717/peerj.4131
145 downloads
570 views

Background Streptomyces are well known for their capability to produce many bioactive secondary metabolites with medical and industrial importance. Here we report a novel bioactive phenazine compound, 6-((2-hydroxy-4-methoxyphenoxy) carbonyl) phenazine-1-carboxylic...

["Bioinformatics","Biotechnology","Genomics","Drugs and Devices"]
doi:10.7717/peerj.3738
119 downloads
510 views

Extensive investigations over the recent decades have established the anatomical, biomechanical and functional importance of the meniscus in the knee joint. As a functioning part of the joint, it serves to prevent the deterioration of articular cartilage and subsequent...

["Biotechnology","Kinesiology","Orthopedics"]
doi:10.7717/peerj.4076
138 downloads
514 views

In industry, the yeast Rhodotorula mucilaginosa is commonly used for the production of carotenoids. The production of carotenoids is important because they are used as natural colorants in food and some carotenoids are precursors of retinol (vitamin A). However,...

["Biotechnology","Genomics","Microbiology","Mycology","Plant Science"]
doi:10.7717/peerj.4030
116 downloads
464 views

Background Dengue disease is a leading cause of illness and death in the tropics and subtropics. Most severe cases occur among patients secondarily infected with a different dengue virus (DENV) serotype compared with that from the first infection, resulting in...

["Biotechnology","Molecular Biology","Virology","Infectious Diseases"]
doi:10.7717/peerj.4021
1 citation
114 downloads
384 views

Background Aspergillus niger, along with many other lignocellulolytic fungi, has been widely used as a commercial workhorse for cellulase production. A fungal cellulase system generally includes three major classes of enzymes i.e., β-glucosidases, endoglucanases...

["Biochemistry","Biotechnology","Molecular Biology"]
doi:10.7717/peerj.3909

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