Peer-reviewed Articles

Autophagy serves as a turnover mechanism for the recycling of redundant and/or damaged macromolecules present in eukaryotic cells to re-use them under starvation conditions via a double-membrane structure known as autophagosome. A set of eukaryotic genes called...

["Bioinformatics","Cell Biology","Computational Biology"]
doi:10.7717/peerj.2878
89 downloads
573 views

Recently, there has been a move encouraged by many stakeholders towards generating big, open data in many areas of research. One area where big, open data is particularly valuable is in research relating to complex heterogeneous disorders such as Autism Spectrum...

["Bioinformatics","Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.2880
111 downloads
462 views

The importance of 16S rRNA gene amplicon profiles for understanding the influence of microbes in a variety of environments coupled with the steep reduction in sequencing costs led to a surge of microbial sequencing projects. The expanding crowd of scientists and...

["Bioinformatics","Ecology","Microbiology"]
doi:10.7717/peerj.2836
46 downloads
211 views

Biomaterial scaffolds have the potential to enhance neuronal development and regeneration. Understanding the genetic responses of astrocytes and neurons to biomaterials could facilitate the development of synthetic environments that enable the specification of...

["Bioengineering","Bioinformatics","Cell Biology","Genomics","Neuroscience"]
doi:10.7717/peerj.2829
20 downloads
243 views

Solar salterns are excellent model ecosystems for studying virus-microbial interactions because of their low microbial diversity, environmental stability, and high viral density. By using the power of CRISPR spacers to link viruses to their prokaryotic hosts, we...

["Bioinformatics","Computational Biology","Ecology","Genomics","Microbiology"]
doi:10.7717/peerj.2844
44 downloads
322 views

Background Chrysophytes are protist model species in ecology and ecophysiology and important grazers of bacteria-sized microorganisms and primary producers. However, they have not yet been investigated in detail at the molecular level, and no genomic and only little...

["Biodiversity","Bioinformatics","Ecology","Evolutionary Studies","Genomics"]
doi:10.7717/peerj.2832
72 downloads
228 views

Background The oriental melon (Cucumis melo L. var. makuwa) is one of the most important cultivated cucurbits grown widely in Korea, Japan, and northern China. It is cultivated because its fruit has a sweet aromatic flavor and is rich in soluble sugars, organic...

["Agricultural Science","Bioinformatics","Genomics","Molecular Biology","Plant Science"]
doi:10.7717/peerj.2834
89 downloads
502 views

Metagenomic experiments attempt to characterize microbial communities using high-throughput DNA sequencing. Identification of the microorganisms in a sample provides information about the genetic profile, population structure, and role of microorganisms within...

["Bioinformatics","Computational Biology"]
doi:10.7717/peerj-cs.104
49 downloads
517 views

Diseases of marine mammals can be difficult to diagnose because of their life history and protected status. Stranded marine mammals have been a particularly useful resource to discover and comprehend the diseases that plague these top predators. Additionally, advancements...

["Bioinformatics","Marine Biology","Microbiology","Veterinary Medicine","Virology"]
doi:10.7717/peerj.2819
94 downloads
262 views

Background The involvement of multiple genes and missing heritability, which are dominant in complex diseases such as multiple sclerosis (MS), entail using network biology to better elucidate their molecular basis and genetic factors. We therefore aimed to integrate...

["Bioinformatics","Computational Biology","Immunology","Neurology"]
doi:10.7717/peerj.2775
57 downloads
328 views

We developed a bio-inspired robot controller combining an artificial genome with an agent-based control system. The genome encodes a gene regulatory network (GRN) that is switched on by environmental cues and, following the rules of transcriptional regulation,...

["Bioinformatics","Computational Biology","Evolutionary Studies"]
doi:10.7717/peerj.2812
117 downloads
205 views

Melioidosis, an infection caused by the facultative intracellular pathogen Burkholderia pseudomallei, has been classified as an emerging disease with the number of patients steadily increasing at an alarming rate. B. pseudomalleipossess various virulence determinants...

["Bioinformatics","Microbiology","Infectious Diseases"]
doi:10.7717/peerj.2532
140 downloads
490 views

We examined RNA-Seq data on 211 biological samples from 24 different Arabidopsis experiments carried out by different labs. We grouped the samples according to tissue types, and in each of the groups, we identified genes that are stably expressed across biological...

["Bioinformatics","Computational Biology","Genetics","Genomics","Molecular Biology"]
doi:10.7717/peerj.2791
100 downloads
387 views

Understanding the distribution of taxa and associated traits across different environments is one of the central questions in microbial ecology. High-throughput sequencing (HTS) studies are presently generating huge volumes of data to address this biogeographical...

["Bioinformatics","Ecology","Environmental Sciences","Microbiology"]
doi:10.7717/peerj.2690
100 downloads
306 views

Background Primary biodiversity records (PBR) are essential in many areas of scientific research as they document the biodiversity through time and space. However, concerns about PBR quality and fitness-for-use have grown, especially as derived from taxonomical,...

["Biodiversity","Biogeography","Bioinformatics","Ecosystem Science","Zoology"]
doi:10.7717/peerj.2743

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