Peer-reviewed Articles

13 downloads
160 views

Natural medicinal products possess diverse chemical structures and have been an essential source for drug discovery. Therefore, in this study, α-mangostin (AM) is a plant-derived compound was investigated for the apoptotic effect on human cervical cancer cells...

["Biochemistry","Cell Biology"]
doi:10.7717/peerj.3460
23 downloads
207 views

The death-associated protein kinase 1 (DAPK1) can act as an oncogene or a tumor suppressor gene depending on the cellular context as well as external stimuli. Our study aims to investigate the prognostic significance of DAPK1 in liver cancer in both mRNA and protein...

["Biochemistry","Gastroenterology and Hepatology","Oncology","Translational Medicine","Histology"]
doi:10.7717/peerj.3568
46 downloads
389 views

The fibronectin leucine rich transmembrane (FLRT) protein family consists in humans of 3 proteins, FLRT1, -2, and -3. The FLRT proteins contain two extracellular domains separated by an unstructured linker. The most membrane distal part is a leucine rich repeat...

["Biochemistry","Cell Biology","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.3550
36 downloads
216 views

Eastern spruce budworm (Choristoneura fumiferiana Clemens) (ESBW) is a major forest pest which feeds on young shoots of white spruce (Picea glauca) and can cause landscape level economic and ecological losses. Release of acetophenone metabolites, piceol and pungenol,...

["Biochemistry","Plant Science"]
doi:10.7717/peerj.3535
45 downloads
397 views

Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases containing three domains: an extracellular receptor domain, a single transmembrane helix, and an intracellular tyrosine kinase domain. FGFRs are activated by fibroblast growth...

["Biochemistry","Biotechnology"]
doi:10.7717/peerj.3512
51 downloads
228 views

Background Amoebiasis is the third most common parasitic cause of morbidity and mortality, particularly in countries with poor hygienic settings. There exists an ambiguity in the diagnosis of amoebiasis, and hence there arises a necessity for a better diagnostic...

["Biochemistry","Bioinformatics","Parasitology","Infectious Diseases"]
doi:10.7717/peerj.3160
47 downloads
218 views

The Gram-negative bacteria Photorhabdus and Xenorhabdus are known to produce a variety of different natural products (NP). These compounds play different roles since the bacteria live in symbiosis with nematodes and are pathogenic to insect larvae in the soil....

["Biochemistry","Biotechnology","Microbiology","Molecular Biology"]
doi:10.7717/peerj.3471
37 downloads
219 views

Clostridium septicum produces a number of diseases in human and farm animals which, in most of the cases, are fatal without clinical intervention. Alpha toxin is an important agent and the unique lethal virulent factor produced by Clostridium septicum. This toxin...

["Biochemistry","Biotechnology"]
doi:10.7717/peerj.3407
66 downloads
262 views

Background Pharyngitis is an inflammatory condition of the pharynx and associated structures commonly caused by the Group A streptococci (GAS). There is a growing interest in discovering plant-based anti-inflammatory compounds as potential alternatives to conventional...

["Agricultural Science","Biochemistry","Cell Biology","Food Science and Technology","Infectious Diseases"]
doi:10.7717/peerj.3469
71 downloads
398 views

Photosynthates released by benthic primary producers (BPP), such as reef algae and scleractinian corals, fuel the dissolved organic carbon (DOC) production on tropical coral reefs. DOC concentrations near BPP have repeatedly been observed to be elevated compared...

["Biochemistry","Ecology","Environmental Sciences","Marine Biology"]
doi:10.7717/peerj.3456
90 downloads
400 views

TH(AGYLLGHINLHHLAHL(Aib)HHIL-NH2), a histidine-rich, cell-penetrating peptide with acid-activated pH response, designed and synthesized by our group, can effectively target tumor tissues with an acidic extracellular environment. Since the protonating effect of...

["Biochemistry","Cell Biology","Oncology"]
doi:10.7717/peerj.3429
74 downloads
393 views

The changes of protein expression that are monitored in proteomic experiments are a type of biological transformation that also involves changes in chemical composition. Accompanying the myriad molecular-level interactions that underlie any proteomic transformation,...

["Biochemistry","Mathematical Biology","Oncology"]
doi:10.7717/peerj.3421
70 downloads
376 views

Background Synthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this...

["Biochemistry","Molecular Biology","Oncology","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.3365
79 downloads
305 views

Background Several studies report aberrant expression of sine oculis homeobox (SIX) homolog family members during cancer development and progression. SIX4 participates in organ development, such as myogenesis and neurogenesis. However, the expression and clinical...

["Biochemistry","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.3394
105 downloads
678 views

Background Bumblebees (Hymenoptera: Apidae: Bombus) are well known for their important inter- and intra-specific variation in hair (or pubescence) color patterns, but the chemical nature of the pigments associated with these patterns is not fully understood. For...

["Biochemistry","Entomology","Evolutionary Studies","Zoology"]
doi:10.7717/peerj.3300

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