Peer-reviewed Articles

36 downloads
286 views

Background Deficiencies in lysosomal a-mannosidase (LAM) activity in animals, caused either by mutations or by consuming toxic alkaloids, lead to severe phenotypic and behavioural consequences. Yet, epialleles adversely affecting LAM expression exist in the honey...

["Biochemistry","Developmental Biology","Molecular Biology","Toxicology"]
doi:10.7717/peerj.3109
69 downloads
377 views

Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, three-dimensional molecular structure analysis of P-type ATPases...

["Biochemistry","Bioinformatics","Biophysics","Computational Biology","Computational Science"]
doi:10.7717/peerj.3087
62 downloads
299 views

American trypanosomiasis is a chronic and endemic disease which affects millions of people. Trypanosoma cruzi, its causative agent, has a life cycle that involves complex morphological and functional transitions, as well as a variety of environmental conditions....

["Biochemistry","Genomics","Molecular Biology","Parasitology","Infectious Diseases"]
doi:10.7717/peerj.3017
37 downloads
224 views

Trypanosoma brucei brucei (TBB) belongs to the unicellular parasitic protozoa organisms, specifically to the Trypanosoma genus of the Trypanosomatidae class. A variety of different vertebrate species can be infected by TBB, including humans and animals. Under particular...

["Biochemistry","Bioinformatics","Computational Biology","Evolutionary Studies","Parasitology"]
doi:10.7717/peerj.3061
65 downloads
310 views

Background Sesquiterpenes are 15-carbon terpenes synthesized by sesquiterpene synthases using farnesyl diphosphate (FPP) as a substrate. Recently, a sesquiterpene synthase gene that encodes a 65 kDa protein was isolated from the aromatic plant Persicaria minor....

["Biochemistry","Biotechnology","Molecular Biology"]
doi:10.7717/peerj.2961
79 downloads
461 views

Tartrazine is a synthetic organic azo dye widely used in food and pharmaceutical products. The current study aimed to evaluate the possible adverse effect of this coloring food additive on renal and hepatic structures and functions. Also, the genotoxic potential...

["Biochemistry","Molecular Biology","Zoology","Histology"]
doi:10.7717/peerj.3041
62 downloads
603 views

Acute temperature fluctuations are common in surface waters, and aquatic organisms may manifest physiological responses to punctuated temperature spikes long before behavioral responses. Ectotherms, especially cryophilic stenotherms such as those endemic to Lake...

["Aquaculture, Fisheries and Fish Science","Biochemistry","Ecology","Environmental Sciences","Marine Biology"]
doi:10.7717/peerj.2864
55 downloads
297 views

Synaptotagmin I (Syt I) is most abundant in the brain and is involved in multiple cellular processes. Its two C2 domains, C2A and C2B, are the main functional regions. Our present study employed a pull-down combined with proteomic strategy to identify the C2 domain-interacting...

["Biochemistry","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.2973
146 downloads
503 views

Rhodomyrtone, a natural antimicrobial compound, displays potent activity against many Gram-positive pathogenic bacteria, comparable to last-defence antibiotics including vancomycin and daptomycin. Our previous studies pointed towards effects of rhodomyrtone on...

["Biochemistry","Computational Biology","Microbiology","Drugs and Devices","Infectious Diseases"]
doi:10.7717/peerj.2962
95 downloads
416 views

A metabolomic study has been performed to identify sensitive and robust biomarkers of malnutrition in farmed fish, using gilthead sea bream (Sparus aurata) as a model. The metabolomic fingerprinting of serum from fasted fish was assessed by means of ultra-high...

["Aquaculture, Fisheries and Fish Science","Biochemistry","Bioinformatics","Nutrition","Metabolic Sciences"]
doi:10.7717/peerj.2920
55 downloads
229 views

Five tropical seaweeds, Kappaphycus alvarezii (Doty) Doty ex P.C. Silva, Padina australis Hauck, Sargassum binderi Sonder ex J. Agardh (syn. S. aquifolium (Turner) C. Agardh), Sargassum siliquosum J. Agardh and Turbinaria conoides (J. Agardh) Kützing, were incubated...

["Aquaculture, Fisheries and Fish Science","Biochemistry","Environmental Sciences","Marine Biology"]
doi:10.7717/peerj.2918
97 downloads
445 views

Jellyfish species are widely distributed in the world’s oceans, and their population is rapidly increasing. Jellyfish extracts have several biological functions, such as cytotoxic, anti-microbial, and antioxidant activities in cells and organisms. However, the...

["Biochemistry","Cell Biology","Marine Biology"]
doi:10.7717/peerj.2895
79 downloads
772 views

Background The wood frog, Rana sylvatica, tolerates freezing as a means of winter survival. Freezing is considered to be an ischemic/anoxic event in which oxygen delivery is significantly impaired. In addition, cellular dehydration occurs during freezing because...

["Biochemistry","Cell Biology","Genetics","Molecular Biology","Zoology"]
doi:10.7717/peerj.2797
75 downloads
478 views

Type I restriction-modification enzymes are multisubunit, multifunctional molecular machines that recognize specific DNA target sequences, and their multisubunit organization underlies their multifunctionality. EcoR124I is the archetype of Type I restriction-modification...

["Biochemistry","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.2887
53 downloads
180 views

Background Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the ablation techniques of electrolytic ablation with cryosurgery. The goal of this study is to examine the hypothesis that electrolysis can take place in a...

["Biochemistry","Bioengineering","Biophysics","Oncology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2810

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