Peer-reviewed Articles

16 downloads
197 views

The present study first identified the biotransformation of starch as a novel preparation method was investigated using the alpha-transglucosidase-producing Geobacillus stearothermophilus U2. Subsequently, 5 L- and 20 L-scale fermentations were performed. After...

["Biochemistry","Biotechnology","Microbiology"]
doi:10.7717/peerj.5086
35 downloads
271 views

The phosphoinositide 3-kinase (PI3K) pathway shows frequent aberrant alterations and pathological activation in breast cancer cells. While PI3K inhibitors have not achieved expectant therapeutic efficacy in clinical trials, and several studies provide promising...

["Biochemistry","Oncology"]
doi:10.7717/peerj.5092
16 downloads
200 views

Background Entolimod is a Salmonella enterica flagellin derivate. Previous work has demonstrated that entolimod effectively protects mice and non-human primates from ionizing radiation. However, it caused a “flu-like” syndrome after radioprotective and anticancer...

["Biochemistry","Bioengineering","Biotechnology"]
doi:10.7717/peerj.5043
18 downloads
197 views

The archaellum, the rotating motility structure of archaea, is best studied in the crenarchaeon Sulfolobus acidocaldarius. To better understand how assembly and rotation of this structure is driven, two ATP-binding proteins, FlaI and FlaH of the motor complex of...

["Biochemistry","Microbiology","Molecular Biology"]
doi:10.7717/peerj.4984
46 downloads
324 views

Every cell in an individual has largely the same genomic sequence and yet cells in different tissues can present widely different phenotypes. This variation arises because each cell expresses a specific subset of genomic instructions. Control over which instructions,...

["Biochemistry","Genetics","Molecular Biology","Metabolic Sciences"]
doi:10.7717/peerj.5062
32 downloads
317 views

Thymidylate synthase (TS, E.C. 2.1.1.45) is a crucial enzyme for de novo deoxythymidine monophosphate (dTMP) biosynthesis. The gene for this enzyme is thyA, which encodes the folate-dependent TS that converts deoxyuridine monophosphate group (dUMP) into (dTMP)...

["Aquaculture, Fisheries and Fish Science","Biochemistry","Marine Biology","Microbiology","Drugs and Devices"]
doi:10.7717/peerj.5023
32 downloads
306 views

Chemokine (C-C motif) ligand 7 (CCL7), a CC chemokine, is a chemotactic factor and attractant for various kinds of leukocytes, including monocytes and neutrophils. CCL7 is widely expressed in multiple cell types and can participate in anti-inflammatory responses...

["Biochemistry","Cell Biology","Molecular Biology","Oncology"]
doi:10.7717/peerj.4928
39 downloads
244 views

We applied multi-omics approaches (transcriptomics, proteomics and metabolomics) to study the effect of iron starvation on the Gram-positive human pathogen Streptococcus pneumoniae to elucidate global changes in the bacterium in a condition similar to what can...

["Biochemistry","Microbiology","Data Science"]
doi:10.7717/peerj.4966
62 downloads
592 views

Salt bridges form between pairs of ionisable residues in close proximity and are important interactions in proteins. While salt bridges are known to be important both for protein stability, recognition and regulation, we still do not have fully accurate predictive...

["Biochemistry","Computational Biology"]
doi:10.7717/peerj.4967
33 downloads
283 views

L-amino acid oxidases (LAAOs) are ubiquitous enzymes in nature. Bioactivities described for these enzymes include apoptosis induction, edema formation, induction or inhibition of platelet aggregation, as well as antiviral, antiparasite, and antibacterial actions....

["Biochemistry","Biotechnology","Microbiology","Toxicology"]
doi:10.7717/peerj.4924
43 downloads
275 views

Background Pyruvate kinase (PK) is responsible for the final reaction in glycolysis. As PK is a glycolytic control point, the analysis of PK posttranslational modifications (PTM) and kinetic changes reveals a key piece of the reorganization of energy metabolism...

["Biochemistry","Molecular Biology"]
doi:10.7717/peerj.4918
43 downloads
298 views

Late embryogenesis abundant (LEA) proteins accumulate in plants during adverse conditions and their main attributed function is to confer tolerance to stress. One of the deleterious effects of the adverse environment is the accumulation of metal ions to levels...

["Biochemistry","Biophysics","Plant Science"]
doi:10.7717/peerj.4930
51 downloads
407 views

Tenderness and intramuscular fat content are key attributes for beef sensory qualities. Recently some proteomic analysis revealed several proteins which are considered as good biomarkers of these quality traits. This study focuses on the analysis of 20 of these...

["Agricultural Science","Biochemistry","Food Science and Technology","Genomics"]
doi:10.7717/peerj.4891
43 downloads
257 views

Background The highly valued medicinal tiger milk mushroom (also known as Lignosus rhinocerus) has the ability to cure numerous ailments. Its anticancer activities are well explored, and recently a partially purified cytotoxic protein fraction termed F5 from the...

["Biochemistry","Genetics","Oncology","Translational Medicine","Data Mining and Machine Learning"]
doi:10.7717/peerj.4940
54 downloads
508 views

Background Carnivorous plants have been fascinating researchers with their unique characters and bioinspired applications. These include medicinal trait of some carnivorous plants with potentials for pharmaceutical industry. Methods This review will cover recent...

["Biochemistry","Biotechnology","Genomics","Plant Science"]
doi:10.7717/peerj.4914

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