Peer-reviewed Articles

Type I restriction-modification enzymes are multisubunit, multifunctional molecular machines that recognize specific DNA target sequences, and their multisubunit organization underlies their multifunctionality. EcoR124I is the archetype of Type I restriction-modification...

["Biochemistry","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.2887
10 downloads
44 views

Background Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the ablation techniques of electrolytic ablation with cryosurgery. The goal of this study is to examine the hypothesis that electrolysis can take place in a...

["Biochemistry","Bioengineering","Biophysics","Oncology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2810
46 downloads
300 views

Sponges are efficient filter feeders, removing significant portions of particulate and dissolved organic matter (POM, DOM) from the water column. While the assimilation and respiration of POM and DOM by sponges and their abundant microbial symbiont communities...

["Biochemistry","Marine Biology","Microbiology"]
doi:10.7717/peerj.2870
65 downloads
236 views

Cofactor-less oxygenases perform challenging catalytic reactions between singlet co-substrates and triplet oxygen, in spite of apparently violating the spin-conservation rule. In 1-H-3-hydroxy-4-oxoquinaldine-2,4-dioxygenase, the active site has been suggested...

["Biochemistry"]
doi:10.7717/peerj.2805
68 downloads
179 views

The aim of this study was to test the hypothesis that consuming manuka honey, which contains antimicrobial methylglyoxal, may affect the gut microbiota. We undertook a mouse feeding study to investigate whether dietary manuka honey supplementation altered microbial...

["Biochemistry","Food Science and Technology","Microbiology","Nutrition"]
doi:10.7717/peerj.2787
64 downloads
247 views

Major research efforts have been devoted to the discovery and development of new chemical entities that could inhibit the protein–protein interaction between HIF-1α and the von Hippel–Lindau protein (pVHL), which serves as the substrate recognition subunit of an...

["Biochemistry","Computational Biology","Pharmacology"]
doi:10.7717/peerj.2757
119 downloads
601 views

Plants react to biotic and abiotic stresses with a variety of responses including the production of reactive oxygen species (ROS), which may result in programmed cell death (PCD). The mechanisms underlying ROS production and PCD have not been well studied in microalgae....

["Aquaculture, Fisheries and Fish Science","Biochemistry","Molecular Biology","Plant Science"]
doi:10.7717/peerj.2748
41 downloads
341 views

Background Preanalytic factors such as time and temperature can have significant effects on laboratory test results. For example, ammonium concentration will increase 31% in blood samples stored at room temperature for 30 min before centrifugation. To reduce preanalytic...

["Biochemistry","Veterinary Medicine","Emergency and Critical Care","Gastroenterology and Hepatology","Hematology"]
doi:10.7717/peerj.2732
88 downloads
381 views

Several members of the genus Legionella cause Legionnaires’ disease, a potentially debilitating form of pneumonia. Studies frequently focus on the abundant number of virulence factors present in this genus. However, what is often overlooked is the role of secondary...

["Biochemistry","Genomics","Microbiology","Molecular Biology"]
doi:10.7717/peerj.2720
92 downloads
585 views

Temperature and salinity are important abiotic factors for aquatic invertebrates. We investigated the influence of different salinity regimes on thermotolerance, energy metabolism and cellular stress defense mechanisms in amphipods Gammarus lacustris Sars from...

["Biochemistry","Ecology","Environmental Sciences"]
doi:10.7717/peerj.2657
92 downloads
464 views

Background Hepatitis C virus (HCV) core protein, in addition to its structural role to form the nucleocapsid assembly, plays a critical role in HCV pathogenesis by interfering in several cellular processes, including microRNA and mRNA homeostasis. The C-terminal...

["Biochemistry","Biophysics","Virology"]
doi:10.7717/peerj.2670
98 downloads
408 views

Mountain ash (Sorbus decora and S. americana) is used by the Cree Nation of the James Bay region of Quebec (Eeyou Istchee) as traditional medicine. Its potential as an antidiabetic medicine is thought to vary across its geographical range, yet little is known about...

["Biochemistry","Genetics","Plant Science","Diabetes and Endocrinology","Coupled Natural and Human Systems"]
doi:10.7717/peerj.2645
76 downloads
373 views

Hepatocyte growth factor (HGF) is a paracrine hormone that plays an important role in epithelial-mesenchymal transition. HGF secreted by mesenchymal cells affects many properties of epithelial cells, such as proliferation, motility, and morphology. HGF has been...

["Biochemistry","Cell Biology","Molecular Biology","Toxicology"]
doi:10.7717/peerj.2624
77 downloads
291 views

Background A carbon dioxide (CO2) laser has been used to morphologically and chemically modify the dental enamel surface as well as to make it more resistant to demineralization. Despite a variety of experiments demonstrating the inhibitory effect of a CO2 laser...

["Biochemistry","Dentistry"]
doi:10.7717/peerj.2458
99 downloads
363 views

After being a matter of hot debate for years, the presence of lipid membranes in the last common ancestor of extant organisms (i.e., the cenancestor) now begins to be generally accepted. By contrast, cenancestral cell walls have attracted less attention, probably...

["Biochemistry","Evolutionary Studies","Genomics","Microbiology"]
doi:10.7717/peerj.2626

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