Peer-reviewed Articles

2 downloads
167 views

The genome of the chlorarchiniophyte Bigelowiella natans codes for a protein annotated as an α-actinin-like protein. Analysis of the primary sequence indicate that this protein has the same domain structure as other α-actinins, a N-terminal actin-binding domain...

["Biochemistry","Biophysics","Developmental Biology"]
doi:10.7717/peerj.4288
19 downloads
179 views

Background With the continuous discovery of microRNA’s (miRNA) association with a wide range of biological and cellular processes, expression profile-based functional characterization of such post-transcriptional regulation is crucial for revealing its significance...

["Biochemistry","Bioinformatics","Computational Biology","Molecular Biology","Data Mining and Machine Learning"]
doi:10.7717/peerj.4262
50 downloads
310 views

Mushrooms are recognized as one of the main contributors to internal radiation exposure from the activity concentration of radiocesium released by the accident at the Chernobyl nuclear power plant (CNNP). We evaluated the activity concentrations of the artificial...

["Biochemistry","Biophysics","Environmental Sciences","Mycology","Public Health"]
doi:10.7717/peerj.4222
49 downloads
283 views

Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2. In order to be functional,...

["Biochemistry","Cell Biology","Immunology","Nutrition"]
doi:10.7717/peerj.4212
179 downloads
553 views

Cherries are fruits containing fiber and bioactive compounds (e.g., polyphenolics) with the potential of helping patients with diabetes and weight disorders, a phenomenon likely related to changes in the complex host-microbiota milieu. The objective of this study...

["Biochemistry","Microbiology","Molecular Biology","Diabetes and Endocrinology","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4195
123 downloads
521 views

Tumor occurrence, progression and metastasis depend on the crosstalk between tumor cells and stromal cells and on extrinsic factors outside the tumor microenvironment. Exosomal microRNA (miRNA) not only is involved in communications within the tumor microenvironment...

["Biochemistry","Oncology"]
doi:10.7717/peerj.4196
36 downloads
290 views

Arbutin (p-hydroxyphenyl-β-D-glucopyranoside), a well-known tyrosinase inhibitor, has been widely used as a cosmetic whitening agent. Although its natural role is to scavenge free radicals within cells, it has also exhibited useful activities for the treatment...

["Animal Behavior","Biochemistry","Molecular Biology"]
doi:10.7717/peerj.4170
91 downloads
953 views

Background Carbonic anhydrases (CAs) are ubiquitous, essential enzymes which catalyze the conversion of carbon dioxide and water to bicarbonate and H+ ions. Vertebrate genomes generally contain gene loci for 15–21 different CA isoforms, three of which are enzymatically...

["Biochemistry","Bioinformatics","Evolutionary Studies"]
doi:10.7717/peerj.4128
42 downloads
259 views

The microtubule depolymerising kinesin-13, MCAK, is phosphorylated at residue T537 by Cdk1. This is the only known phosphorylation site within MCAK’s motor domain. To understand the impact of phosphorylation by Cdk1 on microtubule depolymerisation activity, we...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7717/peerj.4034
36 downloads
244 views

A striking and unexpected biochemical phenotype was found in an insertion mutant line in the model plant Arabidopsis thaliana. One of two investigated insertion mutant lines in the gene encoding the phosphate transporter PHT4;1 demonstrated a prominent loss of...

["Biochemistry","Genetics","Plant Science"]
doi:10.7717/peerj.4134
106 downloads
608 views

The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse...

["Biochemistry","Biophysics","Drugs and Devices"]
doi:10.7717/peerj.4068
62 downloads
249 views

The wood frog (Rana sylvatica) can endure freezing of up to 65% of total body water during winter. When frozen, wood frogs enter a dormant state characterized by a cessation of vital functions (i.e., no heartbeat, blood circulation, breathing, brain activity, or...

["Biochemistry","Molecular Biology"]
doi:10.7717/peerj.4014
45 downloads
346 views

Robotic labs, in which experiments are carried out entirely by robots, have the potential to provide a reproducible and transparent foundation for performing basic biomedical laboratory experiments. In this article, we investigate whether these labs could be applicable...

["Biochemistry","Science Policy","Computational Science"]
doi:10.7717/peerj.3997
103 downloads
493 views

Background Deficiency of available forms of phosphorus is common in most soils and causes reduction of crop plants growth and yield. Recently, model plants responses to phosphate (Pi) deficiency have been intensively studied. However, acclimation mechanisms of...

["Agricultural Science","Biochemistry","Environmental Sciences","Plant Science","Soil Science"]
doi:10.7717/peerj.3989
158 downloads
554 views

Clinical evidence points to neuroprotective effects of smoking in Parkinson’s disease (PD), but the molecular mechanisms remain unclear. We investigated the pharmacological pathways involved in these neuroprotective effects, which could provide novel ideas for...

["Biochemistry","Molecular Biology","Neuroscience","Neurology","Pharmacology"]
doi:10.7717/peerj.3933

Refine by manuscript type

Top subject areas - Articles

Top subject areas - People

View all subject areas