Peer-reviewed Articles

40 downloads
234 views

Background There is a dearth of drugs to manage a dose-limiting painful peripheral neuropathy induced by paclitaxel in some patients during the treatment of cancer. Gamma-aminobutyric acid transporter-1 (GAT-1) whose expression is increased in the brain and spinal...

["Animal Behavior","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7717/peerj.2798
72 downloads
281 views

Paclitaxel, a chemotherapeutic agent, causes neuropathic pain whose supraspinal pathophysiology is not fully understood. Dysregulation of sodium channel expression, studied mainly in the periphery and spinal cord level, contributes to the pathogenesis of neuropathic...

["Molecular Biology","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7717/peerj.2702
77 downloads
314 views

Background Anesthetic postconditioning is a cellular protective approach whereby exposure to a volatile anesthetic renders a tissue more resistant to subsequent ischemic/reperfusion event. Sevoflurane postconditioning (SPostC) has been shown to exert cardioprotection...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology","Diabetes and Endocrinology"]
doi:10.7717/peerj.2659
42 downloads
179 views

Ischemic postconditioning (IPC) and ATP sensitive potassium channel (KATP) agonists (e.g. pinacidil and diazoxide) postconditioning are effective methods to defeat myocardial ischemia-reperfusion (I/R) injury, but their specific mechanisms of reducing I/R injury...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.2612
172 downloads
635 views

Pain burden is high in people living with HIV (PLWH), but the effect of this pain on functionality is equivocal. Resilience, the ability to cope with adversity, may promote adaptation to pain, so we hypothesised that higher resilience would correlate with less...

["Anaesthesiology and Pain Management","HIV","Psychiatry and Psychology"]
doi:10.7717/peerj.2464
277 downloads
620 views

Objective The current study is an innovative exploratory investigation, aiming at identifying differences in personality profiles within Fibromyalgia Syndrome (FMS) and Chronic Fatigue Syndrome (CFS) patients. Method In total, 344 participants (309 female, 35 male)...

["Anaesthesiology and Pain Management","Psychiatry and Psychology","Rheumatology"]
doi:10.7717/peerj.2421
981 downloads
592 views

Background Laparoscopic cholecystectomies (LC) are generally performed in a 12 mmHg-pressured pneumoperitoneum in a slight sitting position. Considerable thromboembolism risk arises in this operation due to pneumoperitoneum, operation position and risk factors...

["Anaesthesiology and Pain Management","Gastroenterology and Hepatology","Hematology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2375
63 downloads
374 views

Background Postpartum hemorrhage (PPH) is a leading cause of obstetric morbidity. There is limited understanding of patients’ knowledge about blood loss at delivery, PPH, and PPH-related morbidities, including transfusion and anemia. Methods We surveyed 100 healthy...

["Anaesthesiology and Pain Management","Women\u2019s Health"]
doi:10.7717/peerj.2361
93 downloads
405 views

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and...

["Anaesthesiology and Pain Management","Drugs and Devices","Pharmacology","Public Health","Science and Medical Education"]
doi:10.7717/peerj.2255
4 citations
201 downloads
828 views

Ischemia postconditioning (IPo) is a promising strategy in reducing myocardial ischemia reperfusion (I/R) injury (MIRI), but its specific molecular mechanism is incompletely understood. Langendorff-perfused isolated rat hearts were subjected to global I/R and received...

["Biochemistry","Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.1706
120 downloads
608 views

The effects of isoflurane on the determinants of blood flow during Coronary Artery Bypass Graft (CABG) surgery are not completely understood. This study characterized the influence of isoflurane on the diastolic Pressure-Flow (P-F) relationship and Critical Occlusion...

["Anaesthesiology and pain management","Cardiology","Clinical trials","Emergency and critical care","Surgery and surgical specialties"]
doi:10.7717/peerj.1619
138 downloads
586 views

Background. Nd:YAP laser is widely used to investigate the nociceptive and pain systems, generating perpetual and laser-evoked neurophysiological responses. A major procedural concern for the use of Nd:YAP laser stimuli in experimental research is the risk of skin...

["Neuroscience","Anaesthesiology and Pain Management","Dermatology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.1577
1 citation
144 downloads
806 views

Proper glycemic control is one of the most important goals in perioperative patient management. Insulin secretion from pancreatic β-cells in response to an increased blood glucose concentration plays the most critical role in glycemic control. Several animal and...

["Cell Biology","Anaesthesiology and Pain Management","Diabetes and Endocrinology","Pharmacology"]
doi:10.7717/peerj.1498
2 citations
175 downloads
593 views

Background and Objectives. Cardiovascular diseases are the leading cause of death worldwide, with coronary artery disease being the most common. With increasing numbers of patients, Coronary Artery Bypass Grafting (CABG) has become the most common operation in...

["Anaesthesiology and Pain Management","Cardiology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.1414
112 downloads
683 views

Background. Postoperative morbidity has immediate and delayed consequences for surgical patients, including excess risk of premature death. Capturing these data objectively and routinely in large electronic databases using tools such as the Postoperative Morbidity...

["Anaesthesiology and Pain Management","Epidemiology","Surgery and Surgical Specialties","Translational Medicine","Statistics"]
doi:10.7717/peerj.1466

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