Peer-reviewed Articles

8 downloads
90 views

Background Hypoxia-inducible factor (HIF)-1 is involved in the regulation of hypoxic preconditioning in cardiomyocytes. Under hypoxic conditions, HIF-1α accumulates and is translocated to the nucleus, where it forms an active complex with HIF-1β and activates transcription...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.3662
43 downloads
696 views

Background Previous studies in human patients suggest depth of sedation may be affected by environmental noise or music; however, related data in domestic animals is limited. The objective of the current study was to investigate the effect of noise and music on...

["Animal Behavior","Veterinary Medicine","Anaesthesiology and Pain Management"]
doi:10.7717/peerj.3659
74 downloads
299 views

Background Deliberate hypotension is one way to achieve a bloodless surgical field in endoscopic sinus surgery (ESS). We compared two anaesthesia regimens to induce deliberate hypotension and attempted to determine the most efficient one. Methods Fifty-nine patients...

["Anaesthesiology and Pain Management","Clinical Trials","Otorhinolaryngology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.3370
1 citation
268 downloads
913 views

Background The ergogenic effects of analgesic substances suggest that pain perception is an important regulator of work-rate during fatiguing exercise. Recent research has shown that endogenous inhibitory responses, which act to attenuate nociceptive input and...

["Neuroscience","Anaesthesiology and Pain Management","Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.3028
279 downloads
1,674 views

Background Illusions that alter perception of the body provide novel opportunities to target brain-based contributions to problems such as persistent pain. One example of this, mirror therapy, uses vision to augment perceived movement of a painful limb to treat...

["Neuroscience","Anaesthesiology and Pain Management","Drugs and Devices","Human-Computer Interaction"]
doi:10.7717/peerj.3023
88 downloads
522 views

Background There is a dearth of drugs to manage a dose-limiting painful peripheral neuropathy induced by paclitaxel in some patients during the treatment of cancer. Gamma-aminobutyric acid transporter-1 (GAT-1) whose expression is increased in the brain and spinal...

["Animal Behavior","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7717/peerj.2798
2 citations
136 downloads
455 views

Paclitaxel, a chemotherapeutic agent, causes neuropathic pain whose supraspinal pathophysiology is not fully understood. Dysregulation of sodium channel expression, studied mainly in the periphery and spinal cord level, contributes to the pathogenesis of neuropathic...

["Molecular Biology","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7717/peerj.2702
4 citations
157 downloads
533 views

Background Anesthetic postconditioning is a cellular protective approach whereby exposure to a volatile anesthetic renders a tissue more resistant to subsequent ischemic/reperfusion event. Sevoflurane postconditioning (SPostC) has been shown to exert cardioprotection...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology","Diabetes and Endocrinology"]
doi:10.7717/peerj.2659
2 citations
95 downloads
365 views

Ischemic postconditioning (IPC) and ATP sensitive potassium channel (KATP) agonists (e.g. pinacidil and diazoxide) postconditioning are effective methods to defeat myocardial ischemia-reperfusion (I/R) injury, but their specific mechanisms of reducing I/R injury...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.2612
1 citation
275 downloads
873 views

Pain burden is high in people living with HIV (PLWH), but the effect of this pain on functionality is equivocal. Resilience, the ability to cope with adversity, may promote adaptation to pain, so we hypothesised that higher resilience would correlate with less...

["Anaesthesiology and Pain Management","HIV","Psychiatry and Psychology"]
doi:10.7717/peerj.2464
1 citation
381 downloads
908 views

Objective The current study is an innovative exploratory investigation, aiming at identifying differences in personality profiles within Fibromyalgia Syndrome (FMS) and Chronic Fatigue Syndrome (CFS) patients. Method In total, 344 participants (309 female, 35 male)...

["Anaesthesiology and Pain Management","Psychiatry and Psychology","Rheumatology"]
doi:10.7717/peerj.2421
1,017 downloads
791 views

Background Laparoscopic cholecystectomies (LC) are generally performed in a 12 mmHg-pressured pneumoperitoneum in a slight sitting position. Considerable thromboembolism risk arises in this operation due to pneumoperitoneum, operation position and risk factors...

["Anaesthesiology and Pain Management","Gastroenterology and Hepatology","Hematology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2375
146 downloads
593 views

Background Postpartum hemorrhage (PPH) is a leading cause of obstetric morbidity. There is limited understanding of patients’ knowledge about blood loss at delivery, PPH, and PPH-related morbidities, including transfusion and anemia. Methods We surveyed 100 healthy...

["Anaesthesiology and Pain Management","Women\u2019s Health"]
doi:10.7717/peerj.2361
153 downloads
554 views

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and...

["Anaesthesiology and Pain Management","Drugs and Devices","Pharmacology","Public Health","Science and Medical Education"]
doi:10.7717/peerj.2255
6 citations
279 downloads
1,111 views

Ischemia postconditioning (IPo) is a promising strategy in reducing myocardial ischemia reperfusion (I/R) injury (MIRI), but its specific molecular mechanism is incompletely understood. Langendorff-perfused isolated rat hearts were subjected to global I/R and received...

["Biochemistry","Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.1706

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