Peer-reviewed Articles - Medicine

25 downloads
126 views

Background Autism spectrum disorder (ASD) is a complex heterogeneous developmental disease with a significant genetic background that is frequently caused by rare copy number variants (CNVs). Microarray-based whole-genome approaches for CNV detection are widely...

["Pediatrics","Translational Medicine","Medical Genetics"]
doi:10.7717/peerj.6183
50 downloads
151 views

Background New reagents have emerged allowing researchers to assess a growing number of vaccine-associated immune parameters. Multiplex immunoassay(s) are emerging as efficient high-throughput assays in malaria serology. Currently, commercial vendors market several...

["Global Health","Immunology","Infectious Diseases","Translational Medicine"]
doi:10.7717/peerj.6120
122 downloads
644 views

Patient-derived xenograft (PDX) models are increasingly being used in oncology drug development because they offer greater predictive value than traditional cell line models. Using novel tools to critique model validity and reliability we performed a systematic...

["Oncology","Translational Medicine"]
doi:10.7717/peerj.5981
82 downloads
386 views

Articular cartilage is an avascular tissue with limited regenerative property. Therefore, a defect or trauma in articular cartilage due to disease or accident can lead to progressive tissue deterioration. Cartilage tissue engineering, by replacing defective cartilage...

["Bioengineering","Biotechnology","Cell Biology","Developmental Biology","Translational Medicine"]
doi:10.7717/peerj.5809
104 downloads
426 views

Leaves from three varieties of Ficus deltoidea, colloquially termed small- (FDS), medium- (FDM), and big-type leaf (FDB), were subjected to water extraction. The crude extracts were fractionated using water (WF) and ethyl acetate (EAF). The phenolic and flavonoid...

["Biochemistry","Cell Biology","Food Science and Technology","Plant Science","Translational Medicine"]
doi:10.7717/peerj.5694
88 downloads
376 views

Objective The benefits of IL-35 treatment have been verified in multiple animal models of diseases, while its influence on T cells immunity under normal condition still needs to be elucidated. The present study was designed to investigate the effects modulating...

["Immunology","Translational Medicine"]
doi:10.7717/peerj.5638
112 downloads
515 views

Background High myopia is a common ocular disease worldwide. To expand our current understanding of the genetic basis of high myopia, we carried out a whole exome sequencing (WES) study to identify potential causal gene mutations. Methods A total of 20 individuals...

["Bioinformatics","Computational Biology","Genetics","Genomics","Translational Medicine"]
doi:10.7717/peerj.5552
74 downloads
343 views

Background Growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) was previously found to be associated with risk of several kinds of human tumors. Here, we studied the expression and clinical significance of GADD45A in breast cancer. Methods We performed...

["Oncology","Translational Medicine"]
doi:10.7717/peerj.5344
174 downloads
836 views

Background When suffering from chronic pain, attempts to control or avoid pain often compete with other daily activities. Engaging in one activity excludes engaging in another, equally valued activity, which is referred to as “goal conflict.” As yet, the presence...

["Anesthesiology and Pain Management","Psychiatry and Psychology","Public Health","Translational Medicine"]
doi:10.7717/peerj.5272
159 downloads
1,172 views

Background Antibiotic-associated gastrointestinal signs (AAGS) occur commonly in cats. Co-administration of synbiotics is associated with decreased AAGS in people, potentially due to stabilization of the fecal microbiome and metabolome. The purpose of this double-blinded...

["Microbiology","Veterinary Medicine","Gastroenterology and Hepatology","Internal Medicine","Translational Medicine"]
doi:10.7717/peerj.5130
135 downloads
644 views

Background It is possible that physical education professionals, especially those who participate in aerobic activities, have predisposing factors, signs and symptoms of overreaching (OVR) and overtraining (OVT) due to a high load and volume of exercise followed...

["Anatomy and Physiology","Global Health","Kinesiology","Translational Medicine"]
doi:10.7717/peerj.4994
139 downloads
558 views

Background The highly valued medicinal tiger milk mushroom (also known as Lignosus rhinocerus) has the ability to cure numerous ailments. Its anticancer activities are well explored, and recently a partially purified cytotoxic protein fraction termed F5 from the...

["Biochemistry","Genetics","Oncology","Translational Medicine","Data Mining and Machine Learning"]
doi:10.7717/peerj.4940
1 citation
196 downloads
1,385 views

Background Fecal Microbiota Transplantation (FMT) is an innovative means of treating recurrent Clostridium difficile infection (rCDI), through restoration of gut floral balance. However, there is a lack of data concerning the efficacy of FMT and its impact on the...

["Microbiology","Gastroenterology and Hepatology","Infectious Diseases","Pediatrics","Translational Medicine"]
doi:10.7717/peerj.4663
126 downloads
501 views

Background Antibiotic misuse in the community contributes to antimicrobial resistance. One way to address this may be by better utilizing community pharmacists’ skills in antibiotic prescribing. The aims of this study were to examine the level of support for “down-scheduling”...

["Health Policy","Translational Medicine"]
doi:10.7717/peerj.4726
1 citation
169 downloads
875 views

Background We established a glioma biobank at Beijing Tiantan Hospital in November, 2010. Specialized residents have been trained to collect, store and manage the biobank in accordance with standard operating procedures. Methods One hundred samples were selected...

["Neurology","Oncology","Translational Medicine"]
doi:10.7717/peerj.4450

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