Peer-reviewed Articles - Medicine

63 downloads
487 views

Background Cognitive dysfunction in fibromyalgia (FM) encompasses objective cognitive difficulties, as measured in neuropsychological tests, and self-reported cognitive complaints. Although it has been suggested that FM patients display problems in working memory,...

["Neuroscience","Cognitive Disorders","Psychiatry and Psychology","Rheumatology","Women\u2019s Health"]
doi:10.7717/peerj.5907
172 downloads
800 views

Background Osteoarthritis and spinal pain are common and burdensome conditions; however, the majority of patients with these conditions do not receive care that is consistent with clinical practice guidelines. Telehealth models of care have the potential to improve...

["Clinical Trials","Rheumatology"]
doi:10.7717/peerj.5846
85 downloads
475 views

Background Osteoclast differentiation in the inflamed synovium of rheumatoid arthritis (RA) affected joints leads to the formation of bone lesions. Reconstruction and analysis of protein interaction networks underlying specific disease phenotypes are essential...

["Bioinformatics","Computational Biology","Genomics","Immunology","Rheumatology"]
doi:10.7717/peerj.5743
101 downloads
404 views

Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish...

["Cell Biology","Veterinary Medicine","Zoology","Rheumatology"]
doi:10.7717/peerj.5739
1 citation
790 downloads
8,610 views

Background Experimental and clinical evidence support a link between body representations and pain. This proof-of-concept study in people with painful knee osteoarthritis (OA) aimed to determine if: (i) visuotactile illusions that manipulate perceived knee size...

["Neuroscience","Anesthesiology and Pain Management","Orthopedics","Psychiatry and Psychology","Rheumatology"]
doi:10.7717/peerj.5206
68 downloads
445 views

Background Genome-wide association studies have identified a plethora of risk genes for both Crohn’s disease (CD) and ankylosing spondylitis (AS). A subset of genes found to be risk factors for CD have also been found to be risk factors for AS. The objective of...

["Genetics","Rheumatology"]
doi:10.7717/peerj.5088
99 downloads
530 views

Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure...

["Dentistry","Epidemiology","Immunology","Public Health","Rheumatology"]
doi:10.7717/peerj.5109
155 downloads
583 views

Objective Tumor necrosis factor-inducible gene 6 (TSG-6) has anti-inflammatory and chondroprotective effects in mouse models of inflammatory arthritis. Because cartilage damage and inflammation are also observed in osteoarthritis (OA), we determined the effect...

["Cell Biology","Molecular Biology","Rheumatology"]
doi:10.7717/peerj.4771
214 downloads
1,026 views

Background Obesity is a possible factor which affects severity of symptoms and disease activity in fibromyalgia syndrome (FMS). The aim of our study was to determine the association between body mass index (BMI) and pain, tender point count (TPC), disease activity,...

["Anesthesiology and Pain Management","Public Health","Rheumatology"]
doi:10.7717/peerj.4917
200 downloads
831 views

Context Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with unknown etiology. Objective Human plasma is comprised of over 10 orders of magnitude concentration of proteins and tissue leakages. The changes in the abundance of these...

["Biochemistry","Rheumatology"]
doi:10.7717/peerj.4730
232 downloads
586 views

Objectives To evaluate the outcomes of patients with rheumatoid arthritis (RA) of the knee who underwent five portal arthroscopic synovectomy, with or without post-operative negative pressure drainage (NPD). Material and Methods A prospective clinical trial was...

["Clinical Trials","Immunology","Orthopedics","Rheumatology"]
doi:10.7717/peerj.4727
1 citation
157 downloads
933 views

Identifying the separate parts in ultrasound images such as bone and skin plays a crucial role in the synovitis detection task. This paper presents a detector of bone and skin regions in the form of a classifier which is trained on a set of annotated images. Selected...

["Orthopedics","Radiology and Medical Imaging","Rheumatology","Human\u2013Computer Interaction","Computational Science"]
doi:10.7717/peerj.4411
172 downloads
995 views

Background Systemic lupus erythematosus (SLE) disease has been shown to be associated with the generation of multiple auto-antibodies. Among these, anti-dsDNA antibodies (anti-DNAs) are specific and play a pathogenic role in SLE. Indeed, anti-DNA+ SLE patients...

["Cell Biology","Immunology","Rheumatology"]
doi:10.7717/peerj.4294
270 downloads
983 views

Background Autoimmune thyroid disease (AITD), which is characterized by an increased presence of thyroid autoantibodies (TAbs), such as antibodies against thyroid peroxidase (TPOAbs) and antibodies against thyroglobulin (TgAbs), has been reported to be associated...

["Diabetes and Endocrinology","Immunology","Rheumatology"]
doi:10.7717/peerj.4216
1,829 downloads
7,074 views

Background Low back pain clinical practice guidelines consistently recommend against the routine ordering of spinal imaging; however, imaging is frequently requested in primary care, without evidence of benefit. Imaging reports frequently identify degenerative...

["Evidence Based Medicine","Orthopedics","Radiology and Medical Imaging","Rheumatology"]
doi:10.7717/peerj.4151

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