Peer-reviewed Articles - Medicine

40 downloads
249 views

Background Osteoclast differentiation in the inflamed synovium of rheumatoid arthritis (RA) affected joints leads to the formation of bone lesions. Reconstruction and analysis of protein interaction networks underlying specific disease phenotypes are essential...

["Bioinformatics","Computational Biology","Genomics","Immunology","Rheumatology"]
doi:10.7717/peerj.5743
53 downloads
240 views

Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish...

["Cell Biology","Veterinary Medicine","Zoology","Rheumatology"]
doi:10.7717/peerj.5739
742 downloads
8,236 views

Background Experimental and clinical evidence support a link between body representations and pain. This proof-of-concept study in people with painful knee osteoarthritis (OA) aimed to determine if: (i) visuotactile illusions that manipulate perceived knee size...

["Neuroscience","Anesthesiology and Pain Management","Orthopedics","Psychiatry and Psychology","Rheumatology"]
doi:10.7717/peerj.5206
58 downloads
367 views

Background Genome-wide association studies have identified a plethora of risk genes for both Crohn’s disease (CD) and ankylosing spondylitis (AS). A subset of genes found to be risk factors for CD have also been found to be risk factors for AS. The objective of...

["Genetics","Rheumatology"]
doi:10.7717/peerj.5088
75 downloads
472 views

Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure...

["Dentistry","Epidemiology","Immunology","Public Health","Rheumatology"]
doi:10.7717/peerj.5109
114 downloads
489 views

Objective Tumor necrosis factor-inducible gene 6 (TSG-6) has anti-inflammatory and chondroprotective effects in mouse models of inflammatory arthritis. Because cartilage damage and inflammation are also observed in osteoarthritis (OA), we determined the effect...

["Cell Biology","Molecular Biology","Rheumatology"]
doi:10.7717/peerj.4771
164 downloads
921 views

Background Obesity is a possible factor which affects severity of symptoms and disease activity in fibromyalgia syndrome (FMS). The aim of our study was to determine the association between body mass index (BMI) and pain, tender point count (TPC), disease activity,...

["Anesthesiology and Pain Management","Public Health","Rheumatology"]
doi:10.7717/peerj.4917
153 downloads
692 views

Context Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with unknown etiology. Objective Human plasma is comprised of over 10 orders of magnitude concentration of proteins and tissue leakages. The changes in the abundance of these...

["Biochemistry","Rheumatology"]
doi:10.7717/peerj.4730
197 downloads
521 views

Objectives To evaluate the outcomes of patients with rheumatoid arthritis (RA) of the knee who underwent five portal arthroscopic synovectomy, with or without post-operative negative pressure drainage (NPD). Material and Methods A prospective clinical trial was...

["Clinical Trials","Immunology","Orthopedics","Rheumatology"]
doi:10.7717/peerj.4727
1 citation
122 downloads
861 views

Identifying the separate parts in ultrasound images such as bone and skin plays a crucial role in the synovitis detection task. This paper presents a detector of bone and skin regions in the form of a classifier which is trained on a set of annotated images. Selected...

["Orthopedics","Radiology and Medical Imaging","Rheumatology","Human\u2013Computer Interaction","Computational Science"]
doi:10.7717/peerj.4411
134 downloads
701 views

Background Systemic lupus erythematosus (SLE) disease has been shown to be associated with the generation of multiple auto-antibodies. Among these, anti-dsDNA antibodies (anti-DNAs) are specific and play a pathogenic role in SLE. Indeed, anti-DNA+ SLE patients...

["Cell Biology","Immunology","Rheumatology"]
doi:10.7717/peerj.4294
224 downloads
849 views

Background Autoimmune thyroid disease (AITD), which is characterized by an increased presence of thyroid autoantibodies (TAbs), such as antibodies against thyroid peroxidase (TPOAbs) and antibodies against thyroglobulin (TgAbs), has been reported to be associated...

["Diabetes and Endocrinology","Immunology","Rheumatology"]
doi:10.7717/peerj.4216
1,744 downloads
6,879 views

Background Low back pain clinical practice guidelines consistently recommend against the routine ordering of spinal imaging; however, imaging is frequently requested in primary care, without evidence of benefit. Imaging reports frequently identify degenerative...

["Evidence Based Medicine","Orthopedics","Radiology and Medical Imaging","Rheumatology"]
doi:10.7717/peerj.4151
1 citation
1,406 downloads
1,279 views

Background We examined the United States National Health and Nutrition Examination Survey (NHANES) database to determine factors associated with rheumatoid arthritis (RA) in adults 20 to 55 years of age. Methods NHANES data collected between 2007 and 2014, excluding...

["Public Health","Rheumatology"]
doi:10.7717/peerj.4035
2 citations
163 downloads
803 views

Aims Periodontitis and psoriatic disease, including psoriasis (PS) and psoriatic arthritis (PsA), share the common risk factors and co-morbidities. However, the risk of periodontitis in patients with psoriatic disease still needs further investigation. This study...

["Dentistry","Dermatology","Epidemiology","Public Health","Rheumatology"]
doi:10.7717/peerj.4064

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