Peer-reviewed Articles - Medicine

37 downloads
107 views

Background The US mainland is experiencing an epidemic of opioid overdoses. Unfortunately, the US Territories (Guam, Puerto Rico, and the Virgin Islands) have often been overlooked in opioid pharmacoepidemiology research. This study examined common prescription...

["Drugs and Devices","Epidemiology","Health Policy","Pharmacology","Public Health"]
doi:10.7717/peerj.6272
39 downloads
185 views

Background Breast cancer is the most common type of cancer among females. Hypoxia mediates cancer hallmarks and results from reduced oxygen level due to irregularities in tumor vascularization or when the tumor size prevents oxygen diffusion and triggers angiogenesis...

["Cell Biology","Oncology","Pharmacology"]
doi:10.7717/peerj.5990
41 downloads
235 views

Background Patients with dilated cardiomyopathy, increased ventricular volume, pressure overload or dysynergistic ventricular contraction and relaxation are susceptible to develop serious ventricular arrhythmias (VA). These phenomena are primarily based on a theory...

["Bioinformatics","Cardiology","Pharmacology"]
doi:10.7717/peerj.6110
89 downloads
370 views

Background Green synthesis of metallic nanoparticles has gained significant attention in the field of nanomedicine as an environment-friendly and cost-effective alternative in comparison with other physical and chemical methods. Several metals such as silver, gold,...

["Biochemistry","Bioengineering","Microbiology","Nutrition","Pharmacology"]
doi:10.7717/peerj.6086
40 downloads
347 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.6082
58 downloads
263 views

Medicinal plants play a crucial role in the search for components that are capable of neutralizing the multiple mechanisms of fungal resistance. Psidium salutare (Kunth) O. Berg is a plant native to Brazil used as both food and traditional medicine to treat diseases...

["Microbiology","Infectious Diseases","Pharmacology"]
doi:10.7717/peerj.5476
86 downloads
376 views

Background Secondhand smoke (SHS) exposure has adverse effects on the cardiovascular system. This study aimed to determine the effects of SHS on the cardiovascular disease biomarkers, namely the metabolic, inflammatory, and oxidative stress markers in healthy adult...

["Pharmacology","Public Health"]
doi:10.7717/peerj.5758
124 downloads
654 views

Background Benzodiazepines (BZDs) and z-drugs are effective drugs, but they are prescribed excessively worldwide. International guidelines recommend a maximum treatment duration of 4 weeks. Although these drugs are effective in the short-term, long-term BZD therapy...

["Geriatrics","Pharmacology"]
doi:10.7717/peerj.5535
162 downloads
379 views

Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in clinical practice, which can have adverse effects on the osteoblast. The objective of this study was to determine the effect of NSAIDs on the osteoblast by analyzing the gene expression...

["Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.5415
186 downloads
566 views

Background Acute kidney injury (AKI) is associated with a significant increase in morbidity, mortality, and health care costs. In intensive care units (ICU), AKI is commonly multifactorial and frequently involves diverse factors, such as hypovolemia, sepsis, and...

["Nephrology","Pharmacology","Public Health"]
doi:10.7717/peerj.5405
147 downloads
405 views

Sustained-release formulations of ivermectin (IVM) are useful for controlling parasitic diseases in animals. In this work, an IVM bolus made from microcrystalline cellulose (MCC), starch and low-substituted hydroxypropyl cellulose (LS-HPC) was optimized by response...

["Veterinary Medicine","Pharmacology"]
doi:10.7717/peerj.5418
127 downloads
792 views

Studies have suggested that oxidative stress may contribute to the pathogenesis of mental disorders. In this context, molecules with antioxidant activity may be promising agents in the treatment of these deleterious conditions. Acetyl-L-carnitine (ALC) is a multi-target...

["Neuroscience","Pharmacology"]
doi:10.7717/peerj.5309
304 downloads
959 views

Background There are many problems with fitness trackers, such as device usability, which limit their large-scale application, and relevant studies are limited in terms of their sample size and evaluation methods. The purpose of the study was to evaluate the perceived...

["Pharmacology","Public Health","Human-Computer Interaction","Computational Science","Data Science"]
doi:10.7717/peerj.5350
220 downloads
945 views

Background Cassia fistula (L.) (Fabaceae) is a medicinal plant from tropical Asia. It is known for its marked antioxidant activity, which is attributed to its high phenolic content. The present study aims at testing both the antioxidant and neuroprotective effects...

["Plant Science","Pharmacology"]
doi:10.7717/peerj.5159
1 citation
143 downloads
672 views

Honey has been shown to have a range of therapeutic effects in humans, with anti-inflammatory and anti-bacterial effects among those previously characterised. Here, we examine the possibility of New Zealand thyme, manuka and honeydew honeys, and their major sugar...

["Cell Biology","Toxicology","Oncology","Pharmacology"]
doi:10.7717/peerj.5115

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