Peer-reviewed Articles - Medicine

69 downloads
256 views

Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder. In addition to its highly debilitating motor symptoms, non-motor symptoms may precede their motor counterparts by many years, which may characterize a prodromal phase of PD....

["Neuroscience","Pharmacology"]
doi:10.7717/peerj.4957
70 downloads
213 views

Passiflora suberosa L. belonging to the family Passifloraceae is an important medicinal plant used in traditional medicinal system in Sri Lanka to treat diabetes, hypertension and skin diseases. We extracted P. suberosa leaves under reflux conditions using different...

["Microbiology","Plant Science","Pharmacology"]
doi:10.7717/peerj.4804
66 downloads
490 views

Background Ceratonia siliqua pods (carob) have been nominated to control the high blood glucose of diabetics. In Yemen, however, its antihyperglycemic activity has not been yet assessed. Thus, this study evaluated the in vitro inhibitory effect of the methanolic...

["Diabetes and Endocrinology","Pharmacology"]
doi:10.7717/peerj.4788
47 downloads
200 views

Background Concomitant drug administration is a general phenomenon in patients with chronic diseases such as diabetes mellitus. Among the currently available oral antidiabetic drugs, gliclazide is a commonly prescribed drug considering its multiple benefits in...

["Diabetes and Endocrinology","Pharmacology"]
doi:10.7717/peerj.4798
57 downloads
328 views

Introduction The long-term use of benzodiazepines (BZD) and z-drugs in older populations is associated with a variety of sociodemographic and health-related factors. Recent studies reported that long-term BZD and z-drugs use is associated with increased age, female...

["Geriatrics","Pharmacology","Psychiatry and Psychology","Public Health"]
doi:10.7717/peerj.4614
75 downloads
353 views

The blood–brain barrier (BBB), an interface between the systemic circulation and the nervous system, can be a target of cytokines in inflammatory conditions. Pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) induce damage in...

["Cell Biology","Neuroscience","Pharmacology"]
doi:10.7717/peerj.4774
85 downloads
304 views

Background Vitexin is a kind of lignan compound which has been shown to possess a variety of pharmacological effects, such as anti-inflammatory, anti-oxidative and anti-cancer activities. However the effect of vitexin on hair regeneration has not been elaborated....

["Cell Biology","Molecular Biology","Dermatology","Pharmacology"]
doi:10.7717/peerj.4737
83 downloads
324 views

Background Beyond its traditional uses in the Balkan area, Sideritis scardica (known as Greek mountain tea, Lamiaceae) is currently extensively investigated for its pharmacological activity in the central nervous system. Antidepressant, psychostimulating, cognition-enhancing...

["Cognitive Disorders","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.4683
59 downloads
455 views

Background Trichotillomania (TTM) is an impulse control disorder characterized by repetitive hair pulling/trimming. Barbering behavior (BB) observed in laboratory animals is proposed as a model of TTM. The neurobiological basis of TTM is unclear, but involves striatal...

["Animal Behavior","Neuroscience","Pharmacology","Psychiatry and Psychology"]
doi:10.7717/peerj.4635
87 downloads
292 views

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids....

["Dermatology","Pharmacology","Medical Genetics"]
doi:10.7717/peerj.4637
132 downloads
744 views

Background The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life. Here we aim to examine the expression profiles of transient...

["Molecular Biology","Neuroscience","Anesthesiology and Pain Management","Oncology","Pharmacology"]
doi:10.7717/peerj.4622
100 downloads
513 views

Background Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. There are many important...

["Veterinary Medicine","Pharmacology","Translational Medicine"]
doi:10.7717/peerj.4387
1 citation
194 downloads
498 views

Leaves of Passiflora suberosa L. (Family: Passifloraceae; common name: wild passion fruit, devil’s pumpkin) are used in Sri Lankan traditional medicine for treating diabetes. The present study investigated the in vivo ability of P. suberosa leaves to manage blood...

["Pharmacology"]
doi:10.7717/peerj.4389
107 downloads
854 views

There is growing interest in applying detailed mathematical models of the heart for ion-channel related cardiac toxicity prediction. However, a debate as to whether such complex models are required exists. Here an assessment in the predictive performance between...

["Mathematical Biology","Toxicology","Cardiology","Pharmacology"]
doi:10.7717/peerj.4352
165 downloads
759 views

Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases. Herein, we report our results in identifying...

["Biochemistry","Pharmacology","Computational Science"]
doi:10.7717/peerj.4206

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