Peer-reviewed Articles - Medicine

23 downloads
97 views

Background Green synthesis of metallic nanoparticles has gained significant attention in the field of nanomedicine as an environment-friendly and cost-effective alternative in comparison with other physical and chemical methods. Several metals such as silver, gold,...

["Biochemistry","Bioengineering","Microbiology","Nutrition","Pharmacology"]
doi:10.7717/peerj.6086
22 downloads
109 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.6082
48 downloads
234 views

Medicinal plants play a crucial role in the search for components that are capable of neutralizing the multiple mechanisms of fungal resistance. Psidium salutare (Kunth) O. Berg is a plant native to Brazil used as both food and traditional medicine to treat diseases...

["Microbiology","Infectious Diseases","Pharmacology"]
doi:10.7717/peerj.5476
70 downloads
312 views

Background Secondhand smoke (SHS) exposure has adverse effects on the cardiovascular system. This study aimed to determine the effects of SHS on the cardiovascular disease biomarkers, namely the metabolic, inflammatory, and oxidative stress markers in healthy adult...

["Pharmacology","Public Health"]
doi:10.7717/peerj.5758
107 downloads
611 views

Background Benzodiazepines (BZDs) and z-drugs are effective drugs, but they are prescribed excessively worldwide. International guidelines recommend a maximum treatment duration of 4 weeks. Although these drugs are effective in the short-term, long-term BZD therapy...

["Geriatrics","Pharmacology"]
doi:10.7717/peerj.5535
148 downloads
350 views

Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in clinical practice, which can have adverse effects on the osteoblast. The objective of this study was to determine the effect of NSAIDs on the osteoblast by analyzing the gene expression...

["Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.5415
177 downloads
530 views

Background Acute kidney injury (AKI) is associated with a significant increase in morbidity, mortality, and health care costs. In intensive care units (ICU), AKI is commonly multifactorial and frequently involves diverse factors, such as hypovolemia, sepsis, and...

["Nephrology","Pharmacology","Public Health"]
doi:10.7717/peerj.5405
106 downloads
379 views

Sustained-release formulations of ivermectin (IVM) are useful for controlling parasitic diseases in animals. In this work, an IVM bolus made from microcrystalline cellulose (MCC), starch and low-substituted hydroxypropyl cellulose (LS-HPC) was optimized by response...

["Veterinary Medicine","Pharmacology"]
doi:10.7717/peerj.5418
116 downloads
733 views

Studies have suggested that oxidative stress may contribute to the pathogenesis of mental disorders. In this context, molecules with antioxidant activity may be promising agents in the treatment of these deleterious conditions. Acetyl-L-carnitine (ALC) is a multi-target...

["Neuroscience","Pharmacology"]
doi:10.7717/peerj.5309
273 downloads
887 views

Background There are many problems with fitness trackers, such as device usability, which limit their large-scale application, and relevant studies are limited in terms of their sample size and evaluation methods. The purpose of the study was to evaluate the perceived...

["Pharmacology","Public Health","Human-Computer Interaction","Computational Science","Data Science"]
doi:10.7717/peerj.5350
184 downloads
871 views

Background Cassia fistula (L.) (Fabaceae) is a medicinal plant from tropical Asia. It is known for its marked antioxidant activity, which is attributed to its high phenolic content. The present study aims at testing both the antioxidant and neuroprotective effects...

["Plant Science","Pharmacology"]
doi:10.7717/peerj.5159
1 citation
130 downloads
620 views

Honey has been shown to have a range of therapeutic effects in humans, with anti-inflammatory and anti-bacterial effects among those previously characterised. Here, we examine the possibility of New Zealand thyme, manuka and honeydew honeys, and their major sugar...

["Cell Biology","Toxicology","Oncology","Pharmacology"]
doi:10.7717/peerj.5115
93 downloads
526 views

Objective This study was undertaken to detect if free fatty acids (FFA) induce hepatocyte senescence in L-02 cells and if huperzine A has an anti-aging effect in fatty liver cells. Methods L-02 cells were treated with a FFA mixture (oleate/palmitate, at 3:0, 2:1,...

["Gastroenterology and Hepatology","Pharmacology","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.5145
104 downloads
424 views

Depressive disorders (DD) are known to be associated with increased DNA damage, the impairment of DNA damage repair, and the presence of single-nucleotide polymorphisms (SNPs) in DNA damage repair genes. Some indirect evidence also suggests that uracil metabolism...

["Genetics","Cognitive Disorders","Pharmacology","Psychiatry and Psychology"]
doi:10.7717/peerj.5116
146 downloads
684 views

Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder. In addition to its highly debilitating motor symptoms, non-motor symptoms may precede their motor counterparts by many years, which may characterize a prodromal phase of PD....

["Neuroscience","Pharmacology"]
doi:10.7717/peerj.4957

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