Peer-reviewed Articles - Medicine

30 downloads
124 views

Background Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy...

["Nephrology","Oncology","Pathology","Pediatrics","Urology"]
doi:10.7717/peerj.6212
31 downloads
287 views

Background Among over 100 types of Herpesviridae viruses, eight can infect humans: herpes simplex viruses (HSV-1, HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). After...

["Epidemiology","Infectious Diseases","Neurology","Pathology"]
doi:10.7717/peerj.6095
144 downloads
848 views

Congenital heart disease (CHD) affects a considerable number of children and adults worldwide. This implicates not only developmental disorders, high mortality, and reduced quality of life but also, high costs for the healthcare systems. CHD refers to a variety...

["Cell Biology","Developmental Biology","Anatomy and Physiology","Cardiology","Pathology"]
doi:10.7717/peerj.5805
82 downloads
390 views

Background Urothelial carcinoma (UC) is the fifth most common malignancy that accounts for 5% of all cancers. Diagnostic markers that predict UC progressions are inadequate. NF-κB contributes towards disease progression upon constitutive activation in many solid...

["Bioinformatics","Pathology","Urology"]
doi:10.7717/peerj.5563
78 downloads
416 views

Background Except for a few studies with contradictory observations, information is lacking on the possibility of association between DNA mismatch repair (MMR) status and the presence of cancer stem cells in colorectal carcinoma (CRC), two important aspects in...

["Gastroenterology and Hepatology","Pathology"]
doi:10.7717/peerj.5530
247 downloads
991 views

Although most of the cervical cancer cases are reported to be closely related to the Human Papillomavirus (HPV) infection, there is a need to study genes that stand up differentially in the final actualization of cervical cancers following HPV infection. In this...

["Bioinformatics","Computational Biology","Pathology","Computational Science","Data Mining and Machine Learning"]
doi:10.7717/peerj.5285
411 downloads
646 views

Managing injury risk requires an understanding of how and when athletes sustain certain injuries. Such information guides organisations in establishing evidence-based priorities and expectations for managing injury risk. In order to minimise the impact of sports...

["Epidemiology","Health Policy","Pathology","Public Health","Data Science"]
doi:10.7717/peerj.4895
216 downloads
526 views

Background Stargardt disease (SD) is characterized by the accumulation of the age-pigment lipofuscin in the retinal pigment epithelium (RPE) and subsequent neuroretinal degeneration. The disease leads to vision loss early in life. Here, we investigate age-dependent...

["Cell Biology","Neuroscience","Ophthalmology","Pathology","Histology"]
doi:10.7717/peerj.5215
1 citation
89 downloads
477 views

Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson’s disease (PD). Alpha-synuclein is a protein that is a major component of Lewy bodies, histopathological hallmarks of PD, and is involved in regulation of dopamine (DA)...

["Developmental Biology","Neuroscience","Neurology","Pathology"]
doi:10.7717/peerj.4779
159 downloads
574 views

Background In China, there is insufficient evidence to support that screening programs can detect breast cancer earlier and improve outcomes compared with patient self-reporting. Therefore, we compared the pathological characteristics at diagnosis between self-detected...

["Epidemiology","Pathology"]
doi:10.7717/peerj.4567
148 downloads
582 views

Background Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods In a nationwide renal biopsy survey including...

["Diabetes and Endocrinology","Epidemiology","Nephrology","Pathology"]
doi:10.7717/peerj.4522
131 downloads
618 views

Background The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx...

["Dentistry","HIV","Immunology","Pathology"]
doi:10.7717/peerj.4407
229 downloads
1,377 views

This study assessed in detail the influence of four different human proteins on the activation of CD4+ and CD8+ T lymphocytes and on the formation of regulatory T cells. Human whole-blood samples were incubated with four different human proteins. The effects of...

["Allergy and Clinical Immunology","Immunology","Internal Medicine","Pathology","Pediatrics"]
doi:10.7717/peerj.4462
1 citation
190 downloads
706 views

Backgrounds and Aims Melanosis coli (MC) is a noninflammatory, benign, and reversible colonic disorder, but its detection rates in China are unclear. We therefore aimed to analyze the epidemiological characteristics of MC in China. Methods We assessed the detection...

["Epidemiology","Evidence Based Medicine","Gastroenterology and Hepatology","Pathology"]
doi:10.7717/peerj.4483
228 downloads
1,268 views

Triple negative breast cancer (TNBC) is a belligerent carcinoma that is unresponsive to targeted receptor therapies. Development of new treatment strategies would benefit from an expanded repertoire of in vitro cell culture systems, such as those that support tridimensional...

["Cell Biology","Anatomy and Physiology","Oncology","Pathology","Histology"]
doi:10.7717/peerj.4340

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