Peer-reviewed Articles - Medicine

85 downloads
639 views

Although most of the cervical cancer cases are reported to be closely related to the Human Papillomavirus (HPV) infection, there is a need to study genes that stand up differentially in the final actualization of cervical cancers following HPV infection. In this...

["Bioinformatics","Computational Biology","Pathology","Computational Science","Data Mining and Machine Learning"]
doi:10.7717/peerj.5285
353 downloads
363 views

Managing injury risk requires an understanding of how and when athletes sustain certain injuries. Such information guides organisations in establishing evidence-based priorities and expectations for managing injury risk. In order to minimise the impact of sports...

["Epidemiology","Health Policy","Pathology","Public Health","Data Science"]
doi:10.7717/peerj.4895
71 downloads
276 views

Background Stargardt disease (SD) is characterized by the accumulation of the age-pigment lipofuscin in the retinal pigment epithelium (RPE) and subsequent neuroretinal degeneration. The disease leads to vision loss early in life. Here, we investigate age-dependent...

["Cell Biology","Neuroscience","Ophthalmology","Pathology","Histology"]
doi:10.7717/peerj.5215
67 downloads
353 views

Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson’s disease (PD). Alpha-synuclein is a protein that is a major component of Lewy bodies, histopathological hallmarks of PD, and is involved in regulation of dopamine (DA)...

["Developmental Biology","Neuroscience","Neurology","Pathology"]
doi:10.7717/peerj.4779
102 downloads
483 views

Background In China, there is insufficient evidence to support that screening programs can detect breast cancer earlier and improve outcomes compared with patient self-reporting. Therefore, we compared the pathological characteristics at diagnosis between self-detected...

["Epidemiology","Pathology"]
doi:10.7717/peerj.4567
96 downloads
415 views

Background Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods In a nationwide renal biopsy survey including...

["Diabetes and Endocrinology","Epidemiology","Nephrology","Pathology"]
doi:10.7717/peerj.4522
88 downloads
464 views

Background The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx...

["Dentistry","HIV","Immunology","Pathology"]
doi:10.7717/peerj.4407
176 downloads
875 views

This study assessed in detail the influence of four different human proteins on the activation of CD4+ and CD8+ T lymphocytes and on the formation of regulatory T cells. Human whole-blood samples were incubated with four different human proteins. The effects of...

["Allergy and Clinical Immunology","Immunology","Internal Medicine","Pathology","Pediatrics"]
doi:10.7717/peerj.4462
129 downloads
580 views

Backgrounds and Aims Melanosis coli (MC) is a noninflammatory, benign, and reversible colonic disorder, but its detection rates in China are unclear. We therefore aimed to analyze the epidemiological characteristics of MC in China. Methods We assessed the detection...

["Epidemiology","Evidence Based Medicine","Gastroenterology and Hepatology","Pathology"]
doi:10.7717/peerj.4483
169 downloads
950 views

Triple negative breast cancer (TNBC) is a belligerent carcinoma that is unresponsive to targeted receptor therapies. Development of new treatment strategies would benefit from an expanded repertoire of in vitro cell culture systems, such as those that support tridimensional...

["Cell Biology","Anatomy and Physiology","Oncology","Pathology","Histology"]
doi:10.7717/peerj.4340
154 downloads
604 views

Objectives To investigate the frequency and prognostic role of deficient mismatch repair (dMMR) and RAS mutation in Chinese patients with colorectal carcinoma. Methods Clinical and pathological information from 813 patients were reviewed and recorded. Expression...

["Gastroenterology and Hepatology","Oncology","Pathology","Medical Genetics"]
doi:10.7717/peerj.4341
129 downloads
970 views

Background Long non-coding RNAs (lncRNAs) have been reported to modulate cardiovascular diseases, and expression dynamics of lncRNAs in the bloodstream were proposed to be potential biomarkers for clinical diagnosis. However, few cardiovascular diseases-related...

["Molecular Biology","Cardiology","Pathology","Public Health"]
doi:10.7717/peerj.4246
419 downloads
822 views

Background Beaches are recreational spots for people. However, beach sand contains harmful microbes that affect human health, and there are no established methods for either sampling and identifying beach-borne pathogens or managing the quality of beach sand. Method...

["Biotechnology","Marine Biology","Allergy and Clinical Immunology","Pathology","Public Health"]
doi:10.7717/peerj.4245
1 citation
459 downloads
1,353 views

Background Few studies compared the diagnostic value of procalcitonin with a combination of other tests including lactate and high-sensitivity C-reactive protein in the prediction of pathogenic bacteremia in emergency department adult patients. Methods We performed...

["Emergency and Critical Care","Infectious Diseases","Internal Medicine","Pathology"]
doi:10.7717/peerj.4094
197 downloads
709 views

Small interference RNA has been widely used to suppress gene expression. Three different short hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal...

["Neuroscience","Neurology","Pathology"]
doi:10.7717/peerj.3905

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