Peer-reviewed Articles - Medicine

71 downloads
276 views

Background Stargardt disease (SD) is characterized by the accumulation of the age-pigment lipofuscin in the retinal pigment epithelium (RPE) and subsequent neuroretinal degeneration. The disease leads to vision loss early in life. Here, we investigate age-dependent...

["Cell Biology","Neuroscience","Ophthalmology","Pathology","Histology"]
doi:10.7717/peerj.5215
74 downloads
324 views

Purpose RNA sequencing analysis has demonstrated bidirectional changes in metabolism, structural and immune pathways during early induction of defocus induced myopia. Thus, the aim of this study was to investigate whether similar gene pathways are also related...

["Bioinformatics","Genomics","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7717/peerj.5048
105 downloads
432 views

Diabetic retinopathy (DR) is the most common chronic complication of diabetes. It can cause impaired vision and even blindness. However, the pathological mechanism of DR is still unknown. In the present study, we use bioinformatic analysis to reveal the pathological...

["Bioinformatics","Ophthalmology"]
doi:10.7717/peerj.4762
233 downloads
823 views

Background Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated...

["Drugs and Devices","Ophthalmology"]
doi:10.7717/peerj.4549
108 downloads
944 views

Objective In the foveola of the eye, photoreceptors and Müller cells with a unique morphology have been described, but little is known about their 3D structure and orientation. Considering that there is an angle-dependent change in the foveolar photoreceptor response...

["Biophysics","Cell Biology","Anatomy and Physiology","Ophthalmology","Histology"]
doi:10.7717/peerj.4482
137 downloads
761 views

Based on the existing research on sound symbolism and crossmodal correspondence, this study proposed an extended research on cross-modal correspondence between various sound attributes and color properties in a group of non-synesthetes. In Experiment 1, we assessed...

["Ophthalmology","Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.4443
155 downloads
927 views

Objective Although research on muscle dysmorphia (MD), a body dysmorphic disorder subtype, has recently increased, the causes and mechanisms underlying this disorder remain unclear. Results from studies examining disorders associated with body image suggest the...

["Kinesiology","Ophthalmology","Psychiatry and Psychology","Public Health"]
doi:10.7717/peerj.4273
1 citation
613 downloads
2,093 views

Recent studies have implicated exotropia as a risk factor for schizophrenia. We determined whether schizophrenia biomarkers have abnormal levels of expression in extraocular muscles from patients with strabismus and explored whether differences in gene expression...

["Ophthalmology","Psychiatry and Psychology"]
doi:10.7717/peerj.4214
159 downloads
2,894 views

Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or whether mammalian...

["Developmental Biology","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7717/peerj.4093
2 citations
299 downloads
1,151 views

The purpose of this study was to investigate the benefits of exercises with different cognitive demands for cognitive functions (Executive and non-Executive) in healthy older adults. A cross-sectional design was adopted. In total, 84 healthy older adults were enrolled...

["Neuroscience","Geriatrics","Neurology","Ophthalmology"]
doi:10.7717/peerj.3943
1 citation
228 downloads
938 views

Background/Aim Strabismus is a common condition with misalignment between two eyes that may lead to decrease of visual acuity, lack of binocularity, and diplopia. It is caused by heterogeneous environmental and genetic risk factors. Our previous research has identified...

["Genetics","Genomics","Ophthalmology","Medical Genetics"]
doi:10.7717/peerj.3935
97 downloads
515 views

Background In late 2015, cut-off points were published for foveal thickness to diagnose diabetic macular oedema taking into account the presence of intraretinal fluid using optical coherence tomography (OCT) in primary care patients (90 µm in the presence of intraretinal...

["Diabetes and Endocrinology","Epidemiology","Evidence Based Medicine","Ophthalmology","Public Health"]
doi:10.7717/peerj.3922
1 citation
153 downloads
966 views

A new method for automatic optic disc localization and segmentation is presented. The localization procedure combines vascular and brightness information to provide the best estimate of the optic disc center which is the starting point for the segmentation algorithm....

["Computational Science","Human-Computer Interaction","Ophthalmology","Radiology and Medical Imaging"]
doi:10.7717/peerj.3763
4 citations
134 downloads
877 views

Objective The trabecular meshwork (TM) is the primary substrate of outflow resistance in glaucomatous eyes. Repopulating diseased TM with fresh, functional TM cells might be a viable therapeutic approach. Decellularized TM scaffolds have previously been produced...

["Bioengineering","Biotechnology","Ophthalmology"]
doi:10.7717/peerj.3629
197 downloads
927 views

Background Working memory is critical for various cognitive processes and can be separated into two stages: short-term memory storage and manipulation processing. Although previous studies have demonstrated that increased physical activity (PA) improves working...

["Kinesiology","Ophthalmology","Psychiatry and Psychology","Public Health"]
doi:10.7717/peerj.3430

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