Peer-reviewed Articles - Medicine

40 downloads
143 views

Purpose The most common virus vector used in gene therapy research for ophthalmologic diseases is the adeno-associated virus (AAV) vector, which has been used successfully in a number of preclinical and clinical studies. It is important to evaluate novel AAV vectors...

["Virology","Ophthalmology"]
doi:10.7717/peerj.6317
56 downloads
365 views

Background Several technology-assisted aids are available to help blind and visually impaired people perform their daily activities. The current research uses the state-of-the-art technology to enhance the utility of traditional navigational aids to produce solutions...

["Drugs and Devices","Ophthalmology","Human\u2013Computer Interaction","Data Mining and Machine Learning"]
doi:10.7717/peerj.6058
56 downloads
392 views

Segmentation of the retinal blood vessels using filtering techniques is a widely used step in the development of an automated system for diagnostic retinal image analysis. This paper optimized the blood vessel segmentation, by extending the trainable B-COSFIRE...

["Ophthalmology","Radiology and Medical Imaging","Human-Computer Interaction","Computational Science"]
doi:10.7717/peerj.5855
146 downloads
1,220 views

We aimed to investigate the detection of idiopathic macular holes (MHs) using ultra-wide-field fundus images (Optos) with deep learning, which is a machine learning technology. The study included 910 Optos color images (715 normal images, 195 MH images). Of these...

["Ophthalmology","Computational Science"]
doi:10.7717/peerj.5696
75 downloads
1,642 views

Background The Stroop test is frequently used to assess deficits in inhibitory control in people with multiple sclerosis (MS). This test has limitations and antisaccade eye movements, that also measure inhibitory control, may be an alternative to Stroop. Objectives...

["Cognitive Disorders","Neurology","Ophthalmology","Psychiatry and Psychology"]
doi:10.7717/peerj.5737
109 downloads
415 views

Müller glia in the zebrafish retina respond to retinal damage by re-entering the cell cycle, which generates large numbers of retinal progenitors that ultimately replace the lost neurons. In this study we compared the regenerative outcomes of adult zebrafish exposed...

["Cell Biology","Developmental Biology","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7717/peerj.5646
216 downloads
526 views

Background Stargardt disease (SD) is characterized by the accumulation of the age-pigment lipofuscin in the retinal pigment epithelium (RPE) and subsequent neuroretinal degeneration. The disease leads to vision loss early in life. Here, we investigate age-dependent...

["Cell Biology","Neuroscience","Ophthalmology","Pathology","Histology"]
doi:10.7717/peerj.5215
1 citation
177 downloads
597 views

Purpose RNA sequencing analysis has demonstrated bidirectional changes in metabolism, structural and immune pathways during early induction of defocus induced myopia. Thus, the aim of this study was to investigate whether similar gene pathways are also related...

["Bioinformatics","Genomics","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7717/peerj.5048
204 downloads
581 views

Diabetic retinopathy (DR) is the most common chronic complication of diabetes. It can cause impaired vision and even blindness. However, the pathological mechanism of DR is still unknown. In the present study, we use bioinformatic analysis to reveal the pathological...

["Bioinformatics","Ophthalmology"]
doi:10.7717/peerj.4762
451 downloads
1,097 views

Background Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated...

["Drugs and Devices","Ophthalmology"]
doi:10.7717/peerj.4549
2 citations
153 downloads
1,184 views

Objective In the foveola of the eye, photoreceptors and Müller cells with a unique morphology have been described, but little is known about their 3D structure and orientation. Considering that there is an angle-dependent change in the foveolar photoreceptor response...

["Biophysics","Cell Biology","Anatomy and Physiology","Ophthalmology","Histology"]
doi:10.7717/peerj.4482
1 citation
234 downloads
1,074 views

Based on the existing research on sound symbolism and crossmodal correspondence, this study proposed an extended research on cross-modal correspondence between various sound attributes and color properties in a group of non-synesthetes. In Experiment 1, we assessed...

["Ophthalmology","Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.4443
1 citation
225 downloads
1,152 views

Objective Although research on muscle dysmorphia (MD), a body dysmorphic disorder subtype, has recently increased, the causes and mechanisms underlying this disorder remain unclear. Results from studies examining disorders associated with body image suggest the...

["Kinesiology","Ophthalmology","Psychiatry and Psychology","Public Health"]
doi:10.7717/peerj.4273
1 citation
868 downloads
2,608 views

Recent studies have implicated exotropia as a risk factor for schizophrenia. We determined whether schizophrenia biomarkers have abnormal levels of expression in extraocular muscles from patients with strabismus and explored whether differences in gene expression...

["Ophthalmology","Psychiatry and Psychology"]
doi:10.7717/peerj.4214
1 citation
202 downloads
3,141 views

Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or whether mammalian...

["Developmental Biology","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7717/peerj.4093

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