Peer-reviewed Articles - Medicine

34 downloads
205 views

The phosphoinositide 3-kinase (PI3K) pathway shows frequent aberrant alterations and pathological activation in breast cancer cells. While PI3K inhibitors have not achieved expectant therapeutic efficacy in clinical trials, and several studies provide promising...

["Biochemistry","Oncology"]
doi:10.7717/peerj.5092
35 downloads
231 views

Background Cervical cancer is one of the most common cancers in women worldwide. Malignant tumors develop resistance mechanisms and are less sensitive to or do not respond to irradiation. With the development of high-throughput sequencing technologies, circular...

["Bioinformatics","Oncology"]
doi:10.7717/peerj.5011
49 downloads
332 views

A robust and accurate gene expression signature is essential to assist oncologists to determine which subset of patients at similar Tumor-Lymph Node-Metastasis (TNM) stage has high recurrence risk and could benefit from adjuvant therapies. Here we applied a two-step...

["Bioinformatics","Gastroenterology and Hepatology","Oncology","Data Mining and Machine Learning"]
doi:10.7717/peerj.4942
31 downloads
243 views

Chemokine (C-C motif) ligand 7 (CCL7), a CC chemokine, is a chemotactic factor and attractant for various kinds of leukocytes, including monocytes and neutrophils. CCL7 is widely expressed in multiple cell types and can participate in anti-inflammatory responses...

["Biochemistry","Cell Biology","Molecular Biology","Oncology"]
doi:10.7717/peerj.4928
43 downloads
197 views

Background The highly valued medicinal tiger milk mushroom (also known as Lignosus rhinocerus) has the ability to cure numerous ailments. Its anticancer activities are well explored, and recently a partially purified cytotoxic protein fraction termed F5 from the...

["Biochemistry","Genetics","Oncology","Translational Medicine","Data Mining and Machine Learning"]
doi:10.7717/peerj.4940
32 downloads
241 views

Background Hepatocellular carcinoma (HCC) is the most common and aggressive type of malignant liver tumor. HCC progression depends significantly on its vascularization and formation of new blood vessels. Vascular endothelial growth factor A (VEGFA) is a crucial...

["Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.4915
59 downloads
329 views

Sorting nexin-1 (SNX1) is an important functional protein in cell endocytosis, efflux, protein sorting, cell signal transduction, etc; however, the expression, the role and clinical relevance of SNX1 have not been investigated in gastric cancer (GC). In this study,...

["Gastroenterology and Hepatology","Oncology","Histology"]
doi:10.7717/peerj.4829
120 downloads
469 views

Cancer progression is a polygenic procedure in which the exosomes can function as substantial roles. Exosomes are tiny, phospholipid bilayer membrane nanovesicles of endocytic derivation with a diameter of 40–100 nm. These nanovesicles can transport bioactive molecules...

["Genetics","Oncology"]
doi:10.7717/peerj.4763
39 downloads
177 views

Objectives The prognosis of people with pancreatic cancer is extremely unfavorable. However, the prognostic factors remain largely undefined. We aimed to perform comprehensive analyses of clinicopathologic characteristics, laboratory parameters, and treatment protocols...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.4893
112 downloads
414 views

Background Breast cancer stem cells (BCSCs) are associated with the invasion of breast cancer. In recent years, studies have demonstrated different phenotypes among BCSCs. Furthermore, BCSCs of diverse phenotypes are present at different tumour sites and different...

["Cell Biology","Oncology"]
doi:10.7717/peerj.4805
96 downloads
363 views

Background Using DNA microarrays, we previously identified 451 genes expressed in 19 different human tissues. Although ubiquitously expressed, the variable expression patterns of these “housekeeping genes” (HKGs) could separate one normal human tissue type from...

["Bioinformatics","Computational Biology","Genomics","Oncology","Medical Genetics"]
doi:10.7717/peerj.4719
127 downloads
455 views

Background Gastric cancer (GC) is one of the most common cancers with high mortality globally. However, the molecular mechanisms of GC are unclear, and the prognosis of GC is poor. Therefore, it is important to explore the underlying mechanisms and screen for novel...

["Bioinformatics","Genetics","Oncology"]
doi:10.7717/peerj.4692
76 downloads
466 views

In 2015, as part of the Prostate Cancer Foundation–Movember Foundation Reproducibility Initiative, we published a Registered Report (Shan et al., 2015) that described how we intended to replicate selected experiments from the paper “Androgen Receptor Splice Variants...

["Cell Biology","Oncology"]
doi:10.7717/peerj.4661
119 downloads
739 views

Objective A subgroup of parents of children who have been treated for childhood cancer report high levels of psychological distress. To date there is no empirically supported psychological treatment targeting cancer-related psychological distress in this population....

["Clinical Trials","Oncology","Pediatrics","Psychiatry and Psychology"]
doi:10.7717/peerj.4570
134 downloads
772 views

Background The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life. Here we aim to examine the expression profiles of transient...

["Molecular Biology","Neuroscience","Anesthesiology and Pain Management","Oncology","Pharmacology"]
doi:10.7717/peerj.4622

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