Peer-reviewed Articles - Medicine

37 downloads
108 views

Objective This study aims to reveal the regulation network of lncRNAs-miRNAs-mRNA in endometrial carcinoma (EC), to investigate the underlying mechanisms of EC occurrence and progression, to screen prognostic biomarkers. Methods RNA-seq and miRNA-seq data of endometrial...

["Gynecology and Obstetrics","Oncology"]
doi:10.7717/peerj.6091
20 downloads
138 views

Background Colorectal cancer remains a serious public health problem due to the poor prognosis. In the present study, we attempted to develop and validate a prognostic signature to predict the individual mortality risk in colorectal cancer patients. Materials and...

["Bioinformatics","Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.6061
43 downloads
166 views

Background DNA repair is essential to counteract damage to DNA induced by endo- and exogenous factors, to maintain genome stability. However, challenges to the faithful discrimination between damaged and non-damaged DNA strands do exist, such as mismatched pairs...

["Biochemistry","Cell Biology","Genetics","Molecular Biology","Oncology"]
doi:10.7717/peerj.6029
75 downloads
293 views

Background Bladder cancer is a malignant tumor in the urinary system with high mortality and recurrence rates. However, the causes and recurrence mechanism of bladder cancer are not fully understood. In this study, we used integrated bioinformatics to screen for...

["Bioinformatics","Oncology","Data Mining and Machine Learning"]
doi:10.7717/peerj.6036
79 downloads
470 views

Patient-derived xenograft (PDX) models are increasingly being used in oncology drug development because they offer greater predictive value than traditional cell line models. Using novel tools to critique model validity and reliability we performed a systematic...

["Oncology","Translational Medicine"]
doi:10.7717/peerj.5981
46 downloads
321 views

Background Prostate cancer (PC) diagnostics and treatment often present a challenging task due to cancer subtype heterogeneity and differential disease progression in patient subgroups. Hence, the critical issue is finding a reliable and sensitive diagnostic and...

["Cell Biology","Molecular Biology","Oncology"]
doi:10.7717/peerj.5970
40 downloads
370 views

Background Previous studies show that mTOR inhibitors decrease the risk of cancer development after kidney transplantation. However, the effect of cumulative doses of mTOR inhibitors on cancer after kidney transplantation is not well known. Methods In the current...

["Internal Medicine","Oncology"]
doi:10.7717/peerj.5864
72 downloads
251 views

Ovarian cancer (OC) is the second most common gynecologic malignancy. A clinical observational study was performed to investigate whether indicators that assess the risk of metastasis can identify recurrence earlier in OC patients. By successfully recruiting 41...

["Gynecology and Obstetrics","Oncology"]
doi:10.7717/peerj.5912
60 downloads
234 views

Colorectal cancer ranks third among the most commonly diagnosed cancers in the United States. Current therapies have a range of side effects, and the development of a reliable animal model to speed the discovery of safe effective preventative therapies would be...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5602
74 downloads
323 views

Aim Anaplastic thyroid carcinoma (ATC) is the most lethal thyroid malignancy. Identification of novel drug targets is urgently needed. Materials & Methods We re-analyzed several GEO datasets by systematic retrieval and data merging. Differentially expressed genes...

["Genetics","Diabetes and Endocrinology","Oncology"]
doi:10.7717/peerj.5822
57 downloads
213 views

Objective To investigate the interaction of non-coding RNAs (ncRNAs) in hepatocellular carcinoma. Methods We compared the ncRNAs and mRNAs expression profiles of hepatocellular carcinoma and adjacent tissue by microarray and RT-PCR. The relationship between different...

["Gastroenterology and Hepatology","Oncology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.5787
55 downloads
204 views

Background Oxidative stress (OS) is a key characteristic feature in cancer initiation and progression. Among multiple cancers, NADPH oxidase (NOX) dependent free radical production is implicated in oxidative stress. P22phox, a subunit of NADPH oxidase encoded by...

["Genetics","Oncology","Medical Genetics"]
doi:10.7717/peerj.5509
103 downloads
389 views

Background Acetylsalicylic acid was renamed aspirin in 1899, and it has been widely used for its multiple biological actions. Because of the diversity of the cellular processes and diseases that aspirin reportedly affects and benefits, uncertainty remains regarding...

["Bioinformatics","Drugs and Devices","Oncology"]
doi:10.7717/peerj.5667
68 downloads
247 views

Introduction The present study investigated the crucial role of inflammation-based prognostic scores in locally advanced cervical esophageal squamous cell carcinoma (ESCC) patients who underwent curative concurrent chemoradiotherapy (CCRT). Methods There were 411...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5655

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