Peer-reviewed Articles - Medicine

19 downloads
107 views

Introduction The present study investigated the crucial role of inflammation-based prognostic scores in locally advanced cervical esophageal squamous cell carcinoma (ESCC) patients who underwent curative concurrent chemoradiotherapy (CCRT). Methods There were 411...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5655
39 downloads
190 views

Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause the disease. Chromosomal amplifications have been identified as a source of upregulation for cervical cancer driver genes but cannot fully explain...

["Computational Biology","Microbiology","Oncology"]
doi:10.7717/peerj.5590
50 downloads
176 views

Purpose Most studies on neuroblastoma (NB) have been conducted in Western countries or Japan. The objective of our study was to analyze clinical and pathological features, MYCN status, surgical methods, and prognosis in Chinese NB patients. Methods A retrospective,...

["Oncology","Pediatrics","Surgery and Surgical Specialties"]
doi:10.7717/peerj.5665
32 downloads
493 views

Objectives The five-year survival rate of head and neck cancer (HNC) after radiotherapy (RT) varies widely from 35% to 89%. Many studies have addressed the effect of socioeconomic status and urban dwelling on the survival of HNC, but a limited number of studies...

["Dentistry","Oncology","Otorhinolaryngology","Public Health"]
doi:10.7717/peerj.5591
23 downloads
134 views

Combination Index (CI) analysis suggested that MBIC and doxorubicin synergistically inhibited up to 97% of cell proliferation in ER+/PR+MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. Moreover, treatment of the breast cancer cells with the combined...

["Cell Biology","Oncology"]
doi:10.7717/peerj.5577
30 downloads
132 views

Background Abnormal methylation of TNFRSF10C was found to be associated with different types of cancers, excluding colorectal cancer (CRC). In this paper, the performance of TNFRSF10C methylation in CRC was studied in two stages. Method The discovery stage was...

["Biochemistry","Genetics","Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5336
79 downloads
307 views

Objective The mechanism underlying colon cancer metastasis remain unclear. This study aimed to elucidate the genes alteration during the metastasis of colon cancer and identify genes that crucial to the metastasis and survival of colon cancer patients. Methods...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5433
153 downloads
623 views

Objectives To comprehensively analyse the global scientific outputs of hepatocellular carcinoma (HCC) research. Methods Data of publications were downloaded from the Web of Science Core Collection. We used CiteSpace IV and Excel 2016 to analyse literature information,...

["Gastroenterology and Hepatology","Oncology","Statistics"]
doi:10.7717/peerj.5477
52 downloads
253 views

Background Growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) was previously found to be associated with risk of several kinds of human tumors. Here, we studied the expression and clinical significance of GADD45A in breast cancer. Methods We performed...

["Oncology","Translational Medicine"]
doi:10.7717/peerj.5344
50 downloads
296 views

Selection of the right reference gene(s) is crucial in the analysis and interpretation of gene expression data. The aim of the present study was to discover and validate a minimal set of internal control genes in head and neck tumor studies. We analyzed data from...

["Genomics","Oncology"]
doi:10.7717/peerj.5207
107 downloads
380 views

Oral squamous cell carcinoma (OSCC) is a major malignant cancer of the head and neck. Long non-coding RNAs (lncRNAs) have emerged as critical regulators during the development and progression of cancers. This study aimed to identify a lncRNA-related signature with...

["Bioinformatics","Oncology","Computational Science"]
doi:10.7717/peerj.5307
84 downloads
373 views

Background Differently expressed circular RNAs (circRNAs) have been reported to play a considerable role in tumor behavior; however, the expression profile and biological function of circRNAs in papillary thyroid carcinoma (PTC) remains unknown. Thus, the study...

["Genetics","Diabetes and Endocrinology","Oncology"]
doi:10.7717/peerj.5363
109 downloads
434 views

Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts are non-responsive...

["Bioinformatics","Immunology","Oncology"]
doi:10.7717/peerj.5056
126 downloads
476 views

Background We have previously reported anticancer activities of Melicope ptelefolia (MP) leaf extracts on four different cancer cell lines. However, the underlying mechanisms of actions have yet to be deciphered. In the present study, the anticancer activity of...

["Biochemistry","Biotechnology","Oncology"]
doi:10.7717/peerj.5203
142 downloads
506 views

Background Long non-coding RNAs (lncRNAs) play crucial roles in the initiation and progression of renal cell carcinoma (RCC) by competing in binding to miRNAs, and related competitive endogenous RNA (ceRNA) networks have been constructed in several cancers. However,...

["Bioinformatics","Oncology","Urology"]
doi:10.7717/peerj.5124

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