Peer-reviewed Articles - Medicine

11 downloads
85 views

Background We have previously reported anticancer activities of Melicope ptelefolia (MP) leaf extracts on four different cancer cell lines. However, the underlying mechanisms of actions have yet to be deciphered. In the present study, the anticancer activity of...

["Biochemistry","Biotechnology","Oncology"]
doi:10.7717/peerj.5203
21 downloads
110 views

Background Long non-coding RNAs (lncRNAs) play crucial roles in the initiation and progression of renal cell carcinoma (RCC) by competing in binding to miRNAs, and related competitive endogenous RNA (ceRNA) networks have been constructed in several cancers. However,...

["Bioinformatics","Oncology","Urology"]
doi:10.7717/peerj.5124
43 downloads
236 views

Honey has been shown to have a range of therapeutic effects in humans, with anti-inflammatory and anti-bacterial effects among those previously characterised. Here, we examine the possibility of New Zealand thyme, manuka and honeydew honeys, and their major sugar...

["Cell Biology","Toxicology","Oncology","Pharmacology"]
doi:10.7717/peerj.5115
42 downloads
234 views

Several studies have indicated that α-mangostin exerts anti-metastasis and anti-subsistence effects on several types of cancer cells. Especially, the anti-metastatic effect of α-mangostin on cancer cells is a prospective function in cancer treatment. However, the...

["Biotechnology","Cell Biology","Oncology"]
doi:10.7717/peerj.5027
71 downloads
371 views

The phosphoinositide 3-kinase (PI3K) pathway shows frequent aberrant alterations and pathological activation in breast cancer cells. While PI3K inhibitors have not achieved expectant therapeutic efficacy in clinical trials, and several studies provide promising...

["Biochemistry","Oncology"]
doi:10.7717/peerj.5092
82 downloads
389 views

Background Cervical cancer is one of the most common cancers in women worldwide. Malignant tumors develop resistance mechanisms and are less sensitive to or do not respond to irradiation. With the development of high-throughput sequencing technologies, circular...

["Bioinformatics","Oncology"]
doi:10.7717/peerj.5011
99 downloads
482 views

A robust and accurate gene expression signature is essential to assist oncologists to determine which subset of patients at similar Tumor-Lymph Node-Metastasis (TNM) stage has high recurrence risk and could benefit from adjuvant therapies. Here we applied a two-step...

["Bioinformatics","Gastroenterology and Hepatology","Oncology","Data Mining and Machine Learning"]
doi:10.7717/peerj.4942
53 downloads
382 views

Chemokine (C-C motif) ligand 7 (CCL7), a CC chemokine, is a chemotactic factor and attractant for various kinds of leukocytes, including monocytes and neutrophils. CCL7 is widely expressed in multiple cell types and can participate in anti-inflammatory responses...

["Biochemistry","Cell Biology","Molecular Biology","Oncology"]
doi:10.7717/peerj.4928
60 downloads
302 views

Background The highly valued medicinal tiger milk mushroom (also known as Lignosus rhinocerus) has the ability to cure numerous ailments. Its anticancer activities are well explored, and recently a partially purified cytotoxic protein fraction termed F5 from the...

["Biochemistry","Genetics","Oncology","Translational Medicine","Data Mining and Machine Learning"]
doi:10.7717/peerj.4940
51 downloads
348 views

Background Hepatocellular carcinoma (HCC) is the most common and aggressive type of malignant liver tumor. HCC progression depends significantly on its vascularization and formation of new blood vessels. Vascular endothelial growth factor A (VEGFA) is a crucial...

["Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.4915
80 downloads
444 views

Sorting nexin-1 (SNX1) is an important functional protein in cell endocytosis, efflux, protein sorting, cell signal transduction, etc; however, the expression, the role and clinical relevance of SNX1 have not been investigated in gastric cancer (GC). In this study,...

["Gastroenterology and Hepatology","Oncology","Histology"]
doi:10.7717/peerj.4829
162 downloads
674 views

Cancer progression is a polygenic procedure in which the exosomes can function as substantial roles. Exosomes are tiny, phospholipid bilayer membrane nanovesicles of endocytic derivation with a diameter of 40–100 nm. These nanovesicles can transport bioactive molecules...

["Genetics","Oncology"]
doi:10.7717/peerj.4763
51 downloads
279 views

Objectives The prognosis of people with pancreatic cancer is extremely unfavorable. However, the prognostic factors remain largely undefined. We aimed to perform comprehensive analyses of clinicopathologic characteristics, laboratory parameters, and treatment protocols...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.4893
129 downloads
529 views

Background Breast cancer stem cells (BCSCs) are associated with the invasion of breast cancer. In recent years, studies have demonstrated different phenotypes among BCSCs. Furthermore, BCSCs of diverse phenotypes are present at different tumour sites and different...

["Cell Biology","Oncology"]
doi:10.7717/peerj.4805
113 downloads
468 views

Background Using DNA microarrays, we previously identified 451 genes expressed in 19 different human tissues. Although ubiquitously expressed, the variable expression patterns of these “housekeeping genes” (HKGs) could separate one normal human tissue type from...

["Bioinformatics","Computational Biology","Genomics","Oncology","Medical Genetics"]
doi:10.7717/peerj.4719

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