Peer-reviewed Articles - Medicine

45 downloads
295 views

Chemerin is an adipocyte derived signalling molecule (adipokine) that serves as a ligand activator of Chemokine-like receptor 1(CMKLR1). Chemerin/CMKLR1 signalling is well established to regulate fundamental processes in metabolism and inflammation. The composition...

["Bioinformatics","Genomics","Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.5494
76 downloads
262 views

Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder. This study aims to consider effects of resveratrol, exercise and their combination on Farnesoid X receptor (Fxr), the liver X receptor (Lxr) and Sirtuin 1 (Sirt 1) genes...

["Biochemistry","Molecular Biology","Anatomy and Physiology","Metabolic Sciences"]
doi:10.7717/peerj.5522
126 downloads
403 views

Background Metabolic syndrome (MS) is a construct used to separate “healthy” from “unhealthy” obese patients, and is a major risk factor for type 2 diabetes (T2D) and cardiovascular disease. There is controversy over whether obese “metabolically well” persons have...

["Nutrition","Public Health","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.5410
44 downloads
255 views

Background Previous research suggests motion induced fatigue contributes to significant performance degradation and is likely related to a higher incidence of accidents and injuries. However, the exact effect of continuous multidirectional platform perturbations...

["Biophysics","Kinesiology","Metabolic Sciences"]
doi:10.7717/peerj.5439
76 downloads
318 views

Background Adult rat epididymal adipocytes are able to convert large amounts of glucose to lactate and glycerol. However, fatty acid efflux is much lower than that expected from glycerol levels if they were the product of lipolysis. Use of glucose for lipogenesis...

["Biochemistry","Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.5440
87 downloads
336 views

Socioeconomic status is a known determinant of health. In secondary data analyses, we assessed whether socioeconomic status affected health-related quality of life in a group of overweight (body mass index 25–30 kg/m2) middle-aged (45.9 ± 5.4 years) men, recruited...

["Public Health","Metabolic Sciences"]
doi:10.7717/peerj.5193
194 downloads
658 views

Background Obesity-induced glucose metabolism disorder is associated with chronic, low-grade, systemic inflammation and is considered a risk factor for diabetes and metabolic syndrome. Resveratrol (RES), a natural anti-inflammatory compound, is observed to improve...

["Diabetes and Endocrinology","Immunology","Nutrition","Metabolic Sciences"]
doi:10.7717/peerj.5173
73 downloads
462 views

Objective This study was undertaken to detect if free fatty acids (FFA) induce hepatocyte senescence in L-02 cells and if huperzine A has an anti-aging effect in fatty liver cells. Methods L-02 cells were treated with a FFA mixture (oleate/palmitate, at 3:0, 2:1,...

["Gastroenterology and Hepatology","Pharmacology","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.5145
233 downloads
824 views

Every cell in an individual has largely the same genomic sequence and yet cells in different tissues can present widely different phenotypes. This variation arises because each cell expresses a specific subset of genomic instructions. Control over which instructions,...

["Biochemistry","Genetics","Molecular Biology","Metabolic Sciences"]
doi:10.7717/peerj.5062
1 citation
93 downloads
425 views

Background Fetuin-A and leukocyte cell-derived chemotaxin-2 (LECT-2) are liver-derived proteins. Fetuin-A is an independent risk factor for type 2 diabetes (T2D) and obese patients with T2D have higher plasma fetuin-A levels than those without T2D. LECT-2 has positive...

["Gastroenterology and Hepatology","Nutrition","Surgery and Surgical Specialties","Metabolic Sciences"]
doi:10.7717/peerj.4884
114 downloads
554 views

Objectives Osteoarthritis (OA) and vitamin D deficiency are common health conditions in older people. Whether vitamin D concentration is associated with knee OA is controversial. In this study, we aimed to determine the association between serum concentrations...

["Anesthesiology and Pain Management","Orthopedics","Metabolic Sciences"]
doi:10.7717/peerj.4670
1 citation
200 downloads
886 views

Background Cardiovascular disease is a major cause of mortality and morbidity in people with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an important risk factor for the development of macrovascular disease. The landmark...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4578
124 downloads
690 views

Background Hypoglycemia occurs in an appreciable number of individuals with type 2 diabetes mellitus (T2DM) who are receiving glycemic therapy. Iatrogenic hypoglycemia induces not only complications but also a substantial medical expense. Intervention for relevant...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4348
178 downloads
846 views

Objective To investigate the risk factors for osteoporosis in male Taiwanese patients with chronic obstructive pulmonary disease (COPD). Methods This cross-sectional study evaluated male COPD outpatients and age-matched male subjects at a regional teaching hospital....

["Geriatrics","Internal Medicine","Nutrition","Respiratory Medicine","Metabolic Sciences"]
doi:10.7717/peerj.4232
1 citation
160 downloads
764 views

Background Prader-Willi syndrome (PWS) is a complex, multisystem genetic disorder characterized by a variety of physical, cognitive, and behavioral impairments. PWS is a unique sarcopenia model characterized by an abnormal increase in body fat mass and a decrease...

["Diabetes and Endocrinology","Pediatrics","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.4097

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