Peer-reviewed Articles - Medicine

20 downloads
114 views

Every cell in an individual has largely the same genomic sequence and yet cells in different tissues can present widely different phenotypes. This variation arises because each cell expresses a specific subset of genomic instructions. Control over which instructions,...

["Biochemistry","Genetics","Molecular Biology","Metabolic Sciences"]
doi:10.7717/peerj.5062
1 citation
22 downloads
151 views

Background Fetuin-A and leukocyte cell-derived chemotaxin-2 (LECT-2) are liver-derived proteins. Fetuin-A is an independent risk factor for type 2 diabetes (T2D) and obese patients with T2D have higher plasma fetuin-A levels than those without T2D. LECT-2 has positive...

["Gastroenterology and Hepatology","Nutrition","Surgery and Surgical Specialties","Metabolic Sciences"]
doi:10.7717/peerj.4884
59 downloads
343 views

Objectives Osteoarthritis (OA) and vitamin D deficiency are common health conditions in older people. Whether vitamin D concentration is associated with knee OA is controversial. In this study, we aimed to determine the association between serum concentrations...

["Anesthesiology and Pain Management","Orthopedics","Metabolic Sciences"]
doi:10.7717/peerj.4670
163 downloads
617 views

Background Cardiovascular disease is a major cause of mortality and morbidity in people with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an important risk factor for the development of macrovascular disease. The landmark...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4578
93 downloads
476 views

Background Hypoglycemia occurs in an appreciable number of individuals with type 2 diabetes mellitus (T2DM) who are receiving glycemic therapy. Iatrogenic hypoglycemia induces not only complications but also a substantial medical expense. Intervention for relevant...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4348
137 downloads
576 views

Objective To investigate the risk factors for osteoporosis in male Taiwanese patients with chronic obstructive pulmonary disease (COPD). Methods This cross-sectional study evaluated male COPD outpatients and age-matched male subjects at a regional teaching hospital....

["Geriatrics","Internal Medicine","Nutrition","Respiratory Medicine","Metabolic Sciences"]
doi:10.7717/peerj.4232
111 downloads
509 views

Background Prader-Willi syndrome (PWS) is a complex, multisystem genetic disorder characterized by a variety of physical, cognitive, and behavioral impairments. PWS is a unique sarcopenia model characterized by an abnormal increase in body fat mass and a decrease...

["Diabetes and Endocrinology","Pediatrics","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.4097
1 citation
114 downloads
500 views

Muscle mass loss and wasting are characteristic features of patients with chronic conditions including cancer. Therapeutic options are still scarce. We hypothesized that cachexia-induced muscle oxidative stress may be attenuated in response to treatment with beta2-adrenoceptor-selective...

["Respiratory Medicine","Metabolic Sciences"]
doi:10.7717/peerj.4109
1 citation
224 downloads
652 views

Background Food selection and ingestion both in humans and rodents, often is a critical factor in determining excess energy intake and its related disorders. Methods Two different concepts of high-fat diets were tested for their obesogenic effects in rats; in both...

["Biochemistry","Nutrition","Metabolic Sciences"]
doi:10.7717/peerj.3697
223 downloads
849 views

Background Obesity, a common metabolic disease, is a known cause of male infertility due to its associated health risk. Long noncoding RNAs (lncRNAs) have also been reported to be associated with male reproductive diseases; however, their role in the association...

["Developmental Biology","Molecular Biology","Metabolic Sciences"]
doi:10.7717/peerj.3518
3 citations
152 downloads
731 views

Background Little is known about the role of dietary intake in obstructive sleep apnea (OSA), which could prove important in improving clinical outcomes for people with obesity and/or cardiovascular disease within these populations. Reduction in energy intake typically...

["Epidemiology","Evidence Based Medicine","Nutrition","Respiratory Medicine","Metabolic Sciences"]
doi:10.7717/peerj.3259
1 citation
227 downloads
839 views

Background Synthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this...

["Biochemistry","Molecular Biology","Oncology","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.3365
1 citation
322 downloads
1,184 views

Stellaria dichotoma L. is widely distributed in Ningxia and surrounding areas in northwestern China. Its root, Radix Stellariae (RS), has been used in herbal formulae for treating asthenic-fever, infection, malaria, dyspepsia in children and several other symptoms....

["Molecular Biology","Diabetes and Endocrinology","Global Health","Pharmacology","Metabolic Sciences"]
doi:10.7717/peerj.3305
174 downloads
781 views

Background Nutritional programming takes place in early development. Variation in the quality and/or quantity of nutrients in early development can influence long-term health and viability. However, little is known about the mechanisms of nutritional programming....

["Animal Behavior","Bioinformatics","Evolutionary Studies","Genetics","Metabolic Sciences"]
doi:10.7717/peerj.3275
3 citations
182 downloads
908 views

Background Individuals with type 2 diabetes are at an increased risk of cardiovascular disease. Alterations in circulating lipid levels, total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) are heritable...

["Bioinformatics","Genomics","Diabetes and Endocrinology","Translational Medicine","Metabolic Sciences"]
doi:10.7717/peerj.3187

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