Peer-reviewed Articles - Medicine

25 downloads
129 views

Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years...

["Clinical Trials","Immunology","Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.6037
37 downloads
161 views

The parasite Toxoplasma gondii causes an opportunistic infection, that is, particularly severe in immunocompromised patients, infants, and neonates. Current antiparasitic drugs are teratogenic and cause hypersensitivity-based toxic side effects especially during...

["Biotechnology","Molecular Biology","Parasitology","Plant Science","Immunology"]
doi:10.7717/peerj.5780
34 downloads
166 views

Background Dry eye disease (DED), a chronic ocular disease, is associated with numerous medical issues, including asthma. However, studies on these associations are limited. In this study, we investigated the incidence of DED among patients with asthma and its...

["Allergy and Clinical Immunology","Immunology"]
doi:10.7717/peerj.5941
40 downloads
209 views

Multiplex bead assays are an extension of the commonly used sandwich ELISA. The advantage over ELISA is that they make simultaneous evaluation of several analytes possible. Several commercial assay systems, where the beads are acquired on a standard flow cytometer,...

["Immunology","Computational Science"]
doi:10.7717/peerj.5794
72 downloads
403 views

Background Osteoclast differentiation in the inflamed synovium of rheumatoid arthritis (RA) affected joints leads to the formation of bone lesions. Reconstruction and analysis of protein interaction networks underlying specific disease phenotypes are essential...

["Bioinformatics","Computational Biology","Genomics","Immunology","Rheumatology"]
doi:10.7717/peerj.5743
69 downloads
337 views

Objective The benefits of IL-35 treatment have been verified in multiple animal models of diseases, while its influence on T cells immunity under normal condition still needs to be elucidated. The present study was designed to investigate the effects modulating...

["Immunology","Translational Medicine"]
doi:10.7717/peerj.5638
98 downloads
824 views

Background Silver nanoparticles (AgNPs) have been widely used in many commercial products due to their excellent antibacterial ability. The AgNPs are released into the environment, gradually accumulate in the ocean, and may affect animals at high trophic levels,...

["Toxicology","Veterinary Medicine","Immunology","Ecotoxicology","Environmental Contamination and Remediation"]
doi:10.7717/peerj.5432
84 downloads
388 views

Background Minimal change disease (MCD) is a form of idiopathic nephrotic syndrome. Compared to children, adult-onset MCD patients are reported to have delayed responses to glucocorticoid treatment. Several studies of children have suggested detecting urinary CD80...

["Immunology","Nephrology"]
doi:10.7717/peerj.5400
1 citation
92 downloads
444 views

Background Pemphigus is a common life-threatening, autoimmune bullous disease effecting both cutaneous and mucous membranes. Previous diagnosis of pemphigus is based on clinical presentations, histopathology, immunofluorescence and enzyme-linked immunosorbent assay....

["Allergy and Clinical Immunology","Dermatology","Immunology"]
doi:10.7717/peerj.5388
130 downloads
377 views

Disease relapse occurs in unrelated cord blood transplantation (CBT) even when the alleles of human leukocyte antigen (HLA) are fully matched between donor and recipient. This is similar to that observed in other types of hematopoietic stem cell transplantation....

["Immunology"]
doi:10.7717/peerj.5228
100 downloads
702 views

Background Buruli ulcer is a disease of the skin and soft tissues caused by infection with a slow growing pathogen, Mycobacterium ulcerans. A vaccine for this disease is not available but M. ulcerans possesses a giant plasmid pMUM001 that harbours the polyketide...

["Microbiology","Immunology","Infectious Diseases"]
doi:10.7717/peerj.5294
135 downloads
558 views

Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts are non-responsive...

["Bioinformatics","Immunology","Oncology"]
doi:10.7717/peerj.5056
79 downloads
312 views

Background The importance of circulating antibodies as biomarkers of kidney disease has recently been recognized. However, no study has systematically described the methodology of sample preparation and storage regarding antibodies as biomarkers of kidney disease....

["Immunology","Internal Medicine","Nephrology"]
doi:10.7717/peerj.5178
132 downloads
581 views

HLA class II proteins are important elements of human adaptive immune recognition and are associated with numerous infectious and immune-mediated diseases. These highly variable molecules can be classified into DP, DQ and DR groups. It has been proposed that in...

["Computational Biology","Immunology"]
doi:10.7717/peerj.5118
113 downloads
612 views

Ovine footrot is a degenerative disease of sheep feet leading to the separation of hoof-horn from the underlying skin and lameness. This study quantitatively examined histological features of the ovine interdigital skin as well as their relationship with pro-inflammatory...

["Agricultural Science","Veterinary Medicine","Immunology","Histology"]
doi:10.7717/peerj.5097

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