Peer-reviewed Articles - Medicine

19 downloads
187 views

Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure...

["Dentistry","Epidemiology","Immunology","Public Health","Rheumatology"]
doi:10.7717/peerj.5109
63 downloads
183 views

Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that has caused tremendous economic losses worldwide. In this study, we designed a chimeric nanoparticles (CNPs) vaccine that displays the predominant epitope of the serotype O...

["Bioengineering","Biotechnology","Immunology"]
doi:10.7717/peerj.4823
58 downloads
939 views

Background Epidemiologic data supporting the epilepsy–asthma association are insufficient. Therefore, we examined this association in this study. Methods By using claims data from the National Health Insurance Research Database (Taiwan), we executed a retrospective...

["Epidemiology","Immunology","Internal Medicine","Neurology"]
doi:10.7717/peerj.4792
73 downloads
452 views

Background Periodontitis is associated with increased concentration of inflammatory markers and saliva has been proposed as a non-invasive diagnostic fluid in oral and systemic diseases. The levels of salivary biomarkers, such as cytokines, could potentially be...

["Dentistry","Epidemiology","Immunology","Nursing"]
doi:10.7717/peerj.4710
64 downloads
325 views

Objectives To evaluate the outcomes of patients with rheumatoid arthritis (RA) of the knee who underwent five portal arthroscopic synovectomy, with or without post-operative negative pressure drainage (NPD). Material and Methods A prospective clinical trial was...

["Clinical Trials","Immunology","Orthopedics","Rheumatology"]
doi:10.7717/peerj.4727
116 downloads
489 views

Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors. Early studies of serpins focused on their functions in haemostasis...

["Biochemistry","Microbiology","Parasitology","Immunology"]
doi:10.7717/peerj.4557
94 downloads
514 views

Background Kawasaki disease (KD) is an immune-mediated systemic vasculitis, and infection plays an important role in the pathophysiology of KD. The susceptibility to infectious disease in patients with KD remains largely unclear. This study aimed to investigate...

["Allergy and Clinical Immunology","Cardiology","Immunology","Infectious Diseases","Pediatrics"]
doi:10.7717/peerj.4539
70 downloads
337 views

Background The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx...

["Dentistry","HIV","Immunology","Pathology"]
doi:10.7717/peerj.4407
118 downloads
598 views

This study assessed in detail the influence of four different human proteins on the activation of CD4+ and CD8+ T lymphocytes and on the formation of regulatory T cells. Human whole-blood samples were incubated with four different human proteins. The effects of...

["Allergy and Clinical Immunology","Immunology","Internal Medicine","Pathology","Pediatrics"]
doi:10.7717/peerj.4462
442 downloads
1,680 views

The Centers for Disease Control and Prevention (CDC) and many public health jurisdictions continue to advocate for the most sensitive rapid HIV test that is available. Currently, the recommendation is to utilize tests that can detect HIV infection biomarkers within...

["Biotechnology","HIV","Immunology","Infectious Diseases","Public Health"]
doi:10.7717/peerj.4430
86 downloads
379 views

Obesity and sleep fragmentation (SF) are often co-occurring pro-inflammatory conditions in patients with obstructive sleep apnea. Leptin is a peptide hormone produced by adipocytes that has anorexigenic effects upon appetite while regulating immunity. The role...

["Diabetes and Endocrinology","Immunology","Neurology"]
doi:10.7717/peerj.4423
90 downloads
389 views

Background Systemic lupus erythematosus (SLE) disease has been shown to be associated with the generation of multiple auto-antibodies. Among these, anti-dsDNA antibodies (anti-DNAs) are specific and play a pathogenic role in SLE. Indeed, anti-DNA+ SLE patients...

["Cell Biology","Immunology","Rheumatology"]
doi:10.7717/peerj.4294
152 downloads
775 views

Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2. In order to be functional,...

["Biochemistry","Cell Biology","Immunology","Nutrition"]
doi:10.7717/peerj.4212
171 downloads
542 views

Background Autoimmune thyroid disease (AITD), which is characterized by an increased presence of thyroid autoantibodies (TAbs), such as antibodies against thyroid peroxidase (TPOAbs) and antibodies against thyroglobulin (TgAbs), has been reported to be associated...

["Diabetes and Endocrinology","Immunology","Rheumatology"]
doi:10.7717/peerj.4216
119 downloads
454 views

In this study, equine source polyclonal anti-Bacillus anthracis immunoglobulins were generated and utilized to demonstrate passive protection of mice in a lethal challenge assay. Four horses were hyper-immunized with B. anthracis Sterne strain for approximately...

["Immunology","Infectious Diseases"]
doi:10.7717/peerj.3907

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